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Excess pore pressure behavior and evolution in deep coalbed methane reservoirs

International Journal of Mining Science and Technology 2024年第6期34卷 763-781页

作者： Changqing liu Zhaobiao yang Yong qin Xia yan Yunhai Wang Zhe Wang Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process Ministry of EducationChina University of Mining and TechnologyXuzhou 221008China School of Resources and Geosciences China University of Mining and TechnologyXuzhou 221116China National Engineering Research Center of Coalbed Methane Development&Utilization Beijing 100095China PetroChina Coalbed Methane Company Limited Beijing 102200China SINOPEC East China Oil and Gas Company Nanjing 210000China

Deep coalbed methane(DCBM),an unconventional gas reservoir,has undergone significant advancements in recent years,sparking a growing interest in assessing pore pressure dynamics within these *** some production data analysis techniques have been adapted from conventional oil and gas wells,there remains a gap in the understanding of pore pressure generation and evolution,particularly in wells subjected to large-scale hydraulic *** address this gap,a novel technique called excess pore pressure analysis(EPPA)has been introduced to the coal seam gas industry for the first time to our knowledge,which employs dual-phase flow principles based on consolidation *** technique focuses on the generation and dissipation for excess pore-water pressure(EPWP)and excess pore-gas pressure(EPGP)in stimulated deep coal *** have been developed respectively and numerical solutions have been provided using the finite element method(FEM).Application of this model to a representative field example reveals that excess pore pressure arises from rapid loading,with overburden weight transferred under undrained condition due to intense hydraulic fracturing,which significantly redistributes the weight-bearing role from the solid coal structure to the injected fluid and liberated gas within artificial pores over a brief ***,field application indicates that the dissipation of EPWP and EPGP can be actually considered as the process of well production,where methane and water are extracted from deep coalbed methane wells,leading to consolidation for the artificial ***,history matching results demonstrate that the excess-pressure model established in this study provides a better explanation for the declining trends observed in both gas and water production curves,compared to conventional practices in coalbed methane reservoir engineering and petroleum *** research not only enhances the understanding of DCBM re

关键词： Deep coalbed methane Consolidation Excess pore-water pressure Excess pore-gas pressure Production data analysis

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Reheat effect on the improvement in efficiency of the turbine driven by pulse detonation

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Defence Technology（防务技术） 2024年第1期31卷 200-210页

作者： Junyu liu Zhiwu Wang Zixu Zhang Junlin Li Weifeng qin Jingjing Huang School of Power and Energy Northwestern Polytechnical UniversityXi’an 710072China Shenzhen Research Institute of Northwestern Polytechnical University Shenzhen 518057China Mechanical Engineering College Xi’an Shiyou UniversityXi’an 710065China

Due to the strong unsteadiness of pulse detonation,large flow losses are generated when the detonation wave interacts with the turbine blades,resulting in low turbine *** that the flow losses are dissipated into the gas as heat energy,some of them can be recycled during the expansion process in subsequent stages by the reheat effect,which should be helpful to improve the detonationdriven turbine *** this into account,this paper developed a numerical model of the detonation chamber coupled with a two-stage axial turbine,and a stoichiometric hydrogen-air mixture was *** improvement in turbine efficiency attributable to the reheat effect was calculated by comparing the average efficiency of the stages with the efficiency of the two-stage *** research indicated that the first stage was critical in suppressing the flow unsteadiness caused by pulse detonation,which stabilized the intake condition of the second stage and consequently allowed much of the flow losses from the first stage to be recycled,so that the efficiency of the two-stage turbine was *** a 95%confidence level,the efficiency improvement was stable at 4.5%—5.3%,demonstrating that the reheat effect is significant in improving the efficiency of the detonation-driven turbine.

关键词： Pulse detonation turbine engine Hydrogen detonation Turbine efficiency Reheat effect Multi-cycle detonation

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Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO liu-jing liu Li-ya CHEN You-qin HAN Yu-ying WEI Li-hui yaO Meng-ying FANG Yi WU Mei-zhu CHENG Ying Thomas J.Sferra liu Hui-xin LI Li PENG Jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (P<0.05). PNO1 overexpression attenuated the effects of PZH treatment, including the expression of p53 and p21, cell growth, cell viability, cell cycle arrest and cell apoptosis in vitro (P<0.05). PNO1 knockdown eliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (P<0.05). Similarly, PNO1 knockdown attenuated the effects of PZH treatment on the down-regulation of PNO1 and up-regulation of p53 and p21 in vivo (P<0.05).ConclusionThe mechanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： liu Xiao-rong LI Shuo-fu MEI Wen-ya liu Xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(P<0.05).Isorhamnetin downregulated the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1βin RA-FLS(P<0.05).The overexpression of either MMP2 or MMP9 reversed isorhamnetin-inhibited RA-FLS migration and invasion,as well as the levels of TNF-α,IL-6,and IL-1β(P<0.05).Furthermore,isorhamnetin bound to SRC and reduced the phosphorylation of SRC,ERK,and CREB(P<0.05).SRC overexpression reversed the inhibitory effect of isorhamnetin on RA-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

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Scale offers the possibility of identifying adherence to lifestyle interventions in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第25期30卷 3179-3181页

作者： Cen-qin liu Bing Hu Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology/Medical Engineering Integration Laboratory of Digestive Endoscopy West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disorder,and dietary and lifestyle interventions remain the mainstays of NAFLD *** et al established a prediction system to evaluate adherence to lifestyle interventions in patients with NAFLD and choose optimal ***,we discuss the application scenarios of the scale and the areas warranting further attention,aiming to provide a possible reference for clinical recommend-ations.

关键词： Nonalcoholic fatty liver disease Dietary and lifestyle interventions Scale Adherence Exercise

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Recent progress on rapid diagnosis of COVID-19 by point-of-care testing platforms

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Chinese Chemical Letters 2024年第3期35卷 66-75页

作者： ya-Nan Tang Dingding Jiang Xuejun Wang Yunqi liu Dacheng Wei State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Institute of Molecular Materials and Devices Fudan UniversityShanghai 200433China

The outbreak of COVID-19 has drawn great attention around the ***-CoV-2 is a highly infectious virus with occult transmission by many mutations and a long incubation *** particular,the emergence of asymptomatic infections has made the epidemic even more ***,early diagnosis and timely management of suspected cases are essential measures to control the spread of the *** simple,portable,and accurate diagnostic techniques for SARS-CoV-2 is the key to epidemic *** advantages of point-of-care testing technology make it play an increasingly important role in viral detection and *** review summarizes the point-of-care testing platforms developed by nucleic acid detection,immunological detection,and nanomaterial-based biosensors ***,this paper provides a prospect for designing future highly accurate,cheap,and convenient SARS-CoV-2 diagnostic technology.

关键词： COVID-19 Point-of-care testing platforms Nucleic acid detection Asymptomatic infection Biosensors

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Electrically-driven ultrafast out-of-equilibrium light emission from hot electrons in suspended graphene/hBN heterostructures

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International Journal of Extreme Manufacturing 2024年第1期6卷 328-338页

作者： Qiang liu Wei Xu Xiaoxi Li Tongyao Zhang Chengbing qin Fang Luo Zhihong Zhu Shiqiao qin Mengjian Zhu Kostya S Novoselov College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano-optoelectronic Information Materials and Devices National University of Defense TechnologyChangshaHunan 410073People’s Republic of China Nanhu Laser Laboratory National University of Defense TechnologyChangshaHunan 410073People’s Republic of China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006People’s Republic of China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006People’s Republic of China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006People’s Republic of China Institute for Functional Intelligent Materials National University of SingaporeSingapore 117544Singapore Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

Nanoscale light sources with high speed of electrical modulation and low energy consumption are key components for nanophotonics and *** record-high carrier mobility and ultrafast carrier dynamics of graphene make it promising as an atomically thin light emitter which can be further integrated into arbitrary platforms by van der Waals ***,due to the zero bandgap,graphene is difficult to emit light through the interband recombination of carriers like conventional ***,we demonstrate ultrafast thermal light emitters based on suspended graphene/hexagonal boron nitride(Gr/hBN)*** in biased graphene are significantly heated up to 2800 K at modest electric fields,emitting bright photons from the near-infrared to the visible spectral *** eliminating the heat dissipation channel of the substrate,the radiation efficiency of the suspended Gr/hBN device is about two orders of magnitude greater than that of graphene devices supported on SiO2or *** demonstrate that hot electrons and low-energy acoustic phonons in graphene are weakly coupled to each other and are not in full thermal *** cooling ofhigh-temperature hot electrons to low-temperature acoustic phonons is enabled by the significant near-field heat transfer at the highly localized Gr/hBN interface,resulting in ultrafast thermal emission with up to 1 GHz bandwidth under electrical *** is found thatsuspending the Gr/hBN heterostructures on the SiO2trenches significantly modifies the light emission due to the formation of the optical cavity and showed a~440%enhancement inintensity at the peak wavelength of 940 nm compared to the black-body thermal *** demonstration of electrically driven ultrafast light emission from suspended Gr/hBNheterostructures sheds the light on applications of graphene heterostructures in photonicintegrated circuits,such as broadband light sources and ultrafast thermo-optic phase modulat

关键词： suspended graphene ultrafast light emitter van der Waals heterostructures thermal radiation electron–phonon interaction

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Kaempferol ameliorated levodopa-induced dyskinesia in experimental rats: A role of brain monoamines, cFOS, FosB, Parkin, Pdyn, TH, and p-JNK

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BIOCELL 2024年第3期48卷 513-523页

作者： PEI qin MIAO liu XIN WANG JIANHUA MA Geriatrics Department Chengde Central HospitalChengde067000China

Background:L-dopa(Levodopa)is well known for managing PD(Parkinson’s disease);however,its prolonged use caused dyskinesia(LID).Due to the varied presentation of LID,effective treatment options are *** reported their neuroprotective activity by ameliorating acetylcholinesterase,monoamine oxidase,and neuroinﬂ*** is anotherﬂavonoid bearing these ***:To evaluate neuroprotective activity of kaempferol in dyskinetic ***:PD was developed in Sprague-Dawley rats by injecting combination of L-ascorbic acid(10µL)+6-OHDA(12µg)in medial forebrain bundle to induce neuronal damage in substantial nigra(SNr).LID was induced by administrating combination of L-dopa(20 mg/kg)+benserazide HCl(5 mg/kg)for 42 *** were concomitantly treated with amantadine(40 mg/kg)or kaempferol(25,50,and 100 mg/kg,p.o.).Results:Kaempferol(50 and 100 mg/kg)markedly(p<0.05)inhibited LID-induced abnormal involuntary movements(AIMs)and alternation in motor *** administration considerably(p<0.05)inhibited reduced mitochondrial complex activities,serotonin and dopamine levels,Bcl-2,and Tyrosine hydroxylase protein expressions in ***,kaempferol considerably(p<0.05)attenuated increased cFOS,FosB,Parkin,and Pdyn mRNAs expressions,Bax,cleaved caspase-3,caspase-3,and pJNK proteins levels;DOPAC and 5-HIAA levels in SNr.A positive correlation was reported between cFOS,FosB,Parkin,Pdyn,apoptosis,and TH with ***:Kaempferol effectively attenuated L-dopa-induced AIMs and dyskinesia via amelioration of alterations in cFOS,FosB,Parkin,Pdyn,Tyrosine hydroxylase,and apoptosis in the brain SNr.

关键词： AIMs cFOS Kaempferol Levodopa-induced dyskinesia Pdyn

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An investigation on topologies of hybrid manifold,impinging-jet nozzle and micro-pin-fin heat sinks

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Science China(Technological Sciences) 2024年第4期67卷 1061-1076页

作者： SHI QianLei yaO XiaoLe liu Qian qin Le JU Xing XU Chao Key Laboratory of Power Station Energy Transfer Conversion and System of MOE North China Electric Power UniversityBeijing 102206China

The hybrid manifold micro-pin-fin(MMPF)heat sink combined nozzle jets is an option for large-scale integrated circuits(LSI).The demond for uniform and ultra-high heat flux removal by MMPF heat sink has not been adequately *** work aims to solve the problem of fluid *** proposed basic tiling topologies,including square,regular hexagon,30°rhombus,and 60°rhombus topologies,provide different organized fluid flows and heat transfer *** present study focuses on comparing these topologies according to independent porous medium parameters,such as nozzle pore size D_(Z),flow pore size D_(X,Y),and porosityε.The results show that the square topology achieves the smallest total thermal resistance R_(tot)value of0.0975×10^(-4)K m^2/W,while the hexagon topology achieved the highest value of COP/?T,which was 2033.9 K^(-1).According to the sensitivity analysis results,the optimal total thermal resistance can be obtained by balancing the influences of nozzle pore size,flow pore size,and *** optimal pressure drop can be obtained by maximizing the porosity.

关键词： heat sink ultra-high heat flux manifold micro-pin-fin impinging-jet topology

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A residual denoising and multiscale attention-based weighted domain adaptation network for tunnel boring machine main bearing fault diagnosis

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Science China(Technological Sciences) 2024年第8期67卷 2594-2618页

作者： ZHONG Tao qin ChengJin SHI Gang ZHANG ZhiNan TAO JianFeng liu ChengLiang State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

As a critical component of a tunnel boring machine(TBM),the precise condition monitoring and fault analysis of the main bearing is essential to guarantee the safety and efficiency of the TBM cutter ***,under conditions of strong noise and complex working environments,traditional signal decomposition and machine learning methods struggle to extract weak fault features and achieve high fault classification *** address these issues,we propose a novel residual denoising and multiscale attention-based weighted domain adaptation network(RDMA-WDAN)for TBM main bearing fault *** approach skillfully designs a deep feature extractor incorporating residual denoising and multiscale attention modules,achieving better domain adaptation despite significant domain *** residual denoising component utilizes a convolutional block to extract noise features,removing them via residual ***,the multiscale attention module uses a 4-branch convolution and 3 pooling strategy-based channel–spatial attention mechanism to extract multiscale features,concentrating on deep fault *** training,a weighting mechanism is introduced to prioritize domain samples with clear fault *** optimizes the deep feature extractor to obtain common features,enhancing domain adaptation.A low-speed and heavy-loaded bearing testbed was built,and fault data sets were established to validate the proposed *** experiments show that in noise domain adaptation tasks,proposed the RDMA–WDAN significantly improves target domain classification accuracy by 42.544%,23.088%,43.133%,16.344%,5.022%,and 9.233%over dense connection network(DenseNet),squeeze–excitation residual network(SE-ResNet),antinoise multiscale convolutional neural network(ANMSCNN),multiscale attention module-based convolutional neural network(MSAMCNN),domain adaptation network,and hybrid weighted domain adaptation(HWDA).In combined noise and working condition domain a

关键词： tunnel boring machine(TBM) main bearing fault diagnosis domain adaptation antinoise cross working RDMA-WDAN

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