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Frontiers of Environmental Science & Engineering 2014年第4期8卷 607-615页

作者： min liu Rusong WANG Jinlou HUANG State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

A typical fiver in Yangzhou City was used to study the effects of artificial aeration, eco-brick cover, biological packing cover, and low-sited plant floating beds on the release of heavy metals from urban river sediments. This work showed that 1） the Cr release rate was decreased by 50.3%-89.6%, with an average of 59.3%, thereby reducing the Cr pollution load to the overlying water by 36.6%-82.7%, with an average of 53.3%; 2） the Zn release rate was reduced by 21.0%-88.9%, with an average of 42.3%, and the Zn pollution load of the overlying water was reduced by 38.0%-67.1%, with an average of 55.0%; 3） the Cu release rate was reduced by 27.5%-91.0%, with an average of 55.3%, and the Cu load of the overlying water was reduced by 57.1%-83.7%, with an average of 71.7%; 4） the Pb release rate was reduced by 11.8%- 79.3%, with an average of 41.2%, and the Pb pollution load of the overlying water was reduced by -1.3%-70.7%, with an average of 29.8%. We also found that the effects of in situ biological treatments on the release of heavy metals were affected by the extent of sediment disturbance. For integrated applications, high-disturbance treatments should be combined with low-disturbance treatments to reduce the explosive release of pollutants caused by sediment disturbance during the treatment operation to achieve better overall treatment effects.

关键词： in situ biological treatments urban river sediment heavy metal pollution

Stream Surface Strip Element Method and Simulation of Three-Dimensional Deformation of Continuous Hot Rolled Strip

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Journal of Iron and Steel Research International 2004年第2期11卷 18-24页

作者： liu Hong-min WANG Ying-rui Yanshan University

A new method,the stream surface strip element method,for simulating the three-dimensional deformation of plate and strip rolling process was *** rolling deformation zone was divided into a number of stream surface(curved surface)strip elements along metal flow traces,and the stream surface strip elements were mapped into the corresponding plane strip elements for analysis and *** longitudinal distributions of the lateral displacement and the altitudinal displacement of metal were respectively constructed to be a quartic curve and a quadratic curve,of which the lateral distributions were expressed as the third-power spline function,and the altitudinal distributions were fitted in the quadratic *** the flow theory of plastic mechanics,the mathematical models of the three-dimensional deformations and stresses of the deformation zone were *** with the streamline strip element method proposed by the first author of this paper,the stream surface strip element method takes into account the uneven distributions of stresses and deformations along altitudinal direction,and realizes the precise three-dimensional analysis and *** simulation example of continuous hot rolled strip indicates that the method and the model accord with facts and provide a new reliable engineering-computation method for the three-dimensional mechanics simulation of plate and strip rolling process.

关键词： hot-rolling strip plate three-dimensional deformation stream surface strip element method unit rolling pressure friction stress tension stress

Rh(Ⅰ)-catalyzed regio-and enantioselective allylic alkylation of Meldrum's acid

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Chinese Chemical Letters 2021年第1期32卷 385-388页

作者： min liu Haiying Zhao Changkun Li Inner Mongolia Key Laboratory of Fine Organic Syrthesis Cllge of Chemistry and Chemical Enginpering Inner Mongolia UniversityHohhor 010021China Shanghai Key Laboratory for Molcular Engineering of Chirnl Drugs School of Chemistry and Chermical Engineering Shanghai Jiao Tong UiversitShanghai 200240China

A Rh(Ⅰ)-catalyzed highly regio-and enantioselective allylic alkylation of Meldrum acid with racemic allylic substrates bearing alkyl groups has been *** applying of chiral bisoxazopinephosphine ligand is essential for the high yields and *** method provides a rapid access to various chiral β-alkyl-γ,δ-unsaturated carboxylic acids and their derivatives.

关键词： Rhodium Bisoxazolinephosphine Allylic substitution Meldrum’s acid Asymmetric catalysis

The dispersion of particles in turbulent semi-circular duct flows

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Petroleum Science 2021年第4期18卷 1240-1255页

作者： min liu Jun Yao Yan-Lin Zhao International Joint Laboratory on Clean Energy Science and Technology College of Mechanical and Transportation EngineeringChina University of Petroleum-BeijingBeijing102249People's Republic of China Beijing Key Laboratory of Process Fluid Filtration and Separation College of Mechanical and Transportation EngineeringChina University of Petroleum-BeijingBeijing102249People's Republic of China

The flow field in a semi-circular duct is simulated by Large Eddy Simulation(LES)and its particle field is simulated by Lagrange particle tracking *** number Reb(based on bulk velocity and hydraulic diameter)is 80,000 and Ret(based on friction velocity and hydraulic diameter)is *** diameter dpis chosen as 10,50,100,500 mm corresponding to St as 0.10,2.43,9.72,*** results show that the intensity of the secondary flow near the ceiling is less than that near the floor because the ceiling is curved and able to inhibit the secondary *** is found that the difference between the semicircular duct and the square duct is that the secondary flow in a corner of the semi-circular duct is not symmetrical along the diagonal although they have the same generation *** the particles,small particles(dp≤10 mm)are found to uniformly distribute in the duct,while large particles(dp≥50 mm)preferentially distribute in the corner and floor *** maximum particles(dp=500mm)fall on the floor quickly and their dispersion mainly depends on the secondary flow near the *** deposition in the corner depends on particle size due to the effect of secondary flow and *** effect of lift force on particles becomes more significant for 50 and 100 mm particles in comparison with other smaller *** the end,the effect of secondary flow is found to be more significant to dominate particle behavior than that of flow fluctuation.

关键词： Semi-circular duct Secondary flow Particle dispersion Turbulence Large eddy simulation

Deformation dependence of symmetry energy coefficients of nuclei

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Science China(Physics,Mechanics & Astronomy) 2015年第8期58卷 33-38页

作者： MO QiuHong liu min CHENG LiChun WANG Ning Department of Physics Guangxi Normal University School of Material Science and Engineering Guilin University of Electronic Technology

Based on the semi-classical Thomas-Fermi approximation together with the Skyrme energy-density functional, we study the deformation dependence of symmetry energy coefficients of finite nuclei. The symmetry energy coefficients of nuclei with mass number A = 40, 100, 150, 208 are extracted from two-parameter parabola fitting to the calculated energy per particle. We find that the symmetry energy coefficients decrease with the increase of nuclear quadrupole deformations, which is mainly due to the isospin dependence of the difference between the proton and neutron surface diffuseness. Large deformations of nuclei can cause the change of the symmetry energy coefficient by about 0.5 Me V and the influence of nuclear deformations on the symmetry energy coefficients is more evident for light and intermediate nuclei.

关键词： symmetry energy Skyrme energy-density functional nuclear deformation Thomas-Fermi

A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors

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Acta Pharmaceutica Sinica B 2021年第3期11卷 750-762页

作者： Yihui Song min Zhao Yahong Wu Bin Yu Hong-min liu School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China School of Life Sciences Zhengzhou UniversityZhengzhou 450001China

The protein tyrosine phosphatase Src homology phosphotyrosyl phosphatase 2(SHP2) is implicated in various cancers, and targeting SHP2 has become a promising therapeutic approach. We herein described a robust cross-validation high-throughput screening protocol that combined the fluorescence-based enzyme assay and the conformation-dependent thermal shift assay for the discovery of SHP2 inhibitors. The established method can effectively exclude the false positive SHP2 inhibitors with fluorescence interference and was also successfully employed to identify new protein tyrosine phosphatase domain of SHP2(SHP2-PTP) and allosteric inhibitors. Of note, this protocol showed potential for identifying SHP2 inhibitors against cancer-associated SHP2 mutation SHP2-E76 A. After initial screening of our in-house compound library(w2300 compounds), we identified 4 new SHP2-PTP inhibitors(0.17%hit rate) and 28 novel allosteric SHP2 inhibitors(1.22% hit rate), of which SYK-85 and WS-635 effectively inhibited SHP2-PTP(SYK-85: IC_(50) Z 0.32 mmol/L;WS-635: IC_(50) Z 4.13 mmol/L) and thus represent novel scaffolds for designing new SHP2-PTP inhibitors. TK-147, an allosteric inhibitor, inhibited SHP2 potently(IC_(50) Z 0.25 mmol/L). In structure, TK-147 could be regarded as a bioisostere of the well characterized SHP2 inhibitor SHP-099, highlighting the essential structural elements for allosteric inhibition of SHP2. The principle underlying the cross-validation protocol is potentially feasible to identify allosteric inhibitors or those inactivating mutants of other proteins.

关键词： SHP2 High-throughput screening Enzyme assay Thermal shift assay Allosteric inhibitors

Homologous fault monitoring technology of redundant INS in airborne avionics systems

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Journal of Systems Engineering and Electronics 2013年第6期24卷 1038-1044页

作者： Xiuzhi Wu Jizhou Lai min liu Pin Lv College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Redundant technology plays an important role in improving the reliability and fault-tolerance of the airborne avionics systems. A Markov state transition model is introduced to the reliability analysis of the redundant inertial navigation system （RINS） in airborne navigation systems. An information processing mechanism based on difference filtering is put forward to strengthen the consistency between the outputs of the equal-precision inertial navigation system （INS）. On this basis, the homologous fault monitoring algorithm is designed to realize the homologous fault monitoring of RINS. The simulation is carried out based on the above algorithms, and the results verify the effectiveness of the proposed fault monitoring algorithm based on difference filtering. Research results have good reference value for the configuration and design of RINS in airborne integrated avionics systems.

关键词： inertial navigation redundant configuration difference filtering homologous fault monitoring

Progress in Enclave Tourism Study of Overseas:A Literature Review

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Chinese Journal of Population,Resources and Environment 2007年第3期5卷 76-81页

作者： liu Aili liu Jiaming liu min Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Graduate University of Chinese Academy of Sciences Beijing 100039 China

In response to the "isolated island" phenomenon emerging from the development of tourist resorts in China, this paper reviews the study of enclave tourism overseas, which has similar features to the resort "island". Based on the literatures related to enclave tourism from Tourism Management and Annals of Tourism Research, this paper reviews the study of enclave tour- ism from the following aspects: definition discussion, theories used, causation of enclaves, characteristics and impacts of enclave tourism. The understanding of the overseas researches on enclave tourism would provide instructions for the study on the problems of Chinese resorts, such as enclavity and "island effects", and suggest measures for the sustainable development of resorts in China. This paper is divided into three sections. Section 1 briefly introduces the development of enclave tourism in developing countries and the outline of enclave tourism study. Section 2 elaborates on the contents of enclave tourism research and gives deep insights into the study on concepts, characteristics, causations and effects respectively, which is the key part of this paper; Section 3 concludes the review and proposes suggestions for the enclave tourism study in China.

关键词： enclave tourism characteristics impacts study progress

Global Epidemic of Ebola Virus Disease and the Importation Risk into China: An Assessment Based on the Risk Matrix Method

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Biomedical and Environmental Sciences 2023年第1期36卷 86-93页

作者： SHANG Wei Jing JING Wen Zhan liu Jue liu min School of Public Health Peking UniversityBeijing 100191China

Objective To analyze the global epidemic status of the Ebola virus disease(EVD) and assess the importation risk into *** Data from World Health Organization reports were used. We described the global epidemic status of EVD from 1976–2021, and assessed and ranked the importation risk of EVD from the diseaseoutbreaking countries into China using the risk matrix and Borda count methods, *** From 1976–2021, EVD mainly occurred in western and central Africa, with the highest cumulative number of cases(14,124 cases) in Sierra Leone, and the highest cumulative fatality rate(85%) in the Congo. Outbreaks of EVD have occurred in the Democratic Republic of the Congo and Guinea since 2018. The importation risk into China varies across countries with outbreaks of *** Democratic Republic of the Congo had an extremely high risk(23 Borda points), followed by Guinea and Liberia. Countries with a moderate importation risk were Nigeria, Uganda, Congo, Sierra Leone,Mali, and Gabon, while countries with a low importation risk included Sudan, Senegal, and Co te d’*** China is under the risk of EVD importation with the globalization and severe epidemic status of EVD. Key attention need to be paid to the Democratic Republic of the Congo, Guinea, and Liberia. Therefore, it is necessary to prevent and prepare in advance for importation risk in China.

关键词： Ebola virus disease Infectious disease Importation risk Risk matrix method