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科技期刊青年编辑人才队伍建设现状及发展建议

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天津科技 2024年第1期51卷 52-54页

作者：刘静雅刘惠琴 CancerBiology&Medicien 《中国肿瘤临床》编辑部天津医科大学肿瘤医院国家恶性肿瘤临床医学研究中心天津市恶性肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津300060

为探讨科技期刊青年编辑队伍发展中存在的问题,探寻青年编辑的发展诉求和发展对策,通过文献调研、小型研讨会等形式,采集信息和相关资料,整合归纳科技期刊青年编辑人才培养中面临的问题和发展建议。针对科技期刊青年编辑普遍存在的职业... 详细信息

为探讨科技期刊青年编辑队伍发展中存在的问题,探寻青年编辑的发展诉求和发展对策,通过文献调研、小型研讨会等形式,采集信息和相关资料,整合归纳科技期刊青年编辑人才培养中面临的问题和发展建议。针对科技期刊青年编辑普遍存在的职业认知和定位模糊、综合素质有待提升等问题,提出相应举措,多渠道助力青年编辑成长。

关键词：科技期刊青年编辑人才队伍建设

A Liquid–Solid Interface-Based Triboelectric Tactile Sensor with Ultrahigh Sensitivity of 21.48 kPa-1

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Nano-Micro Letters 2022年第6期14卷 28-38页

作者： jingya liu Zhen Wen Hao Lei Zhenqiu Gao Xuhui Sun Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123People’s Republic of China

Traditional triboelectric tactile sensors based on solid–solid interface have illustrated promising application prospects through optimization ***,the poor sensitivity and reliability caused by hard contact-electrification still poses challenges for the practical *** this work,a liquid–solid interface ferrofluid-based triboelectric tactile sensor(FTTS)with ultrahigh sensitivity is *** on the fluidity and magnetism of ferrofluid,the topography of microstructure can be flexibly adjusted by directly employing ferrofluid as triboelectric material and controlling the position of outward *** date,an ultrahigh sensitivity of 21.48 k Pa;for the triboelectric sensors can be achieved due to the high spike microstructure,low Young’s modulus of ferrofluid and efficient solid–liquid interface *** detection limit of FTTS of 1.25 Pa with a wide detection range to 390 k Pa was also *** addition,the oleophobic property between ferrofluid and poly-tetra-fluoro-ethylene triboelectric layer can greatly reduce the wear and tear,resulting in the great improvement of ***,a strategy for personalized password lock with high security level has been demonstrated,illustrating a great perspective for practical application in smart home,artificial intelligence,Internet of things,etc.

关键词： Ferrofluid Tactile sensor Triboelectric nanogenerator Microstructure Ultrahigh sensitivity

牦牛乳酪蛋白磷酸肽纯化工艺优化及其促钙吸收作用

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现代食品科技 2024年第7期40卷 184-192页

作者：刘静雅王泽郑亮李咪咪陈炼红西南民族大学食品科学与技术学院四川成都610041 炉霍康巴圣德牦牛产业有限公司四川甘孜626500

为了探究牦牛乳酪蛋白磷酸肽(Casein Phosphopeptide,CPP)产品性质和持钙能力,该试验以牦牛乳酪蛋白为原料,采用胰蛋白酶酶解,静态吸附试验确定洗脱剂,同时分析上样量、上样流速、洗脱液浓度对CPP纯化工艺的影响;测定纯化后CPP的基本成... 详细信息

为了探究牦牛乳酪蛋白磷酸肽(Casein Phosphopeptide,CPP)产品性质和持钙能力,该试验以牦牛乳酪蛋白为原料,采用胰蛋白酶酶解,静态吸附试验确定洗脱剂,同时分析上样量、上样流速、洗脱液浓度对CPP纯化工艺的影响;测定纯化后CPP的基本成分、功能性质、体外抑制磷酸钙和亚铁离子沉淀能力;建立低钙小鼠模型,以体质量、脏器指数、血清生化、股骨指数、骨密度和骨钙为指标,探究CPP在小鼠体内促钙吸收能力。结果表明:以0.2 mol/L稀盐酸为洗脱液,上样流速3 mL/min,上样量100 mL条件下获得的CPP纯化效果最优,其氮磷摩尔比为6.8,磷回收率为95.5%,谷氨酸含量18.55%,丝氨酸含量6.01%;体外促钙实验表明纯化后CPP能有效阻止磷酸钙、亚铁离子沉淀;动物实验结果表明:经28 d喂养,所有小鼠内脏指数均在合理范围内,纯化后CPP无慢性毒性,中高剂量组血钙、血磷含量显著高于模型组(P<0.05),碱性磷酸酶(Alkaline Phosphatase,ALP)值极显著低于模型组(P<0.01),高剂量组股骨指数显著高于碳酸钙组(P<0.05),CPP中、高剂量组骨钙、骨密度显著高于模型组(P<0.05)。综上,该实验可为牦牛乳功能性食品开发提供理论依据,为后续牦牛乳生物活性肽的相关研究提供参考。

关键词：牦牛乳酪蛋白磷酸肽纯化工艺促钙吸收

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Co-culture of astrocytes with neurons from injured brain A time-dependent dichotomy

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Neural Regeneration Research 2011年第35期6卷 2768-2772页

作者： Xiaojing Xu Min Wang Jing liu jingya Lv Yanan Hu Huanxiang Zhang Department of Cell Biology Medical College of Soochow University Jiangsu Provincial Key Laboratory of Stem Cell Research Suzhou 215123 Jiangsu Province China

As supportive cells for neuronal growth and development, much effort has been devoted to the role of astrocytes in the normal state. However, the effect of the astrocytes after injury remains elusive. In the present study, neurons isolated from the subventricular zone of injured neonatal rat brains were co-cultured with astrocytes. After 6 days, these astrocytes showed a mature neuron-like appearance and the number of surviving neurons, primary dendrites and total branches was significantly higher than those at 3 days. The neurons began to shrink at 9 days after co-culture with shorter and thinner processes and the number of primary dendrites and total branches was significantly reduced. These experimental findings indicate that astrocytes in the injured brain promote the development of neurons in the early stages of co-culture while these cells reversely inhibit neuronal growth and development at the later states.

关键词： injured brain astrocytes neurons neural plasticity neurogenesis neural regeneration

Metal-free synthesis of N-sulfonylformamidines via skeletal reconstruction of sulfonyl oximonitriles

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Organic Chemistry Frontiers 2022年第3期9卷 627-632页

作者： Feng Li Ziyan Wu Jingjing Wang Siyuan Zhang Jiaxin Yu Zhen Yuan jingya liu Renzeng Shen Yao Zhou Lantao liu Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals College of Chemistry and Chemical EngineeringShangqiu Normal UniversityShangqiuHenan476000P.R.China Hubei Key Laboratory of Pollutant Analysis&Reuse Technology College of Chemistry and Chemical EngineeringHubei Normal UniversityHuangshiHubei435002P.R.China College of Chemistry Zhengzhou UniversityZhengzhouHenan450052P.R.China

We developed for the first time an unprecedented domino reaction of sulfonyl oximonitriles with secondary amines to streamline the synthesis of N-sulfonylformamidines in decent to high yields under mild reaction *** addition,scale-up experiments and late-stage functionalization of drugs were also *** studies indicate that the loss of a cyano-/benzyloxy-group and a sulfonyl migration process are involved in this reaction.

关键词： reaction conditions synthesis

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高新技术企业成长理论和发展机理研究

河南科技 2024年第4期51卷 155-157页

作者：朱燚波刘静雅张怀民李哲辉张瑞河南《创新科技》杂志社河南郑州450003 河南省科学技术协会学会服务中心河南郑州450003 河南省科学技术情报中心河南郑州450003

【目的】梳理高新技术企业相关理论研究现状,找出新的研究方向。【方法】归纳总结高新技术企业相关理论,分析研究不足之处。【结果】得出高新技术企业发展的政策环境要求和制度根源研究的不足。【结论】提出开展高新技术企业政策效应及... 详细信息

【目的】梳理高新技术企业相关理论研究现状,找出新的研究方向。【方法】归纳总结高新技术企业相关理论,分析研究不足之处。【结果】得出高新技术企业发展的政策环境要求和制度根源研究的不足。【结论】提出开展高新技术企业政策效应及度量的相关研究,为高新技术企业的深入开展提供了思路。

关键词：高新技术企业成长理论发展机理

神经肌肉电刺激同步反复促通疗法联合治疗对卒中后偏瘫手功能的影响

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中国老年保健医学 2024年第3期22卷 3-6页

作者：顾彬王文帅诸桥直纪黄富表刘静娅首都医科大学康复医学院 100068 中国康复研究中心北京博爱医院 100068 日本畿央大学 635-0832

目的观察神经肌肉电刺激(NMES)同步反复促通疗法(RFE)联合治疗对卒中后偏瘫手功能的影响。方法选取2022年1月至2023年8月北京博爱医院收治的卒中恢复期偏瘫患者30例为研究对象,随机分为对照组与试验组,每组15例。在常规治疗基础上,对照... 详细信息

目的观察神经肌肉电刺激(NMES)同步反复促通疗法(RFE)联合治疗对卒中后偏瘫手功能的影响。方法选取2022年1月至2023年8月北京博爱医院收治的卒中恢复期偏瘫患者30例为研究对象,随机分为对照组与试验组,每组15例。在常规治疗基础上,对照组采用神经肌肉电刺激治疗,试验组采用神经肌肉电刺激同步反复促通疗法联合治疗,共4周。观察两组患者Fugl-Meyer评定量表上肢部分(FMA-UE)、简易上肢功能检查(STEF)及改良Barthel指数(MBI)的变化,比较两组的治疗效果。结果治疗4周后,两组在FMA-UE、STEF和MBI评分上均较治疗前显著改善(均P<0.001);且试验组在三项评分上均显著优于对照组(均P<0.05)。结论神经肌肉电刺激同步反复促通疗法联合治疗可改善卒中恢复期偏瘫患者手功能和日常生活活动能力。

关键词：神经肌肉电刺激反复促通疗法偏瘫手功能

Asymmetrically ligated single atomic nickel sites for efficient hydrogen peroxide electrosynthesis

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Nano Research 2024年第3期17卷 1094-1100页

作者： Xusheng Cheng Jinwen Hu Wenzhe Shang jingya Guo Cuncun Xin Songlin Zhang Suchan Song Wei liu Yantao Shi State Key laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsSchool of ChemistryDalian University of TechnologyDalian 116024China

Atomic transition-metal-nitrogen-carbon electrocatalysts hold great promise as alternatives to benchmark Pt in the oxygen reduction *** pristine metal centers with quasi square-planar D_(4h) configuration,however,still suffer from unfavorable energetics and thereby strong activity/selectivity trade-off during the catalytic *** we present a ligand-field engineering of single-atom Ni-N-C catalysts to boost the sluggish kinetics via rationally constructing prototypical asymmetrically ligated Ni-N_(3)O_(1) *** as-obtained Ni-supported multi-walled carbon nanotubes with molten salt-treated(defined as Ni/CNS)catalyst delivered an excellent H_(2)O_(2) selectivity(>90%)within a wide potential window(0.2–0.7 V *** hydrogen electrode(RHE))and robust stability(for 10 h)in alkaline *** electron paramagnetic resonance and theoretical analysis rationalize this finding and demonstrate that the broken symmetry facilitates the electron transfer of a σ* to O–O orbital as compared to the Ni-N_(4) counterpart,playing an indispensable role in efficient O_(2) activation.

关键词： broken D4h single nickel sites oxygen reduction H_(2)O_(2)production

Genome-wide CRISPR screening reveals key genes and pathways associated with 20-hydroxyecdysone signal transduction in the silkworm(Bombyx mori)

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Insect Science 2024年第1期31卷 47-58页

作者： Hao Sun jingya Chen Ruolin Wang Dan liu Na Zhang Tong Zhang Ling Jia Sanyuan Ma Qingyou Xia State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqingChina Biological Science Research Center Southwest UniversityChongqingChina

Metamorphosis is a complex developmental process involving multiple pathways and a large number of genes that are regulated by juvenile hormone(JH)and 20-hydroxyecdysone(20E).Despite important progress in understanding various aspects of silkworm biology,the hormone signaling pathway in the silkworm remains poorly ***-wide screening using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)-based libraries has recently emerged as a novel method for analyzing genome function,enabling further research into essential genes,drug targets,and virus-host ***,we constructed a genome-wide CRISPR/Cas9-based library of the silkworm(Bombyx mori)and successfully revealed the genes involved in biotic or abiotic stress factor *** this study,we used our silkworm CRISPR library and large-scale genome-wide screening to analyze the key genes in the silkworm 20E signaling pathway and their mechanisms of *** annotation showed that 20E regulates key proteins in processes that mainly occur in the cytoplasm and *** enrichment analysis showed that 20E can activate phosphorylation and may affect innate immunity,interfere with intracellular nutrition and energy metabolism,and eventually cause cell *** screening results were experimentally validated by generating cells with knockout alleles of the relevant genes,which had increased tolerance to *** findings provide a panoramic overview of signaling in response to 20E in the silkworm,underscoring the utility of genome-wide CRISPR mutant libraries in deciphering hormone signaling pathways and the mechanisms that regulate metamorphosis in insects.

关键词： CRISPR/Cas9 CRISPR library screening ecdysone 20E signal transduction silkworm whole genome editing