检索结果-南通市图书馆

How can we establish animal models of HIV-associated lymphoma?

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2024年第4期7卷 484-496页

作者： Qing Xiao liuyue Zhai Xiaomei Zhang Yi liu Jun Li Xiaoqing Xie Guofa Xu Sanxiu He Huihui Fu Yifeng Tang Fujie Zhang Yao liu Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Department of Hematology-OncologyChongqing University Cancer HospitalChongqingChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina

Human immunodeficiency virus(HIV)infection is strongly associated with a height-ened incidence of *** mirror the natural course of human HIV infection,animal models have been *** models serve as valuable tools to inves-tigate disease pathobiology,assess antiretroviral and immunomodulatory drugs,ex-plore viral reservoirs,and develop eradication ***,there are currently no validated in vivo models of HIV-associated lymphoma(HAL),hampering progress in this crucial domain,and scant attention has been given to developing animal models dedicated to studying HAL,despite their pivotal role in advancing *** re-view provides a comprehensive overview of the existing animal models of HAL,which may enhance our understanding of the underlying pathogenesis and approaches for malignancies linked to HIV infection.

关键词： animal model HIV-associated lymphoma(HAL) human immunodeficiency virus(HIV) immunodeficient mice primate model

Rice gene OsUGT75A regulates seedling emergence under deep-sowing conditions

在线全文

学校读者我要写书评

暂无评论

The Crop Journal 2024年第1期12卷 133-141页

作者： Jia Zhao Siyu liu Xiaoqian Zhao Zhibo Huang Shan Sun Zixuan Zeng Yongqi He Zhoufei Wang The Laboratory of Seed Science and Technology Guangdong Key Laboratory of Plant Molecular BreedingNational Engineering Research Center of Plant Space BreedingSouth China Agricultural UniversityGuangzhou 510642GuangdongChina

Poor seedling emergence is a challenge for direct seeding of rice under deep-sowing field *** we reveal that UDP-glucosyltransferase OsUGT75A promotes rice seedling emergence under deepsowing conditions by increasing shoot *** of OsUGT75A was higher in the middle regions of the shoot and in shoots under deep-sowing *** of free abscisic acid(ABA)and jasmonates(JA)were higher in shoots of OsUGT75A mutants than in those of wild-type plants,and OsUGT75A mutants were more sensitive to ABA and JA *** shoot length was attributed to higher ABA INSENSITIVE 3(OsABI3)expression and lower JASMONATE-ZIM domain protein(OsJAZ)expression in *** extension by OsUGT75A is achieved mainly by promotion of cell *** elite haplotype of OsUGT75A associated with increased shoot length was identified among indica rice ***75A acts to increase seedling emergence under deep-sowing conditions.

关键词： Abscisic acid Deep-sowing Jasmonic acid Rice Shoot length

Highly efficient separation of Sc3+ and Y3+ in acid solution by a graphene oxide membrane with interlayer sieving

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第11期42卷 2166-2171页

作者： Huixiong Jiang Jin-Hang liu Xiudong Chen Xiaohua Cao Xiushen Ye Guosheng Shi School of Chemistry and Chemical Engineering Jiangxi Province Engineering Research Center of Ecological Chemical IndustryJiujiang University Shanghai Applied Radiation Institute State Key Lab.Advanced Special SteelShanghai University Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt LakesChinese Academy of Sciences

Sc and Y are key rare earth elements and are widely used in lamp phosphors,lasers and high-performance ***,highly efficient extraction and separation of Sc3+and Y3+is laborious,harmful,slow,and costly,strongly necessitating more efficient extraction and separation ***,we produced hydrated Sc3+-and hydrated Y3+-controlled graphene oxide（GO） membranes and find that both hydrated cations were completely self-rejected by the *** combining this selfrejection effect of the larger hydrated Y3+-controlled GO membrane and the rapid passage of the membrane through the smaller hydrated Sc3+,we proposed a strategy to separate Sc3+and Y3+by using a hydrated Y3+-controlled GO *** experimental results show that the permeation rate of Sc3+exceeds that of Y3+when the separation factor reaches 4.02,which can be attributed to the interlayer sieving effects of the GO *** finding illustrates the use of a forward osmosis process with a GO membrane for the efficient separation of Sc3+and Y3+by interlayer sieving,which provides a new effective and eco-friendly method for the separation of rare earth elements.

关键词： Forward osmosis Graphene oxide membrane Interlayer spacing Membrane separation Rare earths

Elaidic acid-induced intestinal barrier damage led to gut-liver axis derangement and triggered NLRP3 inflammasome in the liver of SD rats

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第3期13卷 1279-1291页

作者： Hui liu Xuenan Li Lu Li Yucai Li Haiyang Yan Yong Pang Wenliang Li Yuan Yuan College of Food Science and Engineering Jilin UniversityChangchun 130062China School of Public Health Jining Medical UniversityJining 272067China

Previous studies have shown that trans fatty acids(TFA) are associated with several chronic diseases,the gut microbiota is directly influenced by dietary components and linked to chronic *** research investigated the effects of elaidic acid(EA),a typical TFA,on the gut microbiota to understand the underlying mechanisms of TFA-related chronic diseases.16S rDNA gene sequencing on faecal samples from Sprague-Dawley rats were performed to explore the composition change of the gut microbiota by EA gavage for 4 *** results showed that the intake of EA increased the abundance of well-documented harmful bacteria,such as Proteobacteria,Anaerotruncus,Oscillibacter and ***,EA induced translocation of lipopolysaccharides(LPS) and the above pathogenic bacteria,disrupted the intestinal barrier,led to gut-liver axis derangement and TLR4 pathway activation in the ***,EA induced intestinal barrier damage and regulated TLR4-MyD88-NF-κB/MAPK pathways in the liver of SD rats,leading to the activation of NLRP3 inflammasome and inflammatory liver damage.

关键词： Elaidic acid(EA) Gut microbiota Intestinal barrier Gut-liver axis TLR4-MyD88-NF-κB/MAPK pathways NLRP3 inflammasome

Nanostructured ZnO/ZnS with Type-II Hetero-junction for Efficient CO_(2) Photoreduction

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2024年第3期40卷 484-489页

作者： XIAO Qi liu Ting ZHOU Qianhe LI Liangyu CHANG Chuntao GAO Dawei LI Danyang YOU Feifei School of Textile Garment and Design Changshu Institute of TechnologyChangshu 215500P.R.China School of Civil and Environmental Engineering The University of New South WalesAustralia College of Textile and Clothing Yancheng Institute of Technology.Yancheng 224051P.R.China Jiangsu Yueda Cotton Spinning Co. Ltd.Yancheng 224051P.R.China

Photocatalytic CO_(2) reduction driven by solar light is a green approach that can decrease the greenhouse effect induced by high CO_(2) concentration in the atmosphere and generate carbon-based chemicals/fuels as *** this paper,non-metal co-catalysts ZnO/ZnS type-II hetero-junction nanoparticles with a rough surface were prepared through a hydrothermal *** used as a photocatalyst for CO_(2) reduction,the optimal one showed good cycle stability and a higher yield rate of 27.8µmol·g^(−1)·h^(−1) for CO_(2) conversion into *** outstanding catalytic activity originated from i)the rich interfaces between ZnO and ZnS in the nanoscale could significantly reduce the delivery path of carriers and improve the utilization efficiency of photo-excited electron/hole pairs and ii)enriched surface oxygen defects could supply much more reaction active sites for CO_(2) adsorption.

关键词： ZnO/ZnS Photocatalytic CO_(2)reduction Oxygen defect

Apatinib and gamabufotalin co-loaded lipid/Prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第5期14卷 707-721页

作者： Binlong Chen Yanzhong Zhao Zichang Lin Jiahao Liang Jialong Fan Yanyan Huang Leye He Bin liu Health Management Center The Third Xiangya HospitalCentral South UniversityChangsha410013China Department of Urology The Third Xiangya HospitalCentral South UniversityChangsha410013China Department of Laboratory Medicine The Third Xiangya HospitalCentral South UniversityChangsha410013China College of Biology Hunan UniversityChangsha410082China

Due to the non-targeted release and low solubility of anti-gastric cancer agent,apatinib(Apa),a first-line drug with long-term usage in a high dosage often induces multi-drug resistance and causes serious side *** order to avoid these drawbacks,lipid-film-coated Prussian blue nanoparticles(PB NPs)with hyaluronan(HA)modification was used for Apa loading to improve its solubility and targeting ***,anti-tumor compound of gamabufotalin(CS-6)was selected as a partner of Apawith reducing dosage for combinational gastric ***,HA-Apa-Lip@PB-CS-6 NPs were constructed to synchronously transport the two drugs into tumor *** vitro assay indicated that HA-Apa-Lip@PB-CS-6 NPs can synergistically inhibit proliferation and invasion/metastasis of BGC-823 cells via downregulating vascular endothelial growth factor receptor(VEGFR)and matrix metalloproteinase-9(MMP-9).In vivo assay demonstrated strongest anti-tumor growth and liver metastasis of HA-Apa-Lip@PB-CS-6 NPs administration in BGC-823 cells-bearing mice compared with other groups due to the excellent penetration in tumor tissues and outstanding synergistic *** summary,we have successfully developed a new nanocomplexes for synchronous Apa/CS-6 delivery and synergistic gastric cancer(GC)therapy.

关键词： Apatinib Gamabufotalin Lipid/Prussian blue nanoparticles Gastric cancer

Deep Learning and Network Analysis:Classifying and Visualizing Geologic Hazard Reports

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2024年第4期35卷 1289-1303页

作者： Wenjia Li Liang Wu Xinde Xu Zhong Xie Qinjun Qiu Hao liu Zhen Huang Jianguo Chen School of Geography and Information Engineering China University of GeosciencesWuhan430078China Key Laboratory of Geological Survey and Evaluation of Ministry of Education China University of GeosciencesWuhan430078China School of Computer Science China University of GeosciencesWuhan430078China Key Laboratory of Urban Land Resources Monitoring and Simulation Ministry of Natural ResourcesShenzhen518034China Hubei Key Laboratory of Intelligent Vision Based Monitoring for Hydroelectric Engineering China Three Gorges UniversityYichang443002China Wuhan Geomatics Institute Wuhan430074China Faculty of Earth Resources China University of GeosciencesWuhan430074China

If progress is to be made toward improving geohazard management and emergency decision-making,then lessons need to be learned from past geohazard information.A geologic hazard report provides a useful and reliable source of information about the occurrence of an event,along with detailed information about the condition or factors of the *** such reports,however,can be a challenging process because these texts are often presented in unstructured long text formats,and contain rich specialized and detailed *** text classification is commonly used to mine disaster text data in open domains(e.g.,news and microblogs).But it has limitations to performing contextual long-distance dependencies and is insensitive to discourse *** deficiencies are most obviously exposed in long text ***,this paper uses the bidirectional encoder representations from Transformers(BERT),to model long ***,utilizing a softmax layer to automatically extract text features and classify geohazards without manual *** latent Dirichlet allocation(LDA)model is used to examine the interdependencies that exist between causal variables to visualize *** proposed method is useful in enabling the machine-assisted interpretation of text-based ***,it can help users visualize causes,processes,and other geohazards and assist decision-makers in emergency responses.

关键词： geologic hazard network analysis latent dirichlet allocation text classification deep learning

New Benthic Fossils from the Late Ediacaran Strata of Southwestern China

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2024年第2期98卷 311-323页

作者： liu Junping LI Ming TANG Feng ZHAO Jiangtai SONG Sicun ZHOU Ying SONG Xiaohan REN liudong School of Earth Science and Resources China University of GeosciencesBeijing 10083China Yunnan Institute of Geological Survey Kunming 650216China Chinese Academy of Geological Sciences Beijing 10037China Key Laboratory for Stratigraphy and Paleontology MNRCBeijing 10037China School of Earth Science and Engineering Nanjing UniversityNanjing 210093China Department of Earth Sciences University College LondonLondon WC1E 6BTU.K. CAS and Shandong Province Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdaoShandong 266071China Institute of Geology Chinese Academy of Geological SciencesBeijing 10037China

The Jiangchuan Biota from the Jiucheng Member(Mb.)of the Dengying Formation(Fm.),discovered in Jiangchuan,eastern Yunnan,China,is marked by copious macrofossils at the apex of the Ediacaran *** fauna features benthic algae with varied holdfasts and other fossils of indeterminate taxonomic affinity and is compositionally unique compared to the Shibantan and Gaojiashan biotas of the Dengying *** the Miaohe and Wenghui biotas of the Doushantuo Fm.,elsewhere in *** novel benthic saccular macroalgal fossil,named here Houjiashania yuxiensis *** ***.,from the Jiangchuan Biota is based on fossils that are sausage-shaped,elongate,tubular,ranging from 0.3 to 4 cm in length,and up to 0.8 cm in *** terminus is blunt and rounded to an obtuse angle,the other is bent with a spread-out surface resembling a holdfast,suggesting a three-dimensional ***,stipe-shaped outgrowths,likely vestiges of sessile saccular life forms,are prevalent in macroalgal fossils of analogous size and shape,as well as present brown algae Scytosiphonaceae,such as Colpomenia and *** new findings augment the diversity of benthic algae,such as those known from the Early Neoproterozoic Longfengshan Biota in North *** benthic algal macrofossils in the Jiucheng *** to knowledge of Late Ediacaran metaphyte diversification and offer more clues about the evolutionary positioning of primitive *** co-occurrence of numerous planktonic and benthic multicellular algae and planktonic microbes might have facilitated ecologically the more extensive later Cambrian explosion evidenced by the Chengjiang Biota in Yunnan.

关键词： paleophytology benthic saccular algae algal evolution Neoproterozoic Jiucheng Member Jiangchuan Biota Yunnan Province

DEAD-box helicase 17(DDX17)protects cardiac function by promoting mitochondrial homeostasis in heart failure

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2774-2790页

作者： Mingjing Yan Junpeng Gao Ming Lan Que Wang Yuan Cao Yuxuan Zheng Yao Yang Wenlin Li Xiaoxue Yu Xiuqing Huang Lin Dou Bing liu Junmeng liu Hongqiang Cheng Kunfu Ouyang Kun Xu Shenghui Sun Jin liu Weiqing Tang Xiyue Zhang Yong Man Liang Sun Jianping Cai Qing He Fuchou Tang Jian Li Tao Shen The Key Laboratory of Geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijing 100730China Peking University Fifth School of Clinical Medicine Beijing 100730China Department of Laboratory Medicine Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Biomedical Pioneering Innovation Center School of Life SciencesPeking UniversityBeijing 100871China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Cardiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Graduate School of Peking Union Medical College Beijing 100730China Department of Health Care Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Department of Pathology and Pathophysiology and Department of Cardiology at Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310058China Department of Cardiovascular Surgery Peking University Shenzhen HospitalShenzhen 518036China Experimental Technology Center for Life Sciences at Beijing Normal University Beijing 100875China

DEAD-box helicase 17(DDX17)is a typical member of the DEAD-box family with transcriptional cofactor *** DDX17 is abundantly expressed in the myocardium,its role in heart is not fully *** generated cardiomyocyte-specific Ddx17-knockout mice(Ddx17-cKO),cardiomyocyte-specific Ddx17 transgenic mice(Ddx17-Tg),and various models of cardiomyocyte injury and heart failure(HF).DDX17 is downregulated in the myocardium of mouse models of heart failure and cardiomyocyte ***-specific knockout of Ddx17 promotes autophagic flux blockage and cardiomyocyte apoptosis,leading to progressive cardiac dysfunction,maladaptive remodeling and progression to heart *** of DDX17 expression in cardiomyocytes protects cardiac function under pathological *** studies showed that DDX17 can bind to the transcriptional repressor B-cell lymphoma 6(BCL6)and inhibit the expression of dynamin-related protein 1(DRP1).When DDX17 expression is reduced,transcriptional repression of BCL6 is attenuated,leading to increased DRP1 expression and mitochondrial fission,which in turn leads to impaired mitochondrial homeostasis and heart *** also investigated the correlation of DDX17 expression with cardiac function and DRP1 expression in myocardial biopsy samples from patients with heart *** findings suggest that DDX17 protects cardiac function by promoting mitochondrial homeostasis through the BCL6-DRP1 pathway in heart failure.

关键词： DDX17 homeostasis cardiac