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桃红四物汤上调Nrf2/HO-1信号通路减轻去势小鼠心肌缺血再灌注损伤

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中国实验方剂学杂志 2024年第13期30卷 11-19页

作者：杨钰铭祝莹刘常昳程婧何非安徽中医药大学护理学院合肥230012 安徽医科大学第二附属医院合肥230601

目的:探讨桃红四物汤对去势(OVX)雌性小鼠心肌缺血再灌注损伤(MIRI)的影响及机制研究。方法:雌性小鼠建立去势模型后,采用酶联免疫吸附测定法(ELISA)检测小鼠的雌二醇(E2)水平验证去势模型;对成功建立去势模型的小鼠抽取60只随机分为6组... 详细信息

目的:探讨桃红四物汤对去势(OVX)雌性小鼠心肌缺血再灌注损伤(MIRI)的影响及机制研究。方法:雌性小鼠建立去势模型后,采用酶联免疫吸附测定法(ELISA)检测小鼠的雌二醇(E2)水平验证去势模型;对成功建立去势模型的小鼠抽取60只随机分为6组:假手术组、模型组、桃红四物汤低、中、高剂量组(9、18、36 g·kg^(-1))、核因子E2相关因子2(Nrf2)抑制剂组,每组10只;采用激光散斑血流仪验证MIRI模型;采用2,3,5-氯化三苯基四氮唑(TTC)染色法与苏木素-伊红(HE)染色法检测心肌组织病理变化;ELISA检测小鼠血清中肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白Ⅰ(CTnⅠ)、丙二醛(MDA)、超氧化物歧化酶(SOD)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)水平;采用免疫荧光染色法观察Nrf2、血红素加氧酶-1(HO-1)的表达情况;蛋白免疫印迹法(Western blot)检测Nrf2、HO-1与凋亡蛋白B细胞淋巴瘤-2(Bcl-2)、Bcl-2相关X蛋白(Bax)、炎症因子白细胞介素-18(IL-18)、白细胞介素-1β(IL-1β)的表达。结果:与假手术组比较,模型组小鼠血清中CK-MB、CTnⅠ、MDA、IL-6水平升高(P<0.01),SOD、IL-10水平降低(P<0.01),心肌组织TTC染色、HE染色损伤评分增加(P<0.01),心肌组织免疫荧光Nrf2、HO-1的表达减少(P<0.01),心肌组织Nrf2、HO-1、Bcl-2蛋白表达量减少,Bax、IL-18、IL-1β蛋白表达量增加(P<0.01);与模型组比较,桃红四物汤剂量组小鼠血清中CK-MB、CTnⅠ、MDA、IL-6明显下降(P<0.05,P<0.01),SOD、IL-10明显增加(P<0.05,P<0.01),心肌组织的TTC染色、HE染色损伤评分显著降低(P<0.01),心肌组织免疫荧光Nrf2、HO-1的表达增加(P<0.01),心肌组织Nrf2、HO-1、Bcl-2蛋白表达量明显增加(P<0.05,P<0.01),Bax、IL-18、IL-1β蛋白表达量明显减少(P<0.05,P<0.01),其中以桃红四物汤高剂量组效果最为显著;Nrf2抑制剂组小鼠血清中CK-MB、CTnⅠ、MDA、IL-6水平明显升高(P<0.05,P<0.01),SOD、IL-10水平明显降低(P<0.05,P<0.01),心肌组织TTC染色、HE染色损伤评分显著增加(P<0.01),心肌组织免疫荧光Nrf2、HO-1的表达显著减少(P<0.01),心肌组织Nrf2、HO-1、Bcl-2蛋白表达量明显减少,Bax、IL-18、IL-1β蛋白表达量显著增加(P<0.01)。结论:桃红四物汤能够减轻去势小鼠心肌缺血再灌注损伤,减轻氧化应激反应,减少炎症因子释放并抑制组织凋亡,对去势MIRI小鼠发挥保护作用,并且该保护作用可能与激活Nrf2/HO-1信号通路有关。

关键词：桃红四物汤心肌缺血再灌注损伤炎症因子凋亡去势

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改性芦苇材料的吸附脱氮性能及其资源化探究

工业水处理 2024年第8期44卷 122-132页

作者：刘畅益田佳旺张浩东秦哲河北大学生态环境系河北保定071002

为了探究废水中硝酸盐氮的资源化协同白洋淀过剩芦苇资源的高值化利用模式,以芦苇秸秆(Reed straw,RS)为原材料制备胺化改性芦苇秸秆(Modified reed straw,MRS),通过吸附-解吸-再生实验、MRS资源化应用实验和SEM、XPS、FT-IR等表征手段... 详细信息

为了探究废水中硝酸盐氮的资源化协同白洋淀过剩芦苇资源的高值化利用模式,以芦苇秸秆(Reed straw,RS)为原材料制备胺化改性芦苇秸秆(Modified reed straw,MRS),通过吸附-解吸-再生实验、MRS资源化应用实验和SEM、XPS、FT-IR等表征手段,探究了MRS在去除废水中硝酸盐氮及其资源化方面的潜在用途。结果表明,MRS对硝酸盐氮的最大吸附量为8.54 mg/g,其吸附行为符合Freundlich吸附等温模型,吸附过程更符合拟二级吸附动力学模型,经过9次吸附-解吸-再生循环试验后吸附剂的吸附性能没有明显下降,将吸附硝酸盐氮的MRS(MRSNO_(3)^(-))用作肥料对植株生长起到了明显的促进作用,实验土壤的pH无变化。综上,MRS是一种低成本高效无害的硝酸盐吸附剂,通过吸附-解吸-再生-资源化技术路线初步实现了废水中硝酸盐氮的资源化协同白洋淀过剩芦苇资源的高值化利用模式。

关键词：芦苇秸秆资源化吸附剂废水硝酸盐氮

Clinical Features of Spontaneous Remission in the Classic Fever of Unknown Origin:A Retrospective Study

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Chinese Medical Sciences Journal 2022年第2期37卷 134-141页

作者： changyi liu Xiaoqing liu Xiaochun Shi School of Basic Medicine Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Infectious Diseases Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Centre for Tuberculosis Research Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Clinical Epidemiology Unit International Epidemiology NetworkChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To summarize the clinical features of spontaneous remission in classic fever of unknown origin(FUO).Methods Medical records of 121 patients diagnosed with FUO at admission in Peking Union Medical College Hospital between January 2018 and June 2018 were reviewed *** who were discharged without etiological diagnoses were followed for 2 *** clinical features and outcomes of these patients were *** logistic regression was used to analyze related factors of spontaneous remission of *** After excluding 2 patients who lost to follow-up,the etiology of 119 FUO patients were as follows:infectious diseases in 30(25.2%)cases,connective tissue diseases in 28(23.5%)cases,tumor diseases in 8(6.7%)cases,other diseases in 6(5.0%)cases,and unknown diagnoses in 47(39.5%)***,41 patients experienced spontaneous remission of fever(the median time from onset to remission was 9 weeks,ranging from 4 to 39 weeks).In patients with spontaneous remission in FUO,lymphadenopathy was less common clinical manifestation,the levels of inflammatory markers including leukocyte count,neutrophil count,neutrophil ratio,C-reactive protein,and ferritin were lower,and the proportion of CD8 positive T lymphocytes expressing CD38 was *** logistic regression analysis of factors with a P-value<0.05 in univariate analysis shown that white blood cell count(OR:0.S45,95%CI:0.306-0.971,P=0.039),neutrophil count(OR:2.074,95%CI:1.004-4.284,P=0.049),and proportion of neutrophils(OR:0.928,95%Cl:0.871-0.990,P=0.022)were independent significant factors associated with spontaneous remission in *** This study suggested that most patients discharged with undiagnosed classic FUO would remit ***,for patients with stable clinical conditions,follow-up and observation could be the best *** with lower level of some inflammatory factors may have a high likelihood of spontaneous remission in classic FUO.

关键词： fever of unknown origin follow-up spontaneous remission diagnosis

轻度放牧和禁牧草地土壤物理力学性质特征--以夏藏滩滑坡区为例

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干旱区研究 2024年第8期41卷 1364-1372页

作者：张培豪邢光延赵吉美刘昌义胡夏嵩青海大学地质工程学院青海西宁810016 青海大学土木水利学院青海西宁810016 青海大学农牧学院青海西宁810016

为研究轻度放牧和禁牧对黄河上游滑坡分布区草地土壤物理力学性质的影响,本研究选取黄河上游夏藏滩滑坡分布区为研究区,通过开展野外勘察、取样以及室内土壤物理力学性质试验,对比分析了轻度放牧和禁牧对滑坡分布区边坡植物生长和土壤... 详细信息

为研究轻度放牧和禁牧对黄河上游滑坡分布区草地土壤物理力学性质的影响,本研究选取黄河上游夏藏滩滑坡分布区为研究区,通过开展野外勘察、取样以及室内土壤物理力学性质试验,对比分析了轻度放牧和禁牧对滑坡分布区边坡植物生长和土壤物理力学性质的影响。结果表明:禁牧草地植物种类数量、平均覆盖度、平均株高均高于轻度放牧草地,分别增长65.1%、62.8%和13.6%;禁牧草地土壤含水率、根系干重密度、土壤黏聚力均显著高于轻度放牧草地(P<0.05),且轻度放牧草地和禁牧草地土壤黏聚力与根系干重密度均呈显著正相关关系(R^(2)=0.841和0.875,P<0.05)。本研究结果可为有效防治研究区流域河岸边坡坡面水土流失、浅层滑坡等次生地质灾害,提供理论依据和实际指导。

关键词：夏藏滩滑坡草本植物土壤抗剪强度黄河上游

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Building a New-Type Power System to Promote Carbon Peaking and Carbon Neutrality in the Power Industry in China

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Chinese Journal of Urban and Environmental Studies 2022年第2期10卷 29-40页

作者： liu changyi TAN Xin liu Yifang Economic & Technology Research Institute Global Energy Interconnection Development and Cooperation Organization

Power industry is the largest carbon emission sector in ***,this industry will play an important role in achieving the carbon peaking and carbon neutrality goals( "dual carbon " goals)for the whole *** this purpose,it is critical to balance four relationships,*** between carbon mitigation and energy security,carbon peaking in the short term and carbon neutrality in the long term,the coordinated carbon mitigation in power industry and other industries,and technical feasibility and economic *** paper proposes the China's Energy Interconnection scenario to promote carbon peaking and carbon neutrality of the society,which can be divided into three stages,*** carbon emissions before 2030,rapid emission reduction during 2030-2050,and comprehensive carbon neutrality before *** is expected that the power system will achieve zero emissions before other industries and contribute negative emissions afterwards,providing emission space for carbon neutrality in other industries across the *** into the future,China's electricity demand will continue to *** energy will become the main power source,the use of coal-fired power will be gradually reduced,and gas-fired power will undertake the function of peak-load *** progress will be made in forming an overall grid pattern with ultra-high voltage(UHV) grid as the backbone and featuring "west-to-east and north-to-south power transmission,a balanced energy mix,and transnational power interconnection." Finally,this paper discusses a new-type of power system characterized by a high proportion of electricity generated from clean energy,high ratio of electric and electronic equipment,and a high proportion of power transmission and reception,together with summer and winter high load periods,and points out the challenges faced by the new-type power system with a high proportion of renewable energy sources in terms of flexibility,safety,and economic effic

关键词： New-type power system carbon peaking carbon neutrality China’s Energy Interconnection UHV power grid

黄河上游夏藏滩巨型滑坡区根-土复合体理化与强度特性

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干旱区研究 2024年第5期41卷 797-811页

作者：樊秋璇杨馥铖付江涛刘昌义胡夏嵩邢光延赵吉美张培豪青海大学地质工程学院青海西宁810016 青海大学农林科学院青海西宁810016 青海大学农牧学院青海西宁810016

为研究黄河上游夏藏滩巨型滑坡分布区土体理化性质及力学强度特征,本研究通过在该滑坡体不同位置制取植物及土体试样,测定各采样点植物生长量指标、土体密度、含水率、含根量、抗剪强度指标以及营养元素含量等指标;在此基础上,通过采用S... 详细信息

为研究黄河上游夏藏滩巨型滑坡分布区土体理化性质及力学强度特征,本研究通过在该滑坡体不同位置制取植物及土体试样,测定各采样点植物生长量指标、土体密度、含水率、含根量、抗剪强度指标以及营养元素含量等指标;在此基础上,通过采用Spearman相关性分析方法,探讨了该滑坡体不同位置植被类型、土体理化性质以及根-土复合体抗剪强度特征。结果表明:植物种类随海拔高度降低表现出增加趋势,其中优势草本植物为异针茅(Stipa aliena)、黄花棘豆(Oxytropis ochrocephala)、沙蒿(Artemisia desertorum)等3种;滑坡分布区土体pH值呈中性至碱性,有机质、全氮、全磷等3种营养元素含量在滑坡体后缘位置变化幅度相对较大,全钾、碱解氮等其余4种营养元素变化幅度较大但未表现出明显变化规律;土体含水率随海拔高度降低呈先增加后降低,土体密度呈增加的变化趋势,即随海拔降低增加幅度分别为7.05%和5.88%;根-土复合体粘聚力c值与含根量均表现出随海拔高度降低呈先增加后降低的变化趋势;此外,通过采用Spearman相关性分析得到,根-土复合体粘聚力c值与海拔高度之间呈负相关关系,而与含根量、有机质、含水率之间则呈正相关关系。研究结果对防治黄河上游龙羊峡至积石峡流域两岸边坡水土流失、浅层滑坡等地质灾害现象具有实际指导意义。

关键词：黄河上游夏藏滩巨型滑坡土体理化性质根-土复合体抗剪强度

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The Impacts and Adaptation of Climate Extremes on the Power System:Insights from the Texas Power Outage Caused by Extreme Cold Wave

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Chinese Journal of Urban and Environmental Studies 2022年第1期10卷 61-76页

作者： MA Zhiyuan ZHAO Zijian liu changyi YANG Fang WANG Mou Global Energy Interconnection Development and Cooperation Organization (GEIDCO) Research Centre for Sustainable Development Chinese Academy of Social Sciences University of Chinese Academy of Social Sciences Research Institute for Eco-civilization Chinese Academy of Social Sciences

Along with the aggravation of climate change, various weather and climate extreme events(abbreviated as climate extremes) are becoming more frequent. During the transition to the use of clean energy, the power system will show increasingly prominent features such as high ratio of clean energy, high ratio of electrification, and a high proportion of electric and electronic equipment, coupled with summer and winter load peaks. Against this backdrop, this paper studies the impacts of climate extremes on the power system using the Texas power outage as an example,and proposes general adaptation measures to cope with climate extremes. For a start, this paper reviews the power outage in Texas caused by an extreme cold wave across the North America in 2021, and conducts an in-depth analysis of its causes. Then, based on the theoretical framework of disaster risk management, this paper analyzes the weather and climate disaster risks, extreme events, exposure, and vulnerability faced by the power system in the context of climate change and extreme events. Finally, in order to build a new power system, this paper establishes an overall framework for the power system to mitigate and adapt to climate change, and summarizes the key techniques involved in power generation, transmission, distribution, and consumption, as well as key technologies in the fields of power supply, power grid, power load, and energy storage, and the strategies and measures for addressing climate change.

关键词： Weather and climate extremes climate change power system mitigation adaptation

Highly Regional Genes:graph-based gene selection for single-cell RNA-seq data

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Journal of Genetics and Genomics 2022年第9期49卷 891-899页

作者： Yanhong Wu Qifan Hu Shicheng Wang changyi liu Yiran Shan Wenbo Guo Rui Jiang Xiaowo Wang Jin Gu MOE Key Laboratory of Bioinformatics BNRIST Bioinformatics DivisionDepartment of AutomationTsinghua UniversityBeijing 100084China

Gene selection is an indispensable step for analyzing noisy and high-dimensional single-cell RNA-seq(scRNA-seq)*** with the commonly used variance-based methods,by mimicking the human maker selection in the 2D visualization of cells,a new feature selection method called HRG(Highly Regional Genes)is proposed to find the informative genes,which show regional expression patterns in the cell-cell similarity *** mathematically find the optimal expression patterns that can maximize the proposed scoring *** comparison with several unsupervised methods,HRG shows high accuracy and robustness,and can increase the performance of downstream cell clustering and gene correlation ***,it is applicable for selecting informative genes of sequencing-based spatial transcriptomic data.

关键词： Single-cell RNA-sequencing Feature selection Spatially resolved transcriptomic data Regional patterns Graphical models

Study of the Carbon Neutral Path in China: A Literature Review

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Chinese Journal of Urban and Environmental Studies 2023年第2期11卷 21-43页

作者： HOU Fangxin liu Yifang MA Zhiyuan liu changyi ZHANG Shining YANG Fang NIE Yuanhong Global Energy Interconnection Group Co. Ltd Economic Research Institute State Grid Anhui Electric Power Co. Ltd

After the carbon peaking and carbon neutrality goals were proposed, different institutions and scholars carried out research on China’s medium-and long-term mitigation pathways. Through the literature review of China’s research on carbon neutrality, this paper finds that the zero-carbon energy transition is the key to achieving carbon neutrality. The main driving factors of reducing energy-related carbon emissions include the cleanliness of primary and secondary energy supply systems, the electrification of energy consumption and the development of hydrogen energy,energy efficiency improvement, carbon capture and storage(CCS), and negative ***, based on the literature, this paper conducts a quantitative comparative analysis, and selects key indicators for comparative analysis and summary from seven dimensions, including economic and social development, carbon emission pathways, primary energy consumption, final energy consumption, final hydrogen energy consumption, electricity demand and supply, and installed capacity and structure of power generation. Main conclusions are as follows:(i) In terms of carbon emission pathways, the institutions generally believed that China will peak carbon emissions around 2028 and achieve carbon neutrality between 2050 and 2060. Achieving net-zero or near-zero emissions first in the power sector is the key to carbon neutrality across the society;(ii) In terms of energy supply, it is a consensus to increase the proportion of clean energy and reduce carbon emissions from the source. The proportion of clean energy in primary energy will increase to more than 85%, and the proportion of clean energy power generation and installed capacity will reach more than 90%;(iii) In terms of energy use, electricity will become the core of final energy consumption in the future. The predicted electricity consumption across the society will range 14.3–18.4 PWh, and the predicted electrification rate will exceed 65%.

关键词： Carbon peaking carbon neutrality cleanliness electrification