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生物细胞(英文) 2023年第9期47卷 1977-1994页

作者： lingyan lv JING ZHAO XUAN WANG LIUYAN XU YINGYI FAN CHUNHUI WANG HONGQIAO FAN XIAOHUA PEI School of Graduate Beijing University of Chinese MedicineBeijing100029China Department of Breast Beijing University of Chinese Medicine Third Affiliated HospitalBeijing100029China Department of Pharmacy Fangshan Hospital of Beijing University of Chinese MedicineBeijing102488China Department of Breast The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Chest and Breast The Xiamen Hospital of Beijing Universality of Chinese MedicineXiamen361001China

Background:The development and prognosis of breast cancer are intricately linked to psychological *** addition,depression is the most common psychological comorbidity among breast cancer survivors,and reportedly,Fang-Xia-Dihuang decoction(FXDH)can effectively manage depression in such ***,its pharmacological and molecular mechanisms remain ***:Public databases were used for obtaining active components and related *** active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry(UPLC-HRMS).Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related *** docking was used to understand the interactions between main compounds and hub *** addition,an animal model of breast cancer combined with depression was established to evaluate the intervention effect of FXDH and verify the pathways screened by network ***:174 active components of FXDH and 163 intersection targets of FXDH,breast cancer,and depression were ***,methyl ferulate,luteolin,ferulaldehyde,wogonin,and diincarvilone were identified as the principal active components of ***–protein interaction and KEGG enrichment analyses revealed that the phosphoinositide-3-kinase–protein kinase B(PI3K/AKT)and Janus kinase/signal transducer and activator of transcription(JAK2/STAT3)signaling pathways played a crucial role in mediating the efficacy of FXDH for inhibiting breast cancer progression induced by *** addition,in vivo experiments revealed that FXDH ameliorated depression-like behavior in mice and inhibited excessive tumor growth in mice with breast cancer and *** treatment downregulated the expression of epinephrine,PI3K,AKT,STAT3,and JAK2 compared with the control treatment(p<0.05).Molecular docking verified the relationship between the six primary components of FXDH and the three most im

关键词： Fang-Xia-Dihuang decoction Breast cancer Psychological stress Depression Network pharmacology PI3K/AKT JAK2/STAT3

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广西地方猪种质资源保护与开发探究

中国畜禽种业 2024年第9期20卷 60-68页

作者：甘凌秀吕玲燕孙如玉张冰刘瑞鑫张家庆广西农业职业技术大学广西南宁530007 广西壮族自治区畜禽品种改良站广西南宁530001 河南省农业科学院畜牧研究所河南郑州450002

畜禽种业是畜牧业产业的“芯片”,科学地保护、开发与利用好广西地方畜禽种质资源,对广西畜牧业的可持续发展及振兴地方经济具有重要意义。该文对广西地方猪种的品种特性特征、品种保护利用情况进行研究,针对广西地方猪种资源在保护与... 详细信息

畜禽种业是畜牧业产业的“芯片”,科学地保护、开发与利用好广西地方畜禽种质资源,对广西畜牧业的可持续发展及振兴地方经济具有重要意义。该文对广西地方猪种的品种特性特征、品种保护利用情况进行研究,针对广西地方猪种资源在保护与开发利用过程中存在的种质资源保护与开发的重视程度不足、政府部门专项经费拨付不到位、管理者工作队伍业务水平参差不齐等问题,指出应从重视种质资源保护与开发、加强现代生物保种技术应用、改善保种手段、加强人才队伍建设等方面做好保护与开发工作,进而为地方猪种质资源保护与开发利用提供参考。

关键词：广西地方猪种质资源保护开发

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我国环境税法体系的构建分析

理论月刊 2010年第9期 114-116页

作者：吕凌燕中国地质大学政法学院湖北武汉430074

税收作为宏观调控的经济杠杆,在保护生态环境、促进可持续发展方面发挥着积极作用,是一种合法有效的法律调节手段。美国和OECD国家都已成功实施了环境税措施。本文立足我国现行的环境和资源税费制度,借鉴国外的成功经验,并结合我国的实... 详细信息

税收作为宏观调控的经济杠杆,在保护生态环境、促进可持续发展方面发挥着积极作用,是一种合法有效的法律调节手段。美国和OECD国家都已成功实施了环境税措施。本文立足我国现行的环境和资源税费制度,借鉴国外的成功经验,并结合我国的实际情况,提出了完善和构建我国的环境税法律制度的构想,以期为我国有效缓解和解决环境资源问题提供一个新的角度和思路。

关键词：环境法律制度税收

Boosting Electrochemical Urea Synthesis via Constructing Ordered Pd–Zn Active Pair

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Nano-Micro Letters 2024年第11期16卷 529-540页

作者： Weiliang Zhou Chao Feng Xuan Li Xingxing Jiang lingyan Jing Shuai Qi Qihua Huo Miaoyuan lv Xinbao Chen Tianchi Huang Jingwen Zhao Na Meng Hengpan Yang Qi Hu Chuanxin He College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060GuangdongPeople’s Republic of China School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi UniversityShihezi 832003XinjiangPeople’s Republic of China

Electrochemical co-reduction of nitrate(NO_(3)^(-))and carbon dioxide(CO_(2))has been widely regarded as a promising route to produce urea under ambient conditions,however the yield rate of urea has remained ***,we report an atomically ordered intermetallic pallium-zinc(PdZn)electrocatalyst comprising a high density of PdZn pairs for boosting urea *** is found that Pd and Zn are responsible for the adsorption and activation of NO_(3)^(-)and CO_(2),respectively,and thus the co-adsorption and co-activation NO_(3)^(-)and CO_(2) are achieved in ordered PdZn *** importantly,the ordered and well-defined PdZn pairs provide a dual-site geometric structure conducive to the key C-N coupling with a low kinetical barrier,as demonstrated on both operando measurements and theoretical ***,the PdZn electrocatalyst displays excellent performance for the co-reduction to generate urea with a maximum urea Faradaic efficiency of 62.78%and a urea yield rate of 1274.42μg mg^(-1) h^(-1),and the latter is 1.5-fold larger than disordered pairs in PdZn *** work paves new pathways to boost urea electrosynthesis via constructing ordered dual-metal pairs.

关键词： Electrochemical C-N coupling Urea electrosynthesis Intermetallic compounds Geometric structures Active pairs

Effects of Different Enucleation Methods on Developmental Potency of Pig Handmade Clone Reconstructed Embryos

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Animal Husbandry and Feed Science 2016年第3期8卷 134-138页

作者： lv lingyan Lu Xingrong Sun Junming Pan Cuiling Lan Haien Wang Yanling Cui Kuiqing Xie Bingkun Guangxi Key Laboratory of Livestock Genetic Improvement Guangxi Institute of Animal SciencesNanning 530001China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources Cuangxi UniversityNanning 530005China

Effects of different enucleation methods on developmental potency of pig handmade clone（HMC）reconstructed embryo was investigated in the *** compared enucleation efficiency of blind cut method,first polar body（Pb1）positioning method and demecolcine（DM）assisted enucleation,as well as their effects on development of HMC reconstructed *** results showed that overall enucleation efficiency of Pb1 positioning method was significantly higher than that of blind cut method（P〈0.05）.The protuberance rate and overall enucleation efficiency of 0.4μg/mL DM treated group for 60 min was significantly higher than that of other concentrations and time treatment groups（P〈0.05）.For effects on development of HMC reconstructed embryos,there was no significant difference between DM-assisted enucleation and Pb1 positioning *** conclusion,appropriate addition of DM could enhance enucleation efficiency of HMC,which had no significant influence on developmental potency of reconstructed embryos.

关键词： Enucleation methods Pig Handmade clone Developmental potency

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动物手工克隆技术研究进展

基因组学与应用生物学 2014年第6期33卷 1362-1366页

作者：吕玲燕刘庆友谢炳坤石德顺广西壮族自治区畜牧研究所广西家畜遗传改良重点实验室南宁530001 广西大学亚热带生物资源保护利用国家重点实验室南宁530005

动物克隆又称动物无性繁殖技术是动物辅助生殖技术研究领域跨时代的进步,在优秀动物个体复制、濒危动物保护以及细胞分化研究中应用广泛。近年来出现的动物手工克隆技术(handmade cloning,HMC)是应用无透明带去核双半卵进行动物克隆的... 详细信息

动物克隆又称动物无性繁殖技术是动物辅助生殖技术研究领域跨时代的进步,在优秀动物个体复制、濒危动物保护以及细胞分化研究中应用广泛。近年来出现的动物手工克隆技术(handmade cloning,HMC)是应用无透明带去核双半卵进行动物克隆的新方法,HMC技术脱离了昂贵的显微操作系统做到全程手工操作。手工克隆技术的应用大大大简化了核移植的操作程序,提高了核移植的总体效率,核移植向畜牧生产转化又迈进了一大步。作者对手工克隆技术的研究进展,操作程序以及影响手工克隆效率的因素等方面进行了系统综述,并对HMC未来发展进行了展望。

关键词：动物手工克隆无透明带核移植

鼓室注射桉柠蒎肠溶软胶囊联合曲安奈德治疗分泌性中耳炎疗效分析

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中国煤炭工业医学杂志 2014年第9期17卷 1381-1383页

作者：王玉芝吕凌燕山东省聊城市第二人民医院耳鼻喉科 252601

目的探讨鼓室注射桉柠蒎肠溶软胶囊联合曲安奈德治疗分泌性中耳炎的疗效。方法将105例(137耳)诊断为分泌性中耳炎的患者随机分为观察组(52例,68耳)与对照组(53例,69耳),患者在治疗前后均行纯音听阈及声导抗检测。二组患者均给予口服大... 详细信息

目的探讨鼓室注射桉柠蒎肠溶软胶囊联合曲安奈德治疗分泌性中耳炎的疗效。方法将105例(137耳)诊断为分泌性中耳炎的患者随机分为观察组(52例,68耳)与对照组(53例,69耳),患者在治疗前后均行纯音听阈及声导抗检测。二组患者均给予口服大环内酯类药物2周,曲安奈德喷鼻4周。观察组患者同期给予鼓膜穿刺抽出鼓室积液后鼓室内注射桉柠蒎肠溶软胶囊联合曲安奈德。对照组患者给予鼓膜穿刺抽出鼓室积液后鼓室内注射地塞米松。结果观察组总有效率89.71%高于对照组66.67%。观察组纯音听阈改善率为86.76%明显高于对照组改善率57.97%(P<0.05);声导抗检测改善率为92.65%,明显高于对照组改善率63.77%(P<0.05),差异有统计学意义。结论鼓室注射桉柠蒎肠溶软胶囊联合曲安奈德治疗分泌性中耳炎的方法疗效肯定。

关键词：桉柠蒎肠溶软胶囊分泌性中耳炎曲安奈德鼓室注射

同期多平面手术对重度阻塞性睡眠呼吸暂停综合征患者生活质量的影响

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中国煤炭工业医学杂志 2014年第8期17卷 1305-1308页

作者：吕凌燕周宣岩曲喆泰山医学院附属聊城市第二人民医院山东省聊城市252600

目的评价同期多平面手术(鼻腔扩容术和腭咽成形术)对重度阻塞性睡眠呼吸暂停综合征(OSAHS)患者生活质量(QOL)的影响。方法 50例患者经多导睡眠图(PSG)监测确诊为重度OSAHS,术前进行明确的阻塞平面定位,均为多平面阻塞,根据阻塞平面的不... 详细信息

目的评价同期多平面手术(鼻腔扩容术和腭咽成形术)对重度阻塞性睡眠呼吸暂停综合征(OSAHS)患者生活质量(QOL)的影响。方法 50例患者经多导睡眠图(PSG)监测确诊为重度OSAHS,术前进行明确的阻塞平面定位,均为多平面阻塞,根据阻塞平面的不同采取相应的手术方法进行治疗。均采取气管插管全身麻醉下同期行鼻腔扩容术、改良腭垂腭咽成形术及颏舌肌前移舌骨悬吊术。术前和术后12个月分别进行Epworth睡眠量表(Epworth sleepiness scale,ESS)及睡眠呼吸暂停生活质量指数(Sleep apnea quality of life ***)评分,将所获资料进行统计学分析。结果 OSHAS患者术前ESS评分与SAQLI总分及各项评分之间存在显著相关性。术后患者多导睡眠监测参数、ESS和SAQLI评分及其余各项指标均有明显改善(P<0.05),手术治疗总有效率为96%,QOL总体改善率为74%。患者术后均未出现严重并发症,无需行气管切开术。结论根据阻塞平面进行同期多平面手术可有效改善重度OSHAS患者的QOL,同期多平面手术治疗重度OSAHS安全有效。

关键词：阻塞性睡眠呼吸暂停综合征生活质量多平面手术同期

基于UPLC-Q-TOF-MS技术的阿司匹林抵抗血清代谢组学研究

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药学与临床研究 2021年第1期29卷 27-30页

作者：蒋志涛吕玲燕韩怡倪磊南京中医药大学附属张家港医院药学部张家港215600

目的:发现阿司匹林抵抗(AR)的潜在生物标志物,探讨AR可能机理。方法:以金黄地鼠的AR模型为研究对象,采用基于超高效液相色谱-飞行时间质谱(UPLC-Q-TOF-MS)技术的代谢组学方法考察血清中内源性代谢物的变化,采用主成分分析、偏最小二乘... 详细信息

目的:发现阿司匹林抵抗(AR)的潜在生物标志物,探讨AR可能机理。方法:以金黄地鼠的AR模型为研究对象,采用基于超高效液相色谱-飞行时间质谱(UPLC-Q-TOF-MS)技术的代谢组学方法考察血清中内源性代谢物的变化,采用主成分分析、偏最小二乘法及置换检验分析等,确定AR血清中潜在生物标志物。结果:与对照组相比,AR组金黄地鼠血清中有脱氧胆酸、硬脂酸、松香酸、谷氨酰胺、肌酸等11个特异性代谢分子。结论:脱氧胆酸、硬脂酸等11个成分可作为AR的潜在生物标志物,提示AR致病机理可能与脂肪酸生物合成、二次胆汁酸生物合成、氨基酸代谢有关,这为进一步研究药物改善AR奠定基础。

关键词：代谢组学阿司匹林抵抗超高效液相色谱-飞行时间质谱潜在生物标志物