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多元方式赋能乡村文化振兴的实践路径

商业经济 2024年第2期 131-134页

作者：刘凌峰尹巧雨沈阳工业大学马克思主义学院辽宁沈阳110870

在多元方式赋能乡村文化振兴的实践路径中,从文旅融合、艺术乡建及数字化三个层面进行动态调整和深度融合,有助于恢复消失的乡村文化、提振村民的文化自信、构建乡村情感共同体、改进农村社会治理体系。要结合各地域的特色,因地制宜,注... 详细信息

在多元方式赋能乡村文化振兴的实践路径中,从文旅融合、艺术乡建及数字化三个层面进行动态调整和深度融合,有助于恢复消失的乡村文化、提振村民的文化自信、构建乡村情感共同体、改进农村社会治理体系。要结合各地域的特色,因地制宜,注重多元文化的保护,整合各方资源,在不断地探索中寻找更多路径推动多元方式赋能乡村文化振兴。

关键词：多元方式乡村文化振兴实践路径

针灸联合替罗非班对急性进展性脑梗死的疗效研究

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天津医科大学学报 2024年第3期30卷 245-249页

作者：刘勇张美云胡冠群刘玲凤天津医科大学人民医院临床学院天津300070 天津市人民医院神经内科天津300121 河北医科大学附属沧州中西医结合医院神经内科沧州061000

目的:分析针灸联合替罗非班对急性进展性脑梗死的疗效。方法:收集2022年8月至2023年7月来天津市人民医院神经内科就诊的114例急性进展性脑梗死患者为研究对象,采用随机对照研究,按随机数字表法分为联合组和对照组,每组57例;对照组给予... 详细信息

目的:分析针灸联合替罗非班对急性进展性脑梗死的疗效。方法:收集2022年8月至2023年7月来天津市人民医院神经内科就诊的114例急性进展性脑梗死患者为研究对象,采用随机对照研究,按随机数字表法分为联合组和对照组,每组57例;对照组给予阿司匹林联合氯吡格雷“双抗”治疗,联合组给予阿司匹林联合氯吡格雷“双抗”治疗+替罗非班联合针灸治疗;记录并比较两组患者临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、简易智能精神状态检查量表(MMSE)评分、血液流变学指标水平及不良反应。结果:联合组临床总有效率为85.96%(49/57),对照组临床总有效率为68.42%(39/57),联合组显著高于对照组(P0.05);第14天,联合组NIHSS评分显著低于对照组,MMSE评分显著高于对照组(P0.05)。结论:针灸联合替罗非班治疗急性进展性脑梗死患者的疗效显著,有效降低了NIHSS评分,提高了MMSE评分,并改善患者血液流变学指标,用药安全性高。

关键词：针灸替罗非班急性进展性脑梗死神经功能血液流变学

基于密度泛函理论研究聚醚类破乳剂的构效关系

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日用化学工业（中英文） 2024年第5期54卷 499-506页

作者：何海峰孙立梅杨风斌刘凌枫王刚于滨吴达中国石油化工股份有限公司胜利油田分公司孤东采油厂山东东营257237 中国石油化工股份有限公司胜利油田分公司石油工程技术研究院山东东营257029 中国石油化工股份有限公司胜利油田分公司孤岛采油厂山东东营257231 山东大学胶体与界面化学教育部重点实验室山东济南250100

油田采出液处理工艺中化学破乳剂的使用能够大大提升工作效率并且节约成本,其中聚醚类破乳剂的应用最为广泛,研究聚醚类破乳剂的构效关系对于新型破乳剂的研发及应用至关重要。本文首先对几种聚醚类破乳剂和反相破乳剂的破乳效果进行了... 详细信息

油田采出液处理工艺中化学破乳剂的使用能够大大提升工作效率并且节约成本,其中聚醚类破乳剂的应用最为广泛,研究聚醚类破乳剂的构效关系对于新型破乳剂的研发及应用至关重要。本文首先对几种聚醚类破乳剂和反相破乳剂的破乳效果进行了评价和比较,然后根据沥青质分子的结构特点及现有聚醚类破乳剂和反相破乳剂的类型,选取了相应的模型分子,通过密度泛函理论(DFT)中B3LYP/6-31G基组得到其最优分子几何构型和静电势分布图,并利用泛函M062X/6-31G基组计算了聚醚类破乳剂模型分子分别与沥青质模型分子和水分子之间的相互作用能。结合聚醚类破乳剂和反相破乳剂的破乳性能评价结果,进而分析了聚醚类破乳剂的构效关系。结果表明,由理论化学计算结果所推测的破乳剂的破乳性能差异与其实际破乳效果相一致:具有支状结构、聚合度较高的聚醚类破乳剂的效果优于线型结构、聚合度较低的聚醚类破乳剂;酚醛树脂聚醚的破乳效果优于酚胺树脂聚醚,而反相破乳剂中则是多元醇聚醚类反相破乳剂的效果较优。该工作的开展表明采用密度泛函理论进行破乳剂的构效关系研究是可行的,能够为未来新型破乳剂的制备及选用奠定重要的理论基础和提供参考依据。

关键词：原油破乳剂聚醚密度泛函理论构效关系

太极柔力球运动对慢性肾脏病维持性血液透析患者肌力和疲劳状态的影响

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当代医学 2024年第3期30卷 110-113页

作者：陈萍吴剑刘灵峰毛林波李咏梅靖江市人民医院康复医学科江苏泰州214500

目的探讨太极柔力球运动对慢性肾脏病(CKD)维持性血液透析(MHD)患者上下肢肌力和疲乏程度的影响。方法选取2019年12月至2020年12月于靖江市人民医院进行血液透析的60例CKD患者作为研究对象,按照随机数字表法分为实验组与对照组,各30例... 详细信息

目的探讨太极柔力球运动对慢性肾脏病(CKD)维持性血液透析(MHD)患者上下肢肌力和疲乏程度的影响。方法选取2019年12月至2020年12月于靖江市人民医院进行血液透析的60例CKD患者作为研究对象,按照随机数字表法分为实验组与对照组,各30例。对照组采取透析期间脚踏车运动,实验组在对照组基础上进行太极柔力球运动。比较两组上下肢肌力[30 s坐站试验(STS-30)、握力测试(HGS)]及疲劳程度[Piper疲乏修订量表(RPFS)]。结果治疗前,两组HGS、STS-30比较差异无统计学意义;治疗2个月后,实验组HGS高于治疗前,两组STS-30均大于治疗前,且实验组HGS高于对照组,STS-30大于对照组,差异有统计学意义(P<0.05)。治疗前,两组RPFS评分比较差异无统计学意义;治疗2个月后,实验组RPFS评分低于治疗前、对照组,差异有统计学意义(P<0.05)。结论太极柔力球能改善MHD患者上下肢肌力和疲劳状况,值得临床推广应用。

关键词：血液透析太极柔力球体能疲乏程度

The suppression of cervical cancer ferroptosis by macrophages:The attenuation of ALOX15 in cancer cells by macrophages-derived exosomes

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药学学报:英文版 2023年第6期13卷 2645-2662页

作者： Yanlin Luo Yibing Chen Huan Jin Benxin Hou Hongsheng Li Xiang Li lingfeng liu Yuan Zhou Yonghua Li Yong Sang Song Quentin liu Zhengzhi Zou Department of Gynecologic Oncology the Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450001China MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science Guangdong Provincial Key Laboratory of Laser Life ScienceCollege of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Institute of Clinical Pharmacology School of Basic Medical ScienceAcademy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Genetic and Prenatal Diagnosis Center Department of Gynecology and ObstetricsFirst Affiliated HospitalZhengzhou UniversityZhengzhou 450001China Department of General Surgery the Third People's Hospital of Hainan ProvinceSanya 572000China Department of Breast Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou 510095China Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China Department of Obstetrics and Gynecology Cancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 03080South Korea State Key Laboratory of Oncology in South China Cancer CenterSun Yat-sen UniversityGuangzhou 510631China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Induction of cancer cell ferroptosis has been proposed as a potential treatment in several cancer ***-associated macrophages(TAMs)play a key role in promoting tumor malignant progression and therapy ***,the roles and mechanisms of TAMs in regulating tumor ferroptosis is still unexplored and remains *** study shows ferroptosis inducers has shown therapeutic outcomes in cervical cancer in vitro and in *** have been found to suppress cervical cancer cells ***,macrophage-derived miRNA-660-5p packaged into exosomes are transported into cancer *** cancer cells,miRNA-660-5p attenuates ALOX15 expression to inhibit ***,the upregulation of miRNA-660-5p in macrophages depends on autocrine IL4/IL13-activated STAT6 ***,in clinical cervical cancer cases,ALOX15 is negatively associated with macrophages infiltration,which also raises the possibility that macrophages reduce ALOX15 levels in cervical ***,both univariate and multivariate Cox analyses show ALOX15 expression is independent prognostic factor and positively associated with good prognosis in cervical ***,this study reveals the potential utility of targeting TAMs in ferroptosis-based treatment and ALOX15 as prognosis indicators for cervical cancer.

关键词： Cervical cancer Tumor-associated macrophage ALOX15 Ferroptosis Exosome miRNA-660-5p Macrophages infiltration STAT6

Durable Design of Superhydrophobic Coatings with TiO_(2)Particles and Al_(2)O_(3)Whiskers for the Enhanced Anti-icing Performance

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Journal of Bionic Engineering 2024年第3期21卷 1360-1374页

作者： Weilan liu Kunlong Li Yizhou Shen Huanyu Zhao Yaru Ni Zeyu Cai lingfeng Zhao Zhen Wang Institute of Advanced Materials(IAM) School of Materials Science and EngineeringNanjing Tech UniversityNanjing211816China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing211100China Aviation Industry Aerodynamics Research Institute of China Shenyang110000China

Superhydrophobic coatings with high non-wetting properties are widely applied in anti-icing ***,the micro-nanostructures on the surfaces of superhydrophobic coatings are fragile under external forces,resulting in reduced ***,mechanical strength and durability play a crucial role in the utilization of superhydrophobic *** this study,we employed a two-step spraying method to fabricate superhydrophobic FEVE-based coatings with exceptional mechanical durability,utilizing fluorinated TiO_(2)nanoparticles and fluorinated Al_(2)O_(3)microwhiskers as the *** composite coating exhibited commendable non-wetting properties,displaying a contact angle of 164.84°and a sliding angle of 4.3°.On this basis,the stability of coatings was significantly improved due to the interlocking effect of Al_(2)O_(3)*** 500 tape peeling cycles,500 sandpaper abrasion tests,and 50 kg falling sand impact tests,the coatings retained superhydrophobicity,exhibiting excellent durability and application ***,the ice adhesion strength on the coatings was measured at only 65.4 kPa,while the icing delay time reached 271.8 s at-15℃.In addition,throughout 500 freezing/melting cycles,statistical analysis revealed that the superhydrophobic coatings exhibited a freezing initiation temperature as low as-17.25℃.

关键词： Superhydrophobic coatings Anti-icing Mechanical durability

Revolutionizing plasmonic platform via magnetic field-assisted confined ultrafast laser deposition of high-density,uniform,and ultrafine nanoparticle arrays

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International Journal of Extreme Manufacturing 2024年第3期6卷 428-438页

作者： Jin Xu lingfeng Wang Peilin Yang Haoqing Jiang Huai Zheng Licong An Xingtao liu Gary J Cheng School of Industrial Engineering Purdue UniversityWest LafayetteIN 47906United States of America Institute of Technological Sciences Wuhan UniversityWuhanHubei 430072People’s Republic of China

The remarkable capabilities of 2D plasmonic surfaces in controlling optical waves havegarnered significant ***,the challenge of large-scale manufacturing of uniform,well-aligned,and tunable plasmonic surfaces has hindered their *** address this,we present a groundbreaking tunable plasmonic platform design achieved throughmagnetic field(MF)assisted ultrafast laser direct deposition in *** precise control of metal nanoparticles(NPs),with cobalt(Co)serving as the model material,employing an MF,and fine-tuning ultrafast laser parameters,we have effectively converted coarse and non-uniform NPs into densely packed,uniform,and ultrafine NPs(~3 nm).This revolutionary advancement results in the creation of customizable plasmonic‘hot spots,’which play a pivotal role insurface-enhanced Raman spectroscopy(SERS)*** profound impact of this designable plasmonic platform lies in its close association with plasmonic resonance and *** the plasmonic nanostructures resonate with incident light,they generate intense local electromagnetic fields,thus vastly increasing the Raman scattering *** enhancement leads to an outstanding 2–18 fold boost in SERS performance and unparalleled sensing sensitivity down to 10^(-10)***,the plasmonic platform also demonstratesrobustness,retaining its sensing capability even after undergoing 50 cycles of rinsing andre-loading of ***,this work adheres to green manufacturing standards,making it an efficient and environmentally friendly method for customizing plasmonic‘hot spots’inSERS *** study not only achieves the formation of high-density,uniform,and ultrafine NP arrays on a tunable plasmonic platform but also showcases the profound relation betweenplasmonic resonance and energy *** outstanding results observed in SERS sensors further emphasize the immense potential of this technology for energy-relatedapplications,including photocatalysis,ph

关键词： magnetic field manipulation laser deposition metasurface SERS

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing liu Hongli Li Lemei Zhu lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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港珠澳大桥岛隧工程建造技术

东南大学学报（自然科学版） 2023年第6期53卷 955-964页

作者：林鸣裴岷山刘晓东林巍刘凌锋中国交通建设集团有限公司北京100088 ²中交公路规划设计院有限公司北京100088

港珠澳大桥是世界最长的跨海大桥,主通航孔临近中国香港机场,为了不影响中国香港机场,采用了6.7km沉管隧道方案,在隧道两端各修建了一个人工岛实现桥隧转换,港珠澳大桥沉管隧道是我国第一次建设的大型跨海沉管隧道.岛隧工程是港珠澳大... 详细信息

港珠澳大桥是世界最长的跨海大桥,主通航孔临近中国香港机场,为了不影响中国香港机场,采用了6.7km沉管隧道方案,在隧道两端各修建了一个人工岛实现桥隧转换,港珠澳大桥沉管隧道是我国第一次建设的大型跨海沉管隧道.岛隧工程是港珠澳大桥的控制性工程,工程位于开散海域,水文气象地质条件复杂;珠江口是世界最繁忙的通航海域之一,安全风险很大.同时,工程需要穿越中华白海豚核心保护区,在生态环境保护方面具有很大挑战性,对港珠澳大桥采用设计施工总承包模式进行建设,并研发了快速筑岛和跨海沉管隧道成套技术.结果表明,在岛隧工程7a的大规模海上工程建设中,实现了安全零伤亡,珠江口白海豚保护区的生物种群和生态环境得到了良好的保护.

关键词：港珠澳大桥岛隧工程人工岛沉管隧道钢圆筒筑岛