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“湖南人”在北京——以沈从文与熊希龄的“交往”为中心

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北京社会科学 2019年第11期 80-87页

作者：凌云岚中国传媒大学人文学院

1926年,沈从文在《世界日报·副刊》登出一则启事,这则启事显现出他初到北京时与熊希龄交往中存在的"问题"。沈从文和熊希龄在北京期间的来往,一方面反映出此时沈从文的生活状态,另一方面也体现出他在早期的生活、写作中如何呈现与确认... 详细信息

1926年,沈从文在《世界日报·副刊》登出一则启事,这则启事显现出他初到北京时与熊希龄交往中存在的"问题"。沈从文和熊希龄在北京期间的来往,一方面反映出此时沈从文的生活状态,另一方面也体现出他在早期的生活、写作中如何呈现与确认自我身份。将此时沈从文笔下的熊希龄和1940年代他对熊希龄的评价做一对比,恰可看出沈从文在不同历史时期如何强化了自己对"湖南人"这一身份的文化认同。

关键词：沈从文熊希龄湖南人身份认同

High-dimensional large-scale mixed-type data imputation under missing at random

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Science China Mathematics 2025年

作者： Wei Liu Guizhen Li ling Zhou lan Luo School of Mathematics Sichuan University Center of Statistical Research and School of Statistics Southwestern University of Finance and Economics Department of Statistics and Actuarial Science University of Iowa

Missingness in mixed-type variables is commonly encountered in a variety of areas. The requirement of complete observations necessities data imputation when a moderate or large proportion of data is ***, inappropriate imputation would downgrade the performance of machine learning algorithms, leading to bad predictions and unreliable statistical inference. For high-dimensional large-scale mixed-type missing data, we develop a computationally efficient imputation method, missing value imputation via generalized factor models（MIG）, under missing at random. The proposed MIG method allows missing variables to be of different types,including continuous, binary, and count variables, and are scalable to both data size n and variable dimension p while existing imputation methods rely on restrictive assumptions such as the same type of missing variables,the low dimensionality of variables, and a limited sample size. We explicitly show that the imputation error of the proposed MIG method diminishes to zero with the rate Op(max{n-1/2, p-1/2}) as both n and p tend to infinity. Five real datasets demonstrate the superior empirical performance of the proposed MIG method over existing methods that the average normalized absolute imputation error is reduced by 5.3%–34.1%.

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正常人各方位视网膜神经纤维层厚度值的测量

中山医科大学学报 2001年第3期22卷 212-214,224页

作者：凌运兰刘杏郑小平中山医科大学中山眼科中心广东广州510060

【目的】应用光学相干断层成像术 (OCT)测量我国正常人视网膜神经纤维层 (RNFL)各钟点范围厚度值和平均值 ;分析RNFL各钟点范围厚度值之间的差异及其与年龄、性别、眼别之间的关系。【方法】用OCT对 10 4例 (183眼 )正常人进行以视乳头... 详细信息

【目的】应用光学相干断层成像术 (OCT)测量我国正常人视网膜神经纤维层 (RNFL)各钟点范围厚度值和平均值 ;分析RNFL各钟点范围厚度值之间的差异及其与年龄、性别、眼别之间的关系。【方法】用OCT对 10 4例 (183眼 )正常人进行以视乳头为中心的环行扫描 ,扫描直径 3 46mm ,记录平均和各个钟点范围的RNFL厚度值并分析其与年龄、性别和眼别的关系。【结果】正常人以 10 :30～、11:30～、12 :30～、1:30～、2 :30～、3:30～、4:30～、5 :30～、6 :30～、7:30～、8:30～、9:30～ 12个钟点范围测量的RNFL厚度 (μm)分别为 144± 14、141± 16、135± 12、10 4± 17、78± 15、90± 18、130± 16、147± 17、145± 13、92± 16、80± 11、10 3± 10 ,而全周平均RNFL厚度值则为 (116± 5 ) μm。颞上 (10 :30～ 12 :30 )、颞下 (5 :30～ 7:30 )和平均RNFL厚度均与年龄呈负相关 (P值为 0 0 0 5～ 0 0 0 0 )。不同性别各钟点范围及平均RNFL厚度均数的比较 ,差异无显著性 (P值为 0 35 6～ 0 781)。正常人左、右眼各钟点范围及平均RNFL厚度之间差异亦无显著性 (P值为 0 15 5～ 0 6 12 )。【结论】正常人各钟点范围RNFL厚度以颞上 (10 :30～ 12 :30 )和颞下 (5 :30～ 7:30 )最厚 ,鼻侧 (2 :30～ )和颞侧

关键词：断层扫描视网膜神经纤维层厚度值测量

Comparison of combined phacotrabeculectomy with trabeculectomy only in the treatment of primary angle-closure glaucoma

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Chinese Medical Journal 2012年第8期125卷 1429-1433页

作者： WANG Mei FANG Min BAI Yu-jing ZHANG Wei-zhong LIN Ming-kai LIU Bing-qian HAO Yuan-tao ling yun-lan ZHUO Ye-hong GE Jian Department of Ophthalmology the Second Affiliated Hospital SunYat-sen University Guangzhou Guangdong 510120 China Shenzhen Ophthalmic Center Shenzhen Eye Hospital JinanUniversity Shenzhen Guangdong 518000 China Department of Ophthalmology Peking University People＇sHospital Beijing 100044 China State Key Laboratory of Ophthalmology Zhongshan OphthalmicCenter Sun Yat-sen University Guangzhou Guangdong 510060China Department of Medical Statistics and Epidemiology School ofPublic Health Sun Yat-sen University Guangzhou Guangdong510040 China

Background Trabeculectomy has become a mainstream treatment in intraocular pressure （lOP） reduction for primary angle-closure glaucoma （PACG）; combined trabeculectomy and cataract surgery was reported to reduce lOP and simultaneously improve vision for patients with PACG and coexisting cataract. This study was specialized to compare the efficacy and safety of combined phacotrabeculectomy with that of trabeculectomy only in the treatment of PACG with coexisting cataract. Methods This is a comparative case series study. Thirty-one patients （31 eyes） with PACG and coexisting cataract were enrolled. Of these, 17 underwent phacotrabeculectomy and 14 underwent trabeculectomy alone, lOP, filtering blebs, and complications were compared at the final follow-up. Complete success was defined as a final lOP less than 21 mmHg without lOP-lowering medication. Results After 10 months of postoperative follow-up, the phacotrabeculectomy and trabeculectomy groups showed no significant differences regarding lOP reduction （（20.59±7.94） vs. （24.85±14.39） mmHg, P=0.614）, complete success rate （88% vs. 71%, P=0.370）, formation rate of functioning blebs （65% （11/17） vs. 93% （13/14）, P=0.094）, and complications （41% （7/17） vs. 57% （8/14）, P=0.380）. lOP-lowering medication was not required for most of the patients in both groups. Additional surgery interventions, including anterior chamber reformation and phacoemulsification, were needed in the trabeculectomy group, whereas no surgery was needed postoperatively in the phacotrabeculectomy group. Conclusion Phacotrabeculectomy and trabeculectomy treatments exhibit similar lOP reduction, successful rates, and complications when it comes to treating PACG patients with coexisting cataract, although additional surgery intervention may be needed for a few cases with cataract and complications after trabeculectomy.

关键词： primary angle-closure glaucoma trabeculectomy phacotrabeculectomy cataract

Glucocorticoids upregulate transepithelial electrical resistance and expression of tight junction-related protein in human trabecular meshwork cells

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Chinese Medical Journal 2005年第20期118卷 1742-1745页

作者： ZHUO Ye-hong, HUANG Ya-lin, WEI Yan-tao, ling yun-lan, LIN Ming-kai and GE Jian Key Laboratory of Ophthalmology, Ministry of Education Zhongshan Ophtha lm ic Center , Sun Yat-sen University, Guangzhou 510060, China Key Laboratory of Ophthalmology Ministry of Education Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China.

The trabecular meshwork is located at the anterior chamber angle, and is the main route for the outflow of aqueous humor. It is composed of perforated sheets of collagen and elastic tissue covered by trabecular meshwork （TM） cells, forming a filter with decreasing pore size as the canal of Schlemm is approached. TM cells have some endothelial properties, such as the presence of intercellular junctional complexes, particularly tight junctions （TJs）. TJs form paracellular seals between adjacent cells and act as fences that segregate protein （ and partially lipid ） components of the apical and basolateral plasma membrane domains.

关键词： glucocorticoids·claudin-1·trabecular meshwork

“婚姻自由”与“教育平等”——以“袁舜英自杀”和“彭襄弃妻”为例

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佛山科学技术学院学报（社会科学版） 2006年第6期24卷 6-12页

作者：凌云岚中国传媒大学文学院北京100024

20世纪20年代湖南长沙发生了两个新闻事件:周南女校学生袁瞬英自杀事件和彭襄弃妻事件,湖南新闻界、教育界和普通社会民众围绕这两起事件发起了关于“婚姻自由”和“教育平等”的争论,此后发生的湖南的女性参政热潮,虽然有更为复杂的区... 详细信息

20世纪20年代湖南长沙发生了两个新闻事件:周南女校学生袁瞬英自杀事件和彭襄弃妻事件,湖南新闻界、教育界和普通社会民众围绕这两起事件发起了关于“婚姻自由”和“教育平等”的争论,此后发生的湖南的女性参政热潮,虽然有更为复杂的区域文化背景原因,这两起事件也是触媒之一。

关键词：婚姻自由教育平等女性解放区域文化

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

激光偏振光扫描仪测量正常人视网膜神经纤维层厚度的初步研究

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中国医学影像技术 2007年第2期23卷 210-213页

作者：黄晶晶刘杏葛坚凌运兰郑小萍中山大学中山眼科中心眼科学国家重点实验室广东广州510060

目的评价激光偏振光扫描仪GDxVCC在正常人视网膜神经纤维层(Retinalnervefiberlayer,RNFL)厚度测量的可重复性,初步确定GDxVCC测量RNFL厚度的正常值。方法用激光偏振光扫描仪GDxVCC对67例(123眼)正常人进行RNFL厚度测量,重复三次,取平... 详细信息

目的评价激光偏振光扫描仪GDxVCC在正常人视网膜神经纤维层(Retinalnervefiberlayer,RNFL)厚度测量的可重复性,初步确定GDxVCC测量RNFL厚度的正常值。方法用激光偏振光扫描仪GDxVCC对67例(123眼)正常人进行RNFL厚度测量,重复三次,取平均值。比较性别、眼别间及同一眼内上下方RNFL厚度的差别,对RNFL厚度的重复测量进行组内相关系数计算。结果67例(123眼)正常人的平均RNFL厚度为:上方(70.30±6.76)μm,下方(67.35±6.77)μm,平均(56.87±4.53)μm;平均TSNIT标准差23.68±4.61;平均双眼对称值0.86±0.11。上方RNFL厚度与下方RNFL厚度值比较,有显著性差异(t=4.952,P=0.000)。男女性别间TSNIT参数比较,无统计学差异。左右眼间TSNIT参数比较,下方RNFL及TSNIT标准差有统计学差异(P=0.005,0.002),上方及平均RNFL无统计学差异(P=0.086,0.529)。所有参数的组内相关系数均>0.5,其中上方、下方及平均RNFL厚度测量的组内相关系数均>0.8。结论用激光偏振光扫描仪GDxVCC测量RNFL厚度的可重复性好,但年龄对GDxVCC测量RNFL厚度的影响仍应进一步研究。

关键词：激光偏振光打描仪视网膜神经纤维层正常人

三种手术方式治疗原发性闭角型青光眼初步疗效比较研究

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中国实用眼科杂志 2006年第7期24卷 695-699页

作者：张秀兰葛坚蔡小于杜绍林凌运兰林明楷中山大学中山眼科中心眼科学国家重点实验室广州510060

目的探讨治疗原发性闭角型青光眼三种手术方式的适应症和初步临床疗效观察。方法采用非随机临床对照研究方法。拟订手术适应症,对临床收治的63例72眼原发性闭角型青光眼进行手术处理:单纯抗青光眼手术——复合式小梁切除术(Trabeculecto... 详细信息

目的探讨治疗原发性闭角型青光眼三种手术方式的适应症和初步临床疗效观察。方法采用非随机临床对照研究方法。拟订手术适应症,对临床收治的63例72眼原发性闭角型青光眼进行手术处理:单纯抗青光眼手术——复合式小梁切除术(Trabeculectomy,Trab)、青-白联合手术——复合式小梁切除联合超声乳化白内障吸除+晶体囊袋折叠式人工晶体植入术(Phacotrabeculectomy+IOL,PhacoTrab+IOL)和单纯白内障手术——超声乳化白内障吸除+晶体囊袋折叠式人工晶体植入术(Phaco+IOL)。比较不同适应症下三种手术方式初步的临床疗效。包括眼压控制情况、前房深度和房水流畅系数(C值)的变化,超声生物显微镜(UBM)观察房角和滤过泡,以及用抗青光药物辅助情况及并发症等。随访时间平均(11.7±4.9)个月。结果均经统计学处理。结果三组术后在随访期内均能将眼压控制在理想范围,术后眼压较术前明显降低(三组P值均0.05);UBM观察房角:PhacoTrab+IOL和Phaco+IOL组明显较术前加宽或重新开放,相应组C值术后较术前提高,差异有统计学意义(P分别<0.001和<0.01),Trab组房角变化不明显,但术后C值较术前亦有改善(P<0.001);三组均未见严重术中并发症;术后早期炎症反应最轻者为Phaco+IOL组;远期并发症Trab组有5眼发生低眼压。最后对视力的变化也作了讨论。结论不同手术方式适合不同的病人情况。超声乳化白内障吸除术因其具有相对房角开放和C值改善以及视力提高等优势,可考虑作为原发性闭角型青光眼治疗的选择性手段之一,但要注意适应症的选择。

关键词：青光眼闭角型小梁切除术超声乳化白内障吸除术人工晶体植入术