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Near Earth Vortices Driving of Field Aligned Currents Based on Magnetosphere Multiscale and Swarm Observations

空间科学学报 2019年第1期39卷 9-17页

作者： ZHANG C SHEN C YANG Y Y DUNLOp M W TI S RUSSELL C T LüHR H BURCH J L lindqvist p a TORBERT R B FRIIS-CHRISTENSEN E State Key Laboratory of Space Weather National Space Science Center College of Earth Science University of Chinese Academy of Sciences College of Science Harbin Institute of Technology Institute of China Seismological Bureau Crustal Stress Space Science Institute School of Astronautics Beihang University Rutherford Appleton Laboratory University of California German Research Center For Geosciences German Research Center for Geosciences Southwest Research Institute Royal Institute of Technology University of New Hampshire Danish National Space Center

A long-standing mystery in the study of Field-Aligned Currents(FACs) has been that: how the currents are generated and why they appear to be much stronger at high altitudes than in the ionosphere. Here we present two events of magnetotail FACs observed by the Magnetospheric Multiscale Spacecraft(MMS) on 1 st July and 14 th July 2016, to show how the Substorm Current Wedges(SCW) were formed. The results show that particles were transferred heading towards the Earth during the expansion phase of *** azimuthal flow formed clockwise(counter-clockwise) vortex-like motion, and then generated downward(upward) FACs on the tailward/poleward side of the distorted field with opposite vorticity on their Earthward/equatorward side. We also analyzed the Region 1 FACs observed by the Earth Explorer Swarm spacecraft on 1 st July 2016 and found that they were associated with FACs observed by MMS, although differing by a factor of 10. This difference suggests that either there was the closure of the currents at altitudes above 500 km or the currents were not strictly parallel to B and closed at longitudes away from where they were generated.

关键词： Substorm current wedge Magnetosphere Field-aligned currents Flow vorticity Multiple spacecraft measurements

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胎盘早剥的风险及风险评估

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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 18-19页

作者： lindqvist p.G. Happach C. 张新艳 Institution of Clinical Science Department of Obstetrics and GynecologyLund University20502 MalmSeSweden

Objective:Several variables related to increased risk of placental abruption are also risk factors for venous thromboembolism. prior second trimester,third trimester,and repeated fetal loss are reported to be associated to thrombophilias. However,it is yet not known if they are also related to placental abruption. Study design:A retrospective case-control study of 161 women with placental abruption and 2371 unselected gravidae without placental abruption. The medical files were scrutinized and the selected variables were investigated in relation to the develop- ment of placental abruption. Results:As compared to controls,previous second trimester-,third trimester-,repeated fetal loss,and prior placental abruption were related to a 3-,13-,3-,and a 25-fold increased risk of placental abruption,respectively. Several other factors were associated with a roughly three-fold increased risk such as:preeclampsia,IUGR,high maternal age ( > 35),family history of venous thromboembolism,smoking,and multiple birth. A risk score was created and as compared with those with no risk factors present,the risk of placental abruption was increasing from 2.5-fold for those with risk score = 1,to almost 100-fold for risk score 4 or above. Conclusion:Easily obtainable information might be used to classify the risk of placental abruption.

关键词：胎盘早剥妊娠晚期血栓形成倾向风险评估反复流产静脉血栓栓塞先兆子痫病例对照研究研究设计

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MMS星座对磁层顶磁通量绳内离子惯性尺度结构的观测

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空间科学学报 2018年第2期38卷 147-168页

作者：刘杨濮祖荫谢伦郭瑞龙王晓钢肖池阶史全岐 DUNLOp M BOGDANOVA Y V MOORE T E RUSSELL C T lindqvist p a TORBERT R B pOLLOCK C ZHAO Cong 北京大学地球与空间科学学院北京100871 中国科学院地质与地球物理研究所北京100029 哈尔滨工业大学物理系哈尔滨150001 北京大学物理学院北京100871 山东大学空间科学与物理学院威海264209 RAL Space Rutherford Appleton LaboratorySTFCDidcotOX11 0QXUK Goddard Space Flight Center NASAGreenbeltMDUSA University of California Los AngelesCAUSA Royal Institute of Technology StockholmSweden University of New Hampshire DurhamNHUSA

利用MMS观测数据,对磁层顶通量绳内离子惯性尺度(d_i)的结构进行分析研究.结果发现,许多不同尺度(约1d_i至数十d_i)的通量绳内都存在具有d_i尺度的电流j_m,其方向在磁层顶局地坐标系的-M方向,即与磁层顶查普曼-费拉罗电流同向,由电子在+... 详细信息

利用MMS观测数据,对磁层顶通量绳内离子惯性尺度(d_i)的结构进行分析研究.结果发现,许多不同尺度(约1d_i至数十d_i)的通量绳内都存在具有d_i尺度的电流j_m,其方向在磁层顶局地坐标系的-M方向,即与磁层顶查普曼-费拉罗电流同向,由电子在+M方向的运动(v_(em))携带.这些电流结构具有以下特征:磁鞘与磁层成分混合,磁场为开放形态;离子去磁化,电子与磁场冻结;N方向(即垂直于磁层顶电流片方向)的电场E_n显著增大,幅度达到约20 mV·m^(-1),并伴有明显的尖峰状起伏,该增强和尖峰状起伏的电场对应于霍尔电场.分析表明,电流、电子与离子运动的偏离以及霍尔电场之间遵从广义欧姆定律,三者密切关联.进一步对磁层顶磁重联的探测数据进行分析发现,在很多重联区内也存在与通量绳内相似的结构,其尺度约为d_i量级,其中霍尔电场E_N、电流j_M和电子速度v_(eM)均与通量绳内对应物理量的方向相同且幅度相近.基于上述观测事实,采用经典FTE通量绳模型,对通量绳内电流、电子运动和霍尔电场的起源进行了初步探讨,认为其来源于磁层顶无碰撞磁重联区内的相应结构,并且后者在离子尺度通量绳的形成过程中起到重要作用.

关键词：磁通量绳离子尺度电流霍尔电场磁层顶磁重联

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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

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含损伤演化的TM耦合数值模型及其应用研究

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力学学报 2006年第4期38卷 505-513页

作者：李连崇唐春安唐世斌 p.-A.lindqvist 东北大学岩石破裂与失稳研究中心沈阳110004 大连理工大学土木水利学院大连116024 Lulea大学

从岩石材料的细观结构层次出发,应用损伤力学和热弹性理论,对热力耦合作用下岩石破裂过程中热一应力相互作用关系进行了分析．初步建立了细观岩石热-力(TM)耦合数值模型,探讨了TM耦合作用下岩石材料的细观结构损伤及其诱发的材料力学性... 详细信息

从岩石材料的细观结构层次出发,应用损伤力学和热弹性理论,对热力耦合作用下岩石破裂过程中热一应力相互作用关系进行了分析．初步建立了细观岩石热-力(TM)耦合数值模型,探讨了TM耦合作用下岩石材料的细观结构损伤及其诱发的材料力学性能演化机制,把岩石热固耦合问题的研究从应力状态分析深入到损伤、破坏过程分析之中．运用该数值模型对某硬岩实验室开展的原位尺度实验中的废料处理井间柱稳定性进行了模拟分析,其应力场、岩石剥离破坏形态及破坏诱发的AE特性等均与实验监测结果表现出了较好的一致性,证明了该数值模型的合理性和有效性．

关键词：岩石破裂非均匀性损伤热应力数值模拟

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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald p.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SpAST spastin

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In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells

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World Journal of Gastroenterology 2025年第3期31卷 84-102页

作者： patricia de la Cruz-Ojeda Ester parras-Martínez Raquel Rey-pérez Jordi Muntané Functional Genomics of Solid Tumors Laboratory Centre de Recherche des CordeliersParis 75006France Department of Oncology Surgery Cell Therapy and Organ TransplantationInstitute of Biomedicine of SevilleVirgen del Rocio University HospitalSeville 41013Spain Biomedical Research Center for Hepatic and Digestive Diseases CIBERehdMadrid 28029Spain Department of Medical physiology and Biophysics University of SevilleSeville 41009Spain

BACKGROUND Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology *** is still a recommended treatment for a large proportion of patients with advanced *** patterns of treatment responsiveness have been identified in differentiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 *** To define the long non-codingRNA-microRNA-mRNA(lncRNA-miRNA-mRNA)predicted signatures related to selected hallmarks of cancer(apoptosis,autophagy,cell stress,cell dedifferentiation and invasiveness)in RNAseq studies using Sorafenib-treated HepG2 and SNU449 *** available software analyses allowed us to establish the lncRNA-miRNA-mRNA regulatory axes following treatment in HepG2 and SNU449 *** HepG2 and SNU449 cells were treated with Sorafenib(10μmol/L)for 24 *** RNA,including small and long RNA,was extracted with a commercial miRNeasy *** was carried out for the identification of changes in lncRNA-miRNA-mRNA regulatory *** MALAT,THAp9-AS1 and SNGH17 appeared to coordinately regulate miR-374b-3p and miR-769-5p that led to upregulation of SMAD7,TIRARp,TFAp4 and FAXDC2 in HepG2 ***12,EpB41 L4A-AS1,LINC01578,SNHG12 and GAS5 interacted with let-7b-3p,miR-195-5p and VEGFA in SNU449 *** axes MALAT1/hsamir-374b-3p/SMAD7 and MALAT1/hsa-mir-769-5p/TFAp4 were of high relevance for Sorafenib response in HepG2 cells,whereas pVT1/hsa-miR-195-5p/VEGFA was responsible for the differential response of SNU449 cells to Sorafenib *** Critical lncRNAs acting as sponges of miRNA were identified that regulated mRNA expression,whose proteins mainly increased the antitumor effectiveness of the treatment(SMAD7,TIRARp,TFAp4,FAXDC2 and ADRB2).However,the broad regulatory axis leading to increased VEGFA expression may be related to the side effect of Sorafenib in SNU449 cells.

关键词： Cell culture Hepatocellular carcinoma Non-coding RNA RNAseq Sorafenib

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Machine learning applications in healthcare clinical practice and research

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World Journal of Clinical Cases 2025年第1期13卷 16-21页

作者： Nikolaos-Achilleas Arkoudis Stavros p papadakos Research Unit of Radiology and Medical Imaging School of MedicineNational and Kapodistrian University of AthensAthens 11528Greece 2^(nd)Department of Radiology “Attikon”General University HospitalMedical SchoolNational and Kapodistrian University of AthensChaidari 12462Greece Department of Gastroenterology Laiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece

Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human *** its various applications,it has proven groundbreaking in healthcare as well,both in clinical practice and *** this editorial,we succinctly introduce ML applications and present a study,featured in the latest issue of the World Journal of Clinical *** authors of this study conducted an analysis using both multiple linear regression(MLR)and ML methods to investigate the significant factors that may impact the estimated glomerular filtration rate in healthy women with and without non-alcoholic fatty liver disease(NAFLD).Their results implicated age as the most important determining factor in both groups,followed by lactic dehydrogenase,uric acid,forced expiratory volume in one second,and *** addition,for the NAFLD-group,the 5th and 6th most important impact factors were thyroid-stimulating hormone and systolic blood pressure,as compared to plasma calcium and body fat for the NAFLD+***,the study's distinctive contribution lies in its adoption of ML methodologies,showcasing their superiority over traditional statistical approaches(herein MLR),thereby highlighting the potential of ML to represent an invaluable advanced adjunct tool in clinical practice and research.

关键词： Machine Learning Artificial Intelligence Clinical practice Research Glomerular filtration rate Non-alcoholic fatty liver disease Medicine

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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi pradeepkiran priyanka Rawat Arubala p.Reddy Erika Orlov pHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAp-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

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