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Two different mutational types of familial gastrointestinal stromal tumors:Two case reports

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4028-4036页

作者： Xiao-Ke Wang Lu-Fan Shen Xin Yang He Su Tao Wu Peng-Xian Tao Hong-ying Lv Tong-Han Yao lin yi Yuan-Hui Gu The First School of Clinical Medical Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina School of Traditional Chinese and Western Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases/million each *** rarer familial GISTs,which often represent a population,differ in screening,diagnosis,and *** GISTs include primary familial GISTs with predominantly KIT/PDGFRA mutations and wild-type ***,whether the same genetic family has different phenotypes has not been *** SUMMARY We report two cases of rare GISTs in the same family:A male patient with the V561D mutation in exon 12 of the PDGFRA gene,who has been taking the targeted drug imatinib since undergoing surgery,and a female patient diagnosed with wild-type GIST,who has been taking imatinib for 3 years since undergoing *** favorable prognosis of these patients during the 7-year follow-up period validates the accuracy of our treatment strategy,and we have refined the entire process of diagnosis and treatment of familial GISTs in order to better manage this rare familial *** Different mutation types of familial GISTs in the same family are very rare,thus it is very important to make the correct diagnosis and treatment strategies according to the results of molecular detection for the management of familial GISTs.

关键词： Gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Wild-type gastrointestinal stromal tumors PDGFRA Imatinib Treatment Case report

Lithium Isotope Analytical Methods and Implications for Rare-Metal Mineralization in Granite-Pegmatite Systems: An Overview

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Journal of Earth Science 2024年

作者： Xiang-ying Ye Bin Li Dong-Bo Tan Ke-Cheng Liu Zhi-Yong Zhu Hafiz Muhammad Siddique yi-lin Xiao Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring (Ministry of Education)， School of Geosciences and Info-physics， Central South University CAS Key Laboratory of Geospace Environment and Department of Plasma Physics and Fusion Engineering， University of Science and Technology of China Institute of Geology， Chinese Academy of Geological Sciences CAS Key Laboratory of Crust-Mantle Materials and Environments， School of Earth and Space Sciences， University of Science and Technology of China Chinese Academy of Sciences Center of Excellence in Comparative Planetology

The origin of highly-fractionated granite-pegmatite systems and their associated rare metal mineralization has been widely studied， but there is still ongoing debate. Prevailing hypotheses suggest that pegmatite formation and the associated rare metal mineralization are closely related to aqueous fluid processes. Lithium (Li) isotope analysis has been widely applied to trace granite-pegmatite evolution. This is because lithium is widely present in various minerals (e.g.， mica， tourmaline) that record the melt and fluid compositions， and lithium isotopes are sensitive to magmatic-hydrothermal processes. We briefly review the methodology of Li isotope analyses， the mechanisms of Li isotopic fractionation， and， in particular， Li isotope fractionation in granite-pegmatite system based on Li isotope data we have collected and the latest developments in Li isotope geochemistry. With the development of analytical technology， high-precision measurement of the Li content and isotopic compositions have facilitated a series of scientific breakthroughs in understanding the magmatic-hydrothermal evolution of rare-element ore deposits. Li isotope analysis on bulk mineral separates show ability to trace various hydrothermal processes (e.g. exotic or exsolved fluids). In situ Li isotope analysis methods has been enhanced by the development of new， homogeneous mineral reference materials. In situ SIMS and LA-MC-ICP-MS Li isotope measurements on minerals (e.g.， tourmaline) will likely become more important in studying the fluid–rock interactions in magmatic， metamorphic， and hydrothermal processes， as well as on pegmatite petrogenesis and rare-metal mineralization.

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2型糖尿病患者体重管理的研究进展与思考

中华内分泌代谢杂志 2024年第3期40卷 252-257页

作者：林毅彭永德上海交通大学医学院附属第一人民医院内分泌代谢科上海200080

全球2型糖尿病患者人数仍在增加,其中肥胖问题不容忽视。肥胖不仅可能导致2型糖尿病的发生,也会进一步增加2型糖尿病患者的心血管疾病风险。因此,近年来2型糖尿病疾病管理的目标已经从控制血糖转变为"控糖、减重"双重管理。现有的减重... 详细信息

全球2型糖尿病患者人数仍在增加,其中肥胖问题不容忽视。肥胖不仅可能导致2型糖尿病的发生,也会进一步增加2型糖尿病患者的心血管疾病风险。因此,近年来2型糖尿病疾病管理的目标已经从控制血糖转变为"控糖、减重"双重管理。现有的减重策略包括生活方式干预、药物治疗和代谢手术,其中药物治疗的发展与日俱进。新型的双重或三重肠道激素受体激动剂的研发,将为2型糖尿病合并超重/肥胖患者提供更多治疗选择。

关键词：糖尿病,2型体重管理多重靶点药物

基于生理信号的危险作业人员心理负荷识别研究

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东北大学学报（自然科学版） 2024年第4期45卷 600-608页

作者：郝锐郑欣李怡霖东北大学资源与土木工程学院辽宁沈阳110819

为识别危险作业岗位作业人员的心理负荷,提高人机系统可靠性,以含能材料起爆作业诱导被试人员心理负荷,采集30名被试人员在静息状态和心理负荷下的心率、脑电图和眼动信号进行心理负荷识别研究.首先,采用配对t检验与秩和检验对采集的心... 详细信息

为识别危险作业岗位作业人员的心理负荷,提高人机系统可靠性,以含能材料起爆作业诱导被试人员心理负荷,采集30名被试人员在静息状态和心理负荷下的心率、脑电图和眼动信号进行心理负荷识别研究.首先,采用配对t检验与秩和检验对采集的心率、脑电图和眼动信号进行统计分析,8种脑电、3种眼动及9种心率特征在静息状态和心理负荷下具有显著变化;其次,对初选获得的生理指标分别采用Pearson相关分析、最大相关最小冗余(MRMR)算法和主成分分析(PCA)进行特征降维;最后,基于上述3种方法降维处理后得到生理指标采用Logistic Regression,KNN,SVM,XG-Boost,Decision Tree和Random Forest机器学习方法进行心理负荷识别.结果表明,基于MRMR的心理负荷特征选择结果,采用Random Forest机器学习方法具有更好的识别性能(ACC=0.917,SN=1.0,SP=0.857,F1=0.909,AUC=0.971).本研究为有效识别危险作业人员心理负荷提供了理论依据.

关键词：危险作业心理负荷识别生理信号机器学习

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极端台风下特大悬索桥的GNSS实时振动监测及动力响应分析

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中国公路学报 2024年第9期37卷 133-146页

作者：余加勇彭志豪孟晓林谢轶伦方振谢义林湖南大学土木工程学院湖南长沙410082 桥梁工程安全与韧性全国重点实验室湖南长沙410082 帝国理工大学工程学部伦敦SW72AZ 湖南省交通科学研究院有限公司湖南长沙410015 江苏省水利科学研究院江苏南京210017

特大桥梁结构健康监测系统为桥梁模态识别、损伤探测和安全评估提供了重要参数信息和决策依据。鉴于传统加速度计、计算机视觉、光纤光栅等方法存在位移测量不精确、易受外界环境干扰、仅获取局部变量等问题,构建了全球导航卫星系统(Glo... 详细信息

特大桥梁结构健康监测系统为桥梁模态识别、损伤探测和安全评估提供了重要参数信息和决策依据。鉴于传统加速度计、计算机视觉、光纤光栅等方法存在位移测量不精确、易受外界环境干扰、仅获取局部变量等问题,构建了全球导航卫星系统(Global Navigation Satellite System, GNSS)特大悬索桥实时振动监测和改进经验小波变换(Empirical Wavelet Transform, EWT)的结构动力响应分析方法。依托由GNSS、加速度计和风速仪等传感器组建的苏格兰福斯公路桥GeoSHM变形监测系统,自2014年起实现对桥塔、主梁的高精度、全自动、全天候、三维实时监测;建立基于改进协方差自回归功率谱的频带划分方法和Pearson相关系数有效固有模态函数筛选准则,提出改进EWT算法进行降噪滤波和位移分解,实现风致桥梁振动响应的动力响应分析。采用上述方法对2020年2月的席亚拉(Ciara)台风GNSS监测数据进行分析,识别出索塔纵向振动位移最大振幅为7.91 cm,动态位移最大振幅为2.84 cm, 2座桥塔上GNSS接收机识别出的模态频率基本吻合,风速与桥塔水平位移呈正相关,索塔的水平位移沿风向增加明显;主梁纵向、横向和竖向振动位移最大振幅分别为5.51、152.47、68.17 cm,其中动态位移最大振幅为3.73、31.93、54.22 cm,与加速度计识别的动态位移及振动频率结果吻合,风速与主梁三维位移亦呈正相关,台风引起的横向振动最大,因此横向位移随风速增加的趋势显著。研究结果表明:构建的GNSS监测技术和改进EWT数据处理方法,可实现特大桥梁风致振动实时监测和动力响应分析,具有重要的科学研究和工程应用价值。

关键词：桥梁工程风致振动全球导航卫星系统经验小波变换模态参数

Highly efficient solution-processed organic photovoltaics enabled by improving packing behavior of organic semiconductors

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Science China Chemistry 2024年第3期67卷 890-897页

作者： Xinyue Cui Hongxiang Li Hao Lu Yuqiang Liu Guangliu Ran Rui Liu Huarui Zhang Xueqing Ma Dawei Li yi lin Jifa Yu Wenkai Zhang Lei Cai Yahui Liu Pei Cheng Andong Zhang Zaifei Ma Guanghao Lu Zhishan Bo College of Textiles and Clothing State Key Laboratory of Bio-fibers and Eco-textilesQingdao UniversityQingdao 266071China State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China Department of Physics and Applied Optics Beijing Area Major Laboratory Center for Advanced Quantum StudiesBeijing Normal UniversityBeijing 100875China Shandong Province Key Laboratory of Medical Physics and Image Processing Technology School of Physics and ElectronicsShandong Normal UniversityJinan 250014China Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing 100875China Center for Advanced Low-Dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China Frontier Institute of Science and Technology Xi'an Jiaotong UniversityXi'an 710054China

Solution processability is a unique property of organic semiconductors. The compact and regular π-π stacking between molecules is paramount in the performance of organic optoelectronic devices. However, it is still a challenge to improve their stacking quality without sacrificing the solution-processability from the aspect of materials design. Here, delicately engineered additives are presented to promote the formation of ordered aggregation of conjugated molecules by regulating their nucleation and growth dynamics. Intriguingly, the long-chain BTP-eC9-4F molecules can realize ordered aggregation comparable to short-chain ones without sacrificing processability. The domain size of BTP-eC9-4F aggregation is enlarged from 24.2 to 32.2 nm in blend *** exciton diffusion and charge transport become faster, contributing to the suppression of recombination losses. As a result, a power conversion efficiency of 19.2% is achieved in D18:BTP-eC9-4F based organic photovoltaics. Our findings demonstrate a facile strategy to improve the packing quality of solution-processed organic semiconductors for high-efficiency photovoltaics and beyond photovoltaics.

关键词： organic semiconductor organic photovoltaic charge transport solution processability

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丝网印刷技术在纸基传感器中的应用

分析化学 2024年第7期52卷 901-909页

作者：陈琳轶田君飞深圳职业技术大学传播工程学院华南理工大学轻工科学与工程学院

随着科技的进步，纸基传感器的研究进展迅速，其应用领域也在不断扩展，纸基微流控和纸基柔性电子已经成为纸基传感器的两个重要发展方向。丝网印刷技术具有成本低廉、制版快速、印刷方便和适用性强等优点，广泛应用于各种纸基传感器的... 详细信息

随着科技的进步，纸基传感器的研究进展迅速，其应用领域也在不断扩展，纸基微流控和纸基柔性电子已经成为纸基传感器的两个重要发展方向。丝网印刷技术具有成本低廉、制版快速、印刷方便和适用性强等优点，广泛应用于各种纸基传感器的制备。本文在简要概述纸基传感器发展历程的基础上，从构建疏水壁以制备纸基微流道、沉积功能性试剂、印刷纸基电极以制备纸基电化学传感器这3个方面重点讨论了基于丝网印刷技术制备纸基生化传感器近年来的研究进展，以及基于丝网印刷技术的纸基物理传感器的研究进展，总结了丝网印刷技术应用于纸基传感器面临的挑战，并对其未来发展前景进行了展望。

关键词：丝网印刷纸基传感器纸基芯片微流控柔性电子评述

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不同冲击角度对复合材料层合板低速冲击损伤特点的影响

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复合材料科学与工程 2024年第1期 30-37,53页

作者：林逸刘玲同济大学航空航天与力学学院上海200092

复合材料结构在服役过程中常受到低速冲击影响,产生不可目视的内部损伤,这将降低结构的承载能力。实际工程中,低速冲击物与结构相互作用时,可能呈现不同的冲击角度。因此,本文针对一种典型铺层的碳纤维/环氧复合材料层合板,采用ABAQUS建... 详细信息

复合材料结构在服役过程中常受到低速冲击影响,产生不可目视的内部损伤,这将降低结构的承载能力。实际工程中,低速冲击物与结构相互作用时,可能呈现不同的冲击角度。因此,本文针对一种典型铺层的碳纤维/环氧复合材料层合板,采用ABAQUS建立90°和不同倾斜角度的低速冲击数值模型,以分析不同冲击角度对层合板接触力与损伤的影响,以及冲头旋转造成的二次接触对损伤的影响。在数值模型中,采用连续介质损伤力学模型和三维Hashin准则模拟层内的失效,并采用内聚力模型与双线性牵引-分离本构关系模拟层间分层。对90°模拟结果与试验结果进行对比分析,结果证明了所建立数值模型的可靠性。不同冲击角度冲击模拟结果表明:在冲击角度从30°升至90°过程中,法向接触力始终增大,切向接触力先增大后减小;随着冲击角度的减小,损伤的整体偏移逐渐明显,并且基体拉伸损伤面积始终较大。不同冲击能量下的二次接触模拟结果表明,随着冲击能量增大,产生二次接触的冲击角度范围减小,且二次接触对层合板顶部造成了新的损伤。

关键词：复合材料低速冲击倾斜冲击损伤

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan yi-lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated