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Clinical study of distribution and drug resistance of pathogens in patients with severe acute pancreatitis

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Chinese Medical Journal 2012年第10期125卷 1772-1776页

作者： SU mao-sheng lin mao-hu ZHAO Qing-hua LIU Zhi-wei HE Lei JIA Ning Department of Hepatobiliary Surgery Chinese People's Liberation Army General HospitalBeijing 100853China Infection Management and Disease Control Division Chinese People's Liberation Army General HospitalBeijing 100853China Department of Urology the First Affiliated Hospital of Chinese People’s Liberation Army General HospitalBeijing 100051China

Background Previous researches about necrotic pancreatic tissue infections are numerous, but the study on systemic infection related to the severe acute pancreatitis （SAP） treatment period is limited. This study aimed to investigate the distribution and drug resistance of pathogenic bacteria in patients who had hepatobiliary surgery for SAP during the past three years. Methods A retrospective study was conducted on the distribution, category and drug resistance of pathogenic bacteria in patients who had hepatobiliary surgery for SAP from 2008 to 2011. Results A total of 594 pathogenic bacteria samples were isolated. Among them 418 isolates （70.4%） were Gram bacteria negative, 142 isolates （23.9%） were Gram bacteria positive, and 34 isolates （5.7%） were found fungi. The most common Gram negative bacteria were Escherichia coli （19.8%）, and the dominant Gram positive pathogenic bacteria were Enterococcus faecium. The distribution of SAP-related infectious pathogens was mainly in peritoneal drainage fluid, sputum, bile, and wound secretions. Almost all the Gram negative pathogenic bacteria were sensitive to carbapenum. Extended-spectrum I]-Iactamases （ESBLs） producing strains were more resistant to penicillins and cephalosprins than the ESBLs non-producing strains. Staphylococcus was sensitive to vancomycin and linezolid. The drug resistance of meticillin-resistant staphylococcus （MRS） to commonly used antibiotics was higher than meticillin-sensitive streptococcus （MSS）. Enterococcus sp. exhibited lower drug-resistance rates to vancomycin and linezolid. Conclusions Gram negative bacteria were the dominant SAP-related infection after hepatobiliary surgery. A high number of fungal infections were reported. Drug resistant rates were high. Rational use of antibiotics according to the site of infection, bacterial species and drug sensitivity, correctly executing the course of treatment and enhancing hand washing will contribute to therapy and prevention of SAP-related infect

关键词： pathogen drug resistance severe acute pancreatitis

Structure of the Manganese (V) Complex-Mn·3/2(μ-DHBQ)·4H_2O·2Cl

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Chinese Chemical Letters 2000年第7期11卷 645-648页

作者： Yi Xiang CHENG mao lin hu Ji Xin YUAN Yun Chu WANG(Department of Chemistry & Chemical Engineering, Southeast University, Nanjing 210096 Department of Chemistry, Wenzhou Teachers College, Wenzhou 325003) Department of Chemistry & Chemical Engineering Southeast University Department of Chemistry Wenzhou Teachers College

The novel complex of Mn(V): Mn·3/2(μ -DHBQ)·4H2O·2Cl (where, H2DHBQ =2,5-dihydroxyl- 1,4-benzoquinone) was synthesized and its crystal structure has been determined by X-ray diffraction. The complex belongs to trigonal system with space group P3(# 147), a= 1 .415(2)nm, c=0.6552(4) nm, V=1 .1371(7) nm-3, Z=2, Dx=1.183 g/cm3, μ=7.37 cm-1, F(000)=408.00,R=0.041, Rw=0.046.

关键词： Manganese (V) crystal structure bridging ligand 2,5-dihydroxyl-1,4-benzoquinone

Efficacy and safety of micafungin for invasive candida infections：a meta-analysis of randomized controlled trials

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Chinese Medical Journal 2012年第2期125卷 345-351页

作者： Chen Qian lin mao-hu Chen Meng-li Liu Zhe-yuan Chai Dong Wang Rui Chinese Peoples Liberat Army Gen Hosp Dept Clin Pharmacol Beijing 100853 Peoples R China Chinese Peoples Liberat Army Gen Hosp Affiliated Hosp 1 Dept Urol Beijing 100853 Peoples R China

Background Invasive fungal infections such as candidiasis and mold infections cause significant morbidity and mortality in seriously ill *** is an echinocandin antifungal agent with potent activity against most species of Candida and *** did this meta-analysis to clarify whether micafungin offers superior efficacy and safety compared with other antifungal agent for treating infections associated with invasive *** We did a meta-analysis of randomized controlled trials to examine whether micafungin has superior efficacy and safety compared with other antifungal agents recommended by the treatment guidelines for fungal *** trials involving 2913 patients were included in this *** ratios （OR） and 95% confidence intervals （CI） were *** Micafungin was associated with significantly better treatment success compared with the comparator antifungal agents （modified intention to treat,2851 patients; random-effects model,OR 1.20,95% CI 1.00-1.45,P=0.0487）.In addition,micafungin was more effective than the comparators for antifungal prophylaxis of neutropenic patients undergoing hematopoietic stem cell transplantation （OR 1.47,95% CI 1.08-2.00,P=0.01）.Although there was no significant difference between the compared regimens in terms of the incidence of adverse drug effects （OR 0.94,95% CI 0.77-1.11）,fewer patients treated with micafungin withdrew from the studies because of adverse events （OR 0.64,95% CI 0.44-0.94）.Conclusions Micafungin has a good safety and tolerability profile,with an efficacy at least comparable to the other antifungal *** offers advantages over other agents for antifungal *** offers an appropriate alternative for antifungal prophylaxis rather than the treatment of invasive candida infections.

关键词： micafungin meta-analysis invasive candida infections antifungal agent

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天然无细胞基质移植物在膀胱重建中的应用

中国组织工程研究 2006年第29期10卷 146-148页

作者：林茂虎解放军总医院第一附属医院泌尿外科北京市100037

目的:近年来天然无细胞基质移植物被应用于动物实验模型中,并显示出广阔的应用前景,本文着重介绍天然无细胞基质移植物的特点、制备及其在膀胱重建中的应用。资料来源:应用计算机检索Medline1995-01/2005-12期间的相关文章,检索词为“ti... 详细信息

目的:近年来天然无细胞基质移植物被应用于动物实验模型中,并显示出广阔的应用前景,本文着重介绍天然无细胞基质移植物的特点、制备及其在膀胱重建中的应用。资料来源:应用计算机检索Medline1995-01/2005-12期间的相关文章,检索词为“tissueengineering,bladder”,限定文章语言种类为Eng-lish。并检索了CBMdisc数据库1995-01/2005-12以及CMCC数据库最新卷的中文相关文献,限定文章语言种类为中文,检索词为“组织工程,膀胱”。资料选择:纳入标准:阅读检索文章摘要,选取中、英文关于组织工程、支架和膀胱重建的文献,实验研究选取随机、对照研究,近5年发表的文献优先;排除重复文献及非中英文文献。资料提炼:Medline中共检索到112篇关于组织工程,支架和膀胱重建的文献,中文相关文献36篇,共纳入21篇,文章内容呈不同程度重复均被排除。资料综合:天然无细胞基质材料主要是将生物的空腔器官通过技术处理将细胞成分去除,仅剩下无细胞的基质,这种材料富含胶元、弹性蛋白、平滑肌的结构和血管的框架,可用于空腔器官的修补与替代。膀胱无细胞基质移植物的制备过程结束后,膀胱由原来的颜色变为白色的无细胞基质,但仍维持其原来的袋样形态。尽管再生组织的肌肉含量少于正常,但同以往的膀胱替代结果相比,能出现肌肉的再生已经显示出了小肠黏膜下层的优越性。鼠膀胱无细胞基质移植物膀胱扩大术后平滑肌再生和体内膀胱功能恢复的时间依赖性发现,移植4个月时,膀胱无细胞基质移植物再生膀胱的神经长入与正常的鼠膀胱无明显差异。将多层细胞覆盖支架,可避免尿液与支架的直接接触,减少炎症反应,更能形成解剖和功能更为精确的复原的膀胱。用于膀胱重建的天然无细胞基质移植物主要有小肠黏膜下层和膀胱无细胞基质移植物,具有生物相容性较好,种子细胞易于粘附、增殖,支架生物降解性好等特点,且制备简单,易于操作。结论:天然无细胞基质移植物为膀胱各种成分的重建提供了良好的框架,尽管它仍处于动物实验阶段,但具有广阔地临床研究和应用的前景。

关键词：生物医学工程组织工程/方法移植物存活膀胱/外科学生物相容性材料/代谢

Penetration of erythromycin through Staphylococcus epidermidis biofilm

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Chinese Medical Journal 2013年第14期126卷 2647-2651页

作者： lin mao-hu HE Lei GAO Jie LIU Yun-xi SUO Ji-jiang XING Yu-bin JIA Ning Department of Urology First Affiliated Hospital of People's Liberation Army General Hospital Beijing 10005 1 China Department of Hepatobiliary Surgery People's Liberation Army General Hospital Beijing 100853 China Department of Pathology People's Liberation Army General Hospital Beijing 100853 China Department of Nosocomial Infection and Disease Control People's Liberation Army General Hospital Beijing 100853 China

Background The catheter related infection caused by Staphylococcus epidermidis biofilm is increasing and difficult to treat by antimicrobial chemotherapy. The properties of biofilms that give rise to antibiotic resistance are only partially understood. This study aimed to elucidate the penetration of erythromycin through Staphylococcus epidermidis biofilm. Methods The penetration ratio of erythromycin through Staphylococcus epidermidis biofilms of 1457, 1457-msrA, and wild isolate $68 was detected by biofilm penetration model at different time points according to the standard regression curve. The RNA/DNA ratio and the cell density within the biofilms were observed by confocal laser microscope and transmission electromicroscope, respectively. Results The penetration ratios of erythromycin through the biofilms of 1457, 1457-msrA, and $68 after cultivation for 36 hours were 0.93, 0.55 and 0.4, respectively. The erythromycin penetration ratio through 1457 biofilm （0.58 after 8 hours） was higher than that through the other two （0.499 and 0.31 after 24 hours）. Lower growth rate of the cells in biofilm was shown, with reduction of RNA/DNA proportion observed by confocal laser microscope through acridine orange stain. Compared with the control group observed by transmission electrmicroscope, the cell density of biofilm air face was lower than that of agar face, with more cell debris. Conclusions Erythromycin could penetrate to the Staphylococcus epidermidis biofilm, but could not kill the cells thoroughly. The lower growth rate of the cells within biofilm could help decreasing the erythromycin susceptibility.

关键词： Staphylococcus epidermidis biofilm antibiotic resistance

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui mao hui-lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang huang Lijie mao Zhimin Zhang Han lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

The quality of total mesorectal excision specimen: A review of its macroscopic assessment and prognostic significance

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Chronic Diseases and Translational Medicine 2018年第1期4卷 51-58页

作者： Shi-Bo Song Guo-Ju Wu Hong-Da Pan hua Yang mao-lin hu Qiang Li Qiu-Xia Yan Gang Xiao Department of Gastrointestinal Surgery Beijing HospitalNational Center of GerontologyBeijing 100730China Peking University Fifth School of Clinical Medicine Beijing 100730China

As a surgical procedure which could significantly lower the recurrence rate of cancers, total mesorectal excision (TME) has been the gold standard for middle and lower rectal cancer treatment. However, previous studies have shown that the procedure did not achieve the ideal theoretical local recurrence rates of rectal cancers. Some researchers pointed out it was very likely that not all so-called TME treatments completely removed the mesorectum, implying that some of these TME surgical treatments failed to meet oncological quality standards. Therefore, a suitable assessment tool for the surgical quality of TME is necessary. The notion of 'macroscopic assessment of mesorectal excision (MAME)' was put forward by some researchers as a better assessment tool for the surgical quality of TME and has been confirmed by a series of studies. Besides providing rapid and accurate surgical quality feedbacks for surgeons, MAME also effectively assesses the prognosis of patients with rectal cancer. However, as a new assessment tool used for TME surgical quality, MAME has an only limited influence on the current guidelines and is yet to be widely applied in most countries. The aims of this review are to provide a detailed introduction to MAME for clinical practice and to summarize the current prognostic significance of MAME.

关键词： Macroscopic assessment of mesorectal excision (MAME) Quality control Total mesorectal excision (TME) Coning

A Review of the Functional and Anatomical Default Mode Network in Schizophrenia

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Neuroscience Bulletin 2017年第1期33卷 73-84页

作者： mao-lin hu Xiao-Fen Zong J. John Mann Jun-Jie Zheng Yan-hui Liao Zong-Chang Li Ying He Xiao-Gang Chen Jin-Song Tang Department of Psychiatry The Second Xiangya HospitalCentral South University Changsha 410011 China Division of Molecular Imaging and Neuropathology New York State Psychiatric Institute and Departments of Psychiatry and Radiology Columbia University New YorkNY 10032 USA Mental Health Institute of Central South University China National Clinical Research Center on Mental Disorders(Xiangya) China National Technology Institute on Mental Disorders Hunan Technology Institute of Psychiatry Hunan Key Laboratory of Psychiatry and Mental Health The Second Xiangya Hospital of Central South University Changsha 410011 China Key Laboratory for Neurolnformation of the Ministry of Education School of Life Science and Technology and Center for Information in BioMedicine University of Electronic Science and Technology of ChinaChengdu 611731 China Department of Psychiatry and Biobehavioral Sciences UCLA Semel Institute for Neuroscience David Geffen School of Medicine Los Angeles CA 90024 USA

Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network （DMN）, since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correlation with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and consider the DMN effects of individualized therapies for schizophrenia.

关键词： Schizophrenia Default mode network Task-negative network Task-positive network Antipsychotics Resting state . fMRI DTI