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High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4320-4337页

作者： Zhi-Wei Mo yue-ming Peng yi-xin zhang Yan Li Bi-Ang Kang Ya-Ting Chen Le Li Mary GSorci-Thomas yi-jun lin Yang Cao Si Chen Ze-Long Liu Jian-jun Gao Zhan-Peng Huang Jia-Guo zhou Mian Wang Guang-Qi Chang Meng-Jie Deng yu-Jia Liu Zhen-Sheng Ma Zuo-jun Hu yu-gang Dong Zhi-jun Ou jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases NHC Key Laboratory of Assisted Circulation(Sun Yat-sen University)Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular DiseasesGuangzhouChina Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Hypertension and Vascular Diseases Department of CardiologyHeart CenterThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Medical College of Wisconsin MilwaukeeWIUSA Center for Translational Medicine Institute of Precision MedicineThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Cardiology Heart CenterThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of Medicine of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080P.R.China

Normal high-density lipoprotein(nHDL)can induce angiogenesis in healthy ***,HDL from patients with coronary artery disease undergoes various modifications,becomes dysfunctional(dHDL),and loses its ability to promote ***,we identified a long non-coding RNA,HDRACA,that is involved in the regulation of angiogenesis by *** this study,we showed that nHDL downregulates the expression of HDRACA in endothelial cells by activating WW domain-containing E3 ubiquitin protein ligase 2,which catalyzes the ubiquitination and subsequent degradation of its transcription factor,Kruppel-like factor 5,via sphingosine 1-phosphate(S1P)receptor *** contrast,dHDL with lower levels of S1P than nHDL were much less effective in decreasing the expression of *** was able to bind to Ras-interacting protein 1(RAIN)to hinder the interaction between RAIN and vigilin,which led to an increase in the binding between the vigilin protein and proliferating cell nuclear antigen(PCNA)mRNA,resulting in a decrease in the expression of PCNA and inhibition of *** expression of human HDRACA in a hindlimb ischemia mouse model inhibited the recovery of *** together,these findings suggest that HDRACA is involved in the HDL regulation of angiogenesis,which nHDL inhibits the expression of HDRACA to induce angiogenesis,and that dHDL is much less effective in inhibiting HDRACA expression,which provides an explanation for the decreased ability of dHDL to stimulate angiogenesis.

关键词： angiogenesis lipoprotein inhibited

Implantation-decay method to study the β-delayed charged particle decay

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Nuclear Science and Techniques 2018年第7期29卷 145-151页

作者： yu-Ting Wang De-Qing Fang xin-xing Xu Li-Jie Sun Kang Wang Peng-Fei Bao Zhen Bai Xi-Guang Cao Zhi-Tao dai Bing Ding Wan-Bing He Mei-rong Huang Shi-lun Jin Cheng-Jian lin ming lu Long-xiang Liu Yong Li Peng Ma jun-Bing Ma Jian-Song Wang Shi-Tao Wang Shao-Qiang Ye Yan-yun Yang Cheng-Long zhou ming-Hui Zhao Huan-Qiao zhang yu-gang Ma Wen-Qing Shen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of the Chinese Academy of Sciences Beijing 100049China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201203China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

In this paper,the implantation-decay method is introduced to study the β-delayed charged particle decay.A silicon detector array was used for the implantation of the incident beams and for the detection of the emitted *** experimental measurement on the β-delayed particle emission from ^(22)Al was used to demonstrate the *** half-life value,charged particle spectroscopy,γ ray spectrum,and γ particle coincidence for the decay process were obtained and compared with previous experimental results for ^(22)*** results show that the implantation-decay method,using a silicon detector array,is a suitable experimental method to study the β-delayed charged particle decay for proton-rich nuclei.

关键词：腐烂粒子培植学习试验性光谱学半衰期原子核

Accumulated Clinical Experiences from Successful Treatment of 1377 Severe and Critically Ill COVID-19 Cases

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Current Medical Science 2020年第4期40卷 597-601页

作者： Yong GAO Hai-bo QIU shu zhou Zhen-ning WANG Jian-chu zhang Zheng-liang zhang Zhao-xin QIAN Hong-bo WANG Shi-huan yu yi-feng luO Ya dan WANG Zhuang LIU Wei-ci WANG ming JIA Li-ming zhang yu zhang Yang JIN Yong zhang Yong LIU Zi-hua zhou ying SU Hui-qing LI Wei-min XIAO Kai HUANG Ping HE gang LI Zhao-hui FU Shi LIU Neng xing lin Fan-jun CHENG Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Zhongda Hospital of Souheast University Nanjing 210009China The First Affiliated Hospital of China Medical University Shenyang 110001China The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004China xiangya Hospital of Zhongnan University Changsha 410008China The First Afiliated Hospital of Harbin Medical University Harbin 150001China The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080China Beijing Friendship Hospital of Capital Medical University Beijing 100050China Beijing Anzhen Hospital of Capital Medical University Beijing 100029China Beijing Chaoyang Hospital of Capital Medical University Beiing 100020China

Summary:In late December 2019,COVID-19 was firstly recognized in Wuhan,China and spread rapidly to all of the provinces of *** West Campus of Wuhan Union Hospital,the designated hospital to admit and treat the severe and critically ill COVID-19 cases,has treated a large number of such patients with great success and obtained lots of valuable experiences based on the Chinese guideline(V7.0).To standardize and share the treatment procedures of severe and critically ill cases,Wuhan Union Hospital has established a working group and formulated an operational recommendation,including the monitoring,early warning indicators,and several treatment principles for severe and critically ill *** treatment experiences may provide some constructive suggestions for treating the severe and critically ill COVID-19 cases all over the world.

关键词： 2019-nCoV COVID-19 pneumonia treatment guidelines

Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)

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Military Medical Research 2020年第3期7卷 249-282页

作者： ying-Hui Jin Qing-yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao yin lin Cai yu-Feng yuan Ji-rong yue Xiao-Chun zhang Qi-Wen Yang Jianguang Ji Jian Xia yi-rong Li Fu-xiang zhou Ya-Dong Gao Zhui yu Feng Xu ming-Li Tu Li-ming Tan Min Yang Fang Chen Xiao-Ju zhang Mei Zeng yu Zhu xin-Can Liu Jian Yang Dong-Chi Zhao yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-gang zhang Wei Li Wen Chen yue-xian Shi Xiu-Zhi Yang Xue-jun Wang Yan-jun Zhong ming-Juan Zhao Bing-Hui Li lin-lu Ma Hao Zi Na Wang yun-yun Wang Shao-Fu yu lu-Yao Li Qiao Huang Hong Weng xiang-ying Ren Li-Sha luo Man-Ru Fan Di Huang Hong-Yang Xue lin-xin yu Jin-Ping Gao Tong Deng xian-Tao Zeng Hong-jun Li Zhen-shun Cheng Xiao-Mei Yao xing-Huan Wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Respiratory Diseases China-Japan Friendship HospitalBeijing 100029China Department of Pulmonary and Critical Care Medicine China-Japan Friendship HospitalBeijing 10029China leishenshan Hospital in Wuhan Wuhan 430200China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institutes of Evidence-based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Medical Imaging Guizhou Provincial People’s HospitalGuiyang 550002China Departments of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Peking Union Medical College Hospital(PUMCH)Peking Union Medical CollegeChinese Academy of Medical Sciences(CAMS)Beijing 100730China Center for Primary Health Care Research Lund University and Region Skåne25002 MalmöSweden Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 403371China Department of Allergology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 43071China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinan 250002China Department of Respiratory and Critical Care Medicine Suizhou Central HospitalHubei University of MedicineSuizhou 441300HubeiChina Department of Clinic Pharmacy Second People’s Hospital of Huaihua Ci

The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the *** and treatment guidelines for clinicians caring for patients are *** the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based *** formed a working group of clinical experts and *** steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge *** searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)*** were either strong or weak,or in the form of ungraded consensus-based ***,we issued 34 *** them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based *** covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung

关键词： COVID-19 SARS-CoV-2 Recommendation Chemoprophylaxis Diagnosis Treatment Discharge management Traditional Chinese medicine guideline

Advances in nuclear detection and readout techniques

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Nuclear Science and Techniques 2023年第12期34卷 281-358页

作者： Rui He Xiao‑Yang Niu yi Wang Hong‑Wei Liang Hong‑Bang Liu Ye Tian Hong‑lin zhang Chao‑Jie Zou Zhi‑yi Liu yun‑Long zhang Hai‑Bo Yang Ju Huang Hong‑Kai Wang Wei‑Jia Han Bei Cao gang Chen Cong dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang xian‑Qin Li xin Li Zhuo‑dai Li yu‑Tie Liang shun Liao De‑Xu lin Cheng‑ming Liu Guo‑Rui Liu jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran xiang‑ming Sun Bo‑Tan Wang Jia Wang Jin‑xiang Wang Qi‑lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong yin Hong yuan Chun‑Hui zhang Rui‑Guang Zhao Ran Zheng Cheng‑xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Key Laboratory of Particle and Radiation Imaging Department of Engineering PhysicsTsinghua UniversityBeijing 100084China School of Integrated Circuits Dalian University of TechnologyDalian 116020China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Electronic Engineering School Heilongjiang UniversityHarbin 150080China Spallation Neutron Source Science Center Dongguan 523803China Micro‑electronic Department Harbin Institute of TechnologyHarbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China Liaoning Academy of Materials Shenyang 110167China Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly School of Mathematics and Physics Chengdu University of TechnologyChengdu 620035China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China State Key Lab of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China School of Computer Science Northwestern Polytechnical UniversityXi’an 710129China

“A Craftsman Must Sharpen His Tools to Do His Job,”said *** detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the ***,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,*** article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout *** explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.

关键词： Silicon detector Wide bandgap detector Time projection chamber(TPC) Multigap resistive plate chamber detector(MRPC) Scintillation detector Calorimeters Cherenkov detector Transition radiation detector Artificial intelligence Trigger-less readout

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-xin Liu yue Huang Guang-Cheng Xiao Qing-Cui Bu Jin-lu Qu shu zhang shuang-Nan zhang shu-Mei Jia Fang-jun lu xiang Ma Lian Tao Wei zhang Li Chen Li-ming Song Ti-Pei Li yu-Peng Xu Xue-lei Cao Yong Chen Cong-Zhan Liu Ce Cai Zhi Chang gang Chen Tian-xiang Chen yi-Bao Chen yu-Peng Chen Wei Cui Wei-Wei Cui jing-Kang Deng Yong-Wei Dong yuan-yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao ming-yu Ge yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo lu-Hua Jiang Wei-Chun Jiang jing Jin Yong-Jie Jin ling-Da Kong Bing Li Cheng-Kui Li gang Li Mao-shun Li Wei Li xian Li Xiao-Bo Li Xu-Fang Li Yang-Guo Li Zheng-Wei Li Xiao-Hua Liang jing-yuan Liao Bai-Sheng Liu Guo-Qing Liu Hong-Wei Liu Xiao-jing Liu yi-Nong Liu Bo lu Xue-Feng lu Qi luo Tao luo Bin Meng yi Nang Jian-yin Nie Ge Ou Na Sai Ren-Cheng Shang xin-ying Song Liang Sun ying Tan You-Li Tuo Chen Wang Guo-Feng Wang Juan Wang ling-jun Wang Weng-shuai Wang yu-Sa Wang xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu shuo Xiao Shao-lin Xiong He Xu Jia-Wei Yang Sheng Yang Yan-Ji Yang yi-jung Yang Qi-Bin yi Qian-Qing yin yuan You Ai-Mei zhang Cheng-Mo zhang Fan zhang Hong-Mei zhang Juan zhang Tong zhang Wan-Chang zhang Wen-Zhao zhang yi zhang yi-Fei zhang Yong-Jie zhang yuan-Hang zhang yue zhang Zhao zhang Zhi zhang Zi-Liang zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke zhou Jian-Feng zhou yu-Xuan Zhu Ren-lin Zhuang yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： jun Liu Dan-Dan Li Wei Dong yu-Qi Liu Yang Wu Da-Xuan Tang Fu-Chun zhang Meng Qiu Qi Hua jing-yu He jun Li Bai Du Ting-Hai Du lin-lin Niu Xue-jun Jiang Bo Cui Jiang-Bin Chen Yang-Gan Wang Hai-rong Wang Qin yu jing He yi-lin Mao Xiao-Fang Bin yue Deng yu-Dan Tian Qing-Hua Han Da-Jin Liu Li-Qin Duan ming-jun Zhao Cui-ying zhang Hai-ying dai Ze-Hua Li ying Xiao You-Zhi Hu Xiao-yu Huang Kun xing xin Jiang Chao-Feng Liu jing An Feng-Chun Li Tao Tao Jin-Fa Jiang ying Yang Yao-rong Dong lei zhang Guang Fu ying Li shu-Wei Huang Li-Ping Dou Lan-jun Sun ying-Qiang Zhao Jie Li yun Xia jun Liu Fan Liu Wen-Jin He ying Li Jian-Cong Tan Yang lin Ya-Bin zhou Jian-Fei Yang Guo-Qing Ma Hui-jun Chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu Xiao-Jia luo Xiao-Hong Bin Ya-Nan yu Hai-Xia Dang Bing Li Fei Teng Wang-Min Qiao Xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan Wang yun-dai Chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-Li luo Hao-Tong zhang Yong-Heng Zhao gang Zhao xiang-Qun Cui Guo-Ping Li Yao-Quan Chu Jian-rong Shi gang Wang Jian-Nan zhang Zhong-Rui Bai Xiao-Yan Chen Feng-Fei Wang Yan-xin Guo Jian-jun Chen Bing Du Xiao Kong Ya-Juan lei yin-Bi Li yi-Han Song yue Wu Yan-Xia zhang xin-lin zhou Fang Zuo Peng Du lin He Wen Hou yi-Qiao Dong Jian Li Guang-Wei Li shuang Li jing Song yuan Tian Meng-xin Wang Yong-Hui Hou Zhi-ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu lei Jia Fang-Hua Jiang xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Qi Li yin-Dun Mao Zheng-Hong Tang Qing-Sheng Tao Liang-Ping Tu Da-Qing Wang Dan Wang Jian-Ping Wang lei Wang Shou-Guan Wang shu-Qing Wang Ya-Nan Wang You Wang yue-Fei Wang ming-Zhi Wei xiang-xiang Xue Xiao-Zheng xing ling-Zhe Xu xin-Qi Xu Yan Xu De-Hua Yang Shi-Hai Yang Zheng-Qiu Yao Yong yu Hui yuan Chao Zhai En-Peng zhang jing zhang Li-Ping zhang Weizhang Yong zhang Zhen-Chao zhang ming Zhao Fang zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

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Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao Jin-xin Hao lu Feng Hugh RAJones Jian Li jing Xu Li-Yong Liu Teng-Fei Song Jian-Feng Wang Hua-lin Chen Yan-Jie Xue Huang Shen Yong-Heng Zhao Zhao-xiang Qi Jian-rong Shi yuan Tian Zheng Wang Xia Wang Jin-Liang Hou Jin-ming Bai Ji Yang Xu zhou Yong-Qiang Yao Jia yin Ali Esamdin Guang-xin Pu Peng Wei Chun-Hai Bai Guo-Jie Feng lu Ma Xuan zhang yu Liu Chong Pei Zhi-Xia Shen yun-ying Jiang Jian-Feng Tian xian-Qun Zeng Zhi-gang Hou Xu Yang jun-Bo zhang Shi-Long Liao Dong-Wei Fan yun-Fei Xu Jian-Ping Xiong Tai-Sheng Yan Xi zhang Chang-Hua Li yi-Han Tao Si-Cheng yu Zhi-Song Cao Hong-shuai Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China yunnan Observatories Chinese Academy of SciencesKunming 650216China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing Kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 March 10 to 2019 March *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing