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Effect of nano-selenium loaded with lycium barbarum polysaccharide on the proliferation of lens epithelial cells after UVB damage in vitro

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 9-14页

作者： Jing-xiang Zhong Shan-Shan Jin Kang-Sheng Wu Guo-cheng Yu Lei-Lei Tu Lian Liu Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina

AIM:To investigate the effect of nano-selenium loaded with different concentrations of lycium barbarum polysaccharide(LBP-Se NPs)on the proliferation of human lens epithelial cells(HLECs)from UV ***:LBP-Se NPs were prepared and their particle size was ***(SRA01/04)were irradiated with UVB for different time(0,10,20,30,40,50,60 min)to construct a damaged model,the survival rate of cells was determined by methylthiazol tetrazolium(MTT)*** 4’,6-Diamidine-2’-phenylindole dihydrochloride(DAPI)staining was used to observe the status of cell nucleus and drug entering cytoplasm through cell membrane in SRA01/04 cells after adding LBP-SENPS loaded with coumarin fluorescence agent 24 h under fluorescence ***01/04 normal and UVB-damaged cells were treated with different amounts of LBP-Se NPs at different concentrations,cells proliferation were ***:The particle size of LBP-Se NPs was stable in the range of 150-200 *** survival rate changes with time after UVB irradiation were statistically *** 10 min of UVB exposure as the time was chosen to construct the cell damage *** DAPI staining,LBPSe NPs were observed to enter the cytoplasm through the cell membrane under fluorescence inverted *** of SRA01/04 at different concentrations of LBPSe NPs were *** survival rate was statistically different compared with the control *** higher the loading concentration of LBP in nano-Se drugs was,the higher the cell proliferation rate was(P<0.05).The lower the concentration of LBP-Se NPs,the higher the cell proliferation rate,showing a negative growth trend(P<0.05).The group with the highest average cell proliferation rate was 0.5μmol/L 2.0 mg/m L LBP-Se NPs(128.80%).When the 2.0 mg/m L LBP-Se NPs group was selected for cell photography,the cell density was higher at 0.5μmol/*** the increase of concentration,SRA01/04 cells appeared more cytoplasm dehydration,cell shrinkage and ap

关键词： lycium barbarum polysaccharide nano-selenium human lens epithelial cells ultraviolet irradiation

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智慧校园楼宇建设与运维一体化管理系统研制探索

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智能建筑电气技术 2024年第1期18卷 22-26页

作者：肖小野石振明李翔肖超谢文黎林敏同济大学上海200092 同济大学建筑设计研究院(集团)有限公司上海200092 毕埃慕(上海)建筑数据技术股份有限公司上海200540

伴随大数据、物联网、人工智能等新兴科学技术的高速发展,智慧校园(城市)建设在整个社会掀起热潮。智慧建筑楼宇群是智慧校园的载体,数据驱动的建筑楼宇群设备自控及智慧运管,也就成为了智慧校园发展的必然趋势。本研究充分发挥了建设... 详细信息

伴随大数据、物联网、人工智能等新兴科学技术的高速发展,智慧校园(城市)建设在整个社会掀起热潮。智慧建筑楼宇群是智慧校园的载体,数据驱动的建筑楼宇群设备自控及智慧运管,也就成为了智慧校园发展的必然趋势。本研究充分发挥了建设主体与运营主体高度统一的优势,以BIM技术为抓手,打通新老建筑设备系统通信的壁垒,深度整合了施工管理平台与运维管理平台,探索研制建设与运维一体化管理系统,为国内同类型智慧校园楼宇建设提供了积极示范。

关键词：智慧校园楼宇建设与运维一体化管理 BIM技术

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Effect of Paired Associative Stimulation on Motor Cortex Excitability in Rats

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Current Medical Science 2018年第5期38卷 903-909页

作者： xiang-yu ZHANG Yan-fang SUI Tie-cheng GUO Sai-hua WANG Yan HU Yin-shan LU Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Rehabilitation Medicine the 5th Hospital of Zhengzhou UniversityZhengzhou 470000China Department of Rehabilitation Medicine the 1st People's Hospital of HaikouHaikou 570208China Department of Rehabilitation Medicine the 1st Hospital of WuhanWuhan 430022China Department of Rehabilitation Medicine Zhongnan HospitalWuhan UniversityWuhan 430071China

Paired associative stimulation (PAS),combining transcranial magnetic stimulation (TMS) with electrical peripheral nerve stimulation (PNS) in pairs with an optimal interstimulus interval (ISI)in between,has been shown to influence the excitability of the motor cortex (MC)in ***,the underlying mechanisms remain *** study was designed to explore an optimal protocol of PAS,which can modulate the excitability of MC in rats,and to investigate the underlying mechanisms. The resting motor thresholds (RMTs) of TMS-elicited motor evoked potentials (MEPs) recorded from the gastrocnemius muscle and the latency of P1 component of somatosensory evoked potentials (SEPs) induced by electrical tibial nerve stimulation were determined in male Sprague-Dawley rats (n=10).Sixty rats were then randomly divided into 3 groups:a PAS group (further divided into 10 subgroups at various ISIs calculated by using the latency of P1,n=5,respectively),a TMS (only)group (n=5)and a PNS (only)group (n=5).Ninety repetitions of PAS,TMS and PNS were administered to the rats in the 3 groups,respectively,at the frequency of 0.05 Hz and the intensity of TMS at 120% RMT and that of PNS at 6 *** and motor evoked potentials'amplitude (MEPamp)were recorded before and immediately after the *** was found that the MEPamp significantly decreased after PAS at ISI of 5 ms (P0.05).PAS at other ISis as well as the sole use of TMS and PNS induced no remarkable changes in MEPamp and *** conclusion,PAS can influence motor cortex excitability in *** TMS alone nor PNS alone shows significant effect.

关键词： paired associative stimulation transcranial magnetic stimulation peripheral nerves electrical stimulation resting motor thresholds motor evoked potentials somatosensory evoked potentials

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Laparoscopic vs open abdominoperineal resection in the multimodality management of low rectal cancers

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World Journal of Gastroenterology 2015年第35期21卷 10174-10183页

作者： Yu-Wei Wang Li-Yong Huang cheng-Li Song Chang-Hua Zhuo De-Bing Shi Guo-xiang Cai Ye Xu San-Jun Cai Xin-xiang Li Department of Colorectal Surgery Fudan University Shanghai Cancer Center Fudan University Department of Oncology Shanghai Medical CollegeFudan University Shanghai Institute for Minimally Invasive Therapy School of Medical Instrument and Food EngineeringUniversity of Shanghai for Science and Technology

AIM: To evaluate the safety and feasibility of laparoscopic abdominoperineal resection compared with the open procedure in multimodality management of rectal ***: A total of 106 rectal cancer patients who underwent open abdominoperineal resection(OAPR) were matched with 106 patients who underwent laparoscopic abdominoperineal resection(LAPR) in a 1 to 1 fashion, between 2009 and 2013 at Fudan University Shanghai Cancer Center. Propensity score matching was carried out based on age, gender, pathological staging of the disease and administration of neoadjuvant chemoradiation. Data regarding preoperative staging, surgical technique, pathologicalresults, postoperative recovery and complications were reviewed and compared between the LAPR and OAPR groups. Perineal closure around the stoma and pelvic floor reconstruction were performed only in OAPR, not in LAPR. Therefore, abdominoperineal resection procedure-specific surgical complications including parastomal hernia and perineal wound complications were compared between the open and laparoscopic procedure. Regular surveillance of the two cohorts was carried out to gather prognostic data. Diseasefree survival was analyzed using Kaplan-Meier estimate and log-rank test. Subgroup analysis was performed in patients with locally advanced disease treated with preoperative chemoradiation followed by surgical resection. RESULTS: No significant difference was found between the LAPR group and the OAPR group in terms of clinicopathological features. The operation time(180.8 ± 47.8 min vs 172.1 ± 49.2 min, P = 0.190), operative blood loss(93.9 ± 60.0 m L vs 88.4 ± 55.2 m L, P = 0.494), total number of retrieved lymph nodes(12.9 ± 6.9 vs 12.9 ± 5.4, P = 0.974), surgical complications(12.3% vs 15.1%, P = 0.549) and pathological characteristics were comparable between the LAPR and OAPR group, respectively. Compared with OAPR patients, LAPR patients showed significantly shorter postoperative analgesia(2.4 ± 0.7 d vs 2.7 ± 0.6

关键词： Abdominoperineal resection Laparoscopy Rectal canc

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MJO potential predictability and predictive skill in IAP AGCM 4.1

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Atmospheric and Oceanic Science Letters 2016年第5期9卷 388-393页

作者： WANG Kun lin Zhao-Hui linG Jian YU Yue WU cheng-Lai International Center for Climate and Environment Sciences(ICCES) Institute of Atmospheric Physics(lAP)Chinese Academy of Sciences(CAS)BeijingChina College of Earth Science University of Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjingChina State Key Laboratory of Numerical Modeling for Atmospheric Science and Geophysical Fluid Dynamics(LASG) IAPCASBeijingChina

A 30-year hindcast was performed using version 4.1 of the IAP AGCM（IAP AGCM4.1）, and its potential predictability of the MJO was then evaluated. The results showed that the potential predictability of the MJO is 13 and 24 days, evaluated using the signal-to-error ratio method based on a single member and the ensemble mean, respectively. However, the MJO prediction skill is only9 and 10 days using the two methods mentioned above. It was further found that the potential predictability and prediction skill depend on the MJO amplitude in the initial conditions. Prediction initiated from conditions with a strong MJO amplitude tends to be more skillful. Together with the results of other measures, the current MJO prediction ability of IAP AGCM4.1 is around 10 days, which is much lower than other climate prediction systems. Furthermore, the smaller difference between the MJO predictability and prediction skill evaluated by a single member and the ensemble mean methods could be ascribed to the relatively smaller size of the ensemble member of the ***, considerable effort should be made to improve MJO prediction in IAP AGCM4.1 through application of a reasonable model initialization and ensemble forecast strategy.

关键词： MJO IAP AGCM 4.1 predictability prediction skill

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Effects of solidification parameters on microstructure and mechanical property of a Ni-based superalloy K35 blade

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Rare Metals 2007年第S1期26卷 274-279页

作者： XUE xiang,and XU lin National Key Laboratory for Precision Hot Processing of Metals,Harbin Institute of Technology,Harbin 150001,China Harbin Inst Technol Natl Key Lab Precis Hot Proc Met Harbin 150001 Peoples R China

A gas turbine blade of Ni-based superalloy K35 was chosen as the test casting and the effects of solidification parameters on microstructure and mechanical property of the blade were investigated.A software package was used to numerically simulate the mold filling and solidification process of the blade casting in order to obtain the solidification parameters in the *** secondary dendrite arm spacing and grain size at different positions of the blade casting were *** relationships of secondary dendrite arm spacing and grain size versus cooling rate and solidification time were quantitatively *** relationships of Vickers-hardness versus solidification structures are also *** results show that Vickers-hardness decreases with the increase of both grain size and secondary dendrite arm *** offers a good basis to predict the microstructure and mechanical property of a gas turbine blade casting through numerical simulation in order to obtain a high-quality gas turbine blade casting.

关键词： superalloy microstructure dendrite arm spacing grain size hardness

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合并双重罕见地中海贫血基因分析

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中国实验血液学杂志 2024年第5期32卷 1479-1484页

作者：李成德冼光宇黄晓佳陈珊梁丽霞林志芳肇庆市第一人民医院检验科广东肇庆526020

目的:回顾性分析2例合并双重罕见型地中海贫血基因型病例的检测及诊断过程,探究罕见地中海贫血的漏诊误诊原因提高罕见地中海贫血诊断水平。方法:结合受检者家族史、血液学表型及血红蛋白电泳分析结果,采用PCR+导流杂交法检测受检者α和... 详细信息

目的:回顾性分析2例合并双重罕见型地中海贫血基因型病例的检测及诊断过程,探究罕见地中海贫血的漏诊误诊原因提高罕见地中海贫血诊断水平。方法:结合受检者家族史、血液学表型及血红蛋白电泳分析结果,采用PCR+导流杂交法检测受检者α和β-地中海贫血常见基因型,DNA测序技术对受检者标本进行罕见α和β蛋白基因测序。结果:两例受检者均为合并双重罕见地中海贫血基因型,该两例罕见地中海贫血基因组合均为首次报道,一例为αα^(*53_55 del TCC)/αα杂合合并β^(IVSⅡ-2(-T))/β^(N)杂合的αβ复合地中海贫血,另一例为αα^(IVS-Ⅱ-55(T→G)inα1)/αα^(4.2-Q)双重杂合的α-地中海贫血,其中αα^(*53_55 del TCC)/αα基因型亦为首次报道。结论:本次报道的中国人群中罕见地中海贫血基因类型αα^(*53_55 del TCC)/αα及两例罕见地中海贫血基因组合案例,丰富了中国人群地中海贫血基因突变谱,为地中海贫血诊断和优生优育咨询提供更丰富的分子信息。

关键词： αβ复合地中海贫血基因变异基因组合

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Analyzing Characters of Plasma Wake with Method of Chaos Dynamics

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Chinese Physics Letters 1998年第12期15卷 889-891页

作者： CAO Jin-xiang FANG Jian-dong ZHAO Hong-bo lin Yi-jun ZHANG Jia-xiang WANG Jie-xia DONG Yong-hui Department of Modern Physics University of Science and Technology of ChinaHefei 230027 Beijing Institute of Aerodynamics Beijing 100074

In this paper,analyzing the experiment data of multiple scanning probes in the arc wind-driven hypersonic plasma flows with the chaos dynamics method,we have obtained the power spectrum,the frequency wavenumber spectral density,the correlation dimension and Kolmogorov entropy of the flows,*** distribution of correlation dimension and Kolmogorov entropy of the blunt cone wakes along the axis and the radius of the flows are presented successfully in the *** distributions clearly show the structure of turbulence and lamination in blunt cone *** the method of minimum Kolmogorov entropy,we observed the structure of the bow shock at far wake region in the blunt cone wakes.

关键词： entropy flows dimension

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某难处理硫铁金矿冶炼沸腾炉技术改造

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硫磷设计与粉体工程 2024年第4期181卷 36-40,I0002页

作者：孙晋琳尹福兴张映群汪国祥段亚林陈树文自鹏桦鹤庆北衙矿业有限公司云南大理671000

某硫铁金矿颗粒较细,且含有害元素砷,采用焙烧+氰化工艺处理,金回收率仅有51%~63%,且无法获得高价值铁精粉。试验分析了硫铁金矿的物化特性,模拟了其焙烧过程,获得了最佳的焙烧效果及控制参数,并根据焙烧试验结果对沸腾炉进行了优化改造... 详细信息

某硫铁金矿颗粒较细,且含有害元素砷,采用焙烧+氰化工艺处理,金回收率仅有51%~63%,且无法获得高价值铁精粉。试验分析了硫铁金矿的物化特性,模拟了其焙烧过程,获得了最佳的焙烧效果及控制参数,并根据焙烧试验结果对沸腾炉进行了优化改造,以提高焙烧效果和金浸出率,获得低含砷的铁产品,从而实现难处理硫铁资源的高效利用。

关键词：硫铁金矿冶炼焙烧试验沸腾炉改造资源利用

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A highly efficient pathway to recover gold from acid aqueous solution by using an amidoxime-functionalized UHMWPE fiber

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Rare Metals 2019年第11期38卷 1105-1112页

作者： Yu-lin Liang Chan Jin Jiang-Tao Hu Zhen Liu Yan Li Jian-Rong Zeng Guo-Zhong Wu xiang-Jun Wei Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

A new amidoxime-functionalized ultrahigh molecular weight polyethylene fibrous adsorbent(UHMWPEg-PAO) was used for the recovery of Au(III) from acid aqueous *** maximum experimental absorption capacity of UHMWPE-g-PAO fiber was found to be approximately 220.0 mg·g^-*** adsorption on UHMWPE-g-PAO was characterized by synchrotron radiation-based microcomputed tomography(SR-μ-CT),transmission electron microscopy(TEM),X-ray absorption near-edge structure spectroscopy(XANES) and synchrotron radiation-based Fourier transform infrared microspectroscopy(SR-FTIR).The SR-μ-CT and TEM results showed the distribution features of gold particles on the *** mechanism of Au(III) recovery from aqueous solutions by UHMWPE-g-PAO was based on the adsorbed Au(III) ions,which were reduced to metallic zero-valent gold(Au(0)) by amino groups(-NH2) in the amidoxime(AO)groups during the adsorption process,as confirmed by highresolution TEM(HRTEM) and XANES analyses.X-ray diffraction(XRD) results indicated that the incineration ashes contained metallic zero-valent *** conclusion,this amidoxime-functionalized fibrous adsorbent is a promising material for recovering gold from aqueous solution.

关键词： UHMWPE-g-PAO Adsorption mechanism Gold Reduction

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