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Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115

Cellular & Molecular Immunology 2024年第3期21卷 275-291页

作者： Zhi-Dong Zhang Chang-Rui Shi Fang-Xu Li Hu Gan Yanhong Wei Qianhui Zhang Xin Shuai Min Chen yu-lin lin Tian-Chen Xiong Xiaoqi Chen Bo Zhong Dandan lin Department of Gastrointestinal Surgery Medical Research InstituteFrontier Science Center of Immunology and MetabolismZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan430071China Department of Virology College of Life SciencesWuhan UniversityWuhan430072China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhan430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan430071China Department of Rheumatology and Immunology Zhongnan Hospital of Wuhan UniversityWuhan430071China Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China

STING(also known as MITA)is an adaptor protein that mediates cytoplasmic DNA-triggered signaling,and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe ***,we show that STING-mediated inflammation and autoimmunity are promoted by RNF115 and alleviated by the RNF115 inhibitor disulfiram(DSF).Knockout of RNF115 or treatment with DSF significantly inhibit systemic inflammation and autoimmune lethality and restore immune cell development in Trex1^(–/–)mice and STING^(N153S/WT) bone marrow chimeric *** addition,knockdown or pharmacological inhibition of RNF115 substantially downregulate the expression of IFN-α,IFN-γand proinflammatory cytokines in PBMCs from patients with systemic lupus erythematosus(SLE)who exhibit high concentrations of dsDNA in peripheral ***,knockout or inhibition of RNF115 impair the oligomerization and Golgi localization of STING in various types of cells transfected with cGAMP and in organs and cells from Trex1^(–/–)***,knockout of RNF115 inhibits the activation and Golgi localization of STINGN153S as well as the expression of proinflammatory cytokines in myeloid cells but not in endothelial cells or *** together,these findings highlight the RNF115-mediated cell type-specific regulation of STING and STINGN153S and provide potential targeted intervention strategies for STING-related autoimmune diseases.

关键词： STING/MITA Disulfiram RNF115 SLE Autoimmunity

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市售药食同源保健花茶物种鉴定研究

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药学学报 2024年第9期59卷 2612-2624页

作者：孙靖黄子怡李思齐李余芳胡艳郭世文胡格申传璞杨芙蓉林余霖辛天怡浦香东安徽医科大学药学院安徽合肥230032 中国医学科学院、北京协和医学院药用植物研究所国家中医药管理局中药资源保护重点研究室北京100193

掺伪混伪严重影响药材质量,进而危及人类健康。药食同源保健食品属于中药衍生物,相比于药物而言,其更易获取且贴近消费者生活。然而,市售药食同源保健食品中的中药组分真伪鉴定尚未引起重视,且无明确标准可依,急需开展系统性研究。本研... 详细信息

掺伪混伪严重影响药材质量,进而危及人类健康。药食同源保健食品属于中药衍生物,相比于药物而言,其更易获取且贴近消费者生活。然而,市售药食同源保健食品中的中药组分真伪鉴定尚未引起重视,且无明确标准可依,急需开展系统性研究。本研究基于DNA条形码分子鉴定技术,结合ITS2、psbA-trnH、matK通用条形码序列及DX、HH、JYH特异性条形码序列对市售药食两用保健花茶真伪进行鉴定,旨在对市场上流通的药食同源保健花茶产品真伪情况进行调查。研究结果显示:180份市售产品中共有164份样品成功获得DNA条形码序列,其余样品因无目标组分或DNA存在降解,无法获得扩增产物。结合性状鉴定研究发现180份样品中共有141份为正品,占总样品量的78.33%;31份样品存在掺伪现象,8份样品无目标组分,共占总样品量的21.67%。此外,水试研究发现,5份红花花茶样品存在红花掺重现象。本研究揭示药食同源保健花茶产品质量存在掺伪及掺重情况,提示监管部门应该加速药食同源保健食品领域质量标准的建立,为药食同源保健食品产业的快速发展提供参考。

关键词：药食同源中药花茶分子鉴定 DNA条形码真伪

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Study on the hepatocellular carcinoma model with metastasis

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Genes & Diseases 2020年第3期7卷 336-350页

作者： yu-lin lin Yan Li Department of Peritoneal Cancer Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing100038China

Hepatocellular carcinoma(HCC)is one of the most common causes of cancerrelated death around the world due to advanced clinical stage at diagnosis,high incidence of recurrence and metastasis after surgical *** is in urgent need to create appropriate animal models to explore the mechanism,patterns,risk factors,and therapeutic strategies of HCC metastasis and ***,most of the established models lack the phenotype of invasion and metastasis in patient,or have unstable *** establish HCC models with stable metastasis phenotype requires profound understanding in cancer metastasis biology and scientific *** the past 3 decades,HCC models with stable metastasis have been extensively *** paper reviewed the history and development of HCC animal models and cell models,focusing on the screening and maintaining of metastatic potential and ***-depth studies using these models vastly promote the understanding of cellular and molecular mechanisms and development of therapeutic strategies on HCC metastasis.

关键词： Animal model Cell model Chemically induced HCC model Genetically engineered mouse model Hepatocellular carcinoma Metastasis Patient derived xenograft model

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On Spinors

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Acta Mathematica Sinica,English Series 2009年第10期25卷 1721-1728页

作者： Yan lin yu lin ZHU Xiu Hong FENG Department of Mathematics Suzhou University Suzhou 215006 P. R. China

For a 2^n-dimensional complex Hermitian vector space S, we prove that any unitary basis of S can be explained as an augmented spinor structure on S. By using this explanation, a SpinC（2n）- action on S is equivalent to an action on a subset of augmented spinor structures. The latter action is a little easy to be understood, and is shown in the last part of this paper. Such kind of understanding could be of use to the discussions of Hermitian manifolds and spin manifolds, especially could help to find connections and elliptical operators.

关键词： Pauli matrices spinor augmented spinor

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A Bio-Inspired Hopping Kangaroo Robot with an Active Tail

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Journal of Bionic Engineering 2014年第4期11卷 541-555页

作者： Guan-Horng Liu Hou-Yi lin Huai-yu lin Shao-Tuan Chen Pei-Chun lin Department of Mechanical Engineering National Taiwan University Taipei 106 Taiwan

Inspired by kangaroo＇s locomotion, we report on developing a kangaroo-style hopping robot. Unlike bipeds, quadrupeds, or hexapods which altemate the legs for forward locomotion, the kangaroo uses both legs synchronously and generates the forward locomotion by continuous hopping behavior, and the tail actively balances the unwanted angular momentum generated by the leg motion. In this work, we generate the Center of Mass （CoM） locomotion of the robot based on the reduced-order Rolling Spring Loaded Inverted Pendulum （R-SLIP） model, for matching the dynamic behavior of the empirical robot legs. In order to compensate the possible body pitch variation, the robot is equipped with an active tail for pitch variation compensation, emulating the balance mechanism of a kangaroo. The robot is empirically built, and various design issues and strategies are addressed. Finally, the experimental evaluation is executed to validate the performance of the kangaroo-style robot with hopping locomotion.

关键词： legged robot kangaroo hopping SLIP tail

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The Enhanced Period Map and Equivariant Deformation Quantizations of Nilpotent Orbits

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Acta Mathematica Sinica,English Series 2024年第3期40卷 885-934页

作者： Shi lin yu Department of Mathematics School of Mathematical SciencesXiamen UniversityXiamen 361005P.R.China

In a previous paper,the author and his collaborator studied the problem of lifting Hamil-tonian group actions on symplectic varieties and Lagrangian subvarieties to their graded deformation quantizations and apply the general results to coadjoint orbit method for semisimple Lie *** even quantizations were considered *** this paper,these results are generalized to the case of general quantizations with arbitrary *** key step is to introduce an enhanced version of the(truncated)period map defined by Bezrukavnikov and Kaledin for quantizations of any smooth sym-plectic variety X,with values in the space of Picard Lie algebroid over *** an application,we study quantizations of nilpotent orbits of real semisimple groups satisfying certain codimension condition.

关键词： Coadjoint orbit method deformation quantization Harish-Chandra modules semisimple Liegroups

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Molecular structure and phylogenetic analyses of the complete chloroplast genomes of three original species of Pyrrosiae Folium

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Chinese Journal of Natural Medicines 2020年第8期18卷 573-581页

作者： YANG Chu-Hong LIU Xia CUI Ying-Xian NIE Li-Ping lin yu-lin WEI Xue-Ping WANG yu YAO Hui Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Engineering Research Center of Chinese Medicine Resources Ministry of EducationBeijing 100193China

Pyrrosia petiolosa,Pyrrosia lingua and Pyrrosia sheareri are recorded as original plants of Pyrrosiae Folium(PF)and commonly used as Chinese herbal *** to the similar morphological features of PF and its adulterants,common DNA barcodes cannot accurately distinguish PF *** of the chloroplast(cp)genome is widely used in species identification,molecular marker and phylogenetic ***,we determined the complete cp genomes of three original species of PF via highthroughput sequencing *** three cp genomes exhibited a typical quadripartite structure with sizes ranging from 158165 to 163026 *** cp genomes of *** and *** encoded 130 genes,whilst that of *** encoded 131 *** complete cp genomes were compared,and five highly divergent regions of pet A-psb J,mat K-rps16,ndh C-trn M,psb M-pet N and psa Cndh E were screened as potential DNA barcodes for identification of Pyrrosia genus *** phylogenetic tree we obtained indicated that *** and *** are clustered in a single clade and,thus,share a close *** study provides invaluable information for further studies on the species identification,taxonomy and phylogeny of Pyrrosia genus species.

关键词： Complete chloroplast genome Pyrrosia petiolosa Pyrrosia lingua Pyrrosia sheareri Identification Phylogenetic relationship

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Treatment outcome analysis of bevacizumab combined with cyclophosphamide and oxaliplatin in advanced pseudomyxoma peritonei

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1149-1158页

作者： Ying Zhang Xin Zhao Chao Gao lin-yu lin Yan Li Department of Peritoneal Cancer Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Pseudomyxoma peritonei(PMP)is a rare peritoneal malignant tumor *** surgery combined with hyperthermic intraperitoneal chemotherapy is its standard ***,there are few studies and insufficient evidence regarding systemic chemotherapy of advanced *** for colorectal cancer are often used clinically,but there is no uniform standard for late-stage *** To determine if bevacizumab combined with cyclophosphamide and oxaliplatin(Bev+CTX+OXA)is effective for treatment of advanced *** primary study endpoint was progression-free survival(PFS).METHODS Retrospective analysis was conducted on the clinical data of patients with advanced PMP who received Bev+CTX+OXA regimen(bevacizumab 7.5 mg/kg ivgtt d1,oxaliplatin 130 mg/m2 ivgtt d1 and cyclophosphamide 500 mg/m2 ivgtt d1,q3w)in our center from December 2015 to December *** response rate(ORR),disease control rate(DCR)and incidence of adverse events were *** was followed ***-Meier method was used to draw survival curve,and log-rank test was used for comparison between *** Cox proportional hazards regression model was used to analyze the independent influencing factors of *** A total of 32 patients were *** 2 cycles,the ORR and DCR were 3.1%and 93.7%,*** median follow-up time was 7.5 *** the follow-up period,14 patients(43.8%)had disease progression,and the median PFS was 8.9 *** analysis showed that the PFS of patients with a preoperative increase in CA125(8.9 vs 2.1,P=0.022)and a completeness of cytoreduction score of 2-3(8.9 vs 5.0,P=0.043)was significantly longer than that of the control *** analysis showed that a preoperative increase in CA125 was an independent prognostic factor for PFS(HR=0.245,95%CI:0.066-0.904,P=0.035).CONCLUSION Our retrospective assessment confirmed that the Bev+CTX+OXA regimen is effective in second-or posterior-line treatment of advan

关键词： Pseudomyxoma peritonei Bevacizumab Oxaliplatin Cyclophosphamide

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Analysis and experimental study on resistance-increasing behavior of composite high efficiency autonomous inflow control device

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Petroleum Science 2024年第2期21卷 1290-1304页

作者： Liang-Liang Dong yu-lin Zhang School of Mechatronic Engineering Southwest Petroleum UniversityChengdu610500SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina Oil and Gas Equipment Technology Sharing and Service Platform of Sichuan ProvinceChengdu610500SichuanChina

Bottom water coning is the main reason to reduce the recovery of horizontal bottom water reservoir. By water coning, we mean the oil-water interface changes from a horizontal state to a mound-shaped cone and breaks through to the wellbore. Autonomous inflow control device(AICD) is an important instrument maintain normal production after bottom water coning, however, the resistance increasing ability of the swirl type AICD is insufficient at present, which seriously affects the water control effect. Aiming this problem, this paper designs a multi-stage resistance-increasing and composite type AICD. The separation mechanism of oil-water two phases in this structure, the resistance form of oil-water single phase and the resistance-increasing principle of water phase are analyzed. Establishing the dual-phase multi-stage separation and resistance-increasing model, and verified by measuring the throttling pressure drop and oil-water volume fraction of the AICD, it is found that the composite type AICD has the effect of ICD and AICD at the same time, which can balance the production rate of each well section at the initial stage of production, delay the occurrence of bottom water coning. In the middle and later stages of production, water-blocking can be effectively increased to achieve water control and stable *** structural sensitivity analysis, the influence law of various structural parameters on the water control performance of composite AICD was obtained. The simulation calculation results show that,compared with the existing swirl type AICD, composite AICD has higher sensitivity to moisture content,the water phase throttling pressure drop is increased by 4.5 times on average. The composite AICD is suitable for the entire stage of horizontal well production.

关键词： Water control Flow separation Flow resistance-increasing AICD device Simulation and experiment

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Recent progress in self-propelled particles

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Journal of Hydrodynamics 2024年第1期36卷 61-77页

作者： Zhen-yu Ouyang Jian-zhong lin Laboratory of Impact and Safety Engineering Ministry of EducationNingbo UniversityNingbo315201China Department of Mechanics State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou310027China

Self-propelled particles are commonly found in a large number of planktonic organisms such as bacteria,fungi,and algae in nature,and researchers have taken a long interest in exploring their swimming mechanisms for more than a *** in the past 20 years,with the development of computational fluid dynamics and flow display technology,as well as the need for the design of synthetic self-propelled particles and micro-swimming devices,self-propelled particles have become the forefront and hotspot of current research in the field of fluid *** paper first introduces the swimming characteristics of common self-propelled particles,leading to a classic“squirmer”type self-propelled particle *** this basis,a systematic introduction and summary of the theoretical and numerical simulation research of“squirmer”will be ***,the main challenges and opportunities faced by the current research will be summarized.

关键词： Self-propelled particles multiphase flow hydrodynamic interaction

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