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Advances in MET tyrosine kinase inhibitors in gastric cancer

Cancer Biology & Medicine 2024年第6期21卷 484-498页

作者： yifan Zhang lin Shen Zhi Peng Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Gastrointestinal Oncology Peking University Cancer Hospital & Institute State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational Research Department of Gastrointestinal Oncology Peking University Cancer Hospital & Institute

Gastric cancer is among the most frequently occurring cancers and a leading cause of cancer-related deaths globally. Because gastric cancer is highly heterogenous and comprised of different subtypes with distinct molecular and clinical characteristics, the management of gastric cancer calls for better-defined, biomarker-guided, molecular-based treatment strategies. MET is a receptor tyrosine kinase mediating important physiologic processes, such as embryogenesis, tissue regeneration, and wound healing. However, mounting evidence suggests that aberrant MET pathway activation contributes to tumour proliferation and metastasis in multiple cancer types, including gastric cancer, and is associated with poor patient outcomes. As such, MET-targeting therapies are being actively developed and promising progress has been demonstrated, especially with MET tyrosine kinase inhibitors. This review aims to briefly introduce the role of MET alterations in gastric cancer and summarize in detail the current progress of MET tyrosine kinase inhibitors in this disease area with a focus on savolitinib, tepotinib, capmatinib, and crizotinib. Building on current knowledge, this review further discusses existing challenges in MET alterations testing, possible resistance mechanisms to MET inhibitors, and future directions of MET-targeting therapies.

关键词： Gastric cancer MET alterations MET testing MET tyrosine kinase inhibitors savolitinib

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Improved catalytic performance of CO_(2) electrochemical reduction reaction towards ethanol on chlorine-modified Cu-based electrocatalyst

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Nano Research 2024年第5期17卷 3761-3768页

作者： yifan Liu Hehua Tang Yitian Zhou Bo-lin lin School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

Effective electrochemical conversion of CO_(2) to value-added liquid multi-carbon products driven by renewable energy is a promising approach to alleviate excessive CO_(2) emission and achieve large-scale renewable energy storage.However,the selectivity and catalytic activity towards liquid multi-carbon products of CO_(2) electroreduction reaction are still unsatisfactory due to the sluggish C-C coupling process and the formation of complex oxygen-containing intermediates.Hence,designing and fabricating highly effective electrocatalysts is crucial for practical applications in this field.Here,we developed Cl-modified Cu catalyst(Cu-Cl)for efficient electrochemical reduction of CO_(2) to ethanol.The optimal Faradaic efficiency and partial current density of ethanol on the Cu-Cl sample reached 26.2%and 343.2 mA·cm^(-2) at-0.74 V(vs.reversible hydrogen electrode(RHE)),which were 1.66 and 1.76 times higher than those of the catalyst without Cl decoration,outperforming those in most previously reported works.Density functional theory(DFT)calculations revealed that the Cl-modified Cu surface suppressed the parasitic hydrogen evolution reaction(HER)and reduced the energy barrier for the C-C coupling process,making the formation of key intermediates favorable for ethanol production.Thus,the decoration of Cl on the Cu surface facilitated ethanol formation.

关键词： CO_(2)electrochemical reduction halogen chlorine Cu-based catalysts ethanol multi-carbon products

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An electrically controlled tunable photonic crystal filter based on thin-film lithium niobate

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Optoelectronics Letters 2024年第4期20卷 200-204页

作者： WANG yifan YAO Yuan ZHANG Hao LIU Bo DUAN Shaoxiang lin Wei Institute of Modern Optics College of Electronic Information and Optical EngineeringNankai UniversityTianjin 300350China Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology Nankai UniversityTianjin 300350China Southern Marine Science and Engineering Guangdong Laboratory Zhuhai 519000China Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology Nankai UniversityTianjin 300350China

In this paper,we present an electrically controlled tunable narrowband filter based on a thin-film lithium niobate two-dimensional(2D)photonic crystal.The filter incorporates a photonic crystal microcavity structure within the straight waveguide,enabling electronic tuning of the transmitted wavelength through added electrode structures.The optimized microcavity filter design achieves a balance between high transmission rate and quality factor,with a transmission center wavelength of 1551.6 nm,peak transmission rate of 96.1%,and quality factor of 5054.Moreover,the filter can shift the central wavelength of the transmission spectrum by applying voltage to the electrodes,with a tuning sensitivity of 13.8 pm/V.The proposed tunable filter adopts a simple-to-fabricate air-hole structure and boasts a compact size(length:11.57μm,width:5.27μm,area:60.97μm^(2)),making it highly suitable for large-scale integration.These features make the filter promising for broad applications in the fields of photonic integration and optical communication.

关键词： tunable tuning waveguide

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Screening of Streptomyces strains helping arbuscular mycorrhizal symbiosis against pepper(Capsicum annuum L.)Phytophthora blight

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Pedosphere 2024年第2期34卷 438-446页

作者： Xin WANG yifan LIU Baiping HE Minghui LI Xiangui lin Fuyong WU Junli HU State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China Ministry of Agriculture and Rural AffairsCollege of Natural Resources and EnvironmentNorthwest A&F UniversityYangling 712100China University of Chinese Academy of Sciences Beijing 100049China

Mycorrhiza helper bacteria(MHB)can promote the formation and functioning of arbuscular mycorrhizal(AM)symbiosis,but their role and application potential in coping with soil-borne diseases are still unclear.A 14-week greenhouse pot experiment was conducted to obtain several actinomycete strains helping AM symbiosis in suppressing the Phytophthora blight of pepper(Capsicum annuum L.),using a soil inoculated with Phytophthora capsici after sterilization.Five Streptomyces strains,including S.pseudogriseolus,S.albogriseolus,S.griseoaurantiacus,S.tricolor,and S.tendae,as well as the AM fungus(Funneliformis caledonium)were tested.The Phytophthora blight severity reached 66%at full productive stage in the uninoculated control,and inoculation of F.caledonium,S.griseoaurantiacus,and S.tricolor alone significantly decreased(P<0.05)it to 47%,40%,and 35%,respectively.Compared to F.caledonium alone,additional inoculation of S.tricolor or S.tendae,which were isolated from the rhizosphere of a healthy individual in an infected field,significantly elevated(P<0.05)root mycorrhizal colonization,root biomass,fruit yield,and total K acquisitions of pepper and further significantly decreased(P<0.05)blight severity.According to the feature of enhancing disease-suppression by AM symbiosis,both S.tricolor and S.tendae were confirmed as MHB strains here.Specifically,S.tendae had a stronger performance in directly accelerating mycorrhization,while S.tricolor was also an antagonist to the pathogenic P.capsici.Furthermore,S.griseoaurantiacus with the independent disease-suppression function was not an MHB strain here.The redundancy analyses demonstrated that when AM fungus was present,root mycorrhizal colonization replaced soil pH becoming the main factor affecting pepper Phytophthora blight.Thus,S.tricolor and S.tendae seemed to have the value of preparation and application in the future to help AM symbiosis against pepper Phytophthora blight.

关键词： actinomycete strain blight severity Funneliformis caledonium mycorrhiza helper bacteria Phytophthora capsici root mycorrhizal colonization soil-bornedisease

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Flexible, Transparent and Conductive Metal Mesh Films with Ultra‑High FoM for Stretchable Heating and Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第5期16卷 201-213页

作者： Zibo Chen Shaodian Yang Junhua Huang yifan Gu Weibo Huang Shaoyong Liu Zhiqiang lin Zhiping Zeng Yougen Hu Zimin Chen Boru Yang Xuchun Gui State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China Guangdong Provincial Key Laboratory of Materials for High Density Electronic Packing Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongPeople’s Republic of China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China

Despite the growing demand for transparent conductive films in smart and wearable electronics for electromagnetic interference(EMI)shielding,achieving a flexible EMI shielding film,while maintaining a high transmittance remains a significant challenge.Herein,a flexible,transparent,and conductive copper(Cu)metal mesh film for EMI shielding is fabricated by self-forming crackle template method and electroplating technique.The Cu mesh film shows an ultra-low sheet resistance(0.18Ω□^(-1)),high transmittance(85.8%@550 nm),and ultra-high figure of merit(>13,000).It also has satisfactory stretchability and mechanical stability,with a resistance increases of only 1.3%after 1,000 bending cycles.As a stretchable heater(ε>30%),the saturation temperature of the film can reach over 110°C within 60 s at 1.00 V applied voltage.Moreover,the metal mesh film exhibits outstanding average EMI shielding effectiveness of 40.4 dB in the X-band at the thickness of 2.5μm.As a demonstration,it is used as a transparent window for shielding the wireless communication electromagnetic waves.Therefore,the flexible and transparent conductive Cu mesh film proposed in this work provides a promising candidate for the next-generation EMI shielding applications.

关键词： Metal mesh Transparent conductive film Stretchable heater Electromagnetic interference shielding

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Joint Model of Wind Speed and Corresponding Direction Based on Wind Rose for Wind Energy Exploitation

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Journal of Ocean University of China 2022年第4期21卷 876-892页

作者： YANG Zihao lin yifan DONG Sheng College of Engineering Ocean University of ChinaQingdao 266100China Huadian Heavy Industries Co. Ltd.Beijing 100070China

As a common and extensive datum to analyze wind,wind rose is one of the most important components of the meteorological elements.In this study,a model is proposed to establish the joint probability distribution of wind speed and direction using grouped data of wind rose.On the basis of the model,an algorithm is presented to generate pseudorandom numbers of wind speed and paired direction data.Afterward,the proposed model and algorithm are applied to two weather stations located in the Liaodong Gulf.With the models built for the two cases,a novel graph representing the continuous joint probability distribution of wind speed and direction is plotted,showing a strong correlation to the corresponding wind rose.Moreover,the joint probability distributions are utilized to evaluate wind energy potential successfully.In cooperation with Monte Carlo simulation,the model can approximately predict annual directional extreme wind speed under different return periods under the condition that the wind rose can represent the meteorological characters of the wind field well.The model is beneficial to design and install wind turbines.

关键词： angular-linear distribution wind speed wind direction wind rose wind energy Monte Carlo simulation

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Flexible pressure sensors with ultrahigh stress tolerance enabled by periodic microslits

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Microsystems & Nanoengineering 2024年第1期10卷 301-311页

作者： Song Wang Chenying Wang yifan Zhao Yujing Zhang Yaxin Zhang Xiangyue Xu Qijing lin Kai Yao Yuheng Wang Feng Han Yu Sun Zhuangde Jiang State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesSchool of Mechanical EngineeringXi’an Jiaotong UniversityXi’anChina State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesSchool of Instrument Science and TechnologyXi’an Jiaotong UniversityXi’anChina The Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingboChina Department of Mechanical and Industrial Engineering University of TorontoTorontoCanada

Stress tolerance plays a vital role in ensuring the effectiveness of piezoresistive sensing films used in flexible pressure sensors.However,existing methods for enhancing stress tolerance employ dome-shaped,wrinkle-shaped,and pyramidal-shaped microstructures in intricate molding and demolding processes,which introduce significant fabrication challenges and limit the sensing performance.To address these shortcomings,this paper presents periodic microslits in a sensing film made of multiwalled carbon nanotubes and polydimethylsiloxane to realize ultrahigh stress tolerance with a theoretical maximum of 2.477 MPa and a sensitivity of 18.092 kPa−1.The periodic microslits permit extensive deformation under high pressure(e.g.,400 kPa)to widen the detection range.Moreover,the periodic microslits also enhance the sensitivity based on simultaneously exhibiting multiple synapses within the sensing interface and between the periodic sensing cells.The proposed solution is verified by experiments using sensors based on the microslit strategy for wind direction detection,robot movement sensing,and human health monitoring.In these experiments,vehicle load detection is achieved for ultrahigh pressure sensing under an ultrahigh pressure of over 400 kPa and a ratio of the contact area to the total area of 32.74%.The results indicate that the proposed microslit strategy can achieve ultrahigh stress tolerance while simplifying the fabrication complexity of preparing microstructure sensing films.

关键词： robot shaped stress

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Preparation and acoustic properties of high-temperature acoustic emission sensor based on La_(3)Ga_(5)SiO_(14) crystal

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Journal of Advanced Dielectrics 2024年第1期14卷 25-32页

作者： Jingxiang Si Changhong Yang Rui Guo yifan Wu Xiujuan lin Shifeng Huang Shandong Provincial Key Laboratory of Preparation and Measurement of Building Materials University of Jinan Jinan 250022P.R.China

With the rapid development of modern industries,the high-temperature piezoelectric sensors that can work in extreme environments are in great demand.In this work,langasite(La_(3)Ga_(5)SiO_(14),LGS),as a high-temperature piezoelectric crystal with stable electro-elastic performance,is used as core element,and air and porous Al_(2)O_(3) are selected as backing layers respectively to prepare two kinds of high-temperature acoustic emission(AE)sensors.The detection sensitivities at 25–500℃ are analyzed by the ball falling test and Hsu–Nielsen experiment.Under the condition of 25–500℃,the received amplitude signals by both sensors are maintained above 90 dB stimulated by the ZrO_(2) ceramic ball dropping.In the Hsu–Nielsen experiment,as the temperature rising from 25℃ to 500℃,the signal amplitude of sensor with air backing layer decays from 447 mV to 365 mV,while the signal amplitude varies from 270 mV to 203 mV for the sensor with porous Al_(2)O_(3) backing layer.Signiffcantly,compared with the bandwidth of the air-backing sensor(37–183 kHz),the sensor with porous Al_(2)O_(3) backing layer broadens bandwidth to 28–273 kHz.These results show that both these AE sensors have strong and stable response ability to AE signals at high-temperature of 500℃.Therefore,piezoelectric AE sensor based on LGS has great potential application in the ffeld of high-temperature structural health monitoring.

关键词： La_(3)Ga_(5)SiO_(14) acoustic emission sensor sensitivity structural health monitoring

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Joint Return Value Estimation of Significant Wave Heights and Wind Speeds with Bivariate Copulas

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中国海洋大学学报:英文版 2023年第5期22卷 1181-1192页

作者： TAO Shanshan DONG Sheng lin yifan GUEDES SOARES Carlos College of Engineering Ocean University of ChinaQingdao 266100China Huadian Heavy Industries Co. Ltd.Beijing 100070China Instituto Superior Técnico Universidade de LisboaLisboa 1049-001Portugal

The joint design criteria of significant wave heights and wind speeds are quite important for the structural reliability of fixed offshore platforms.However,the design method that regards different ocean environmental variables as independent is conservative.In the present study,we introduce a bivariate sample consisting of the maximum wave heights and concomitant wind speeds of the threshold by using the peak-over-threshold and declustering methods.After selecting the appropriate bivariate copulas and univariate distributions and blocking the sample into years,the bivariate compound distribution of annual extreme wave heights and concomitant wind speeds is constructed.Two joint design criteria,namely,the joint probability density method and the conditional probability method,are applied to obtain the joint return values of significant wave heights and wind speeds.Results show that(28.5±0.5)m s^(-1)is the frequently obtained wind speed based on the Atlantic dataset,and these joint design values are more appropriate than those calculated by univariate analysis in the fatigue design.

关键词： joint design wave height wind speed compound distribution copula

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Dynamic changes in butyrate levels regulate satellite cell homeostasis by preventing spontaneous activation during aging

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Science China(Life Sciences) 2024年第4期67卷 745-764页

作者： Shujie Chen Liujing Huang Bingdong Liu Huimin Duan Ze Li yifan Liu Hu Li Xiang Fu Jingchao lin Yinlan Xu Li Liu Dan Wan Yulong Yin Liwei Xie Department of Endocrinology and Metabolism Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Public Health Xinxiang Medical UniversityXinxiang 453003China Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Metabo-Profile Biotechnology(Shanghai)Co.Ltd. Shanghai 201315China Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular DiagnosticsSchool of Medical TechnologyGuangdong Medical UniversityDongguan 524023China Department of Rehabilitation Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China

The gut microbiota plays a pivotal role in systemic metabolic processes and in particular functions,such as developing and preserving the skeletal muscle system.However,the interplay between gut microbiota/metabolites and the regulation of satellite cell(SC)homeostasis,particularly during aging,remains elusive.We propose that gut microbiota and its metabolites modulate SC physiology and homeostasis throughout skeletal muscle development,regeneration,and aging process.Our investigation reveals that microbial dysbiosis manipulated by either antibiotic treatment or fecal microbiota transplantation from aged to adult mice,leads to the activation of SCs or a significant reduction in the total number.Furthermore,employing multi-omics(e.g.,RNA-seq,16S r RNA gene sequencing,and metabolomics)and bioinformatic analysis,we demonstrate that the reduced butyrate levels,alongside the gut microbial dysbiosis,could be the primary factor contributing to the reduction in the number of SCs and subsequent impairments during skeletal muscle aging.Meanwhile,butyrate supplementation can mitigate the antibiotics-induced SC activation irrespective of gut microbiota,potentially by inhibiting the proliferation and differentiation of SCs/myoblasts.The butyrate effect is likely facilitated through the monocarboxylate transporter 1(Mct1),a lactate transporter enriched on membranes of SCs and myoblasts.As a result,butyrate could serve as an alternative strategy to enhance SC homeostasis and function during skeletal muscle aging.Our findings shed light on the potential application of microbial metabolites in maintaining SC homeostasis and preventing skeletal muscle aging.

关键词： gut microbiota aging satellite cells butyrate Slc16a1(Mct1)

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