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Blockage of the habenular nucleus can eliminate dyspnea induced by electrostimulation of the insular cortex

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Neural Regeneration Research 2010年第13期5卷 1025-1029页

作者： Mingxian Li Jinghua Wang Min Huang weihong lin Min Wang Lei Yu Shao Wang Department of Respiratory Medicine First Hospital Jilin University Changchun 130021 Jilin Province China Department of Physiology Bethune School of Medicine Jilin University Changchun 130021 Jilin Province China Department of Neurology First Hospital Jilin University Changchun 130021 Jifin Province China

BACKGROUND： The insular cortex and habenular nucleus may be a regulatory center for obstructive sleep apnea syndrome, and dyspnea may be caused by insular cortex activity. The insular cortex is a cortical representation of obstructive sleep apnea syndrome. The habenular nucleus is a station for descending insular cortex activity. OBJECTIVE： Through actively stimulating the rat insular cortex, to observe rat respiratory movement, myoelectric activities of genioglossus, arterial partial pressure of oxygen, partial pressure of carbon dioxide and acidity-alkalinity, and to verify a hypothesis that the insular cortex is a superior-position regulation center, and the habenular nucleus is an inferior-position nervous nuclei of the insular cortex in patients with obstructive sleep apnea syndrome. DESIGN, TIME AND SETTING： The randomized, controlled animal study was performed at the Laboratory of Electrophysiology, Department of Physiology, Norman Bathune College of Medicine, Jilin University, China from September 2004 to June 2008. MATERIALS： We used L-glutamic acid （Dingguo Biological Product Research Center, Beijing, China）, lidocaine hydrochloride （Seventh Pharmacy Co., Ltd., Wuxi, China）, electric stimulator （Nihon Kohden, Japan）, and an AVL-OPTI blood gas analyzer （AVL Scientific Co., Roswell, GA, USA）. METHODS： The insular cortex of healthy adult Wistar rats underwent electrostimulation and L-glutamic acid stimulation to record changes in the myoelectric activity of genioglossus and respiratory movement. Some rats were injected with lidocaine to block the habenular nucleus before electrostimulation or L-glutamic acid stimulation. L-glutamic acid and lidocaine were injected by microelectrodes embedded in nuclear groups. MAIN OUTCOME MEASURES： Myoelectric activities of genioglossus, arterial partial pressure of oxygen, partial pressure of carbon dioxide and acidity-alkalinity were measured following apnea in rats undergoing electrostimulation in the insular cortex and f

关键词： dyspnea habenular nucleus insular cortex genioglossus neuroelectrophysiology neural regeneration

N-methyl-D-aspartate receptor subunit 1 protein expression in the hippocampus and temporal cortex of kainic acid-induced epilepsy rats

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Neural Regeneration Research 2010年第14期5卷 1045-1049页

作者： Zan Wang Hongyu Jiang Suisheng Wu Hongmei Meng Li Ji Li Cui weihong lin Department of Neurology First Hospital of Jilin University Changchun 130021 Jilin Province China

BACKGROUND： The N-methyl-D-aspartate receptor subunit 1 （NMDAR1） contributes to the incidence of epilepsy. However, the relationship between epilepsy-induced brain injury and NMDAR1 remains poorly understood. OBJECTIVE： To investigate changes in NMDAR1 protein expression in the hippocampus and temporal cortex of kainic acid-induced epilepsy rats. DESIGN, TIME AND SETFING： A randomized, controlled, animal experiment was performed at the Department of Physiology and Department of Pathology, Basic Medical College of Jilin University from March 2002 to March 2003. MATERIALS： Rabbit anti-NMDAR1 antibody was purchased from Wuhan Boster Biological Technology, China. METHODS： A total of 80 healthy, male, Wistar rats, aged 22 weeks, were randomly assigned to sham-surgery （n = 10） and model （n = 70） groups. Epilepsy models were established by injecting kainic acid （1μL） into the right amygdala, and rats were sacrificed at 2, 6, 24, 72 hours, and 7, 15, 30 days after surgery, with 10 animals at each time point. The rats in the sham-surgery group were injected with 1μL phosphate buffered saline into the right amygdala. MAIN OUTCOME MEASURES： NMDAR1 protein expression in the hippocampus and temporal cortex at 2, 6, 24, 72 hours and 7, 15, 30 days after epilepsy was detected using immunohistochemistry and flow cytometry analysis. RESULTS： In the sham-surgery group, a few NMDARl-positive cells were distributed in the hippocampus and temporal cortex. In the model group, NMDARl-positive cells were increased in the hippocampus and temporal cortex at 2 hours following kainic acid-induced epilepsy. They were significantly increased at 6 hours, and slightly decreased at 7 days （CA3 region and temporal cortex）, but remained greater than the sham-surgery group. This continued until day 30 （P 〈 0.01 ）. In addition, there were more NMDAR1 positive cells in the hippocampal CA3 and dentate gyrus than the temporal cortex （P 〈 0.01）. CONCLUSION： In epilepsy model rats, NMDAR1 protein ex

关键词： kainic acid epilepsy N-methyI-D-aspartate receptor rat subunit neural regeneration

不同施药方式与器械防治玉米草地贪夜蛾效果评价

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安徽农学通报 2024年第6期30卷 26-29页

作者：陆志杰阮赞誉胡振海居梦婷林蔚红海宁市农业机械技术服务站浙江嘉兴314400 海宁市土肥植保能源技术服务站浙江嘉兴314400

为明确不同施药方式与施药器械对草地贪夜蛾防效的影响,本研究开展了玉米地草地贪夜蛾药剂防效试验。结果表明,使用点喷法喷施5%甲氨基阿维菌素苯甲酸盐水分散粒剂,6 d后对玉米的保叶率为93.78%、虫口防效为88.09%;药后9 d对玉米的保叶... 详细信息

为明确不同施药方式与施药器械对草地贪夜蛾防效的影响,本研究开展了玉米地草地贪夜蛾药剂防效试验。结果表明,使用点喷法喷施5%甲氨基阿维菌素苯甲酸盐水分散粒剂,6 d后对玉米的保叶率为93.78%、虫口防效为88.09%;药后9 d对玉米的保叶率为96.45%、虫口防效为95.24%,其对玉米草地贪夜蛾的防效均明显优于散喷法。使用植保无人机喷施5%甲氨基阿维菌素苯甲酸盐水分散粒剂,6 d后对玉米的保叶率为89.18%、虫口防效为82.91%;药后9 d对玉米的保叶率为89.35%、虫口防效为91.20%,其防治草地贪夜蛾的速效性低于电动背负式喷雾器处理,药后9 d两种施药器械虫口防效均超过90%。研究结果表明,植保无人机施药可达到理想的防效,且作业效率高,成本大幅降低,推荐生产上应用于玉米地草地贪夜蛾的规模化防控。

关键词：施药方式施药器械草地贪夜蛾田间防效

Catalytic transformation of 4-nitrophenol into 4-aminophenol over ZnO nanowire array-decorated Cu nanoparticles

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Green Chemical Engineering 2024年第2期5卷 205-212页

作者： Anlin Feng Chaoyu lin Huiqin Zhou weihong Jin Yidong Hu Dongyang Li Qingyang Li Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou510632China School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300401China Department of Chemical and Materials Engineering University of AlbertaEdmontonT6G 2H5Canada

To realize economical and effective removal of hazardous 4-nitrophenol from the environment,we developed an easily recyclable ZnO nanowire array decorated with Cu *** salix argyracea-shaped structure not only provides a platform to achieve stable and good dispersion of Cu nanoparticles,but also offers a great deal of catalytically active *** density functional theory calculations reveal that ZnO and Cu have a very beneficial synergistic effect on their catalytic *** synergy is ascribed to the electronic localization occurring at ZnO/Cu interface,which helps improve Cu nanoparticle’s ability to adsorb electro-negatively 4-nitrophenolate ions and to capture hydrogen radicals,thereby accelerating the hydrogen transfer from metal hydride complex to *** from these characteristics,it exhibits high efficiency and reusability towards the catalytic reduction of waste 4-nitrophenol to valuable 4-aminophenol with a rate constant of 43.02×10^(-3)s^(-1)and an average conversion of 96.5%in 90 s during 10 *** activity is superior to that of most reported noble-or non-noble-metal powder,bulk,coating,and array catalysts,indicating its competitive advantages in cost and efficiency,as well as enticing application prospects.

关键词： ZnO nanowire Cu nanoparticle Nano-heterojunction 4-Nitrophenol catalytic reduction Density functional theory

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对位芳纶的结构与缺陷对其力学性能的影响

东华大学学报（自然科学版） 2024年第4期50卷 76-82页

作者：路慧颖唐凯雒瑞银张建红刘书杰于宏广林威宏王忠伟杜志林滕翠青东华大学材料科学与工程学院纤维材料改性国家重点实验室上海宁夏泰和芳纶纤维有限责任公司宁夏回族自治区银川泰和新材集团股份有限公司山东烟台

聚对苯二甲酰对苯二胺(PPTA)纤维具有优异的力学性能、耐化学腐蚀性能以及阻燃性能,在航空航天、国防、民用等领域得到了广泛应用,是一种新型战略性材料。对4种不同规格的对位芳纶的力学性能、相对分子质量、聚集态结构以及纤维表面及... 详细信息

聚对苯二甲酰对苯二胺(PPTA)纤维具有优异的力学性能、耐化学腐蚀性能以及阻燃性能,在航空航天、国防、民用等领域得到了广泛应用,是一种新型战略性材料。对4种不同规格的对位芳纶的力学性能、相对分子质量、聚集态结构以及纤维表面及内部缺陷进行研究,建立纤维结构、缺陷与性能之间的关系。结果表明:在具有相同化学分子结构的前提下,聚合物相对分子质量是影响纤维力学性能的重要因素之一,随着相对分子质量的增加,纤维的强度和模量增加。对位芳纶的拉伸强度主要与其结晶度、取向度、表面缺陷以及内部微孔缺陷有关,其中结晶度和微孔缺陷最为重要。纤维的模量主要与纤维的取向度有关,结晶度及纤维内外部缺陷对纤维模量的影响较小。

关键词：聚对苯二甲酰对苯二胺(PPTA)纤维相对分子质量聚集态结构缺陷力学性能

Whole-genome resequencing identifies candidate genes and allelic variation in the MdNADP-ME promoter that regulate fruit malate and fructose contents in apple

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Plant Communications 2024年第9期5卷 168-183页

作者： weihong Fu lin Zhao Wanjun Qiu Xu Xu Meng Ding Liming Lan Shenchun Qu Sanhong Wang College of Horticulture Nanjing Agricultural UniversityNanjing 210095China Xuzhou Institute of Agricultural Sciences in Xuhuai Region of Jiangsu Xuzhou 221131China

Soluble sugar and organic acids are key determinants of fruit organoleptic quality and directly affect the commodity value and economic returns of fruit *** performed whole-genome sequencing of the apple varieties Gala and Xiahongrou,along with their F1 hybrids,to construct a high-density bin *** quantitative genetic analysis pinpointed 53 quantitative trait loci(QTLs)related to 11 sugar and acid *** identified a candidate gene,MdNADP-ME,responsible for malate degradation,in a stable QTL on linkage group *** analysis revealed an A/C SNP in the promoter region(MEp-799)that influences binding of the MdMYB2 transcription factor,thereby affecting MdNADP-ME *** our study of various apple genotypes,this SNP has been demonstrated to be linked to malate and fructose *** also developed a dCAPS marker associated with fruit fructose *** results substantiate the role of MdNADP-ME in maintaining the equilibrium between sugar and acid contents in apple fruits.

关键词： apple quantitative trait locus malate degradation sugar content promoter

XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation

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Genes & Diseases 2024年第5期11卷 350-359页

作者： Yun Zhang Susan lin Jing Yao Wantong Cai Huaqiu Chen Ailikemu Aierken Zhe Wang weihong Song National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijing 100053China Townsend Family Laboratories Department of PsychiatryThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Institute of Aging Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and the Affiliated Kangning HospitalWenzhou Medical UniversityWenzhouZhejiang 325000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325001China

As a pathological hallmark of type 2 diabetes mellitus(T2DM),islet amyloid is formed by the aggregation of islet amyloid polypeptide(IAPP).Endoplasmic reticulum(ER)stress interacts with IAPP aggregates and has been implicated in the pathogenesis of *** examine the role of ER stress in T2DM,we cloned the hIAPP promoter and analyzed its promoter activity in human *** found that ER stress significantly enhanced hIAPP promoter activity and expression in human b-cells via triggering X-box binding protein 1(XBP1)*** identified a binding site of XBP1 in the hIAPP *** of this binding site by substitution or deletion mutagenesis significantly diminished the effects of ER stress on hIAPP promoter *** of XBP splicing by MKC3946 treatment inhibited ER stress-induced hIAPP up-regulation and improved human b-cell survival and *** study uncovers a link between ER stress and IAPP at the transcriptional level and may provide novel insights into the role of ER stress in IAPP cytotoxicity and the pathogenesis of T2DM.

关键词： b-cell function Endoplasmic reticulum stress Islet amyloid polypeptide Type 2 diabetes mellitus XBP1

Responses of plant rhizosphere to atmospheric CO_2 enrichment

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Chinese Science Bulletin 2000年第2期45卷 97-101页

作者： lin weihong, ZHANG Fusuo & BAI Kezhi Institule of Bolany, Chinese Academy of Sciences, Beijing 100093, China: Department of Plant Nutrition, China AgriculturaI University, Beijing 100094, China Institute of Botany Chinese Academy of Sciences Beijing China Department of Plant Nutrition China Agricultural University Beijing China

Plant root growth is generally stimulated under elevated CO2. This will bring more carbon to the below-ground through root death and exudate. This potential increase in below-ground carbon sink may lead to changes in long-term soil sequestration and relationship between host plants and symbions. On the other hand, changes in litter components due to the changes in plant chemical composition may also affect soil processes, such as litter decomposition, soil organic matter sequestration and hetero-nutritional bacteria activities. These issues are discussed.

关键词： CO2 eurichment rhizosphere microorganism.

Narcolepsy in patient with multiple sclerosis

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Narcolepsy in patient with multiple sclerosis