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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu Yan-Ping Guo Yan-Mei Lu Bei-lin wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(Plinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

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磁性纳米材料与磁场效应加速骨损伤修复

中国组织工程研究 2025年第4期29卷 827-838页

作者：肖放黄雷王琳华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心湖北省武汉市430022 华中科技大学同济医学院附属协和医院检验科湖北省武汉市430022

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进... 详细信息

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进展。方法:在PubMed和Web of Science数据库中进行相关文献检索,检索词为“magnetic nanomaterials,magnetic field,bone repair,bone tissue engineering,stem cell,osteoblast,osteoclast”。检索文献时限为2003-2023年,将其进行筛选和分析,最终纳入98篇文献进行分析。结果与结论:①磁性纳米材料具有促成骨细胞分化、抑制破骨细胞形成和调节免疫微环境等生物效应;此外,磁性纳米材料可调节组织工程支架的机械性能和表面形貌等理化性质,并赋予其磁性,有利于调控干细胞的黏附、增殖与成骨分化。②磁场具有调控细胞内多条信号通路发挥促成骨细胞分化、抑制破骨细胞形成和刺激血管生成等生物学效应,从而加速损伤的骨组织愈合。③磁性纳米材料与磁场的联合应用,通过激活机械转导、增加细胞内磁性纳米粒子含量、增强微磁场效应等加速骨损伤修复,为骨组织工程的研究提供了新的思路。④磁场在临床骨折、骨质疏松症和骨关节炎疾病的治疗中展现出确切疗效,促进骨组织生长、减轻骨质流失和缓解疼痛,改善患者的生活质量。⑤磁性纳米材料与磁场在骨损伤修复与再生中应用潜力大,但磁性纳米材料、磁场和细胞之间的相互作用机制尚未完全阐明,而且磁场调控细胞内分子事件的关键参数,包括磁场类型、强度、频率、作用时间和作用方式等,以及特定磁场对骨细胞的精确生物效应和潜在机制仍有待明确。⑥未来需要进一步关注其对损伤组织微环境中的破骨细胞、神经、血管和免疫细胞的影响,而关于磁性材料用于人体安全性问题,有待系统性研究其分布、代谢以及急性和慢性毒性等。

关键词：磁性纳米材料磁场骨修复骨组织工程干细胞成骨细胞破骨细胞

调和分数Ornstein-Uhlenbeck金融模型的参数估计

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河南师范大学学报（自然科学版） 2025年第1期53卷 75-81页

作者：王继霞王琳李浩然河南师范大学数学与信息科学学院河南新乡453007 湖南大学经济管理研究中心长沙410012

为了描述金融资产价格过程的长相依性和自相似性,首先构建由调和分数布朗运动驱动的分数Ornstein-Uhlenbeck(O-U)模型.由于调和分数布朗运动是分数布朗运动的推广,故所构建的模型具有更广泛的应用.然后基于离散观测样本,利用最小二乘方... 详细信息

为了描述金融资产价格过程的长相依性和自相似性,首先构建由调和分数布朗运动驱动的分数Ornstein-Uhlenbeck(O-U)模型.由于调和分数布朗运动是分数布朗运动的推广,故所构建的模型具有更广泛的应用.然后基于离散观测样本,利用最小二乘方法,得到模型漂移参数的估计量,并证明了估计量的相合性和渐近分布.最后,通过模拟展示了所得估计量的有限样本性质,模拟结果显示估计量的值拟合参数真值的效果较好.

关键词：最小二乘估计调和分数布朗运动 Ornstein-Uhlenbeck过程相合性渐近分布

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Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

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World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen Li Liu Fang-Zhen lin Hai-Min Zeng Hai-Qiang Huang Chun-Fang Zhang Cong-Cong Liu Xiang Chen Jie Peng Yun-Fa wang Zhi-lin wang Bin Chen De-Le Liu Yun Liu Zheng-Zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

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基于智能优化深度网络的档案数据分析方法

电子设计工程 2025年第1期33卷 41-45页

作者：王馨王琳唐山市妇幼保健院病案室河北唐山063000

为提高档案管理的效率和准确性,提出了一种基于智能优化深度网络的档案数据分析方法。该方法结合了Transformer网络的特征提取能力和灰狼优化算法(Grey Wolf Optimizer,GWO)的参数优化能力,显著提高了档案管理的效率和准确性。将提出的... 详细信息

为提高档案管理的效率和准确性,提出了一种基于智能优化深度网络的档案数据分析方法。该方法结合了Transformer网络的特征提取能力和灰狼优化算法(Grey Wolf Optimizer,GWO)的参数优化能力,显著提高了档案管理的效率和准确性。将提出的方法运用到档案数据的多分类任务中,实验结果表明,通过GWO算法优化后的Transformer-GWO模型在与xgboost分类模型结合时取得了最佳性能,其宏观精确度、宏观召回率和宏观F1分数分别达到0.893、0.878以及0.885,提出的方法有效提升了档案管理的智能化水平。

关键词：档案数据 Transformer 灰狼优化算法分类

Transient thermal cracking associated with non-classical heat conduction in cylindrical coordinate system

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Acta Mechanica Sinica 2013年第2期29卷 211-218页

作者： Bao-lin wang Graduate School at Shenzhen Harbin Institute of Technology

This paper studies the fracture behavior of a thermoelastic cylinder subjected to a sudden temperature change on its outer surface within the framework of non-classical heat *** heat conduction equation is solved by separation of variable *** form solution for the temperature field and the associated thermal stress are *** critical parameter governing the level of the transient thermal stress is *** expression for the transient stress intensity factor is obtained for a crack in the *** difference between the non-classical solutions and the classical solution are *** is found that the traditional classical heat conduction considerably underestimates the transient thermal stress and thermal stress intensity factor.

关键词： Thermal stresses·Fracture mechanics·Nonclassical heat conduction

Limit Set Problem of Multi-Agent Systems with Finite States: An Eigenvalue-Based Approach

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Journal of Systems Science & Complexity 2015年第3期28卷 570-579页

作者： wang lin wang Xiaofan wang Jinhuan Department of Automation Shanghai Jiao Tong University and Key Laboratory of System Control and Information Processing Ministry of Education School of Sciences Hebei University of Technology

This paper studies the limit set of multi-agent system with finite states, in which the system is converted into a linear system through an expansion of space. Then, the structure properties of the system matrix are investigated, and the relationships between the eigenvalues and the limit set are developed. As an application, the nilpotent problem of elementary cellular automata(ECA) known as algorithmically undecidable is considered, and all the nilpotent ECA are found out which consists of rules 0, 8, 64, 239, 253, 255.

关键词： Cellular automata eigenvalue finite states limit set multi-agent system nilpotent.

On Robustness of Orbit Spaces for Partially Hyperbolic Endomorphisms

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Chinese Annals of Mathematics,Series B 2016年第6期37卷 899-914页

作者： lin wang College of Mathematics and Information Science Hebei Key Laboratory of Computational Mathematics and ApplicationsHebei Normal University

In this paper, the robustness of the orbit structure is investigated for a partially hyperbolic endomorphism f on a compact manifold M. It is first proved that the dynamical structure of its orbit space （the inverse limit space） M^f of f is topologically quasi-stable under C^0-small perturbations in the following sense： For any covering endomorphism g C^0-close to f, there is a continuous map φ from M^9 to Π-∞^∞ M such that for any {yi}i∈z∈φ（M^9）, yi＋1 and f（yi） differ only by a motion along the center direction. It is then proved that f has quasi-shadowing property in the following sense： For any pseudo-orbit {xi}i∈z, there is a sequence of points {yi}i∈z tracing it, in which yi＋1 is obtained from f（yi） by a motion along the center direction.

关键词： Partially hyperbolic endomorphism Orbit space Quasi-stability Quasi-shadowing

Evolution of donations on scale-free networks during a COVID-19 breakout

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Chinese Physics B 2022年第8期31卷 212-225页

作者： Xian-Jia wang lin-lin wang Economics and Management School Wuhan UniversityWuhan 430072China Institute of Systems Engineering Wuhan UniversityWuhan 430072China

Having a large number of timely donations during the early stages of a COVID-19 breakout would normally be considered rare. Donation is a special public goods game with zero yield for donors, and it has the characteristics of the prisoners’ dilemma. This paper discusses why timely donations in the early stages of COVID-19 occurred. Based on the idea that donation is a strategy adopted by players during interconnection on account of their understanding of the environment, donation-related populations are placed on social networks and the inter-correlation structures in the population are described by scale-free networks. Players in donation-related populations are of four types: donors, illegal beneficiaries,legal beneficiaries, and inactive people. We model the evolutionary game of donation on a scale-free network. Donors,illegal beneficiaries and inactive people learn and update strategies under the Fermi update rule, whereas the conversion between legal beneficiaries and the other three types is determined by the environment surrounding the players. We study the evolution of cooperative action when the agglomeration coefficient, the parameters of the utility function, the noise intensity, the utility coefficient, the donation coefficient and the initial states of the population on the scale-free network change. For population sizes of 50, 100, 150, and 200, we give the utility functions and the agglomeration coefficients for promoting cooperation and study the corresponding steady states and structural characteristics of the population. We identify the best ranges of the noise intensity K, the donation coefficient α and the utility coefficient β for promoting cooperation at different population sizes. Furthermore, with the increase of the population size, the donor traps are *** the same time, it is discovered that the initial states of the population have a great impact on the steady states;thus the upper and lower triangle phenomena are proposed. We also fi

关键词： donation public goods game evolutionary game scale-free network

Identification of pakchoi cultivars with low cadmium accumulation and soil factors that affect their cadmium uptake and translocation

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Frontiers of Environmental Science & Engineering 2014年第6期8卷 877-887页

作者： lin wang Institute of Agro-Environmental Protection Ministry of Agriculture Tianjin 300191 China Key Laboratory of Original Environmental Quality Safety Ministry of Agriculture Tianjin 300191 China Tianjin Key Laboratory of Agro-environment and Agro-product Safety Tianjin 300191 China

The selection and use of low-Cd-accumulating cultivar （LCAC） has been proposed as one of the promising approaches in minimizing the entry of Cd in the human food chain. This study suggests a screening criterion of LCACs focusing on food safety. Pot culture and plot experiments were conducted to screen out LCACs from 35 pakchoi cultivars and to identify the crucial soil factors that affect Cd accumulation in LCACs. Results of the pot culture experiment showed that shoot Cd concentrations under the three Cd treatments significantly varied across cultivars. Two cultivars, Hualv 2 and Huajun 2, were identified as LCACs because their shoot Cd concentrations were lower than 0.2 mg. kg-1 under low Cd treatment and high Cd exposure did not affect the biomass of their shoots. The plot experiment further confirmed the consistency and genotypic stability of the low-Cd- accumulating traits of the two LCACs under various soil conditions. Results also showed that soil phosphorus availability was the most important soil factor in the Cd accumulation of pakchoi, which related negatively not only to Cd uptake by root but also to Cd translocation from root to shoot. The total Cd accumulation and translocation rates were lower in the LCACs than in the high-Cd cultivar, suggesting that Cd accumulation in different cultivars is associated with the Cd uptake by root as well as translocation from root to shoot. This study proves the feasibility of the application of the LCAC strategy in pakchoi cultivation to cope with Cd contamination in agricultural soils.

关键词： pakchoi (Brassica chinensb L.) cadmiumcontamination low-cadmium-accumulating cultivar (LCAC) genotype variation soil factor translocation