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A hybrid machine learning optimization algorithm for multivariable pore pressure prediction

Petroleum Science 2024年第1期21卷 535-550页

作者： song Deng Hao-Yu Pan Hai-Ge Wang Shou-Kun Xu Xiao-Peng Yan Chao-Wei Li ming-Guo Peng Hao-Ping Peng lin Shi Meng Cui Fei Zhao School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhou213164JiangsuChina Tubular Goods Research Institute of CNPC Beijing102249China CNPC Engineering Technology R&D Company Limited Beijing102206China

Pore pressure is essential data in drilling design,and its accurate prediction is necessary to ensure drilling safety and improve drilling *** methods for predicting pore pressure are limited when forming particular structures and *** this paper,a machine learning algorithm and effective stress theorem are used to establish the transformation model between rock physical parameters and pore *** study collects data from three *** 1 had 881 data sets for model training,and Wells 2 and 3 had 538 and 464 data sets for model *** this paper,support vector machine(SVM),random forest(RF),extreme gradient boosting(XGB),and multilayer perceptron(MLP)are selected as the machine learning algorithms for pore pressure *** addition,this paper uses the grey wolf optimization(GWO)algorithm,particle swarm optimization(PSO)algorithm,sparrow search algorithm(SSA),and bat algorithm(BA)to establish a hybrid machine learning optimization algorithm,and proposes an improved grey wolf optimization(IGWO)*** IGWO-MLP model obtained the minimum root mean square error(RMSE)by using the 5-fold cross-validation method for the training *** the pore pressure data in Well 2 and Well 3,the coefficients of determination(R^(2))of SVM,RF,XGB,and MLP are 0.9930 and 0.9446,0.9943 and 0.9472,0.9945 and 0.9488,0.9949 and *** achieves optimal performance on both training and test data,and the MLP model shows a high degree of *** indicates that the IGWO-MLP is an excellent predictor of pore pressure and can be used to predict pore pressure.

关键词： Pore pressure Grey wolf optimization Multilayer perceptron Effective stress Machine learning

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Reduction of photodynamic damage of blood vessels in the protected region by(–)-epigallocatechin gallate

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Journal of Innovative Optical Health Sciences 2024年第3期17卷 93-104页

作者： Tianlong Chen Yi Shen Li lin Huiyun lin Xuejiao song Defu Chen Buhong Li MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Provincial Key Laboratory of Photonics TechnologyFujian Normal UniversityFuzhou 350117P.R.China Key Laboratory of Flexible Electronics and Institute of Advanced Materials Nanjing Technology UniversityNanjing 211800P.R.China School of Medical Technology Beijing Institute of TechnologyBeijing 100081P.R.China

Photodynamic therapy(PDT)has been increasingly used in the clinical treatment of neoplastic,inflammatory and infectious skin ***,the generation of reactive oxygen species(ROS)may induce undesired side effects in normal tissue surrounding the treatment lesion,which is a big challenge for the clinical application of *** date,(–)-Epigallocatechin gallate(EGCG)has been widely proposed as an antiangiogenic and antitumor agent for the protection of normal tissue from ROS-mediated oxidative *** study evaluates the regulation ability of EGCG for photodynamic damage of blood vessels during hematoporphyrin monomethyl ether(Hemoporfin)-mediated *** quenching rate constants of EGCG for the triplet-state Hemoporfin and photosensitized 1O2 generation are determined to be 6.8×10^(8)M^(−1)S^(−1),*** vasoconstriction of blood vessels in the protected region treated with EGCG hydrogel after PDT is lower than that of the control region treated with pure hydrogel,suggesting an efficiently reduced photodamage of Hemoporfin for blood vessels treated with *** study indicates that EGCG is an efficient quencher for triplet-state Hemoporfin and 1O2,and EGCG could be potentially used to reduce the undesired photodamage of normal tissue in clinical PDT.

关键词： (–)-Epigallocatechin gallate(EGCG) photodynamic therapy hemopor¯n singlet oxygen blood vessel vasoconstriction.

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Memory-enhanced text style transfer with dynamic style learning and calibration

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Science China(Information Sciences) 2024年第4期67卷 181-196页

作者： Fuqiang lin Yiping song Zhiliang TIAN Wangqun CHEN Diwen DONG Bo LIU College of Computer Science and Technology National University of Defense Technology Department of Computer Science and Engineering The Hong Kong University of Science and Technology Strategic Assessments and Consultation Institute Academy of Military Sciences

Text style transfer aims to rephrase a sentence to match the desired style while retaining the original content. As a controllable text generation task, mainstream approaches use content-independent style embedding as control variables to guide stylistic generation. Nonetheless, stylistic properties are contextsensitive even under the same style. For example, “delicious” and “helpful” convey positive sentiments,although they are more likely to describe food and people, respectively. Therefore, desired style signals must vary with the content. To this end, we propose a memory-enhanced transfer method, which learns fine-grained style representation concerning content to assist transfer. Rather than employing static style embedding or latent variables, our method abstracts linguistic characteristics from training corpora and memorizes subdivided content with the corresponding style representations. The style signal is dynamically retrieved from memory using the content as a query, providing a more expressive and flexible latent style space. To address the imbalance between quantity and quality in different content, we further introduce a calibration method to augment memory construction by modeling the relationship between candidate *** results obtained using three benchmark datasets confirm the superior performance of our model compared to competitive approaches. The evaluation metrics and case study also indicate that our model can generate diverse stylistic phrases matching context.

关键词： style transfer memory-enhanced method text generation deep learning text representation

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Paleogene integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1290-1325页

作者： Jia LIU Ai song lin DING Tao SU Zhekun ZHOU CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Institute of Paleontology Yunnan UniversityKunming 650500China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

The Paleogene is a crucial period when terrestrial and marine ecosystems recovered from major disruptions and gradually approached their modern *** the Qinghai-Tibetan Plateau and its surrounding regions,the Paleogene also represents a significant phase of tectonic evolution in the Qinghai-Tibetan Plateau-Himalaya orogeny,reorganization of Asian climates,and evolution of *** to limitations in research conditions and understanding,there are still many controversies regarding stratigraphic divisions in the Qinghai-Tibetan Plateau and its surrounding *** recent years,extensive studies on sedimentary petrology,magnetostratigraphy,and isotope dating have been conducted in the *** fossils have been discovered and reported,contributing to a more systematic understanding of *** studies have laid a solid foundation for the comprehensive investigation of the stratigraphy,biotas and paleogeographic evolution of the Qinghai-Tibetan Plateau and its surrounding regions during the *** this paper,we integrate recent research on fossils,isotopic dating,magnetostratigraphy,and geochemistry to refine the stratigraphic divisions and correlation framework of different tectonic units in the region,building upon previous *** the Second Tibetan Plateau Scientific Expedition and Research,the knowledge of Paleogene floras has gradually *** paper discusses the biostratigraphic significance of extinct and newly appeared taxa based on the latest dating results of these plant *** new understanding of fossil species such as the“Eucalyptus”and Arecaceae establishes connections between the Paleogene flora of the Qinghai-Tibetan region and the biotas of Gondwana,specifically Oceania and South *** evolutionary history of key taxa near the Yarlung Zangbo suture zone indicates that the collision between the Indian and Eurasian plates occurred approximately 65-54 *** reconstructions,based o

关键词： Qinghai-Tibetan Plateau Fossils Biostratigraphy Paleoenvironment Paleogeography Paleogene

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High laser damage threshold coatings and damage testing technology

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光学精密工程 2005年第4期13卷 500-504页

作者： MA Ping HU Jian-ping CHEN song-lin TANG ming WANG Zhen LI Wei XU Qiao Chengdu Fine Optical Engineering Research Center Chengdu 610041China

The laser-induced damage threshold(LIDT) of optical coating is a limited factor for development of a high peak power laser. The automatic damage testing facility was built to determine the LIDT of optics at 1 064 nm and 355 nm.. The cleanning and processing procedure of the substrate and coating technique were improved, and the damage resistance of high-reflective coating at 1 064 nm was increased.

关键词：激光涂覆技术 LIDT 自动机械光学仪器激光仪器

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Assembly of highly efficient aqueous light-harvesting system from sequence-defined peptoids for cytosolic microRNA detection

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Nano Research 2024年第2期17卷 788-796页

作者： Yang song Xiaoli Cai mingming Wang Dan Du Yuehe lin Chun-Long Chen Department of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA Division of Physical Sciences Pacific Northwest National LaboratoryRichlandWA 99352USA Department of Chemical Engineering University of WashingtonSeattleWA 98195USA

Precisely controlled spatial distributions of artificial light-harvesting systems in aqueous media are of significant importance for mimicking natural light-harvesting systems;however,they are often restrained by the solubility and the aggregation-caused quenching effect of the hydrophobic ***,we report one highly efficient artificial light-harvesting system based on peptoid nanotubes that mimic the hierarchical cylindrical structure of natural *** high crystallinity of these nanotubes enabled the organization of arrays of donor chromophores with precisely controlled spatial distributions,favoring an efficient Förster resonance energy transfer(FRET)process in aqueous *** FRET system exhibits an extremely high efficiency of 98.6%with a fluorescence quantum yield of 40%and an antenna effect of *** further demonstrated the use of this artificial light-harvesting system for quantifying miR-210 within cancer *** fluorescence intensity ratio of donor to acceptor is linearly related to the concentration of intercellular miR-210 in the range of 3.3–156 copies/*** high sensitivity in intracellular detection of miR-210 using this artificial light-harvesting system offers a great opportunity and pathways for biological imaging and detection,and for the further creation of microRNA(miRNA)toolbox for quantitative epigenetics and personalized medicine.

关键词： light-harvesting peptoid nanotube Förster resonance energy transfer intracellular RNA detection

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Relationship of left heart size and left ventricular mass with exercise capacity in chronic heart failure

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Chinese Medical Journal 2011年第16期124卷 2485-2489页

作者： SHEN Yu-qin WANG Le-min CHE lin song Hao-ming ZHANG Qi-ping Department of Cardiology Shanghai Tongji Hospital Affiliated toTongji University Shanghai 200065 China

Background Impaired exercise capacity is one of the most common clinical manifestations in patients with chronic heart failure （CHF）. The severity of reduced exercise capacity is an indicator of disease prognosis. The aim of the current study was to investigate the association between left heart size and mass with exercise capacity. Methods A total of 74 patients were enrolled in the study, with 37 having congestive heart failure （left ventricular ejection fraction （LVEF）〈0.45） and the other 37 with coronary heart disease （by coronary angiography） serving as the control group （LVEF 〉0.55）. Echocardiography and cardiopulmonary exercise test were performed. The multiply linear regression model was used to evaluate the association between echocardiogrphic indices and exercise capacities. Results The study showed that left ventricular end diastolic / systolic diameter （LVEDD/LVESD）, left atrial diameter （LAD） and left ventricular mass index （LVMI） were significantly enlarged in patients with chronic heart failure compared with controls （P 〈0.01）. The VO2AT, Peak VO2, Load AT, and Load Peak in chronic heart failure patients were also significantly reduced compared with controls （P 〈0.05）, VENCO2 slope was increased in patients with chronic heart failure （P 〈0.01）. Multivariate linear regression analysis indicated that the patients＇ exercise capacity was significantly associated with the left heart size and mass, however, the direction and/or strength of the associations sometimes varied in chronic heart failure patients and controls. Load AT correlated negatively with LVEDD in chronic heart failure patients （P=0.012）, while Load AT correlated positively with LVEDD in control patients （P=0.006）. VENCO2 slope correlated positively with LAD （B=0.477, P 〈0.0001） in chronic heart failure patients, while the VENCO2 slope correlated negatively with LAD in control patients （P=0.009）. Conclusion The study indicates that the size of LVEDD and LAD are important determinants of exe

关键词： echocardiography exercise tolerance exercise test heart failure systolic

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DMF-scMT-seq linking methylome and transcriptome within single cells with digital microfluidics

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Science China Chemistry 2024年第6期67卷 2070-2078页

作者： Xing Xu Xi Zeng Xin lin Shiyan lin Shanshan Liang Tian Tian Rui Su Jia song Chaoyong Yang Collaborative Innovation Center of Chemistry for Energy Materials The MOE Key Laboratory of Spectrochemical Analysis and InstrumentationState Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringThe First Affiliated Hospital of Xiamen UniversityXiamen UniversityXiamen361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai200127China Chemistry and Materials Science College Shanghai Normal UniversityShanghai200234China Chemistry and Biomedicine Innovation Center(ChemBIC) School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China

Single-cell joint analysis of methylome and transcriptome reveals how the methylation regulates the transcriptional ***,traditional bench-top protocols for single-cell DNA methylation and RNA transcription co-detection are laborintensive,cost-ineffective and ***,we establish the DMF-sc MT-seq,a highly-efficient and cost-effective method to simultaneously analyze single-cell DNA methylation and transcriptional activity based on digital *** MT-seq automates the workflow of single-cell isolation,cellular hypotonic lysis,nucleic acid separation and methylome/transcriptome library construction in a contactless and addressable *** system ensures high accuracy(R>0.85),high gene detection ability(14,697 genes per cell at 4 million sequencing depth),and high CpG coverage(677,198 CpG sites per cell at 1million sequencing depth).By using DMF-sc MT-seq,the relationship of DNA methylation and RNA transcription under different genomic contexts is *** further apply DMF-sc MT-seq to study the dynamics of transcription regulation with methylation-inhibiting anti-tumor Decitabine,and identify the methylated promoter/gene body driven genes in response to Decitabine ***-sc MT-seq facilitates the construction of the correlation of DNA methylation and transcriptional activity at the single-cell level in a flexible,sensitive and accurate way,which is anticipated to be a powerful tool in studying single-cell biological systems.

关键词： single-cell analysis digital microfluidics methylome sequencing transcriptome sequencing

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Advances in Polymeric Carbon Nitride Photocatalysts for Enhanced CO_(2)Reduction

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 1-12页

作者： Liu Bing Sun Shangcong song Ye Peng Bo lin Wei SINOPEC Research Institute of Petroleum Processing Co. Ltd.Beijing100083China

Photocatalysis has emerged as a promising alternative for converting and utilizing CO_(2).Polymeric carbon nitride(PCN),typically synthesized through the one-step thermal polycondensation of nitrogen-rich precursors,has shown considerable promise due to its adjustable band structure and inherent *** the past five years,significant literature in this field has identified five primary methods for modifying PCN:morphology modulation,element doping,defect induction,co-catalyst loading,and heterojunction construction.A detailed discussion on how each modification method influences light absorption,charge separation,and surface reaction efficiencies in photocatalysis is *** on these findings,several future directions for the development of PCN-based materials are proposed,such as designing tailored PCN structures for specific photocatalytic reactions and using theoretical calculations to verify and correct results from current characterization *** the challenges associated with the large-scale synthesis of PCN materials with controllable structures and satisfactory performance,this work offers valuable insights for advancing photocatalytic PCN-based systems for large-scale solar fuel production.

关键词： carbon nitride photocatalysis CO_(2)reduction modification

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Excessive manure application stimulates nitrogen cycling but only weakly promotes crop yields in an acidic Ultisol:Results from a 20-year field experiment

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Journal of Integrative Agriculture 2024年第7期23卷 2434-2445页

作者： song Wan Yongxin lin Hangwei Hu Milin Deng Jianbo Fan Jizheng He Key Laboratory for Humid Subtropical Eco-geographical Processes of Ministry of Education School of Geographical Sciences/School of Carbon Neutrality Future TechnologyFujian Normal UniversityFuzhou 350007China School of Agriculture and Food Faculty of ScienceThe University of MelbourneParkvilleVictoria 3010Australia State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China

Population growth and growing demand for livestock products produce large amounts of manure,which can be harnessed to maintain soil sustainability and crop ***,the impacts of excessive manure application on crop yields,nitrogen(N)-cycling processes and microorganisms remain ***,we explored the effects of 20-year of excessive rates(18 and 27 Mg ha^(–1)yr^(–1))of pig manure application on peanut crop yields,soil nutrient contents,N-cycling processes and the abundance of N-cycling microorganisms in an acidic Ultisol in summer and winter,compared with none and a regular rate(9 Mg ha^(–1)yr^(–1))of pig manure ***-term excessive pig manure application,especially at the high-rate,significantly increased soil nutrient contents,the abundance of N-cycling functional genes,potential nitrification and denitrification activity,while it had a weaker effect on peanut yield and plant *** with manure application,seasonality had a much weaker effect on N-cycling gene *** forest analysis showed that available phosphorus(AP)content was the primary predictor for N-cycling gene abundance,with significant and positive associations with all tested N-cycling *** study clearly illustrated that excessive manure application would increase N-cycling gene abundance and potential N loss with relatively weak promotion of crop yields,providing significant implications for sustainable agriculture in the acidic Ultisols.

关键词： denitrification manure amendment nitrification N-cycling functional genes peanut yields

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