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The cardiovascular system at high altitude:A bibliometric and visualization analysis

World Journal of Cardiology 2024年第4期16卷 199-214页

作者： Mao-lin Zhao Zhong-Jie Lu Li Yang sheng Ding Feng Gao Yuan-Zhang Liu Xue-lin Yang Xia Li Si-Yi He Department of Cardiovascular Surgery The General Hospital of Western Theater CommandCollege of MedicineSouthwest Jiaotong UniversityChengdu 610083Sichuan ProvinceChina Department of Cardiovascular Surgery The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina

BACKGROUND When exposed to high-altitude environments,the cardiovascular system undergoes various changes,the performance and mechanisms of which remain *** To summarize the latest research advancements and hot research points in the cardiovascular system at high altitude by conducting a bibliometric and visualization *** The literature was systematically retrieved and filtered using the Web of Science Core Collection of Science Citation Index Expanded.A visualization analysis of the identified publications was conducted employing CiteSpace and *** A total of 1674 publications were included in the study,with an observed annual increase in the number of publications spanning from 1990 to *** United States of America emerged as the predominant contributor,while Universidad Peruana Cayetano Heredia stood out as the institution with the highest publication ***,Jean-Paul Richalet demonstrated the highest productivity among researchers focusing on the cardiovascular system at high ***,Peter Bärtsch emerged as the author with the highest number of cited *** analysis identified hypoxia,exercise,acclimatization,acute and chronic mountain sickness,pulmonary hypertension,metabolism,and echocardiography as the primary research hot research points and emerging directions in the study of the cardiovascular system at high *** Over the past 32 years,research on the cardiovascular system in high-altitude regions has been steadily *** research in this field may focus on areas such as hypoxia adaptation,metabolism,and cardiopulmonary *** interdisciplinary and multi-team collaborations will facilitate further exploration of the pathophysiological mechanisms underlying cardiovascular changes in high-altitude environments and provide a theoretical basis for standardized disease diagnosis and treatment.

关键词： Cardiovascular system High altitude Hypoxia Bibliometric analysis Visualization

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Gut microbiota affects the estrus return of sows by regulating the metabolism of sex steroid hormones

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Journal of Animal Science and Biotechnology 2024年第2期15卷 578-599页

作者： Min Liu Jia Zhang Yunyan Zhou Shuqi xiong Mengqing Zhou lin Wu Qin Liu Zhe Chen Hui Jiang Jiawen Yang Yuxin Liu Yaxiang Wang Congying Chen Lusheng Huang National Key Laboratory of Swine Genetic Improvement and Germplasm Innovation Jiangxi Agricultural UniversityNanchang 330045China

Background Sex hormones play important roles in the estrus return of post-weaning *** studies have demonstrated a complex and bi-directional regulation between sex hormones and gut ***,the extent to which the gut microbiota affects estrus return of post-weaning sows is largely *** In this study,we first screened 207 fecal samples from well-phenotyped sows by 16S rRNA gene sequencing and identified significant associations between microbes and estrus return of post-weaning *** metagenomic sequencing data from 85 fecal samples,we identified 37 bacterial species that were significantly associated with estrus *** returning sows were characterized by increased abundances of *** and *** and decreased abundances of ***,***,and *** changes in gut microbial composition significantly altered the functional capacity of steroid hormone biosynthesis in the gut *** results were confirmed in a validation *** changes in sex steroid hormones and related compounds were found between normal and non-return sows via metabolome *** integrated analysis of differential bacterial species,metagenome,and fecal metabolome provided evidence that normal return-associated bacterial species *** and Prevotella *** in the degradation of pregnenolone,progesterone,and testosterone,thereby promoting estrogen ***,the microbial metabolites related to sow energy and nutrient supply or metabolic disorders also showed relationships with sow estrus *** An integrated analysis of differentially abundant bacterial species,metagenome,and fecal metabolome revealed the involvement of *** and Prevotella *** sow estrus *** findings provide deep insight into the role of gut microbiota in the estrus return of post-weaning sows and the complex cross-talk between gut microbiota and sex hormones,suggesting that the manipulatio

关键词： Estrus return Fecal metabolome Gut microbiota Metagenomics Sex steroid hormones Sow

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Chinese Guidelines for the Diagnosis and Management of Atrial Fibrillation

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Journal of Geriatric Cardiology 2024年第3期21卷 251-314页

作者： Chang-sheng MA Shu-lin WU Shao-Wen LIU Ya-ling HAN Chinese Society of Cardiology Chinese Medical Association Heart Rhythm Committee of Chinese Society of Biomedical Engineering Beijing Anzhen Hospital Capital Medical University Guandong Provincial People’s Hospital Shanghai First People’s Hospital General Hospital of Northern Theater Command 不详

Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,significantly impacting patients’quality of life and increasing the risk of death,stroke,heart failure,and *** the past two decades,there have been significant breakthroughs in AF risk prediction and screening,stroke prevention,rhythm control,catheter ablation,and integrated *** this period,the scale,quality,and experience of AF management in China have greatly improved,providing a solid foundation for the development of guidelines for the diagnosis and management of *** further promote standardized AF management,and apply new technologies and concepts to clinical practice in a timely and comprehensive manner,the Chinese Society of Cardiology of the Chinese Medical Association and the Heart Rhythm Committee of the Chinese Society of Biomedical Engineering have jointly developed the Chinese Guidelines for the Diagnosis and Management of Atrial *** guidelines have comprehensively elaborated on various aspects of AF management and proposed the CHA2DS2-VASc-60 stroke risk score based on the characteristics of AF in the Asian *** guidelines have also reevaluated the clinical application of AF screening,emphasized the significance of early rhythm control,and highlighted the central role of catheter ablation in rhythm control.

关键词： prevention sustained diagnosis

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Risk factors for esophagogastric variceal-related poor outcomes in primary biliary cholangitis:A prospective cohort study

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iLIVER 2024年第1期3卷 30-37页

作者： lin Han Huan Xie Xue-Mei Ma Xiao-Long Lu Jun Zhao Qing-sheng Liang Zheng-sheng Zou Jing-Feng Bi Bo Jin Ying Sun Senior Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases Medicine The Fifth Medical Center of PLA General HospitalBeijing 100039China Graduate School Medical School of Chinese PLABeijing 100039China

Background and aims:Esophagogastric varices(EGV)are common complications of primary biliary cholangitis(PBC).We examined the risk factors for variceal bleeding-related liver transplantation(LT)or ***:This prospective observational cohort study involved PBC in our hospital from 1 January 2005 to 1 January *** clinical endpoints were variceal bleeding-related LT and *** analysis was performed using the Kaplan-Meier estimate,cox regression analysis was performed to investigate risk ***:PBC with EGV had significantly shorter survival than those without(p?0.002).Endoscopic prophylaxis significantly improved poor outcomes in PBC with EGV(plinesterase(CHE)of1.2ULN at baseline,total bilirubin of>1.2ULN,aspartate aminotransferase(AST)of>2.3ULN after 1 year of ursodeoxycholic acid(UDCA)treatment,non-biochemical responders according to the Paris criteria,and no history of endoscopic *** PBC without EGV,risk factors included AST of>2.3ULN,INR of>1.2ULN at baseline,CHE of***:This study provides evidence that AST,INR and CHE are major risk factors for variceal bleedingrelated poor outcomes in *** PBC with EGV,a good biochemical response to UDCA and endoscopic prophylaxis may improve *** findings can aid for guiding initial PBC risk stratification and screening endoscopy in patients without EGV.

关键词： Primary biliary cholangitis Esophagogastric varices Ursodeoxycholic acid Liver transplant-free survival Endoscopic therapy Risk factors

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Return to the Moon:New perspectives on lunar exploration

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Science Bulletin 2024年第13期69卷 2136-2148页

作者： Yangting lin Wei Yang Hui Zhang Hejiu Hui Sen Hu Long Xiao Jianzhong Liu Zhiyong Xiao Zongyu Yue Jinhai Zhang Yang Liu Jing Yang Honglei lin Aicheng Zhang Dijun Guo sheng Gou lin Xu Yuyang He Xianguo Zhang Liping Qin Zongcheng ling xiongyao Li Aimin Du Huaiyu He Peng Zhang Jinbin Cao Xianhua Li Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory for Mineral Deposits Research and School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan 430074China Institute of Geochemistry Chinese Academy of SciencesGuiyang 550002China Planetary Environmental and Astrobiological Research Laboratory School of Atmospheric SciencesSun Yat-sen UniversityZhuhai 519082China National Space Science Center Chinese Academy of SciencesBeijing 100190China Deep Space Exploration Laboratory/CAS Key Laboratory of Crust-Mantle Materials and Environments University of Science and Technology of ChinaHefei 230026China Shandong Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China Technology and Engineering Center for Space Utilization Chinese Academy of SciencesBeijing 100094China School of Space and Environment Beihang UniversityBeijing 100191China

Lunar exploration is deemed crucial for uncovering the origins of the Earth-Moon system and is the first step for advancing humanity’s exploration of deep *** the past decade,the Chinese Lunar Exploration Program(CLEP),also known as the Chang’e(CE)Project,has achieved remarkable *** has successfully developed and demonstrated the engineering capability required to reach and return from the lunar ***,the CE Project has made historic firsts with the landing and on-site exploration of the far side of the Moon,along with the collection of the youngest volcanic samples from the Procellarum KREEP *** achievements have significantly enhanced our understanding of lunar *** on this success,China has proposed an ambitious crewed lunar exploration strategy,aiming to return to the Moon for scientific exploration and *** plan encompasses two primary phases:the first crewed lunar landing and exploration,followed by a thousand-kilometer scale scientific expedition to construct a geological cross-section across the lunar *** the limitations of current lunar exploration efforts and China’s engineering and technical capabilities,this paper explores the benefits of crewed lunar exploration while leveraging synergies with robotic *** study refines fundamental lunar scientific questions that could lead to significant breakthroughs,considering the respective engineering and technological *** research lays a crucial foundation for defining the objectives of future lunar exploration,emphasizing the importance of crewed missions and offering insights into potential advancements in lunar science.

关键词： Crewed lunar exploration Water and volatiles Composition and structure of lunar interior Volcanic activity and evolution of lunar mantle Space weathering and radiation environments Exploration technology

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Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation

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Rare Metals 2024年第10期43卷 5186-5201页

作者： Wen-Jing Zhang Li-Guo Jin Shui-lin Wu Chao-Feng Wang Yu-Feng Zheng Zhao-Yang Li Zhen-Duo Cui Hui Jiang sheng-Li Zhu Xiang-Mei Liu School of Materials Science and Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin University Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer MaterialsMinistry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsSchool of Materials Science&EngineeringHubei University School of Materials Science and Engineering Peking University School of Health Science and Biomedical Engineering Hebei University of Technology

Deep tissue infections caused by pathogenic bacteria seriously threat the lives of *** this study a smart heterostructured Au/Cu-BTA （BTA=1,2,4,5-benzenetetramine） with microwave （MW） response is synthesized via NaBH4reduction of HAuCl4on the ***/Cu-BTA exhibits excellent hyperthermy and dynamics under MW *** MW thermal mechanism of Au/Cu-BTA is attributed to the excellen dielectric loss and polarization of the heterogeneous ***,the surface energy levels of the Cu-BTA interface alleviate the difficulty of electron hopping through multistage ***,MW can excite Cu-BTA to produce free ***,Au nanoparticles rapidly increase electron transfer and inhibit electron-hole ***,the yields of reactive oxygen species can be enhanced for MW dynamic therapy Consequently,under 10 min of MW irradiation,Au/Cu-BTA killed 99.998%±0.001% of Gram-positive Staphylococcus aureus,99.966%±0.014% of methicillin-resistant Staphylococcus aureus,and 96.871%±0.831% of Gram-negative Pseudomonas *** effective MW bacteria-killing strategy designed in this study shows significant potential for application in the MW-responsive treatment of deep tissue infections without antibiotics.

关键词： Anti-infection Antibacterial Microwave therapy

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Toosendanin: upgrade of an old agent in cancer treatment

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Chinese Journal of Natural Medicines 2024年第10期22卷 887-899页

作者： LI Shuwei xiong Qingyi SHEN Yiwen lin Jiayi ZHANG Lijun WU Ye JIN Jinmei LUAN Xin Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital Shanghai University of Traditional Chinese Medicine

Toosendanin(TSN), a tetracyclic triterpenoid derived from Melia toosendan and M. azedarach, demonstrates broad application prospects in cancer treatment. Although previously employed as a pesticide, recent studies have revealed its potential therapeutic value in treating various types of cancer. TSN exerts an anticancer effect via mechanisms including proliferation inhibition, apoptosis induction, migration suppression, and angiogenesis inhibition. However, TSN's toxicity, particularly its hepatotoxicity, significantly limits its therapeutic application. This review explored the dual nature of TSN, evaluating both its anticancer potential and toxicological risks, emphasizing the importance of balancing these aspects in therapeutic applications. Furthermore, we investigated the incorporation of TSN into novel therapeutic strategies, such as Proteolysis-targeting chimeras(PROTAC) technology and nanotechnology-based drug delivery systems(DDS), which enhance treatment efficacy while mitigating toxicity in normal tissues.

关键词： Cancer therapy Hepatotoxicity Nano-delivery systems PROTAC Toosendanin

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The energy response of LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals for GECAM

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Nuclear Science and Techniques 2024年第2期35卷 110-122页

作者： Pei-Yi Feng Xi-Lei Sun Zheng-Hua An Yong Deng Cheng-Er Wang Huang Jiang Jun-Jie Li Da-Li Zhang Xin-Qiao Li Shao-lin xiong Chao Zheng Ke Gong sheng Yang Xiao-Jing Liu Min Gao Xiang-Yang Wen Ya-Qing liu Yan-Bing Xu Xiao-Yun Zhao Jia-Cong Liu Fan Zhang Hong Lu Particle and Astrophysics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Experimental Physics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of South ChinaHengyang 421001China National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.and General Research Institute for Nonferrous MetalsBeijing 100088China

The GECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(GRDs).To investigate the nonlinearity in the detection of low-energy gamma rays and address the errors in the calibration of the E-C relationship,comprehensive tests and comparative studies of the three aforementioned crystals were conducted using Compton electrons,radioactive sources,and mono-energetic *** nonlinearity test results of the Compton electrons and X-rays demonstrated substantial differences,with all three crystals presenting a higher nonlinearity for X/-rays than for Compton *** the LaBr_(3)(Ce)and LaBr_(3)(Ce,Sr)crystals having higher absolute light yields,they exhibited a noticeable nonlinear decrease in the light yield,especially at energies below 400 *** NaI(Tl)crystal demonstrated an"excess"light output in the 6-200 keV range,reaching a maximum"excess"of 9.2%at 30 keV in the X-ray testing and up to 15.5%at 14 keV during Compton electron testing,indicating a significant advantage in the detection of low-energy gamma ***,we explored the underlying causes of the observed nonlinearity in these *** study not only elucidates the detector responses of GECAM,but also initiates a comprehensive investigation of the nonlinearity of domestically produced lanthanum bromide and sodium iodide crystals.

关键词： LaBr_(3)(Ce)detector LaBr_(3)(Ce,Sr)detector NaI(Tl)detector GECAM Energy response Light yield nonlinearity

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Values of macular ganglion cell-inner plexiform layer and 10-2 visual field measurements in detecting and evaluating glaucoma

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 852-860页

作者： Hai-Jian Hu Ping Li Bin Tong Yu-Lian Pang Hong-Dou Luo Fei-Fei Wang Chan xiong Yu-lin Yu Hai He Xu Zhang Affiliated Eye Hospital of Nanchang University Jiangxi Research Institute of Ophthalmology and Visual ScienceJiangxi Clinical Research Center for Ophthalmic DiseaseJiangxi Branch of National Clinical Research Center for Ocular DiseasesNanchang 330006Jiangxi ProvinceChina Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital) Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430015Hubei ProvinceChina

AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced ***:Totally 127 eyes from 89 participants(36 eyes of 19 healthy participants,45 eyes of 31 early glaucoma patients and 46 eyes of 39 advanced glaucoma patients)were *** relationships between the optical coherence tomography(OCT)-derived parameters and VF sensitivity were *** with early glaucoma were divided into eyes with or without central 10°of the VF damages(CVFDs),and the diagnostic performances of OCT-derived parameters were ***:In early glaucoma,the mGCIPLT was significantly correlated with 10-2 VF pattern standard deviation(PSD;with average mGCIPLT:β=-0.046,95%CI,-0.067 to-0.024,P<0.001).In advanced glaucoma,the mGCIPLT was related to the 24-2 VF mean deviation(MD;with average mGCIPLT:β=0.397,95%CI,0.199 to 0.595,P<0.001),10-2 VF MD(with average mGCIPLT:β=0.762,95%CI,0.485 to 1.038,P<0.001)and 24-2 VF PSD(with average mGCIPLT:β=0.244,95%CI,0.124 to 0.364,P<0.001).Except for the minimum and superotemporal mGCIPLT,the decrease of mGCIPLT in early glaucomatous eyes with CVFDs was more severe than that of early glaucomatous eyes without *** area under the curve(AUC)of the average mGCIPLT(AUC=0.949,95%CI,0.868 to 0.982)was greater than that of the average circumpapillary retinal nerve fiber layer thickness(cpRNFLT;AUC=0.827,95%CI,0.674 to 0.918)and rim area(AUC=0.799,95%CI,0.610 to 0.907)in early glaucomatous eyes with CVFDs versus normal ***:The 10-2 VF and mGCIPLT parameters are complementary to 24-2 VF,cpRNFLT and ONH parameters,especially in detecting early glaucoma with CVFDs and evaluating the severity of advanced glaucoma in group level.

关键词： 10-2 visual field ganglion cell-inner plexiform layer retinal nerve fiber layer thickness glaucoma

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Evidence for distortion-induced local electric polarization in α-RuCl_(3)

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 165-173页

作者： Xinrun Mi De Hou Xiao Wang Sabreen Hammouda Caixing Liu Zijian xiong Han Li Yan Liu Guiwen Wang Aifeng Wang Yisheng Chai Yang Qi Wei Li Xiaoyuan Zhou Yixi Su DIKhomskii Mingquan He Zhigao sheng Young Sun College of Physics Center of Quantum Materials and DevicesChongqing UniversityChongqing 401331China Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHefei Institutes of Physical ScienceAnhuiChinese Academy of SciencesHefei 230031 China University of Science and Technology of China Hefei 230026China Jülich Centre for Neutron Scienceat Heinz Maier-Leibnitz Zentrum(JCNS-MLZ) Forschungszentrum Jülich GmbHGarching D-85747Germany School of Physics Beihang UniversityBeijing 100191China Analytical and Testing Center Chongqing UniversityChongqing 401331China State Key Laboratory of Surface Physics Department of PhysicsFudan UniversityShanghai 200433China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Ⅱ.Physikalisches Institut Universität zu KölnKöln D-50937Germany

The spin-orbit assisted Mott insulator α-RuCl_(3) is a prime candidate for material realization of the Kitaev quantum spin *** little attention has been paid to charge degrees of freedom,charge effects,such as electric polarization,may arise in this ***,we report distortion-induced local electric polarization in α-RuCl_(3) as evidenced by single-crystal X-ray diffraction,second harmonic generation(SHG)and dielectric *** SHG signal appears at room temperature and develops substantially in the Kitaev paramagnetic state when short-range spin correlations come into *** sizable pyroelectric currents in the Kitaev paramagnetic state,the absence of hysteresis in the polarization-electric field(P-E)points to the shortrange nature of electric *** localized electric polarization is likely the result of distortion-induced charge dimerization,achieved through virtual hopping-induced charge *** addition,the electric polarization is boosted by short-range spin correlations via spin-phonon coupling in the Kitaev paramagnetic *** results emphasize the importance of charge degrees of freedom in α-RuCl_(3),which establish a novel platform to investigate charge effects in Kitaev materials.

关键词： Mott insulator Kitaev quantum spin liquid electric polarization

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