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Characteristics and Risk Factors for Pediatric Sepsis

Current Medical Science 2024年第3期44卷 648-656页

作者： Yong-bing ZHU Tong-lin LIU Qi DAI Shu-fan LIU Peng xiong Hao HUANG Yi YUAN Tian-nan ZHANG Yu CHEN Department of Pediatric Intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Sepsis is considered a major cause of health loss in children and had high mortality and ***,there is no reliable model for predicting the prognosis of pediatric patients with *** study aimed to analyze the clinical characteristics of sepsis in children and assess the risk factors associated with poor prognosis in pediatric sepsis patients to identify timely interventions and improve their *** This study analyzed the clinical indicators and laboratory results of septic patients hospitalized in the Pediatric Intensive Care Unit of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,China,from January 1,2019,to December 31,*** factors for sepsis were identified by logistic regression *** A total of 355 children with sepsis were enrolled,with 333 children(93.8%)in the good prognosis group,and 22 children(6.2%)in the poor prognosis *** them,there were 255 patients(71.8%)in the sepsis group,and 100 patients(28.2%)in the severe sepsis *** length of hospital stay in the poor prognosis group was longer than that in the good prognosis group(P0.05),and the platelet(PLT),albumin(ALB),and hemoglobin(Hb)levels were lower in the poor prognosis group(P<0.01).The IL-8 levels in the severe sepsis group were higher than those in the sepsis group(P<0.05).Multiple logistic regression analysis suggested that lower Hb levels,ALB levels,peak PLT counts,and higher IL-1βlevels were independent risk factors for poor prognosis in children with *** Lower Hb,ALB,and PLT counts and elevated IL-1βare independent risk factors for poor prognosis in children with sepsis.

关键词： pediatric sepsis inflammation severity prognosis risk factors

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Will partial splenic embolization followed by splenectomy increase intraoperative bleeding?

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 318-330页

作者： Long Huang Qing-lin Li Qing-sheng Yu Hui Peng Zhou Zhen Yi Shen Qi Zhang Department of No.1 Surgery The First Hospital Affiliated to Anhui University of Traditional Chinese MedicineHefei 230031Anhui ProvinceChina Anhui University of Traditional Chinese Medicine Anhui University of Traditional Chinese MedicineHefei 230038Anhui ProvinceChina Department of Surgery The Second Hospital Affiliated to Anhui University of Traditional Chinese MedicineHefei 230061Anhui ProvinceChina

BACKGROUND Partial splenic embolization(PSE)has been suggested as an alternative to splenectomy in the treatment of ***,some patients may experience recurrence of hypersplenism after PSE and require ***,there is a lack of evidence-based medical support regarding whether preoperative PSE followed by splenectomy can reduce the incidence of *** To investigate the safety and therapeutic efficacy of preoperative PSE followed by splenectomy in patients with cirrhosis and *** Between January 2010 and December 2021,321 consecutive patients with cirrhosis and hypersplenism underwent splenectomy at our *** on whether PSE was performed prior to splenectomy,the patients were divided into two groups:PSE group(n=40)and non-PSE group(n=281).Patient characteristics,postoperative complications,and follow-up data were compared between *** score matching(PSM)was conducted,and univariable and multivariable analyses were used to establish a nomogram predictive model for intraoperative bleeding(IB).The receiver operating characteristic curve,Hosmer-Lemeshow goodness-of-fit test,and decision curve analysis(DCA)were employed to evaluate the differentiation,calibration,and clinical performance of the *** After PSM,the non-PSE group showed significant reductions in hospital stay,intraoperative blood loss,and operation time(all P=0.00).Multivariate analysis revealed that spleen length,portal vein diameter,splenic vein diameter,and history of PSE were independent predictive factors for IB.A nomogram predictive model of IB was constructed,and DCA demonstrated the clinical utility of this *** groups exhibited similar results in terms of overall survival during the follow-up *** Preoperative PSE followed by splenectomy may increase the incidence of IB and a nomogram-based prediction model can predict the occurrence of IB.

关键词： Partial splenic embolization Splenectomy Hypertension,Portal Liver Cirrhosis Intraoperative bleeding

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Conformational Disorder Within the Crystalline Region of Silica-Filled Polydimethylsiloxane:A Solid-State NMR Study

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Chinese Journal of Polymer Science 2024年第11期 1780-1792页

作者： Yu-Qi xiong Chang-lin Li Ai Lu Liang-Bin Li Wei Chen National Synchrotron Radiation Laboratory Anhui Provincial Engineering Laboratory of Advanced Functional Polymer FilmCAS Key Laboratory of Soft Matter ChemistryUniversity of Science and Technology of China Institute of Chemical Materials China Academy of Engineering Physics Department of Accelerator Science and Engineering Physics School of Nuclear Science and TechnologyUniversity of Science and Technology of China

The crystallization behavior of silica-filled polydimethylsiloxane （PDMS） was investigated in detail by1H solid-state nuclear magnetic resonance （1H SS-NMR） in combination with synchrotron radiation wide-angle X-ray scattering （WAXS）,and temperature-modulated differential scanning calorimetry （TMDSC） *** neat PDMS,no apparent difference is observed for the crystallinity characterized by1H SS-NMR and WAXS at low-temperature ***,upon filler addition,a 15%-35%lower difference in crystallinity is observed measured by1H SS-NMR compared to *** origin of such mismatch was explored through multi-component structural,dynamics,and chain-order analysis of PDMS samples with different filler *** 1D integrated WAXS results of PDMS with different filler fractions at different temperatures show that the packing structure as well as crystal size basically remain unchanged,but as the filler fraction increases from 0 phr to 60 phr,the rigid component’s dynamics order parameter Srobtained by1H SS-NMR decreases from 0.70 to *** filler fraction-dependent crystallinity calculated based on Srwas compared with experimental values,revealing a behavior of decreasing order in the crystalline *** with the results of accelerated chain dynamics in crystalline region as reflected by T2values,the molecular origin is attributed to the formation of CONDIS crystals,whose conformational order is lost but the position and orientation orders are *** hypothesis is further supported by the TMDSC results,where,as the filler fraction increases from 0 phr to 60 phr,the melting range widens from 8.77 K to 14.56 K,representing a growth of166%.In addition to previous reports related to the condition for forming CONDIS mesophase,i.e.,temperature,pressure,and stretching,the nano-sized filler could also introduce the local conformational disorder for chain packing.

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Personification in Chinese Diplomatic Discourse and the Construction of National Identity Based on Corpus:A Case Study of the Regular Press Conference of Ministry of Foreign Affairs

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Journal of Literature and Art Studies 2024年第5期14卷 360-364页

作者： xiong Jing-lin ZHOU Jing Wuhan University of Technology WuhanChina

With the development of the major country diplomacy with Chinese characteristics,diplomatic discourse,as an important part of building China’s international discourse power,has attracted much *** is a common means in diplomatic *** giving anthropomorphic expressions to countries,regions,institutions and policies,the purpose of building national identity and establishing national image can be *** on conceptual metaphor theory and national identity theory,this paper focuses on personification in diplomatic discourse with a case study of the regular press conference of Ministry of Foreign *** is found that the spokesperson skillfully constructed China’s positive national identity,such as peace-loving,openness and inclusiveness by using a large number of body metaphor,kinship metaphor and role metaphor.

关键词： diplomatic discourse personification identity construction

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Zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy

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Rare Metals 2024年第10期43卷 5152-5163页

作者： Dong-Wei Ma Jing-sheng Lu Xiang-Xin Cao Yan-Wei Cheng Gang Wang Zi-Qian Zhang Bo-Cheng Chen Ning lin Qing Chen College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine Center of Engineering and Technology

The rational design of a specific co-drug delivery platform that can address the unavoidable resistance, toxic side effects and low targeting efficiency of traditional cancer treatments is of great ***, Zn-based MOF-zeolitic imidazole framework-90(ZIF-90) was selected as the drug delivery carrier, with the cancer therapeutic drug mercaptopurine(6-MP) and glucose oxidase(GOD) as the drug models, hyaluronic acid(HA) was used for protection and targeted delivery, which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA). This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome. Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity, which provides new possibilities for the development of more precise and effective treatment strategies.

关键词： Cancer treatment Combination therapy Drug delivery Metal-organic framework Reduced toxicity

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Enhanced soft magnetic properties of SiO_(2)-coated FeSiCr magnetic powder cores by particle size effect

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Chinese Physics B 2024年第10期33卷 405-412页

作者： Mingyue Ge Likang Xiao Xiaoru Liu lin Pan Zhangyang Zhou Jianghe Lan Zhengwei xiong Jichuan Wu Zhipeng Gao Joint Laboratory for Extreme Conditions Matter Properties School of Mathematics and PhysicsSouthwest University of Science and TechnologyMianyang 621010China Southwest Institute of Applied Magnetism Mianyang 621010China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900China Sichuan Civil-military Integration Institute Mianyang 621010China

It has been known that metal FeSiCr powders with large average particle sizes have been typically employed to prepare magnetic powder cores(SMCs),with few studies reported on the influence of magnetic properties for original powders with various average particle sizes less than 10*** this work,SiO_(2)-coated FeSiCr SMCs with different small particle sizes were synthesized using the sol-gel *** contribution of SiO_(2)coating amount and voids to the soft magnetic properties was *** mechanism was revealed such that smaller particle sizes with less voids could be beneficial for reducing core loss in the *** optimizing the core structure,permeability and magnetic loss of 26 and 262 kW/cm^(3)at 100 kHz and 50 mT were achieved at a particle size of 4.8m and ethyl orthosilicate addition of 0.1 mL/*** best DC stacking performance,reaching 87%,was observed at an ethyl orthosilicate addition rate of 0.25 mL/g under 100 *** to other soft magnetic composites(SMCs),the FeSiCr/SiO_(2)SMCs exhibit significantly reduced magnetic *** further reduces the magnetic loss of the powder core,providing a new strategy for applications of SMCs at high frequencies.

关键词： FeSiCr SiO_(2) size effect magnetic properties DC superposition

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Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

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Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-sheng Chen Rui Han Yan-Ting Liu Wei Huang Qi Wang Xin xiong Ying Zhang Jian-Guo Zhao Shi-Hua Li Xiao-Jiang Li Wei-Li Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

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Single crystal growth and transport properties of narrow-bandgap semiconductor RhP_(2)

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Chinese Physics B 2024年第8期33卷 545-549页

作者：吴德胜郑萍雒建林 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China Quantum Science Center of Guangdong–Hong Kong–Macao Greater Bay Area(Guangdong) Shenzhen 518045China

We report the growth of high-quality single crystals of RhP_(2),and systematically study its structure and physical properties by transport,magnetism,and heat capacity ***-crystal x-ray diffraction reveals that RhP_(2) adopts a monoclinic structure with the cell parameters a=5.7347(10)A,b=5.7804(11)A,and c=5.8222(11)A,space group P2_(1)/c(No.14).The electrical resistivityρ(T)measurements indicate that RhP_(2) exhibits narrow-bandgap behavior with the activation energies of 223.1 meV and 27.4 meV for two distinct regions,*** temperaturedependent Hall effect measurements show electron domain transport behavior with a low charge carrier *** find that RhP_(2) has a high mobilityμ_(e)~210 cm^(2)·V^(-1)·s^(-1)with carrier concentrations n_(e)~3.3×10^(18)cm^(3) at 300 K with a narrow-bandgap *** high mobilityμ_(e) reaches the maximum of approximately 340 cm^(2)·V^(-1)·s^(-1)with carrier concentrations n_^(e)~2×10^(18)cm^(-3)at 100 *** magnetic phase transitions are observed from the susceptibilityχ(T)and specific heat C_(p)(T)measurements of RhP_(2).Our results not only provide effective potential as a material platform for studying exotic physical properties and electron band structures but also motivate further exploration of their potential photovoltaic and optoelectronic applications.

关键词： single crystal growth narrow band system electrical transport high mobilities

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Radiomics models to predict bone marrow metastasis of neuroblastoma using CT

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Cancer Innovation 2024年第5期3卷 71-83页

作者： xiong Chen Qinchang Chen Yuanfang Liu Ya Qiu lin Lv Zhengtao Zhang Xuntao Yin Fangpeng Shu Department of Paediatric Urology Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhouChina Department of Paediatric Surgery Guangzhou Institute of PaediatricsGuangzhou Medical UniversityGuangzhouChina Department of Pediatric Cardiology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Structural Heart DiseaseGuangzhouChina Department of Radiology Sun Yat‐sen Memorial HospitalSun Yat‐sen UniversityGuangzhouChina Department of Radiology the First People's Hospital of Kashi PrefectureKashiChina Medical School Sun Yat‐sen UniversityGuangzhouChina Department of Radiology Guangzhou Women and Children's Medical CenterGuangzhouChina

Background:Bone marrow is the leading site for metastasis from neuroblastoma and affects the prognosis of patients with ***,the accurate diagnosis of bone marrow metastasis is limited by the high spatial and temporal heterogeneity of *** analysis has been applied in various cancers to build accurate diagnostic models but has not yet been applied to bone marrow metastasis of ***:We retrospectively collected information from 187 patients pathologically diagnosed with neuroblastoma and divided them into training and validation sets in a ratio of 7:3.A total of 2632 radiomics features were retrieved from venous and arterial phases of contrastenhanced computed tomography(CT),and nine machine learning approaches were used to build radiomics models,including multilayer perceptron(MLP),extreme gradient boosting,and random *** also constructed radiomics‐clinical models that combined radiomics features with clinical predictors such as age,gender,ascites,and lymph gland *** performance of the models was evaluated with receiver operating characteristics(ROC)curves,calibration curves,and risk decile ***:The MLP radiomics model yielded an area under the ROC curve(AUC)of 0.97(95%confidence interval[CI]:0.95–0.99)on the training set and 0.90(95%CI:0.82–0.95)on the validation *** radiomics‐clinical model using an MLP yielded an AUC of 0.93(95%CI:0.89–0.96)on the training set and 0.91(95%CI:0.85–0.97)on the validation ***:MLP‐based radiomics and radiomics‐clinical models can precisely predict bone marrow metastasis in patients with neuroblastoma.

关键词： bone marrow metastasis machine learning neuroblastoma radiomics

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Analytical solutions to the precession relaxation of magnetization with uniaxial anisotropy

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Chinese Physics B 2024年第4期33卷 656-660页

作者：张泽南贾镇林薛德胜 Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000China

Based on the Landau-Lifshitz-Gilbert(LLG)equation,the precession relaxation of magnetization is studied when the external field H is parallel to the uniaxial anisotropic field H_(k).The evolution of three-component magnetization is solved analytically under the condition of H=nH_(k)(n=3,1 and 0).It is found that with an increase of H or a decrease of the initial polar angle of magnetization,the relaxation time decreases and the angular frequency of magnetization *** comparison,the analytical solution for H_(k)=0 is also *** the magnetization becomes stable,the angular frequency is proportional to the total effective field acting on the *** analytical solutions are not only conducive to the understanding of the precession relaxation of magnetization,but also can be used as a standard model to test the numerical calculation of LLG equation.

关键词： precession relaxation Landau-Lifshitz-Gilbert(LLG)equation uniaxial anisotropy analytical solutions

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