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Cyclooxygenase-2 gene -1195G/A genotype is associatedwith the risk of HBV-induced HCC: A case-control study in HanChinese people

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Frontiers of Medicine 2010年第1期4卷 90-95页

作者： Li-Feng LIU Jin-Liang ZHANG Qiong CHEN Ying CHANG Ju-sheng lin Institute of Liver Disease Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma(HCC)with hepatitis B virus(HBV)*** conducted a population-based,case-control study enrolling 630 Han Chinese people in Hubei *** included primary HCC patients with HBV infection(n=210),chronic hepatitis B cases(n=210)and healthy Han Chinese(n=210).-1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)and sequencing *** found-1195A allele carriers had a higher risk of HCC with HBV infection(OR,0.72;95%CI,0.548–0.946).The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.

关键词： cyclooxygenase-2 gene single nucleotide polymorphisms susceptibility primary hepatocellular car-cinoma hepatitis B virus infection

Ineradicable Memory:In Memoriam of Dr. Norman Bethune and the Medical Aid Team to China

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China Today 2015年第11期64卷 61-63页

作者： lin sheng

THIS year marks the 7oth anniversary of the victory of the World Anti-Fascist War and the Chinese People＇s War ofResistance Against Japanese Aggression. It also commemorates the 125th anniversary of the birth of Norman Bethune, legendary international physician and communist, and the 45th anniversary of the establishment of diplomatic relations between the PRC and Canada. For the last seven decades, the image of Dr. Bethune,

关键词：中国人中华人民共和国医疗记忆抗日战争共产主义法西斯加拿大

Hepatoma with cardiac metastasis: An advanced cancer requiring advanced treatment

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World Journal of Gastroenterology 2007年第25期13卷 3513-3516页

作者： Yu-sheng lin Shih-Ming lung Feng-Chun Tsai Chun-Nan Yeh Tzu-Fang Shiu Hsueh-Hua Wu Pyng-Jing lin Pao-Hsien Chu Division of Cardiology Department of Internal MedicineChang Gung Memorial Hospital Chang Gung University Collegeof Medicine Taipei Taiwan China Department of Pathology Chang GungMemorial Children Hospital Chang Gung University College of Medicine Taipei Taiwan China Division of Thoracic and Cardiovascular Surgery Chang Gung University College of Medicine Taipei Taiwan China Department of Surgery Chang Gung Memorial Hospital Chang Gung University College of Medicine TaipeiTaiwan China

AIM: To investigate the clinical and pathologic fi ndings, and to discuss the pathophysiology of hepatocellular carcinoma with cardiac metastasis. METHODS: Eight hepatoma patients with cardiac metastasis, who were treated by surgical excision from 1993 to 2006, were retrospectively studied. Detailed clinical parameters were analyzed. RESULTS: Of those eight patients, two (25%) were women and six (75%) were men, with the mean age of 50 years (range, 40-70 years). The presentations included: asymptomatic (75%), heart failure (25%), and pulmonary embolism (12.5%). All lesions involved the right atrium, and extended to the lung (12.5%), inferior vena cava (25%), and left atrium (12.5%). The level of tumor marker, alpha-fetal protein, was not correlated with the severity of metastasis or disease prognosis. Moreover, the availably estimated doubling time was less than 3 mo. The pathological fi ndings included variablehemorrhage and necrosis. The survival time following surgery also varied from one month to more than 30 mo. CONCLUSION: Hepatoma metastasis to the heart was detected in all eight patients. This study demonstrates that surgery might help the outcome in such cases.

关键词： Hepatoma Cardiac metastasis, Alpha-fetalprotein

Distribution- and Metabolism-Based Drug Discovery: A Potassium-Competitive Acid Blocker as a Proof of Concept

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Research 2022年第4期2022卷 609-620页

作者： Ming-Shu Wang Yi Gong lin-sheng Zhuo Xing-Xing Shi Yan-Guang Tian Chang-Kang Huang Wei Huang Guang-Fu Yang Key Laboratory of Pesticide e Chemical Biology of Ministry of Education International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Nanjing Shuohui Pharmatechnology Co. Ltd.Nanjing 210046China

Conventional methods of drug design require compromise in the form of side effects to achieve sufficient efficacy because targeting drugs to specific organs remains ***,new strategies to design organ-specific drugs that induce little toxicity are *** on characteristic tissue niche-mediated drug distribution(TNMDD)and patterns of drug metabolism into specific intermediates,we propose a strategy of distribution-and metabolism-based drug design(DMBDD);through a physicochemical property-driven distribution optimization cooperated with a well-designed metabolism pathway,SH-337,a candidate potassium-competitive acid blocker(P-CAB),was ***-337 showed specific distribution in the stomach in the long term and was rapidly cleared from the systemic ***,SH-337 exerted a comparable pharmacological effect but a 3.3-fold higher no observed adverse effect level(NOAEL)compared with FDA-approved *** study contributes a proof-of-concept demonstration of DMBDD and provides a new perspective for the development of highly efficient,organ-specific drugs with low toxicity.

关键词： drugs organs Potassium

Sulfur-enriched alkaloids from the root of Isatis indigotica

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Acta Pharmaceutica Sinica B 2018年第6期8卷 933-943页

作者： Qinglan Guo Chengbo Xu Minghua Chen sheng lin Yuhuan Li Chenggen Zhu JiANDong Jiang Yongchun Yang Jiangong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College

Five new sulfur-enriched alkaloids isatithioetherins A–E(1–5), and two pairs of scalemic enantiomers(t)-and( à)-isatithiopyrin B(6 a and 6 b) and isoepigoitrin and isogoitrin(7 a and 7 b), along with the known scalemic enantiomers epigoitrin and goitrin(8 a and 8 b), were isolated and characterized from an aqueous extract of the Isatis indigotica roots. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and theoretical calculations of electronic circular dichroism(ECD) spectra based on the quantum-mechanical time-dependent density functional theory(TDDFT). Compounds 1–5 represent a novel group of sulfur-enriched alkaloids, biogenetically originating from stereoselective assemblies of epigoitrin-derived units. Isolation and structure characterization of 6 a and 6 b support the postulated biosynthetic pathways for the diastereomers 9 a and 9 b via a rare thio-Diels–Alder reaction. Compounds 2 and 4 showed antiviral activity against the influenza virus A/Hanfang/359/95(H3 N2, IC500.60 and 1.92 μmol/L) and the herpes simplex virus 1(HSV-1, IC503.70 and 2.87 μmol/L), and 2 also inhibited Coxsackie virus B3(IC500.71 μmol/L).& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Cruciferae Isatis indigotica Sulfur-containing alkaloids Isatithioetherins A–E Isatithiopyrins A and B Isoepigoitrin Isogoitrin Antiviral activity

Tetraphenylethene based zinc complexes as fluorescent chemosensors for pyrophosphate sensing

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Chinese Chemical Letters 2015年第7期26卷 877-880页

作者： Hao-Ran Xu Kun Li Shu-Yan Jiao ling-ling Li sheng-lin Pan Xiao-Qi Yu Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University

We described a serious of zinc complexes that exhibit characteristic fluorescence responses toward pyrophosphate （PPi） and adenosine triphosphate （ATP） in aqueous media. These novel probes exploited tetraphenylethene （TPE） as fluorophore and macrocycle-polyamine （including 1,4,7,10-tetraazacyclo- dodecane and 1,4,7-triazacyclononane） Zn（ll） complexes as binding group. These ＂OFF-ON＂ type probes exhibited promising selectivity and sensitivity to PPi and ATP via a restriction ofintramolecular rotation （RIR） mechanism. The detection limit for PPi was found within nmol/L range.

关键词： Tetraphenylethene Cyclen PyrophosphatesZinc complex

Gastrolatathioneine,an unusual ergothioneine derivative from an aqueous extract of "tian ma":A natural product co-produced by plant and symbiotic fungus

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Chinese Chemical Letters 2016年第10期27卷 1577-1581页

作者： Qing-Lan Guo sheng lin Ya-Nan Wang Cheng-Gen Zhu Cheng-Bo Xu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College

Gastrolatathioneine （1）, an unusual natural product derived from ergothioneine, a fungal amino acid containing an imidazole-2-thione moiety, was isolated from an aqueous extract of ＂tian ma＂（the Gastrodia elata rhizomes）. The structure of 1 including the absolute configuration was determined by extensive spectroscopic data analysis, combined with comparison of an experimental circular dichroism spectrum and calculated electronic circular dichroism spectra of stereoisomers, and confirmed by X-ray crystallography. The natural origin of 1 was proved by HPLC-ESIMS analysis of the crude extract. A biogenetic pathway of I is proposed on the basis of metabolic post-modification of ergothioneine that is biosynthesized by a symbiotic fungus. The plant and symbiotic fungus are co-uroducers of 1.

关键词： Gastrodia elataOrchidaceaeErgothioneine(+)-L-N N-bis(4-hydroxybenzyl)ergothioneineGastrolatathioneine

Effect of Iodine Additive on Thermostability of Bulk Amorphous Sulfur Prepared by Rapid Compression

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Chinese Physics Letters 2011年第8期28卷 206-208页

作者： lin sheng-Xiong LIU Xiu-Ru SHAO Chun-Guang SHEN Ru HONG Shi-Ming Laboratory of High Pressure Physics Southwest Jiaotong UniversityChengdu 610031 National Engineering Research Center for Advanced Polymer Processing Technology Zhengzhou UniversityZhengzhou 450002 Analysis and Test Center Southwest Jiaotong UniversityChengdu 610031

Bulk amorphous sulfur(a-S)with 1 mol%of phosphorus,selenium and iodine additives and bulk amorphous pure sulfur samples were prepared by rapidly compressing the melts to 2 GPa within 20 *** results of x-ray diffraction,differential scanning calorimetry and in situ wide angle x-ray scattering of the recovered samples are presented and *** the iodine doping case,obvious inhibiting effects on the crystallization and the melting process under high temperatures occurred,as well as on the structure relaxation of a-S at room temperature,suggesting that the thermal stability of amorphous sulfur is remarkably improved by the introduction of iodine additives.

关键词： amorphous iodine Bulk

REE characteristics and genesis of alkaline-rich porphyry, Yunnan Province

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Journal of Central South University of Technology 2001年第1期8卷 45-49页

作者： LAI Jian qing,WU Cheng jian,PENG sheng lin (Institute of Geology, Central South University, Changsha 410083, China) Institute of Geology Central South University Changsha China

The Yunnan Himalayan alkaline rich porphyry occurs as a compound rockbelt and consists of calca alkalic, alkaline and peralkaline intrusions. Its origin is in debate. The paper deals with its origin by studying rock′s REE and Sr isotope. Although the rocks are different in their REE contents varying from 77.53 μg/g to 1 798.3 μg/g, they have very similar features in REE parameters. On the triangalar diagram of REEs, the sample dots are concentrated on the end area of light REEs, representing a product of low degree melting of upper mantle or lower crust materials. The initial 87 Sr/ 86 Sr values of rocks vary between 0.706 4 and 0.709 8, showing a feature of mantle crust mixed source. Moreover, REEs show a logarithmic linear positive correlation between them. This type of correlation strongly supports the fractional partial melting model. The result of geochemistry inversion shows that the source rock of alkaline rich porphyry is plagioclase bearing harzburgite and of mantle crust mixed type. At the early state of melting, some crust components of the source rock were partially melted into intermediate acidic magma; with the crust components consumed, the magma evolved to basic.

关键词： alkaline rich porphyry REE genesis Sr isotope Yunnan