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Predictive value of the unplanned extubation risk assessment scale in hospitalized patients with tubes

World Journal of Clinical Cases 2022年第36期10卷 13274-13283页

作者： Kun Liu Zheng Liu lin-qian Li Meng Zhang Xue-Xue Deng Hong Zhu Department of Cardiology West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Nursing West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Critical patients often had various types of tubes,unplanned extubation of any kind of tube may cause serious injury to the patient,but previous reports mainly focused on endotracheal intubation.The limitations or incorrect use of the unplanned extubation risk assessment tool may lead to improper identification of patients at a high risk of unplanned extubation and cause delay or nonimplementation of unplanned extubation prevention interventions.To effectively identify and manage the risk of unplanned extubation,a comprehensive and universal unplanned extubation risk assessment tool is needed.AIM To assess the predictive value of the Huaxi Unplanned Extubation Risk Assessment Scale in inpatients.METHODS This was a retrospective validation study.In this study,medical records were extracted between October 2020 and September 2021 from a tertiary comprehensive hospital in southwest China.For patients with tubes during hospitalization,the following information was extracted from the hospital information system:age,sex,admission mode,education,marital status,number of tubes,discharge mode,unplanned extubation occurrence,and the Huaxi Unplanned Extubation Risk Assessment Scale(HUERAS)score.Only inpatients were included,and those with indwelling needles were excluded.The best cut-off value and the area under the curve(AUC)of the Huaxi Unplanned Extubation Risk Assessment Scale were been identified.RESULTS A total of 76033 inpatients with indwelling tubes were included in this study,and 26 unplanned extubations occurred.The patients’HUERAS scores were between 11 and 30,with an average score of 17.25±3.73.The scores of patients with or without unplanned extubation were 22.85±3.28 and 17.25±3.73,respectively(P<0.001).The results of the correlation analysis showed that the correlation coefficients between each characteristic and the total score ranged from 0.183 to 0.843.The best cut-off value was 21,and there were 14135 patients with a high risk of unplanned extubation,accounting for 18.59%.The Cronbach’sα,sensi

关键词： Inpatient Unplanned extubation Risk assessment Prediction Tube management

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甘肃省安西县三峰山金矿地质特征与矿床成因浅析

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世界有色金属 2024年第6期 110-112页

作者：钱林武魏永满石为江甘肃省有色金属地质勘查局兰州矿产勘查院甘肃兰州730046

文章详细探讨和分析甘肃省安西县三峰山金矿地质特征,阐述了金矿矿体产状、形态及规模和控矿因素等。

关键词：三峰山地质特征矿床成因找矿标志

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Selective N-Methylation of N-Methylaniline with CO_(2) and H_(2) over Cu/In_(2)O_(3) Catalyst

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Chinese Journal of Chemistry 2024年第3期42卷 276-282页

作者： Huan Zheng Bo qian lin He State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China University of Chinese Academy of Sciences Beijing100049 China

N-Methylation of amines with CO_(2) and H2 is a potential approach for CO_(2) utilization because N-methylated amines can be used as solvents and organic intermediates. In_(2)O_(3)-supported Cu (Cu/In_(2)O_(3)) acts as an effective heterogeneous catalyst for N-methylation reaction of N-methylaniline (MA) with CO_(2) and H_(2),showing higher N,N-dimethylaniline (DMA) selectivity than other supported Cu catalysts. On one hand,the dispersion of Cu can be improved by the defective In_(2)O_(3) support. On the other hand,In_(2)O_(3) support is active in the dissociative adsorption of CO_(2) through C—O bond breaking. In addition,the H_(2) dissociation ability of In_(2)O_(3) can also be enhanced by Cu. The combination of Cu and In_(2)O_(3) is effective in the activation of CO_(2),the adsorption of intermediate N-methylformanilide (MFA),the hydrogenation of MFA to DMA and the prohibition of C—N bond cleavage side reactions,thereby enhancing the reaction rate of MA conversion and the selectivity to DMA.

关键词： N-Methylation CO_(2) Cu/In_(2)O_(3) Supported catalysts Heterogeneous catalysis

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零值绝缘子对超高压500 kV绝缘子串电场分布影响研究

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自动化技术与应用 2024年第1期43卷 178-181页

作者：高拓宇韩学春郝宝欣钱聪钱林清国网江苏超高压公司江苏南京211102 国网江苏省电力有限公司江苏南京210024 国网南通供电公司江苏南通226000

作为超高压输电线路的关键部件绝缘子长期运行后其绝缘性能下降,容易产生零值绝缘子,严重时会造成经济损失。因此,利用有限元方法研究不同位置和数量的零值绝缘子对超高压500 kV绝缘子串电场分布的影响。结果表明:存在零值绝缘子以及零... 详细信息

作为超高压输电线路的关键部件绝缘子长期运行后其绝缘性能下降,容易产生零值绝缘子,严重时会造成经济损失。因此,利用有限元方法研究不同位置和数量的零值绝缘子对超高压500 kV绝缘子串电场分布的影响。结果表明:存在零值绝缘子以及零值绝缘子的位置和数量均会对绝缘子串的电场分布产生一定的影响,高低压端存在零值绝缘子对绝缘子串电场影响最大。且当监测路径不同时,零值绝缘子对于绝缘子电场分布的影响会存在变化。零值绝缘子数量会对电场值影响程度有所改变。最后试验与理论结果对比显示,理论值与试验值在可接受范围之内存在一定的误差。

关键词：有限元零值绝缘子电场强度超高压

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针灸联合生物反馈电刺激治疗产后压力性尿失禁疗效及对ICI-Q-SF评分和盆底肌表面电信号的影响

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辽宁中医药大学学报 2024年第6期26卷 176-181页

作者：刘婷婷林椠杜林山杜美容唐山市妇幼保健院河北唐山063000

目的探讨针灸联合生物反馈电刺激治疗产后压力性尿失禁(postpartum stress urinary incontinence,PSUI)的疗效及对国际尿失禁咨询委员会尿失禁问卷表(Incontinence Questionnaire of the International Incontinence Advisory Committee,ICI-Q-SF)评分和盆底肌表面电信号的影响。方法选取2022年6月—2023年6月于本院就诊的PSUI患者264例,随机分为对照组(n=132)和研究组(n=132),对照组采取生物反馈电刺激治疗,研究组采取针灸联合生物反馈电刺激治疗,均治疗8周,观察两组治疗疗效,对比治疗前后漏尿量、盆底功能、肌力、肌纤维疲劳度、ICI-Q-SF得分、盆底肌表面电信号、尿动力学水平[最大尿道闭合压(MUCP)、最大尿流率(MFR)、达峰时间(Tmax)、咳嗽点膀胱内压(CLPP)]。采用GEE模型评价两种治疗方法对患者ICI-Q-SF评分和盆底肌表面电信号的影响。结果对照组总有效率为74.24%,研究组总有效率为91.67%,两组临床疗效比较差异有统计学意义(P<0.05)。与治疗前比较,治疗4周、6周、8周后两组患者阴道收缩压、静息压、盆底肌表面电信号水平(活力)及尿动力学水平均有显著升高,而膀胱颈活动度、尿道旋转角度、漏尿量、ICI-Q-SF评分、盆底肌表面电信号水平(峰值)显著降低(P<0.05),且研究组优于对照组(P<0.05)。治疗4周、6周、8周后,研究组盆底肌力情况及盆底Ⅰ类、Ⅱ类肌纤维疲劳度均优于对照组,差异均有统计学意义(P<0.05)。采用GEE模型结果显示,治疗时间、治疗方案及两者的交互作用比较差异有统计学意义(P<0.05)。结论针灸联合生物反馈电刺激在治疗产后压力性尿失禁方面具有很好的应用前景,可显著改善患者的ICI-Q-SF评分和盆底肌表面电信号,应用价值较高。

关键词：针灸生物反馈电刺激产后压力性尿失禁国际尿失禁咨询委员会尿失禁问卷表盆底肌表面电信号

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The expression of oxidative stress genes related to myocardial ischemia reperfusion injury in patients with ST-elevation myocardial infarction

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World Journal of Emergency Medicine 2022年第2期13卷 106-113页

作者： qian-lin Gu Peng Jiang Hui-fen Ruan Hao Tang Yang-bing Liang Zhong-fu Ma Hong Zhan Emergency Department the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510000China Huangpu District Emergency Department the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510000China

BACKGROUND:We aimed to investigate the gene expression of myocardial ischemia/reperfusion injury(MIRI)in patients with acute ST-elevation myocardial infarction(STEMI)using stress and toxicity pathway gene chip technology and try to determine the underlying mechanism.METHODS:The mononuclear cells were separated by ficoll centrifugation,and plasma total antioxidant capacity(T-AOC)was determined by the ferric reducing ability of plasma(FRAP)assay.The expression of toxic oxidative stress genes was determined and verified by oligo gene chip and quantitative real-time polymerase chain reaction(qRT-PCR).Additionally,gene ontology(GO)enrichment analysis was performed on DAVID website to analyze the potential mechanism further.RESULTS:The total numbers of white blood cells(WBC)and neutrophils(N)in the peripheral blood of STEMI patients(the AMI group)were significantly higher than those in the control group(WBC:11.67±4.85×10^(9)/L vs.6.41±0.72×10^(9)/L,P<0.05;N:9.27±4.75×10^(9)/L vs.3.89±0.81×10^(9)/L,P<0.05),and WBCs were significantly associated with creatine kinase-myocardial band(CK-MB)on the first day(Y=8.945+0.018X,P<0.05).In addition,the T-AOC was significantly lower in the AMI group comparing to the control group(12.80±1.79 U/mL vs.20.48±2.55 U/mL,P<0.05).According to the gene analysis,eight up-regulated differentially expressed genes(DEGs)included GADD45A,PRDX2,HSPD1,DNAJB1,DNAJB2,RAD50,TNFSF6,and TRADD.Four down-regulated DEGs contained CCNG1,CAT,CYP1A1,and ATM.TNFSF6 and CYP1A1 were detected by polymerase chain reaction(PCR)to verify the expression at different time points,and the results showed that TNFSF6 was up-regulated and CYP1A1 was down-regulated as the total expression.GO and kyoto encyclopedia of genes and genomes(KEGG)enrichment analysis suggested that the oxidative stress genes mediate MIRI via various ways such as unfolded protein response(UPR)and apoptosis.CONCLUSIONS:WBCs,especially neutrophils,were the critical cells that mediating reperfusion injury.MIRI was regulated by various genes,including o

关键词： Acute myocardial infarction Myocardial ischemia/reperfusion injury Oxidative stress TNFSF6 CYP1A1 Unfolded protein response

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Zinc-doped Prussian blue nanoparticles for mutp53-carrying tumor ion interference and photothermal therapy

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Asian Journal of Pharmaceutical Sciences 2022年第5期17卷 767-777页

作者： Quanyi Jin Wenbao Zuo qian lin Ting Wu Cong Liu Nian Liu Jinxue Liu Xuan Zhu Fujian Provincial Key Laboratory of Innovative Drug Target Research School of Pharmaceutical SciencesXiamen UniversityXiamen 361005China Cancer Research Center School of MedicineXiamen UniversityXiamen 361000China

Quite a great proportion of known tumor cells carry mutation in TP53 gene,expressing mutant p53 proteins(mutp53)missing not only original genome protective activities but also acquiring gain-of-functions that favor tumor progression and impede treatment of cancers.Zinc ions were reported as agents cytocidal to mutp53-carrying cells by recovering p53 normal functions and abrogating mutp53.Meanwhile in a hyperthermia scenario,the function of wild type p53 is required to ablate tumors upon heat treatment hence the effects might be hindered in a mutp53 background.We herein synthesized zinc-doped Prussian blue(ZP)nanoparticles(NPs)to combine Zn 2+based and photothermal therapeutic effects.An efficient release of Zn 2+in a glutathione-enriched tumor intracellular microenvironment and a prominent photothermal conversion manifested ZP NPs as zinc ion carriers and photothermal agents.Apoptotic death and autophagic mutp53 elimination were found to be induced by ZP NPs in R280K mutp53-containing MDA-MB-231 cells and hyperthermia was rendered to ameliorate the treatment in vitro through further mutp53 elimination and increased cell death.The combinatorial therapeutic effect was also confirmed in vivo in a mouse model.This study might expand zinc delivery carriers and shed a light on potential interplay of hyperthermia and mutp53 degradation in cancer treatment.

关键词： Zinc Mutant p53 Prussian blue Photothermal therapy Ion interference therapy

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林业汽车起重机液压缸杆密封件金属橡胶性能仿真研究

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林业机械与木工设备 2024年第2期52卷 43-46页

作者：姜英博张恒高奥林一骞钱孟豪徐国祺东北林业大学机电工程学院黑龙江哈尔滨150040

现阶段常见的橡胶密封圈在高温情况下易老化,在油液介质下易腐蚀,在高强度运输下易发生损坏。而主要应用于苛刻工况下密封领域的金属橡胶材料具有工作温度范围大、承载能力强、不易老化等特点。基于金属橡胶材料的优越性能,通过分析液... 详细信息

现阶段常见的橡胶密封圈在高温情况下易老化,在油液介质下易腐蚀,在高强度运输下易发生损坏。而主要应用于苛刻工况下密封领域的金属橡胶材料具有工作温度范围大、承载能力强、不易老化等特点。基于金属橡胶材料的优越性能,通过分析液压缸泄露原因,利用ANSYS分析MR组合密封件与普通O型橡胶密封性能的差异,对比不同密封件在相同边界条件下的接触应力与塑性变形,得出金属橡胶组合密封件在汽车起重机液压油缸的密封中更具有优势的结论。

关键词：起重机液压缸金属橡胶密封性能接触应力塑性变形

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氮、磷、钾肥不同配比对粉葛光合特性及产量和品质的影响

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作物杂志 2024年第3期 216-222页

作者：欧昆鹏王学礼王艳何明慧黄廉康郑德波林茜广西农业科学院生物技术研究所广西南宁530007 广西大学农学院广西南宁530004

研究氮、磷、钾肥不同配比对粉葛各生育期的光合特性影响,为粉葛科学施肥管理提供理论依据。采用“3414”随机区组设计,分析苗期、块根形成期、块根膨大期及淀粉积累期的相对叶绿素含量(SPAD)、净光合速率、气孔导度、胞间CO_(2)浓度、... 详细信息

研究氮、磷、钾肥不同配比对粉葛各生育期的光合特性影响,为粉葛科学施肥管理提供理论依据。采用“3414”随机区组设计,分析苗期、块根形成期、块根膨大期及淀粉积累期的相对叶绿素含量(SPAD)、净光合速率、气孔导度、胞间CO_(2)浓度、蒸腾速率在不同氮、磷、钾配比施肥下的响应特征,以及不同施肥水平对粉葛产量、淀粉和葛根素含量的影响。结果表明,块根形成期是施肥调控粉葛光合效率的较敏感阶段,减量氮(N_(1)P_(2)K_(2))、正常氮、磷、钾(N_(2)P_(2)K_(2))施肥处理可显著提高粉葛的产量,N_(1)P_(2)K_(2)的淀粉含量(40%)最高,减量钾(N_(2)P_(2)K_(1))和过量钾(N_(2)P_(2)K_(3))处理的葛根素含量较其他处理增幅显著。综上,N_(1)P_(2)K_(2)配施方案能够改善粉葛叶片的光合效率,促进粉葛产量的提高并增加块根淀粉和葛根素含量,相比其他施肥方案更能兼顾其产量及品质的提升。

关键词：粉葛光合特性产量品质

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Dynamics of luffing motion of a hydraulically driven shell manipulator with revolute clearance joints

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Defence Technology（防务技术） 2022年第4期18卷 689-708页

作者： Chen Zhi-qun qian lin-fang Chen Guang-song Nie Shou-cheng Yin qiang Yue Cai-cheng School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China Northwest Institute of Mechanical and Electrical Engineering Xianyang712099ShaanxiChina China North Industry Corporation Beijing100053China

In this study,a modeling method for investigating the dynamic characteristics of a hydraulically driven shell manipulator with revolute clearance joints is presented.This model accounts for the effect of the clearance,the flexibility of the rotating beam,and the coupled dynamic characteristics of the hydraulic cylinder.A modified contact force model was developed to simulate the physical properties of realistic revolute joints with small clearances,heavy loads,and variable contact stiffnesses and damping coefficients with variations of the indentations.Considering the strong coupling relationship between the hydraulic cylinder and the flexible beam,a system equation of motion combining the state variables of the hydraulic cylinder and mechanical system was established.The complex nonlinear friction force of the hydraulic cylinder motion was constructed using a modified Lu Gre model,and the parameters of the friction model were identified using intelligent identification algorithms.Moreover,a test system for the shell manipulator was established to achieve experimental validation.Finally,the effects of the clearance size and the stiffness of the cylinder support on the dynamic response were investigated.

关键词： Parameter identification Shell manipulator Hydraulic cylinder Revolute clearance joint

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