检索结果-南通市图书馆

Distributions of Visual Receptive Fields from Retinotopic to Craniotopic Coordinates in the Lateral Intraparietal Area and Frontal Eye Fields of the Macaque

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第2期40卷 171-181页

作者： lin Yang Min Jin Cong Zhang Ning qian Mingsha Zhang Key Laboratory of Cognitive Neuroscience and Learning Division of PsychologyBeijing Normal UniversityBeijing 100875China Institute of Neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of Neuroscience and Zuckerman Institute Columbia UniversityNew York 10027USA

Even though retinal images of objects change their locations following each eye movement,we perceive a stable and continuous world.One possible mechanism by which the brain achieves such visual stability is to construct a craniotopic coordinate by integrating retinal and extraretinal information.There have been several proposals on how this may be done,including eye-position modulation(gain fields)of retinotopic receptive fields(RFs)and craniotopic RFs.In the present study,we investigated coordinate systems used by RFs in the lateral intraparietal(LIP)cortex and frontal eye fields(FEF)and compared the two areas.We mapped the two-dimensional RFs of neurons in detail under two eye fixations and analyzed how the RF of a given neuron changes with eye position to determine its coordinate representation.The same recording and analysis procedures were applied to the two brain areas.We found that,in both areas,RFs were distributed from retinotopic to craniotopic representations.There was no significant difference between the distributions in the LIP and FEF.Only a small fraction of neurons was fully craniotopic,whereas most neurons were between the retinotopic and craniotopic representations.The distributions were strongly biased toward the retinotopic side but with significant craniotopic shifts.These results suggest that there is only weak evidence for craniotopic RFs in the LIP and FEF,and that transformation from retinotopic to craniotopic coordinates in these areas must rely on other factors such as gain fields.

关键词： Reference frames Eye-centered Headcentered Visual stability

纳米银对小鼠H22肝癌腹水瘤抑制作用的实验研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肿瘤预防与治疗 2024年第1期37卷 20-25页

作者：石皓林倩王毓兴许玲郑洋俞红女大连大学附属新华医院中心实验室辽宁大连116000 澄迈县人民医院重症医学科海口571900 大连大学医学院辽宁大连116000

目的:研究纳米银腹腔注射对小鼠H22肝癌腹水瘤的疗效及安全性。方法:昆明小鼠40只经腹腔注射H22细胞建立肝癌腹水瘤模型,24 h后随机分为模型组(生理盐水),顺铂组及纳米银低、中、高剂量组,连续12天腹腔注射给药,记录小鼠一般状况、体重... 详细信息

目的:研究纳米银腹腔注射对小鼠H22肝癌腹水瘤的疗效及安全性。方法:昆明小鼠40只经腹腔注射H22细胞建立肝癌腹水瘤模型,24 h后随机分为模型组(生理盐水),顺铂组及纳米银低、中、高剂量组,连续12天腹腔注射给药,记录小鼠一般状况、体重及腹围,并观察腹水生成及生存情况。另选择健康昆明小鼠20只随机分为对照组及纳米银高剂量组进行药物安全性实验,连续12天腹腔注射相应药物,记录小鼠体重及生存情况,全自动血细胞分析仪、全自动生化分析仪检测小鼠血常规及生化指标。结果:与模型组相比,纳米银组小鼠体重及腹围增加缓慢,生存期延长,纳米银高剂量组小鼠体重和腹围变化及生存期与顺铂组相比差异无统计学意义。安全性实验结果显示,与对照组相比,纳米银高剂量组小鼠体重、生存期、血常规和肝肾功能各项生化指标的差异均无统计学意义。结论:纳米银可抑制肝癌腹水生成并延长腹水瘤小鼠生存期,且无明显毒副作用,或可作为癌性腹水治疗的一种新方法。

关键词：肝癌腹水瘤 H22细胞纳米银小鼠

Characterization of subunits encoded by Sn RK1 and dissection of combinations among these subunits in sorghum(Sorghum bicolor L.)

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2023年第2期22卷 642-649页

作者： XIAO qian-lin HUANG Tian-hui ZHOU Chang CHEN Wei-xi CHA Jian-kui WEI Xi-mei XING Fang-yu qian Meng-ya MA qian-nan DUAN Hong LIU Zhi-zhai College of Agronomy and Biotechnology Southwest UniversityChongqing 400715P.R.China

Sucrose nonfermenting-related protein kinase 1(SnRK1)is one of the critical serine/threonine protein kinases.It commonly mediates plant growth and development,cross-talks with metabolism processes and physiological responses to biotic or abiotic stresses.It plays a key role in distributing carbohydrates and sugar signal transporting.In the present study,eight SnRK1 coding genes were identified in sorghum(Sorghum bicolor L.)via sequences alignment,with three forαsubunits(SnRK1α1 to SnRK1α3),three forβ(SnRK1β1 to SnRK1β3),and one for bothγ(SnRK1γ)andβγ(SnRK1βγ).These eight corresponding genes located on five chromosomes(Chr)of Chr1–3,Chr7,and Chr9 and presented collinearities to SnRK1s from maize and rice,exhibiting highly conserved domains within the same subunits from the three kinds of cereals.Expression results via qRT-PCR showed that different coding genes of SnRK1s in sorghum possessed similar expression patterns except for SnRK1α3 with a low expression level in grains and SnRK1β2 with a relatively high expression level in inflorescences.Results of subcellular localization in sorghum leaf protoplast showed that SnRK1α1/α2/α3/γmainly located on organelles,while the rest four of SnRK1β1/β2/β3/βγlocated on both membranes and some organelles.Besides,three combinations were discovered among eight SnRK1 subunits in sorghum through yeast two hybrid,includingα1-β2-βγ,α2-β3-γ,andα3-β3-γ.These results provide informative references for the following functional dissection of SnRK1 subunits in sorghum.

关键词： sorghum(Sorghum bicolor L.) SnRK1 expression analysis combination pattern

Effects of soy hull polysaccharide on dyslipidemia and pathoglycemia in rats induced by a high-fat-high-sucrose diet

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2022年第1期11卷 49-57页

作者： qian lin lina Yang lin Han Ziyi Wang Mingshuo Luo Danshi Zhu He Liu Xin Li Yu Feng College of Food Science and Technology Bohai UniversityJinzhou 121013China National&Local Joint Engineering Research Center of Storage Processing and Safety Control Technology for Fresh Agricultural and Aquatic ProductsJinzhou 121013China

The present work aimed at investigating the effects of soy hull polysaccharide(SHP)in alleviating adverse effects in rats fed a high-fat-high-sucrose diet.After SHP feeding for 4 weeks,the fasting blood glucose(FBG),serum triglyceride(TG),serum high-density lipoprotein cholesterol(HDL-C),short chain fatty acids(SCFAs),and 16S rDNA gene sequence were determined.Administration of SHP significantly decreased body fat content and TG levels,and increased water intake and HDL-C levels after 4 weeks of treatment.The antihyperglycemic effect of SHP at a dose of 400 mg/kg mb had the most significant effects among the three dosage groups.SHP notably restored the FBG in rats fed a high-fat-high-sucrose diet(P<0.05).Furthermore,SHP at 400 mg/kg mb increased the abundance of Bacteroidetes and decreased that of Firmicutes and Actinobacteria at the phylum level.The polysaccharide treated groups had significantly higher content of total SCFAs,and the main fermentation products were acetic,propionic,n-valeric and i-valeric acids.Thus,SHP restores blood lipid levels in rats fed a high-fat-high sucrose diet through regulation of the gut microbiota.

关键词： Soy hull polysaccharide Antihyperlipidemic Gut microbiota Short-chain fatty acids

Toward a rapid and convenient nanoplastic quantification method in laboratory-scale study based on fluorescence intensity

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第5期18卷 117-126页

作者： Ruiqi Yan Sen lin qian Ding Lei Zhang Xia Yu Wentao Zhao qian Sui State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process School of Resources and Environmental EngineeringEast China University of Science and TechnologyShanghai200237China State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai200092China

The thorough investigation of nanoplastics(NPs)in aqueous environments requires efficient and expeditious quantitative analytical methods that are sensitive to environmentally relevant NP concentrations and convenient to employ.Optical analysis-based quantitative methods have been acknowledged as effective and rapid approaches for quantifying NP concentrations in laboratory-scale studies.Herein,we compared three commonly used optical response indicators,namely fluorescence intensity(FI),ultraviolet absorbance,and turbidity,to assess their performance in quantifying NPs.Furthermore,orthogonal experiments were conducted to evaluate the influence of various water quality parameters on the preferred indicator-based quantification method.The results revealed that FI exhibits the highest correlation coefficient(>0.99)with NP concentration.Notably,the limit of quantification(LOQ)for various types of NPs is exceptionally low,ranging from 0.0089 to 0.0584 mg/L in ultrapure water,well below environmentally relevant concentrations.Despite variations in water quality parameters such as pH,salinity,suspended solids(SS),and humic acid,a robust relationship between detectable FI and NP concentration was identified.However,an increased matrix,especially SS in water samples,results in an enhanced LOQ for NPs.Nevertheless,the quantitative method remains applicable in real water bodies,especially in drinking water,with NP LOQ as low as 0.0157–0.0711 mg/L.This exceeds the previously reported detectable concentration for 100 nm NPs at 40µg/mL using surface-enhanced Raman spectroscopy.This study confirms the potential of FI as a reliable indicator for the rapid quantification of NPs in aqueous environments,offering substantial advantages in terms of both convenience and cost-effectiveness.

关键词： Nanoplastic quantification Fluorescence intensity Drinking water Limit of quantification(LOQ) Matrix effects

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

黏性液膜在水平旋转柱体外的稳态行为

大学物理 2024年第5期43卷 55-59页

作者：林蕴芊雷家睿马宇翰北京师范大学物理学系北京100875

绕水平轴旋转的圆柱杆外表面上黏性液体会随着杆的旋转趋于稳态.本文研究了这一稳态对应的最大液体质量及其在不同条件下丰富的几何形状.在将液体流动近似视为斯托克斯流的前提下,杆上液体的单位最大载荷量W关于液体参数(密度ρ、黏度μ... 详细信息

绕水平轴旋转的圆柱杆外表面上黏性液体会随着杆的旋转趋于稳态.本文研究了这一稳态对应的最大液体质量及其在不同条件下丰富的几何形状.在将液体流动近似视为斯托克斯流的前提下,杆上液体的单位最大载荷量W关于液体参数(密度ρ、黏度μ)及杆参数(转速Ω、半径a)的依赖关系为W∝√ρμΩa^(3).本文设计的控制变量实验表明,这一关系在较小雷诺数情况下(Re≤10)成立.在较高雷诺数(Re>10)区域,黏性液体的惯性效应是导致理论预测与实验结果出现偏差的主要原因.本文进一步探究了液膜横截面形状随杆转速变化的现象,实验观察到了椭圆、叶状、单勾和多勾形状的液膜,并定性解释了其形成原因.此外,实验中还发现了圆柱体轴向上形成液环的现象,液环数量与杆转速、杆半径成正相关.

关键词：黏性液体液膜雷诺数

Tipping Point Detection Using Reservoir Computing

在线全文

学校读者我要写书评

暂无评论

Research 2024年第1期6卷 779-790页

作者： Xin Li Qunxi Zhu Chengli Zhao Xuzhe qian Xue Zhang Xiaojun Duan Wei lin College of Science National University of Defense TechnologyChangshaHunan 410073China Research Institute of Intelligent Complex Systems and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433China Shanghai Artificial Intelligence Laboratory Shanghai 200232China School of Mathematical Sciences SCMSSCAMand CCSBFudan UniversityShanghai 200433China

Detection in high fidelity of tipping points,the emergence of which is often induced by invisible changes in internal structures or/and external interferences,is paramountly beneficial to understanding and predicting complex dynamical systems(CDSs).Detection approaches,which have been fruitfully developed from several perspectives(e.g.,statistics,dynamics,and machine learning),have their own advantages but still encounter difficulties in the face of high-dimensional,fluctuating datasets.Here,using the reservoir computing(RC),a recently notable,resource-conserving machine learning method for reconstructing and predicting CDSs,we articulate a model-free framework to accomplish the detection only using the time series observationally recorded from the underlying unknown CDSs.

关键词： computing record ping

基于整合模式下儿科学专业神经系统课程的探索与实践

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

教育生物学杂志 2024年第2期12卷 121-125页

作者：杨红荣林芊王廉文钮晓音陈怡绮上海交通大学医学院儿科学学院上海200025 上海交通大学医学院附属新华医院儿神经内科上海200092 上海交通大学医学院教务处上海200025

目的探索基于单循环器官系统整合医学模式下儿科学专业神经系统课程的建设。方法2021年6—7月,选取上海交通大学医学院儿科学专业“神经系统与疾病”课程为研究对象,评估该课程体系和课程设计,分析基于整合医学模式下儿科学专业整合课... 详细信息

目的探索基于单循环器官系统整合医学模式下儿科学专业神经系统课程的建设。方法2021年6—7月,选取上海交通大学医学院儿科学专业“神经系统与疾病”课程为研究对象,评估该课程体系和课程设计,分析基于整合医学模式下儿科学专业整合课程建设的优势和挑战。结果“神经系统与疾病”整合课程整合了相关多学科内容,构建了以器官系统为线索的课程体系;强调以学生为中心的学习模式,丰富了授课形式,增加了平时考核的占比,注重学生胜任力的培养。结论单循环器官系统整合课程强化了儿科学专业学生胜任力的培养,是儿科医学教育发展趋势,后续应进一步做好课程评价与反馈,持续改进。

关键词：单循环器官系统神经系统课程建设

A Generalized Existence Theorem of Backward Doubly Stochastic Differential Equations

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2010年第8期26卷 1525-1534页

作者： qian lin School of Mathematics Shandong University Ji'nan 250100 P. R. China and Laboratoire de Mathematiques CNRS UMR 6205 Universite de Bretagne Occidentale6avenue Victor Le Gorgeu CS 93837 29238 Brest cedex 3 France

In this paper, we deal with a class of one-dimensional backward doubly stochastic differential equations （BDSDEs）. We obtain a generalized comparison theorem and a generalized existence theorem of BDSDEs.

关键词： Backward doubly stochastic differential equations comparison theorem existence theorem backward stochastic integral