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Low-Cost and Scalable Platform with Multiplexed Microwell Array Biochip for Rapid Diagnosis of COVID-19

Research 2021年第1期2021卷 94-102页

作者： Yang Wang Kaiju Li Gaolian Xu Chuan Chen Guiqin Song Zaizai Dong long lin Yu Wang Zhiyong Xu Mingxia Yu Xinge Yu Binwu Ying Yubo Fan lingqian Chang Jia Geng Beijing Advanced Innovation Center for Biomedical Engineering Key Laboratory for Biomechanics and MechanobiologySchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Laboratory Medicine State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China Nano Biomedical Research Centre School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Wuhan Chain Medical Labs WuhanHubei 430011China Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Biomedical Engineering City University of Hong KongChina

Sensitive detection of SARS-CoV-2 is of great importance for inhibiting the current pandemic of ***,we report a simple yet efficient platform integrating a portable and low-cost custom-made detector and a novel microwell array biochip for rapid and accurate detection of *** instrument exhibits expedited amplification speed that enables colorimetric read-out within 25 minutes.A polymeric chip with a laser-engraved microwell array was developed to process the reaction between the primers and the respiratory swab RNA extracts,based on reverse transcriptase loop-mediated isothermal amplification(RT-LAMP).To achieve clinically acceptable performance,we synthesized a group of six primers to identify the conserved regions of the ORF1ab gene of *** trials were conducted with 87 PCR-positive and 43 PCRnegative patient *** platform demonstrated both high sensitivity(95.40%)and high specificity(95.35%),showing potentials for rapid and user-friendly diagnosis of COVID-19 among many other infectious pathogens.

关键词： instrument diagnosis specificity

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Incidence and Potential Causes affecting Monozygotic Twin Formation Following in vitro Fertilization and Embryo Transfer

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Journal of Reproduction and Contraception 2012年第2期23卷 93-102页

作者： Li LI Xiao-lin long Hong-zi DU Wen-hong ZHANG Yu SHI Assisted Reproductive Department Institute of Obstetrics and Gynecology of the Third Affiliated Hospital ofGuangzhou Medical CollegeGuangzhou 510150China

Objectives To study the incidence and potential causes of monozygotic twins after in vitro fertilization and embryo transfer （IVF-ET）. Methods A retrospective study was performed on women carrying monozygotic twins （MZTs） after conventional IVF-ET treatment at the Third Affiliated Hospital of Guangzhou Medical College in China from January 2003 to May 2009. The incidence and the miscarriage rate for MZTs following IVF-ET were examined iin relation to maternal age, duration of infertility, type and dose of hormone treatment, conventional IVF-ET cycles versus intracytoplasmic sperm injection （ICSI） cycles, the use of fresh or frozen-thawed embryos, and day （post-fertilization） of embryo transfer. Results Sixteen MZT pregnancies occurred in 2 161 patients （incidence of 0.74%）, of which 5 miscarried （31.25%）. No significant difference was found between MZT and non-MZT groups in terms of maternal age, duration of infertilit）, duration of gonadotropin （Gn） administration, dosage of Gn, number of oocytes retrieved, number of oocytes fertilized, or number of embryos transferred （P〉O.05）. The incidence of MZT was not statistically different between conventional IVF-ET cycles and ICSI cycles, between fresh embryos transfer cycles and frozen-thawed embryo cycles, or between different transfer days （P〉0.05）. Conclusion The incidence of MZTs following IVF-ET treatment greatly exceeds that observed following spontaneous conception. Intracytoplasmic sperm injection, frozenthawed procedures, and embryo transfer on different days were not correlated with an increased incidence of MZT pregnancies.

关键词： monozygotic twinning potential cause IVF-ET

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Honoring a legend: Celebrating the life and legacy of Professor Heng Li

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Plant Diversity 2023年第3期45卷 239-240页

作者： Hui-Jun Guo Jin-ling Huang Yun-Heng Ji Rong Li Chun-lin long Qin-Er Yang Yong-Ping Yang Ting-Shuang Yi National Plateau Wetlands Research Center Southwest Forestry UniversityKunming 650224YunnanChina Department of Biology East Carolina UniversityGreenville 27858NCUSA CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Key Laboratory of Ecology and Environment in Minority Areas(Minzu University of China) National Ethnic Affairs CommissionBeijing 100081China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China CAS Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650GuangdongChina CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbanna 666303YunnanChina Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina

Professor Heng Li(李恒,March 9,1929-January 12,2023)was a legendary plant taxonomist and phytogeographer at the Kunming Institute of Botany,Chinese Academy of Sciences(Fig.1).She made important contributions to our understanding of China's flora,including the biodiversity and biogeography of Dulong Valley and the Gaoligong Mountains,as well as the vegetation of plateau lakes and wetlands in Southwest *** Heng Li received her Bachelor's degree in Russian from Beijing Foreign Studies University in 1956 and immediately joined the Institute of Geography(now Institute of Geographic Sciences and Natural Resources Research),Chinese Academy of Sciences,as a Russian *** 1961,Prof.

关键词： translator plateau Hen

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Phase transitions in bismuth under rapid compression

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Chinese Physics B 2019年第3期28卷 300-303页

作者： Dong-Liang Yang Jing Liu Chuan-long lin Qiu-Min Jing Yi Zhang Yu Gong Yan-Chun Li Xiao-Dong Li Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of Science Center for High Pressure Science and Technology Advanced Research National Key Laboratory for Shock Wave and Detonation Physics Institute of Fluid PhysicsChinese Academy of Engineering Physics

The structural phase transitions of bismuth under rapid compression has been investigated in a dynamic diamond anvil cell using time-resolved synchrotron x-ray diffraction. As the pressure increases, the transformations from phase I,to phase II, to phase III, and then to phase V have been observed under different compression rates at 300 K. Compared with static compression results, no new phase transition sequence appears under rapid compression at compression rate from 0.20 GPa/s to 183.8 GPa/s. However, during the process across the transition from phase III to phase V, the volume fraction of product phase as a function of pressure can be well fitted by a compression-rate-dependent sigmoidal *** resulting parameters indicate that the activation energy related to this phase transition, as well as the onset transition pressure, shows a compression-rate-dependent performance. A strong dependence of over-pressurization on compression rate occurs under rapid compression. A formula for over-pressure has been proposed, which can be used to quantify the over-pressurization.

关键词： bismuth high pressure rapid compression over-pressurization

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福建畲族村落生态景观法律保护机制研究

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贵州民族研究 2016年第11期37卷 18-21页

作者：林龙福州大学法学院福建福州350108 福建农林大学文法学院福建福州350000

福建畲族居住相对集中,在长期历史发展中,由于畲族文化影响和畲族民众的智慧结晶,畲族形成了独特的生态村落景观。畲族村落生态景观的保护关系着畲族旅游业发展,也影响畲族传统文化的传承保护,因此,对于相关景观需要从法律层面上通过立... 详细信息

福建畲族居住相对集中,在长期历史发展中,由于畲族文化影响和畲族民众的智慧结晶,畲族形成了独特的生态村落景观。畲族村落生态景观的保护关系着畲族旅游业发展,也影响畲族传统文化的传承保护,因此,对于相关景观需要从法律层面上通过立法、执法、法治监督等方面建立法律保护机制,同时还要把法律保护机制和财政支持相结合,双管齐下,使畲族村落生态景观在现有基础上更好地维护和发展。

关键词：福建畲族村落生态景观法律保护

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基于集合覆盖和禁忌搜索算法的WCDMA基站布局

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上海交通大学学报 2007年第6期41卷 924-928页

作者：林俊龙何晨上海交通大学电子工程系上海200240

分析和比较了集合覆盖和禁忌搜索两种高效布局算法的优化性能和计算时间.在此基础上提出了一种新的WCDMA基站布局算法,该算法使用集合覆盖进行整体布局,使用禁忌搜索进行局部优化.由于综合利用了集合覆盖算法的快速性和禁忌搜索算法的... 详细信息

分析和比较了集合覆盖和禁忌搜索两种高效布局算法的优化性能和计算时间.在此基础上提出了一种新的WCDMA基站布局算法,该算法使用集合覆盖进行整体布局,使用禁忌搜索进行局部优化.由于综合利用了集合覆盖算法的快速性和禁忌搜索算法的精确性,实际场景仿真结果显示,新算法仅用禁忌搜索算法8.8%的计算时间,就搜索到比禁忌搜索算法优化性能更好的布局配置.

关键词：宽带码分多址基站布局集合覆盖禁忌搜索功率分配

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Stereomeric effects of bisPC_(71)BM on polymer solar cell performance

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Science Bulletin 2016年第2期61卷 132-138页

作者： lin-long Deng Xiang Li Shuai Wang Wen-Peng Wu Si-Min Dai Cheng-Bo Tian Yi Zhao Su-Yuan Xie Rong-Bin Huang Lan-Sun Zheng Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen University State Key Lab for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Institute of Environmental and Analytical Sciences College of Chemistry and Chemical Engineering Henan University

Two stereomers of bisadduct analogues of [6, 6]-phenyl-C71-butyric acid methyl ester （bisPC71BM） were synthesized and their geometrical structures with cis- or trans-configuration were identified by X-ray crystallogra- phy. Although both of the bisPC71BM have similar spec- trometric and electrochemical properties, the spatial orientation of the two addition groups on C7o has impact on crystal packing and molecular assembly of bisPC71BM isomers and, in turn, photovoltaic performance in polymer solar cell based on poly（3-hexylthiophene）（P3HT）（with power conversion efficiency of 1.72 % and 1.84 % for the solar cells involving cis- and trans-bisPC71BM, respec- tively）. Although the power conversion efficiency remains to be improved, this work exemplifies that the photovoltaic properties of fullerene-based electron acceptors areinfluenced by aggregation of the stereomeric molecules and thus extends the guidelines for rational design of efficient fullerene acceptor.

关键词： Polymer solar cells Fullerenederivative Electron acceptor Stereomeric effectsX-ray crystallography

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Neolignans from Selaginella moellendorffii

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Natural Products and Bioprospecting 2016年第3期6卷 161-166页

作者： Jing-Xian Zhuo Yue-Hu Wang Xing-Li Su Ren-Qiang Mei Jun Yang Yi Kong Chun-lin long Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China School of Life Science&Technology China Pharmaceutical UniversityNanjing 210009China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China

Two new neolignans selaginellol(1)and selaginellol 4'-O-β-D-glucopyranoside(2),together with seven known compounds(3–9),were isolated from the whole plant of Selaginella *** structures of the new isolates were determined through spectroscopic data *** 1–9,as well as compounds 10–18 previously isolated from the species,were measured for the activity against platelet aggregation induced by ADP or *** neoligans(8,11,and 12),one flavanone(14),and one alkaloid(16)showed inhibitory activity against ADP-or collagen-induced platelet aggregation as compared with *** dihydrobenzofuran neolignans(8,11,and 12)are more potent than the benzofuran neolignan(13)and other types of neolignans(1–7).Glucosidation of the dihydrobenzofuran neolignans(11 and 12)is helpful for the *** Abstract Two new neolignans selaginellol(1)and selaginellol 40-O-b-D-glucopyranoside(2)were isolated from the whole plant of Selaginella *** compounds from this plant showed the activity against platelet aggregation induced by ADP or collagen.

关键词： Selaginellaceae Selaginella moellendorffii Lignans Antiplatelet

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Chronic intermittent hypoxia from pedo-stage decreases glucose transporter 4 expression in adipose tissue and causes insulin resistance

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Chinese Medical Journal 2010年第4期123卷 463-470页

作者： CHEN lin CAO Zhao-long HAN Fang GAO Zhan-cheng HE Quan-ying Department of Pneumology Peking University People's Hospital Beijing 100044 China

Background The persistence of sleep disordered breathing （SDB） symptoms after tonsil and/or adenoid （T＆A） surgery are common in children with obstructive sleep apnea （OSA）. We tested the hypothesis that disturbances of glucose transporters （GLUTs） in intraabdominal adipose tissue caused by chronic intermittent hypoxia （CIH） from the pedo-period could facilitate the appearance of periphery insulin resistance in Sprague-Dawley （SD） rats. We tested the hypothesis that the changes of GLUTs in adipose tissue may be one of the reasons for persistent SDB among clinical OSA children after T＆A surgery. Methods Thirty 21-day-old SD rats were randomly divided into a CIH group, a chronic continuous hypoxia （CCH） group and a normal oxygen group （control group） and exposed for 40 days. The changes of weight, fasting blood glucose and fasting blood insulin levels were measured. Hyperinsulinemic-euglycemic clamp techniques were used to measure insulin resistance in each animal. Real-time quantitative PCR and Western blotting were used to measure GLUT mRNA and proteins in intraabdominal adipose tissue. Additional intraabdomial white adipose tissue （WAT） was also processed into paraffin sections and directly observed for GLUTs1-4 expression. Results When compared with control group, CIH increased blood fasting insulin levels, （245.07±53.89） pg/ml vs. （168.63±38.70） pg/ml, P=-0.038, and decreased the mean glucose infusion rate （GIR）, （7.25±1.29） mg·kg^-1·min^-1 vs. （13.34±1.54） mg·kg^-1·min^-1, P 〈0.001. GLUT-4 mRNA and protein expression was significantly reduced after CIH compared with CCH or normal oxygen rats, 0.002±0.002 vs. 0.039±0.009, P 〈0.001; 0.642±0.073 vs. 1.000±0.103, P=0.035. Conclusions CIH in young rats could induce insulin resistance via adverse effects on glycometabolism. These findings emphasize the importance of early detection and treatment of insulin insensitivity in obese childhood OSA.

关键词： sleep apnea syndrome insulin resistance glucose transporters hypoxia childhood

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Cross-linkable fullerene interfacial contacts for enhancing humidity stability of inverted perovskite solar cells

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Rare Metals 2021年第7期40卷 1691-1697页

作者： Ming-Wei An Zhou Xing Bao-Shan Wu Fang-Fang Xie Shan-Yu Zheng lin-long Deng Xu Wang Bin-Wen Chen Da-Qin Yun Su-Yuan Xie Rong-Bin Huang Lan-Sun Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces iChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China College of Energy Xiamen UniversityXiamen 361005China

In situ cross-linking encapsulation has been demonstrated to be an efficient strategy for enhancing the humidity stability of perovskite solar cells(PSCs).In this study,a novel cross-linkable fullerene derivative,namely1-(p-benzoate-(p-methylvinylbenzene)-indolino[2,3][60]fullerene(FPPS),was readily synthesized from commercially available building blocks in two *** FPPS was employed as an interfacial modifier on perovskite surfaces in inverted planar p-i-n *** to the fast interfacial charge extraction and efficient trap passivation,PSCs based on the cross-linked FPPS(C-FPPS)exhibited excellent *** PSCs had a top-performing power conversion efficiency(PCE)of 17.82%with negligible hysteresis,compared to the control devices without C-PFFS(16.99%).Moreover,the strong water resistance of the C-FPPS interfacial layer distinctly enhances the ambient stability of PSC devices,exhibiting a t80(the time required to reach 80%of the initial PCE)of 300 h under high-humidity *** significantly surpasses the control devices,whose t80 was only 130 *** results demonstrate that cross-linkable fullerene derivatives can be promising interfacial materials for designing high-efficiency,hysteresis-free,air-stable PSCs.

关键词： Perovskite solar cells Cross-linkable fullerene Fullerene interlayer Power conversion efficiency Humidity stability

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