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Effect of trigger system on experimental dispersion characteristics of active surface wave testing

Earthquake Engineering and Engineering Vibration 2024年第2期23卷 311-318页

作者： lin Shibin Jeramy C.Ashlock Zhu liming Qin Zexiang Li Bo Zhu Xingji Zhai Changhai State Key Laboratory of Precision Blasting Jianghan UniversityWuhan 430056China Hubei Key Laboratory of Blasting Engineering Jianghan UniversityWuhan 430056China Department of Civil Construction&Environmental EngineeringIowa State UniversityAmesIA 50010USA Wuhan Airport Road Development Co. Ltd.Wuhan 430065China School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhen 518055China Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education Harbin Institute of TechnologyHarbin 150090China Key Lab of Smart Prevention and Mitigation of Civil Engineering Disaster of the Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbin 150090China

A trigger system is typically employed in active seismic testing to trigger and synchronize multichannel surface wave data acquisition.The effect of the trigger system on the dispersion image of surface waves is empirically known to be negligible,however,theoretical explanation regarding the effect of the trigger system is insufficient.This study systematically examines the theory for surface wave dispersion analysis and proves that the effect of the trigger system on a dispersion image is negligible via a solid theoretical explanation.Subsequently,based on the new theoretical explanation,an alternative method that uses only the relative phase difference between sensors to extract dispersion characteristics with better conceptual clarity is proposed.Two active surface wave testing cases are considered to validate the theory and method.The results indicate that(1)an accurate trigger system is not necessary for surface wave data acquisition,and(2)it is unnecessary to assume that the impact point is the generation point of the surface waves for the experimental dispersion analysis.

关键词： site investigation surface waves data acquisition dispersion

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Cell softness reveals tumorigenic potential via ITGB8/AKT/glycolysis signaling in a mice model of orthotopic bladder cancer

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Chinese Medical Journal 2024年第2期137卷 209-221页

作者： Shi Qiu Yaqi Qiu linghui Deng ling Nie liming Ge Xiaonan Zheng Di Jin Kun Jin Xianghong Zhou Xingyang Su Boyu Cai Jiakun Li Xiang Tu lina Gong Liangren Liu Zhenhua Liu Yige Bao Jianzhong Ai Tianhai lin Lu Yang Qiang Wei Department of Urology Institute of UrologyNational Clinical Research Center for Geriatrics and Center of Biomedical Big DataWest China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Molecular Oncology Institute of Oncology Research(IOR)Oncology Institute of Southern Switzerland(IOSI)Bellinzona 6500Switzerland Department of Science and Drug Technology University of TurinTurinItaly National Clinical Research Center of Geriatrics The Center of Gerontology and GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610000China Department of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pharmaceutics and Bioengineering School of Chemical EngineeringSichuan UniversityChengduSichuan 610000China

Background:Bladder cancer,characterized by a high potential of tumor recurrence,has high lifelong monitoring and treatment costs.To date,tumor cells with intrinsic softness have been identified to function as cancer stem cells in several cancer types.Nonetheless,the existence of soft tumor cells in bladder tumors remains elusive.Thus,our study aimed to develop a microbarrier microfluidic chip to efficiently isolate deformable tumor cells from distinct types of bladder cancer cells.Methods:The stiffness of bladder cancer cells was determined by atomic force microscopy(AFM).The modified microfluidic chip was utilized to separate soft cells,and the 3D Matrigel culture system was to maintain the softness of tumor cells.Expression patterns of integrinβ8(ITGB8),protein kinase B(AKT),and mammalian target of rapamycin(mTOR)were determined by Western blotting.Double immunostaining was conducted to examine the interaction between F-actin and tripartite motif containing 59(TRIM59).The stem-cell-like characteristics of soft cells were explored by colony formation assay and in vivo studies upon xenografted tumor models.Results:Using our newly designed microfluidic approach,we identified a small fraction of soft tumor cells in bladder cancer cells.More importantly,the existence of soft tumor cells was confirmed in clinical human bladder cancer specimens,in which the number of soft tumor cells was associated with tumor relapse.Furthermore,we demonstrated that the biomechanical stimuli arising from 3D Matrigel activated the F-actin/ITGB8/TRIM59/AKT/mTOR/glycolysis pathways to enhance the softness and tumorigenic capacity of tumor cells.Simultaneously,we detected a remarkable up-regulation in ITGB8,TRIM59,and phospho-AKT in clinical bladder recurrent tumors compared with their non-recurrent counterparts.Conclusions:The ITGB8/TRIM59/AKT/mTOR/glycolysis axis plays a crucial role in modulating tumor softness and stemness.Meanwhile,the soft tumor cells become more sensitive to chemotherapy after stiffening,that offers new insights fo

关键词： Soft tumor cells 3D Matrigel Stemness Non-muscle invasive bladder neoplasms Microfluidic analytical techniques

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环境化学条件对软土电渗排水影响的试验研究

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水力发电学报 2024年第6期43卷 33-42页

作者：张林胡黎明华北电力大学水利与水电工程学院北京102206 清华大学水圈科学与水利工程全国重点实验室北京100084 清华大学水利部水圈科学重点实验室北京100084 清华大学水利水电工程系北京100084

电渗排水在软土地基加固方面具有较大的应用前景。为研究土体环境化学条件对软黏土电渗排水过程的影响,开展了一系列室内试验,从电渗系数、排水量、排水速率、含水率分布等方面进行了对比分析,深入探讨土体pH值和盐度对电渗排水过程的... 详细信息

电渗排水在软土地基加固方面具有较大的应用前景。为研究土体环境化学条件对软黏土电渗排水过程的影响,开展了一系列室内试验,从电渗系数、排水量、排水速率、含水率分布等方面进行了对比分析,深入探讨土体pH值和盐度对电渗排水过程的影响机理。试验结果表明:土体pH值对土体的电渗系数和zeta电位均有明显影响,电渗系数随着pH值的升高而升高,通过测量zeta电位可以准确获取电渗系数;随着土体初始pH值的升高,电渗排水试验后阳极附近土体的含水率逐渐降低,阴极附近土体的含水率逐渐升高;在对较酸性土体的电渗试验中则出现了阴极附近土体排水固结较快的现象,对土体的整体排水过程产生不利影响;随着土体盐度的升高,电渗系数和电渗总排水量降低,能耗增大。低盐度、偏碱性的环境有利于提高电渗加固效果。

关键词：电渗加固电渗系数土体pH值土体盐度软土

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Clinical and molecular significance of homologous recombination deficiency positive non-small cell lung cancer in Chinese population: An integrated genomic and transcriptional analysis

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Chinese Journal of Cancer Research 2024年第3期36卷 282-303页

作者： Yifei Wang Yidan Ma Lei He Jun Du Xiaoguang Li Peng Jiao Xiaonan Wu Xiaomao Xu Wei Zhou Li Yang Jing Di Changbin Zhu liming Xu Tianlin Sun lin Li Dongge Liu Zheng Wang Department of Pathology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Department of Minimally Invasive Tumor Therapies Center Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Department of Thoracic Surgery Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Department of Oncology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Department of Respiratory and Critical Care Medicine Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Amoy Diagnostics Co. Ltd.

Objective: The clinical significance of homologous recombination deficiency(HRD) in breast cancer, ovarian cancer, and prostate cancer has been established, but the value of HRD in non-small cell lung cancer(NSCLC) has not been fully investigated. This study aimed to systematically analyze the HRD status of untreated NSCLC and its relationship with patient prognosis to further guide clinical care.Methods: A total of 355 treatment-na?ve NSCLC patients were retrospectively enrolled. HRD status was assessed using the AmoyDx Genomic Scar Score(GSS), with a score of ≥50 considered HRD-positive. Genomic,transcriptomic, tumor microenvironmental characteristics and prognosis between HRD-positive and HRD-negative patients were analyzed.Results: Of the patients, 25.1%(89/355) were HRD-positive. Compared to HRD-negative patients, HRD-positive patients had more somatic pathogenic homologous recombination repair(HRR) mutations, higher tumor mutation burden(TMB)(P<0.001), and fewer driver gene mutations(P<0.001). Furthermore, HRD-positive NSCLC had more amplifications in PI3K pathway and cell cycle genes, MET and MYC in epidermal growth factor receptor(EGFR)/anaplastic lymphoma kinase(ALK) mutant NSCLC, and more PIK3CA and AURKA in EGFR/ALK wild-type NSCLC. HRD-positive NSCLC displayed higher tumor proliferation and immunosuppression activity.HRD-negative NSCLC showed activated signatures of major histocompatibility complex(MHC)-Ⅱ, interferon(IFN)-γ and effector memory CD8+ T cells. HRD-positive patients had a worse prognosis and shorter progression-free survival(PFS) to targeted therapy(first- and third-generation EGFR-TKIs)(P=0.042). Additionally, HRD-positive, EGFR/ALK wild-type patients showed a numerically lower response to platinum-free immunotherapy regimens.Conclusions: Unique genomic and transcriptional characteristics were found in HRD-positive NSCLC. Poor prognosis and poor response to EGFR-TKIs and immunotherapy were observed in HRD-positive NSCLC. This study highlights potential actionable alterations in HRD-posit

关键词： Non-small cell lung cancer homologous recombination deficiency genetic alterations transcriptional analysis tumor microenvironment prognosis

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Tight gas charging and accumulation mechanisms and mathematical model

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Petroleum Exploration and Development 2023年第6期50卷 1411-1425页

作者： ZHOU Nengwu LU Shuangfang ZHANG Pengfei lin Zizhi XIAO Dianshi LU Jiamin ZHU Yingkang LIU Yancheng lin liming WANG Min JIANG Xinyu LIU Yang WANG Ziyi LI Wenbiao Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572025China Key Laboratory of Continental Shale Hydrocarbon Accumulation and Efficient Development Ministry of EducationNortheast Petroleum UniversityDaqing 163318China School of Geosciences China University of Petroleum(East China)Qingdao 266580China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Exploration and Development Research Institute PetroChina Daqing Oilfield Company LimitedDaqing 163712China China United Coalbed Methane Co. Ltd.Beijing 100083China

The gas-water distribution and production heterogeneity of tight gas reservoirs have been summarized from experimental and geological observations, but the charging and accumulation mechanisms have not been examined quantitatively by mathematical model. The tight gas charging and accumulation mechanisms were revealed from a combination of physical simulation of nuclear magnetic resonance coupling displacement, numerical simulation considering material and mechanical equilibria, as well as actual geological observation. The results show that gas migrates into tight rocks to preferentially form a gas saturation stabilization zone near the source-reservoir interface. When the gas source is insufficient, gas saturation reduction zone and uncharged zone are formed in sequence from the source-reservoir interface. The better the source rock conditions with more gas expulsion volume and higher overpressure, the thicker the gas saturation stabilization and reduction zones, and the higher the overall gas saturation. When the source rock conditions are limited, the better the tight reservoir conditions with higher porosity and permeability as well as larger pore throat, the thinner the gas saturation stabilization and reduction zones, but the gas saturation is high. The sweet spot of tight gas is developed in the high-quality reservoir near the source rock, which often corresponds to the gas saturation stabilization zone. The numerical simulation results by mathematical model agree well with the physical simulation results by nuclear magnetic resonance coupling displacement, and reasonably explain the gas-water distribution and production pattern of deep reservoirs in the Xujiaweizi fault depression of the Songliao Basin and tight gas reservoirs in the linxing-Huangfu area of the Ordos Basin.

关键词： tight gas charging and accumulation mechanism mathematical model Xujiaweizi fault depression Songliao Basin linxing-Huangfu area Ordos Basin

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Expert consensus on irrigation and intracanal medication in root canal therapy

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International Journal of Oral Science 2024年第1期16卷 26-35页

作者： Xiaoying Zou Xin Zheng Yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen Zhang liming Chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao Song Shen Xuedong Zhou lin Yue Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Center of Stomatology Peking University HospitalBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Emergency Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Restorative Dental Sciences EndodonticsFaculty of DentistryThe University of Hong KongPok Fu LamHong Kong SARChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina State Key Laboratory of Oral&Maxillofacial Reconstruction and R

Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes.

关键词： treatment irrigation Expert

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Graded and Quantitative Technology and Application of Coal-Bearing Reservoir Based on Seismic Reflection Characteristics

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Journal of Geoscience and Environment Protection 2024年第6期12卷 279-290页

作者： Hao Zhang Huan Wan liming lin Wenjun Xing Tiemei Yang Longgang Zhou Lijun Gao Guangchao Zhi Xin Liu Xiaowen Song CNOOC EnerTech-Drilling & Production Co. Tianjin China China United Coalbed Methane Co. Ltd. Beijing China

Taiyuan formation is the main exploration strata in Ordos Basin, and coals are widely developed. Due to the interference of strong reflection of coals, we cannot completely identify the effective reservoir information of coal-bearing reservoir on seismic data. Previous researchers have studied the reservoir by stripping or weakening the strong reflection, but it is difficult to determine the effectiveness of the remaining reflection seismic data. In this paper, through the establishment of 2D forward model of coal-bearing strata, the corresponding geophysical characteristics of different reflection types of coal-bearing strata are analyzed, and then the favorable sedimentary facies zones for reservoir development are predicted. On this basis, combined with seismic properties, the coal-bearing reservoir is quantitatively characterized by seismic inversion. The above research shows that the Taiyuan formation in LS block of Ordos Basin is affected by coals and forms three or two peaks in different locations. The reservoir plane sedimentary facies zone is effectively characterized by seismic reflection structure. Based on the characteristics of sedimentary facies belt and petrophysical analysis, the reservoir is semi quantitatively characterized by attribute analysis and waveform indication, and quantitatively characterized by pre stack geostatistical inversion. Based on the forward analysis of coal measure strata, this technology characterizes the reservoir facies belt through seismic reflection characteristics, and describes coal measure reservoirs step by step. It effectively guides the exploration of LS block in Ordos Basin, and has achieved good practical application effect.

关键词： Coal-Bearing Reservoir Seismic Reflection Characteristics Waveform Indication Inversion Geostatistics Inversion

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壳聚糖支架在周围神经修复中的应用研究进展

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功能高分子学报 2024年第3期37卷 251-261页

作者：衣振伟林浩东赵黎明华东理工大学生物反应器工程国家重点实验室上海200237 华东理工大学中国轻工业生物基材料工程重点实验室上海200237 上海交通大学医学院附属第一人民医院创伤临床医学中心上海201600

天然高分子材料壳聚糖具有生物相容性好、降解行为安全和免疫原性低等优点,被广泛应用于组织工程的多个领域。在神经组织工程中,利用壳聚糖构建不同形式神经工程支架,模拟周围神经天然结构、引导缺损神经再生已成为当前周围神经修复的... 详细信息

天然高分子材料壳聚糖具有生物相容性好、降解行为安全和免疫原性低等优点,被广泛应用于组织工程的多个领域。在神经组织工程中,利用壳聚糖构建不同形式神经工程支架,模拟周围神经天然结构、引导缺损神经再生已成为当前周围神经修复的主要研究方向。本文综述了不同形式壳聚糖支架(水凝胶、薄膜、微球、导管)在周围神经损伤修复中的应用及研究进展,并对存在的问题和未来研究方向进行了探讨,为促进壳聚糖神经组织工程支架的研究和临床应用提供了思路。

关键词：壳聚糖组织工程支架周围神经再生

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湖南省农业科技园区创新发展能力多维评价研究

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经济地理 2024年第1期44卷 139-147页

作者：刘灿廖婷谭力铭雷筱娱石琳湘潭大学商学院湖南湘潭411105 湖南省科学技术信息研究所湖南长沙410001

文章从创新研发、创新服务、创新带动、创新驱动4个维度选取18个要素指标,构建农业科技园区(以下简称“农科园”)创新发展能力评价指标体系,运用多因子加权综合评价法、GIS空间分析法、K聚类分析等方法对湖南省42家农业科技园区的创新... 详细信息

文章从创新研发、创新服务、创新带动、创新驱动4个维度选取18个要素指标,构建农业科技园区(以下简称“农科园”)创新发展能力评价指标体系,运用多因子加权综合评价法、GIS空间分析法、K聚类分析等方法对湖南省42家农业科技园区的创新发展能力进行空间布局和分层分类分析。结果表明:(1)湖南省农科园的创新发展能力呈现出以长株潭为核心、各市(州)国家级农科园为散点的“一核多点”式布局特征,全省农科园整体创新带动能力较强、创新研发能力相对较弱。(2)湖南省42家农科园可分为三类,其中13家国家农科园为创新发展引领类农科园,浏阳、祁东等21家农科园为创新发展稳健类农科园,临湘、南县等8家农科园为创新发展起步类农科园。建议湖南省对照国家农科园“333”布局,加大农科园培育力度,完善层次分明的农科园体系;提升农科园自主创新能力,打造农业产业集群;建立常态化的全省农科园创新发展能力监测评价与服务机制。

关键词：农业科技园区创新发展能力 GIS空间分析多因子加权 K聚类分析

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黄河宁蒙河段凌情灾害成因分析及防御措施研究

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人民黄河 2024年第4期46卷 62-67,85页

作者：马莅茗卞昱霖蔺冬黄河勘测规划设计研究院有限公司河南郑州450003 水利部黄河流域水治理与水安全重点实验室(筹) 河南郑州450003 东北农业大学水利与土木工程学院黑龙江哈尔滨150038

随着经济社会的高速发展,对黄河的防凌安全提出了更高的要求,研究凌情灾害成因及防御措施变化显得尤为重要。通过分析,影响宁蒙河段凌情变化的因素主要包括热力条件、水动力条件和河道边界条件。通过梳理1989年以来宁蒙河段典型凌灾情况... 详细信息

随着经济社会的高速发展,对黄河的防凌安全提出了更高的要求,研究凌情灾害成因及防御措施变化显得尤为重要。通过分析,影响宁蒙河段凌情变化的因素主要包括热力条件、水动力条件和河道边界条件。通过梳理1989年以来宁蒙河段典型凌灾情况,发现造成冰凌灾害的严重凌情多受剧烈天气过程、河道流量变化、复杂河道条件等因素影响。为避免宁蒙河段凌汛灾害,针对热力因素,应及早开展凌汛期气温凌情预报工作;针对水动力因素,应优化凌汛期水库群和分凌工程联合调度;针对河道边界条件,应提前拆除临时阻水建筑物,保证河道畅通,协调空军部队在险情发生时及时轰炸破冰,并加快黑山峡水利枢纽建设,恢复和长期维持较大的中水河槽过流能力,为宁蒙河段防凌防洪提供基本条件。

关键词：凌情灾害凌情影响因素灾害成因防御措施黄河宁蒙河段

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