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知识生产者还是阅读打工人?线上读书会中的劳动之困

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编辑之友 2024年第5期 11-16页

作者：李林容赵雅馨西南政法大学新闻传播学院重庆401120

数字经济时代,出版行业的数字化进程带动了其自身的技术创新与融合发展,也催生了社会化阅读的普及和阅读衍生业务的诞生,以互动为核心的线上读书会是结合阅读和社交的知识生产场。然而线上读书会也受数字技术与平台逻辑宰制,知识生产也... 详细信息

数字经济时代,出版行业的数字化进程带动了其自身的技术创新与融合发展,也催生了社会化阅读的普及和阅读衍生业务的诞生,以互动为核心的线上读书会是结合阅读和社交的知识生产场。然而线上读书会也受数字技术与平台逻辑宰制,知识生产也面临着隐形无偿劳动转向。本文对线上读书会知识生产进行历时性分析,从批判的视角考察平台作为读书会基础设施何以构建线上读书会参与者的劳动逻辑,试图让平台语境中阅读的文本、关系与情感劳动面向重新可见,以期规避平台劳动之困对阅读边界的侵蚀,为推进全民阅读指明新的可能。

关键词：线上读书会知识生产数字劳动出版业改革

Synthesis,Crystal Structure and Fluorescent Properties of 1-(4-(Dimethylamino)benzylidene)-4-(naphthalen-1-yl) Thiosemicarbazide

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Chinese Journal of Structural Chemistry 2006年第10期25卷 1197-1202页

作者： YU Yun lin li-rong HUANG rong-Bin Department of Chemistry Longyan College Longyan Fujian 364000 China Department of Chemistry Xiamen University Xiamen 361005 China

The title compound, 1-4-（dimethylamino）benzylidene）-4-（naphthalene-1-yl） thiosemicarbazide （DMABNTS, C20H20N4S, Mr = 348.47）, was synthesized and characterized by elemental analysis, 1R, ^1H NMR and MS. The crystal structure of DMABNTS with 1,4-dioxane （Diox, C4H8O2） solvent molecules （DMABNTS·2Diox, C28H36N4O4S, Mr = 524.67） was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic system, space group P21/c with a = 14.418（4）, b = 7.1702（19）, c = 28.350（7）°A,β= 101.154（6）°, V= 2875.4（13） °A^3, Z= 4, Dc= 1.212 g/cm^3, F（000） = 1120 and μ= 0.151 mm^-1. A total of 6458 reflections were collected, of which 4671 were unique. The structure was solved by direct methods and refined to the final R = 0.0732 and wR = 0.2127 for 3921 observed reflections （I〉 2σ（I））. There exist intermolecular hydrogen bonds （N（2）-H（2B）…S（1A）and N（1）-H（1A）…O（4B）） in the structure. The study of fluorescent properties ＇shows that DMABNTS emits bright solid-state fluorescence in the visible region and exhibits blue photoluminescence.

关键词： 1-(4-(dimethylamino)benzylidene)-4-(naphthalen- 1-yl)thiosemicarbazide synthesis crystal structure fluorescence

R-CHOP resistance in diffuse large B-cell lymphoma:biological and molecular mechanisms

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Chinese Medical Journal 2021年第3期134卷 253-260页

作者： liang Wang lin-rong li Department of Hematology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Breast Surgery Peking Union Medical College HospitalBeijing 100730China

Although the first-line rituximab plus cyclophosphamide,doxorubicin,vincristine,and prednisone regimen(R-CHOP)substantially improved outcomes for patients with diffuse large B-cell lymphoma(DLBCL),40%of the patients suffered from relapsed/refractory disease and had poor survival *** detailed mechanism underlying R-CHOP resistance has not been well *** this review,we conducted a thorough search for literature and clinical trials involving DLBCL *** discussed DLBCL biology,epigenetics,and aberrant signaling of the B-cell receptor(BCR),phosphatidylinositol 3-kinase(PI3K)/Akt,nuclear factor kappa light chain enhancer of activated B-cells(NF-κB),and the Janus kinase(JAK)/signal transducer and activator of transcription 3(STAT3)pathways as defining mechanisms of DLBCL heterogeneity and R-CHOP *** cell of origin,double-or triple-hit lymphoma and double-protein-expression,clonal evolution,tumor microenvironment,and multi-drug resistance help to contextualize DLBCL resistance in an(epi)genetically and biologically comparative *** better understanding of the biological and molecular landscape of DLBCL,a more detailed classification system and tailored treatments will ideally become available to further improve the prognosis of DLBCL patients.

关键词： Diffuse large B-cell lymphoma Tumor microenvironment Multi-drug resistance Genetic heterogeneity

Two properties of sequence of vector measures on effect algebras

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Applied Mathematics(A Journal of Chinese Universities) 2010年第4期25卷 475-480页

作者： lin Qing-shui li rong-lu Department of Mathematics Harbin Institute of Technology Harbin 150006 China

Let （L, ,0, 1） be an effect algebra and let X be a Banach space. A function ： L→ X is called a vector measure if μ（a b） =μ（a）＋ μ（b） whenever a⊥b in L. The function μ is said to be 8-bounded if limn→∞μ（an） = 0 in X for any orthogonal sequence （an）n∈N in L. In this paper, we introduce two properties of sequence of s-bounded vector measures and give some results on these properties.

关键词： Effect algebra s-bounded vector measure.

Alphastatin downregulates vascular endothelial cells sphingosine kinase activity and suppresses tumor growth in nude mice bearing human gastric cancer xenografts

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World Journal of Gastroenterology 2006年第26期12卷 4130-4136页

作者： lin Chen Tao li rong li Bo Wei Zheng Peng Department of General Surgery General Hospital of Chinese PLA Beijing 100853 China

AIM： To investigate whether alphastatin could inhibit human gastric cancer growth and furthermore whether sphingosine kinase （SPK） activity is involved in this process. METHODS： Using migration assay, MTT assay and Matrigel assay, the effect of alphastatin on vascular endothelial cells （ECs） was evaluated in vitro. SPK and endothelial differentiation gene （EDG）-1, -3, -5 mRNAs were detected by reverse transcription-polymerase chain reaction （RT-PCR）. SPK activity assay was used to evaluate the effect of alphastatin on ECs. Matrigel plug assay in nude mice was used to investigate the effect of alphastatin on angiogenesis in vivo. Female nude mice were subcutaneously implanted with human gastric cancer cells （BGC823） for the tumor xenografts studies. Micro vessel density was analyzed in Factor Ⅷ-stained tumor sections by the immunohistochemical SP method. RESULTS： In vitro, alphastatin inhibited the migration and tube formation of ECs, but had no effect on proliferation of ECs. RT-PCR analysis demonstrated that ECs expressed SPK and EDG-1, -3, -5 mRNAs. In vivo, alphastatin sufficiently suppressed neovascularization of the tumor in the nude mice. Daily administration of alphastatin produced significant tumor growth suppression. Immunohistochemical studies of tumor tissues revealed decreased micro vessel density in alphastatin-treated animals as compared with controls. CONCLUSION： Downregulating ECs SPK activity may be one of the mechanisms that alphastatin inhibits gastric cancer angiogenesis. Alphastatin might be a useful and relatively nontoxic adjuvant therapy in the treatment of gastric cancer.

关键词： Stomach neoplasm Angiogenesis Endothelial cells Sphingosine kinase Cancer therapy

Synthesis and Structure of O-Ethyl S-Hydrogen Isoquinolin-1-ylcarbonothioimidate

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Chinese Journal of Structural Chemistry 2006年第5期25卷 604-608页

作者： YU Yun lin li-rong YOU Jun HUANG rong-Bin ZHENG Lan-Sun Department of Chemistry Longyan College Longyan Fujian 364000 China Department of Chemistry Xiamen University Xiamen 361005 China State Key Laboratory for Physical Chemistry of Solid Surfaces Xiamen University Xiamen 361005 China

O-Ethyl S-hydrogen isoquinolin-l-ylcarbonothioimidate was synthesized and its structure was characterized by IR, MS, ^1H NMR, elemental analysis and single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P21/c with a = 10.9471（19）, b = 9.3968（17）, c = 10.6125（19） A, β = 100.761 （3）°, V = 1072.5（3） A^3, Z = 4, Dc = 1.439 g/cm^3, F（000） = 488 and μ = 0.279 mm^-1. A total of 7763 reflections were collected, of which 2090 were unique. The structure was refined to the final R = 0.0322 and wR = 0.0882 for 2016 observed reflections with Ⅰ 〉 2σ（Ⅰ）. The crystal structure shows that there are intramolecular N-H…S hydrogen bonds and π-π stacking interactions between adjacent molecules.

关键词： O-ethyl S-hydrogen isoquinolin-1-ylcarbonothioimidate synthesis crystal structure

The inf luence of soil drying- and tillage-induced penetration resistance on maize root growth in a clayey soil

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Journal of Integrative Agriculture 2016年第5期15卷 1112-1120页

作者： lin li-rong HE Yang-bo CHEN Jia-zhou Key Laboratory of Arable Land Conservation(Middle and Lower Reaches of Yangtze River) Ministry of Agriculture Huazhong Agricultural University

Soil drying may induce a number of stresses on crops. This paper investigated maize（Zea mays L.） root growth as affected by drought and soil penetration resistance（PR）, which was caused by soil drying and tillage in a clayey red soil. Compared with conventional tillage（C） and deep tillage（D）, soil compaction（P） and no-till（N） significantly increased soil PR in the 0-15 cm layer. The PR increased dramatically as the soil drying increased, particularly in soil with a high bulk density. Increased soil PR reduced the maize root mass density distribution not only in the vertical profile（0-20 cm） but also in the horizontal layer at the same distance（0-5, 5-10, 10-15 cm） from the maize plant. With an increase in soil PR in pots, the maize root length, root surface area and root volume significantly decreased. Specifically, the maize root length declined exponentially from 309 to 64 cm per plant with an increase in soil PR from 491 to 3 370 k Pa; the roots almost stopped elongating when the soil PR was larger than 2 200 k Pa. It appeared that fine roots（〈2.5 mm in diameter） thickened when the soil PR increased, resulting in a larger average root diameter. The average root diameter increased linearly with soil PR, regardless of soil irrigation or drought. The results suggest that differences in soil PR caused by soil drying is most likely responsible for inconsistent root responses to water stress in different soils.

关键词： clayey soil root diameter root elongation soil compaction water stress

Existence and Exponential Stability of Almost Periodic Solution for BAM Neural Networks with Impulse

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Journal of Mathematical Research and Exposition 2010年第6期30卷 1039-1047页

作者： Bao lin li rong WANG College of Mathematics and Information Science Northwest Normal UniversityGansu 730070P.R.China

This paper discusses a class of the bidirectional associative memories（BAM） type neural networks with *** using the Banach fixed point theory and some analysis technology,we obtain the existence of almost periodic s... 详细信息

关键词： BAM neural networks almost periodic solution impulse stability Banach fixed point theory.

Optimization of Fermentation Medium for Epothilones Production with Sequential Statistical Approach

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Chemical Research in Chinese Universities 2010年第1期26卷 86-91页

作者： MENG Fan-xin li You-xin GUO Wei-liang LU Jia-hui DU lin-na TENG li-rong College of life Science Jilin University Changchun 130012 P. R. China

A sequential statistical approach was applied to optimizing the fermentation medium of epothilones（Epos） production by means of a mutant which was obtained by treating polyangium cellulosum ATCC 15384 with nitrite and ultraviolet. The effects of different carbon sources and nitrogen sources on the fermentation medium were tested, and the suitable ones were selected. Then a uniform design was employed to design the experiments. A linear model was developed for identifying the significant components in fermentation medium, while a third degree polynomial model was used for studying the relationship between the concentration of the components in fermentation medium and the yield of Epos（YEPs）. A pattern search method was used for searching the optimum fermentation medium in the test space, which was as follows（g/L）： potassium nitrate 8.00, soybean peptone 17.60, potassium hydrogen phos- phate 1.00, beef extraction 6.46, yeast extraction 1.00, calcium chloride 0.25, sodium chloride 1.00 and ferric chloride 0.02. The optimum fermentation medium was expected to result in a yield of Epos（YEPs） of 2.48 mg/L. The validation experiments with the optimum medium were performed in triplicate and the average yield of Epos was 2.45 mg/L which was 7.78 times higher than that of Epos prepared without optimization.

关键词： Statistical approach Epothilones Uniform design Optimization of fermentation medium