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Efficacy and safety of propofol target-controlled infusion combined with butorphanol for sedated colonoscopy

World Journal of Clinical Cases 2023年第3期11卷 610-620页

作者： Feng Guo De-Feng Sun Yan Feng lin Yang Jing-lin Li Zhong-Liang Sun Department of Anesthesiology No.967 HospitalJoint Logistics Support Force of Chinese People’s Liberation ArmyDalian 116011Liaoning ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Neuroelectrophysiology The First Affiliated Hospital of Dalian Medical UniversityDalian 11601Liaoning ProvinceChina

BACKGROUND Propofol is a short-acting,rapid-recovering anesthetic widely used in sedated colonoscopy for the early detection,diagnosis and treatment of colon ***,the use of propofol alone may require high doses to achieve the induction of anesthesia in sedated colonoscopy,which has been associated with anesthesia-related adverse events(AEs),including hypoxemia,sinus bradycardia,and ***,propofol co-administrated with other anesthetics has been proposed to reduce the required dose of propofol,enhance the efficacy,and improve the satisfaction of patients receiving colonoscopy under *** To evaluate the efficacy and safety of propofol target-controlled infusion(TCI)in combination with butorphanol for sedation during *** In this controlled clinical trial,a total of 106 patients,who were scheduled for sedated colonoscopy,were prospectively recruited and assigned into three groups to receive different doses of butorphanol before propofol TCI:Low-dose butorphanol group(5μg/kg,group B1),high-dose butorphanol group(10μg/kg,group B2),and control group(normal saline,group C).Anesthesia was achieved by propofol *** primary outcome was the median effective concentration(EC50)of propofol TCI,which was measured using the up-and-down sequential *** secondary outcomes included AEs in perianesthesia and recovery *** The EC50 of propofol for TCI was 3.03μg/mL[95%confidence interval(CI):2.83-3.23μg/mL]in group B2,3.41μg/mL(95%CI:3.20-3.62μg/mL)in group B1,and 4.05μg/mL(95%CI:3.78-4.34μg/mL)in group *** amount of propofol necessary for anesthesia was 132 mg[interquartile range(IQR),125-144.75 mg]in group B2 and 142 mg(IQR,135-154 mg)in group ***,the awakening concentration was 1.1μg/mL(IQR,0.9-1.2μg/mL)in group B2 and 1.2μg/mL(IQR,1.025-1.5μg/mL)in group ***,the propofol TCI plus butorphanol groups(groups B1 and B2)had a lower incidence of anesthesia AEs,when compared to group ***

关键词： Colonoscopy Sedated colonoscopy Propofol Butorphanol Target-controlled infusion Effective concentration Adverse event

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Amphipods fail to suppress the accumulation of Ulva lactuca biomass in eutrophic Yundang Lagoon

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Acta Oceanologica Sinica 2014年第12期33卷 155-162页

作者： ZHENG Xinqing HUANG lingfeng WANG Qian lin Rongcheng Third Institute of Oceanography State Oceanic Administration Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems Xiamen University College of the Environment and Ecology Xiamen University China Ocean Press

The Gross growth efficiency （GGE） is defined as the amount of consumer carbon produced relative to the amount of prey ingested in a given time interval. In population ecology, it can be considered as an index for the ability of a consumer to convert the biomass of food into its population production. In this study, it was firstly applied to estimate the role of amphipods grazing in the biomass dynamics of macroalgae （Ulva lactuca） in Yundang Lagoon （a subtropical eutrophic coastal lagoon, Xiamen City, China）. It was found that amphipods were the dominant group （82.2%-98.7%） in the benthic assemblage, in which five amphipod species （Corophium uenoi, Ampithoe valida, Grandidierella japonica, Grammaropsis laevipalmata andCa-prella panantis） were observed in the lagoon. However, onlyA. valida significantly consumedU. lactuca among these amphipod species. A series of experiments were conducted to estimate the consumption of U. lactuca byA. valida. It was suggested that the monthly secondary production （P） ofA. valida using size frequency method ranged from 2.39 to 13.68 g/***. valida exponentially reduced with body size and was closely associated with water temperature. Therefore,GGE equation for different months using the temperature recorded during the field investigation was fitted. The monthly consumption ofU. lactuca was figured out to be 86.7-1 549.0 g/m2 by the sum of consumption （P/GGE） byA. valida at different size, ac-counting for 2.0%-37.5% ofU. lactucaproduction. It indicates that the grazing effect ofA. valida did play a role in reducingthe accumulation ofU. lactucabiomass whenA. valida was abundant, but it finally fails to limit the U. lactucagrowth in Yundang Lagoon. Low abundance of A. valida and high nutrient loading may be two major reasons for the outbreak ofU. lactuca bloom in the lagoon.

关键词： amphipods Ampithoe valida consumption gross growth efficiency secondary production,Ulva lactuca

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The synthesis of benzoxaboroles and their applications in medicinal chemistry

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Science China Chemistry 2013年第10期56卷 1372-1381页

作者： ZHANG Jiong ZHU MingYan lin YiNan ZHOU HuChen School of Pharmacy Shanghai Jiao Tong University

Benzoxaborole,as a versatile scaffold,plays important roles in organic synthesis,molecular recognition and supramolecular *** is also a privileged structure in medicinal chemistry due to its desirable physicochemical and drug-like ***,benzoxaboroles were widely applied as antifungal,antibacterial,antiviral,anti-parasite,and anti-inflammatory *** review covers the properties,synthetic methods and applications of benzoxaboroles in medicinal chemistry.

关键词： benzoxaboroles synthetic methods medicinal chemistry

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An earth observation potential evaluation model and its application to SDG indicators

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International Journal of Digital Earth 2022年第1期15卷 1187-1203页

作者： Meng Jin Ming lin Yufu Liu Yuqi Bai Department of Earth System Science Institute for Global Change StudiesMinistry of Education Ecological Field Station for East Asian Migratory BirdsTsinghua UniversityBeijing 100084China

Thousands of satellites and instruments are providing very unique long-term,refined,and diverse perception capabilities for the states and changes of the Earth's surface *** leveraging Earth Observation(EO)techniques in SDG monitoring in specific regions,an important prerequisite is to evaluate whether EO could meet user requirements in terms of spatial coverage,temporal frequency and observing variables or *** is highly expected to have a quantitative model that can not only represent EO capabilities and observation requirements but also evaluate the potential of EO capability to fulfil these *** paper first describes EO capabilities from the satellite's orbit,operation time,spatial resolution,revisit cycle,accessibility and observation relevance level to *** requirements and priorities are then derived from SDG ***,the potential model is established to match EO capabilities and user *** SDG 14.1.1 as an example,this model is capable of returning an ordered list of satellites and instruments for users to refer *** model meets the gap of evaluating EO potential to fulfil SDG *** could make full use of the available EO capabilities worldwide to meet SDG indicator monitoring requirements.

关键词： Earth Observation remote sensing Sustainable Development Goals

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Lanthanide-catalyzed cyclocarbonylation and cyclothiocarbonylation: a facile synthesis of benzannulated 1,3-diheteroatom five- and six-membered heterocycles

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Science China Chemistry 2014年第8期57卷 1117-1125页

作者： JING YuFeng LIU RuiTing lin YangHui ZHOU XiGeng Shanghai Key Laboratory of Molecular Catalysis and Innovative Material Department of Chemistry Fudan University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry

La[N(SiMe3)2]3 proves to be an efficient catalyst system for the cyclocarbonylation of 1,2-disubstituted benzenes with isocyanates. In this approach, aryl/alkyl isocyanates react with o-phenylenediamine, o-aminophenol, o-aminothiophenol, catechols and anilines ortho-substituted by CH2NH2 and CONH2 to form, respectively, the corresponding benzimidazolones, benzoxazolones, benzothiazolones, benzodioxolones, 3,4-dihydroquinazolin-2(1H)-one, and quinazolinediones. These results represent the first example of lanthanide-catalyzed carbonylation. This methodology is also applicable for the preparation of various benzannulated 1,3-diheteroatom cyclic thioketones starting from aryl/alkyl isothiocyanates or CS2 in good to excellent yields. Based on the results of experiments performed using an o-aminobenzamido dianion lanthanide complex, a general mechanism, involving the tandem reaction of two lanthanide-ligand bonds with one heterocumulene molecule, is proposed as well.

关键词： lanthanide catalyst 1 2-disubstituted benzene isocyanate isothiocyanates cyclocarbonylation cyclothiocarbonylation

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The Clustering Coefficient and the Diameter of Small-world Networks

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Acta Mathematica Sinica,English Series 2013年第1期29卷 199-208页

作者： Lei GU Hui lin HUANG Xiao Dong ZHANG School of Mathematical Sciences Fudan University College of Mathematics and Information Science Wenzhou University Department of Mathematics and MOE-LSC Shanghai Jiao Tong University

The small-world network, proposed by Watts and Strogatz, has been extensively studied for the past over ten years. In this paper, a generalized smMl-world network is proposed, which extends severM small-world network models. Furthermore, some properties of a special type of generalized small-world network with given expectation of edge numbers have been investigated, such as the degree distribution and the isoperimetric number. These results are used to present a lower and an upper bounds for the clustering coefficient and the diameter of the given edge number expectation generalized small-world network, respectively. In other words, we prove mathematically that the given edge number expectation generalized small-world network possesses large clustering coefficient and small diameter.

关键词： Generalized small-world network clustering coefficient diameter Laplacian spectra

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Abnormal Event Correlation and Detection Based on Network Big Data Analysis

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Computers, Materials & Continua 2021年第10期69卷 695-711页

作者： Zhichao Hu Xiangzhan Yu Jiantao Shi lin Ye School of Cyberspace Science Harbin Institute of TechnologyHarbin150001China Department of Computer and Information Science Temple UniversityPhiladelphia42101USA

With the continuous development of network technology,various large-scale cyber-attacks continue to *** attacks pose a severe threat to the security of systems,networks,and ***,how to mine attack patterns from massive data and detect attacks are urgent *** this paper,an approach for attack mining and detection is proposed that performs tasks of alarm correlation,false-positive elimination,attack mining,and attack *** on the idea of CluStream,the proposed approach implements a flow clustering method and a two-step algorithm that guarantees efficient streaming and *** context of an alarm in the attack chain is analyzed and the LightGBM method is used to perform falsepositive recognition with high *** accelerate the search for the filtered alarm sequence data to mine attack patterns,the PrefixSpan algorithm is also updated in the store *** updated PrefixSpan increases the processing efficiency and achieves a better result than the original one in *** Bayesian theory,the transition probability for the sequence pattern string is calculated and the alarm transition probability table constructed to draw the attack ***,a long-short-term memory network and embedding word-vector method are used to perform online *** of numerical experiments show that the method proposed in this paper has a strong practical value for attack detection and prediction.

关键词： Attack scene false positive alarm correlation sequence mining multi-step attack

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Modeling of Hot Deformation Behavior of55SiMnMo Medium-Carbon Steel

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Journal of Iron and Steel Research International 2013年第11期20卷 125-130页

作者： YAN Tao YU En-lin ZHAO Yu-qian National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan University College of Mechanical Engineering Yanshan University Control Engineering College Northeast University at Qinhuangdao

The hot deformation behavior of 55SiMnMo steel was studied by hot isothermal compression tests at 950- 1 100 ℃ and strain rates of 0.01 -10 s ^-1 using a Gleeble 3500 thermal simulation machine. Experimental results show that the peak stress increases with decreasing deformation temperature and increasing strain rate. When the strain rate ε= 0.01 s^- 1 , or when ε =0.1 s^- 1 and the deformation temperature T≥1000 ℃, the dynamic recrystalli- zation （DRX） of 55SiMnMo steel occurs. The hot flow stress constitutive equation, peak strain equation, as well as critical stress and strain for DRX initiation are obtained based on the experimental data. A comparison between the theoretical and experimental results verifies the reliability of the flow stress equation.

关键词： dynamic recrystallization constitutive equation work hardening activation energy

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Molecular dynamics study on the nano-void growth and coalescence at grain boundary

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Science China(Physics,Mechanics & Astronomy) 2012年第1期55卷 86-93页

作者： lin EnQiang NIU LiSha SHI HuiJi DUAN Zheng Applied Mechanics Laboratory School of Aerospace Tsinghua University Beijing 100084 China

Molecular dynamics simulations using embedded atom method (EAM) potential were performed to study nano-void growth and coalescence at grain boundary in face-centered cubic bicrystal copper. Thin-plate specimens subjected to uniaxial tension strain with one-void and two-void at the centered grain boundary were employed to analyze the effect of specimen size, temperature and applied strain rate on the stress-strain response, incipient yield strength and macroscopic effective Young's modulus. The evolutions of dislocations, twin bands and void shapes under different specimen sizes were also presented. The obtained results show that, regardless of the void numbers, the specimen sizes, temperature, the applied strain rate had significant influence on the void shape evolution, stress-strain curve and incipient yield strength, while negligible effects on the macroscopic effective Young's modulus except for the temperature. Moreover, the voids growth rate along the grain boundary was also found to be associated with the specimen sizes.

关键词： bicrystal void growth void coalescence grain boundary molecular dynamics simulations embedded atom method

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Relationship between Landslides and Active Normal Faulting in the Epicentral Area of the AD 1556 M～8.5 Huaxian Earthquake,SE Weihe Graben(Central China)

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Journal of Earth Science 2017年第3期28卷 545-554页

作者： Gang Rao Yali Cheng Aiming lin Bing Yan School of Earth Sciences Zhejiang University Department of Geophysics Graduate School of Science Kyoto University School of Earth Sciences and Engineering Nanjing University

In this paper, we focus on the characteristics of the landslides developed in the epicentral area of AD 1556 M^8.5 Huaxian Earthquake, and discuss their relations to the active normal faults in the SE Weihe Graben, Central China. The results from analyzing high-resolution remote-sensing imagery and digital elevation models（DEMs）, in combination with field survey, demonstrate that：（i） the landslides observed in the study area range from small-scale debris/rock falls to large-scale rock avalanches;（ii） the landslides are mostly developed upon steep slopes of ≥30°; and（iii） the step-like normal-fault scarps along the range-fronts of the Huashan Mountains as well as the thick loess sediments in the Weinan area may facilitate the occurrence of large landslides. The results presented in this study would be helpful to assess the potential landslide hazards in densely-populated areas affected by active normal faulting.

关键词： landslides active normal faults Huaxian Earthquake Weihe Graben Ordos Block

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