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Chemical Research in Chinese Universities 2008年第6期24卷 726-730页

作者： DING Jie-lian lin ling XU jian-dong ZENG Chong-yu College of Chemistry and Chemical Engineering Nanjing University of Technology Nanjing 210009 P R. China

0.5%Pt-K/γ-Al2O3 catalysts for the synthesis of o-phenylphenol（OPP） from o-cyclohexenyl-cyclohexanone （dimer） dehydrogenation were prepared by means of a two subsequent impregnation method. The effects of catalyst preparation parameters, such as K promoters, calcination, and reduction conditions, were investigated. The results showed that the addition of K2SO4 to Pt/γ-Al2O3 catalyst notably promoted the selectivity of OPP, and its optimum content was found to be 6% in mass fraction. The higher activity was obtained when Pt/γ-Al2O3 catalyst was calcined in nitrogen atmosphere at 400--500 ℃ and then reduced at the same temperature for 3 h in hydrogen atmosphere. The conversion of the dimer and the selectivity of OPP were always above 99% and 90%, respectively, over 0.5%Pt-6% K2SO4/γ-Al2O3 catalyst during the pilot scale test of 8000 h.

关键词： o-Phenylphenol Pt catalyst K promoters Calcinations Reduction

PLASMA RESISTIN LEVELS AND SINGLE-NUCLEOTIDE POLYMORPHISMS IN RESISTIN GENE 5 FLANKING REGION IN PATIENTS WITH STROKE

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Chinese Medical Sciences Journal 2007年第1期22卷 27-32页

作者： Xing-jian lin Ying-dong Zhang Qing-shan Guan Qing Di Jing-ping Shi Wei-guo Liu Department of Neurology Nanjing Brain Hospital Nanjing Medical University Nanjing 210029

Objective To analyze the role of resistin in insulin resistance (IR) through investigating the variation of plasma resistin levels and single-nucleotide polymorphisms (SNPs) in resistin gene 5’ flanking region in stroke *** In 103 atherothrombotic cerebral infarction (ACI) patients, 85 lacunar infarction (LI) patients, 70 intracerebral hemorrhage (ICH) patients, and 86 healthy controls, plasma resistin and insulin levels were measured by ELISA , SNPs in resistin gene 5’ flanking region were detected by PCR and direct DNA sequencing. The subjects’ body height and weight, the body mass index, quantitative insulin sensitivity check index (QUICKI), blood pressure, and the concentration of fasting plasma glucose, triglyceride, total cholesterol, creatinine, low-density lipoprotein, and high-density lipoprotein were also determined. Results QUICKI was significantly lower in the ACI and ICH patients (0.316±0.037 and 0.309±0.032, respectively) than that in the controls (0.342±0.043, PG and -537A>C SNPs were not significantly different among the different groups, and those SNPs were not correlated with other clinical and biochemical *** Plasma resistin is associated with stroke by participating in the development of IR. The SNPs in resistin gene 5’ flanking region has no impact on the plasma resistin level.

关键词： resistin insulin resistance single-nucleotide polymorphisms stroke

Critical care management of patients with barium poisoning: a case series

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Chinese Medical Journal 2020年第6期133卷 724-725页

作者： Jun-Feng Su Dao-Ping Le Chun-He Liu jian-dong lin Xiong-jian Xiao Department of Critical Care Medicine The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350000China Department of Critical Care Medicine Ningde Hospital Affiliated to Fujian Medical UniversityNingdeFujian 352000China Department of Critical Care Medicine Gutian County Hospital of Fujian ProvinceNingdeFujian 352000China

Acute barium poisoning is uncommon in clinical *** occurs primarily due to the ingestion of soluble barium compounds such as BaCJ that causes gastroenteritis(vomiting,diarrhea,and abdominal pain),hypokalemia,hypertension,cardiac arrhythmia,and skeletal muscle ***,several related cases of barium poisoning due to food contamination occurred in the vicinity of our *** present the data for these cases and describe a representative case that we managed.

关键词： Acute barium diarrhea

Application of systems biology to the study of chronic kidney disease

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Chinese Medical Journal 2012年第14期125卷 2603-2609页

作者： CAO Yu-han LU lin-li ZHANG jian-dong LIU Bi-cheng Institute of Nephrology Zhong Da Hospital Southeast UniversityNanjing Jiangsu 210009 China

Chronic kidney disease （CKD） is a major public health problem that affects about 10% of the general population. Current approaches to characterize the category and progression of CKD are normally based on renal histopathological results and clinical parameters. However, this information is not sufficient to predict CKD progression risk reliably or to guide preventive interventions. Nowadays, the appearance of systems biology has brought forward the concepts of ＂-omics＂ technologies, including genomics, transcriptomics, proteomics, and metabolomics. Systems biology, together with molecular analysis approaches such as microarray analysis, genome-wide association studies （GWAS）, and serial analysis of gene expression （SAGE）, has provided the framework for a comprehensive analysis of renal disease and serves as a starting point for generating novel molecular diagnostic tools for use in nephrology. In particular, analysis of urinary mRNA and protein levels is rapidly evolving as a non-invasive approach for CKD monitoring. All these systems biological molecular approaches are required for application of the concept of ＂personalized medicine＂ to progressive CKD, which will result in tailoring therapy for each patient, in contrast to the ＂one-size-fits-all＂ therapies currently in use.

关键词： ' systems biology chronic kidney disease, microarray analysis, genome-wide association study,serial analysis of gene expression

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热轧支承辊堆焊技术研究

电焊机 2009年第7期39卷 85-89页

作者：林剑东攀枝花钢铁研究院四川攀枝花617000

针对热轧板厂70Cr3NiMo表面淬火锻钢支承辊进行堆焊修复后使用寿命低的情况,以及国内尚无较为成熟的支承辊堆焊材料的现状,自主研制了PRJ225药芯焊丝,匹配107焊剂,采用合适的堆焊工艺对支承辊进行堆焊。与目前常用的H25Cr3Mo2MnVA焊丝+S... 详细信息

针对热轧板厂70Cr3NiMo表面淬火锻钢支承辊进行堆焊修复后使用寿命低的情况,以及国内尚无较为成熟的支承辊堆焊材料的现状,自主研制了PRJ225药芯焊丝,匹配107焊剂,采用合适的堆焊工艺对支承辊进行堆焊。与目前常用的H25Cr3Mo2MnVA焊丝+SJ301焊剂匹配相比,PRJ225焊丝的堆焊层在硬度、耐磨性和裂纹扩展速率方面均优于H25Cr3Mo2MnVA焊丝。从工业试验结果来看,修复后的支承辊不仅耐磨性良好,而且具有较好的耐接触疲劳性能,其平均过钢量达到65万t以上,最高过钢量达到了112.6万t,超过了目前国内其他钢铁公司热轧支承辊堆焊修复后的过钢量,居国内领先水平。

关键词：支承辊堆焊平均寿命

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乌司他丁对脓毒症大鼠脑组织基因表达的影响

中国危重病急救医学 2011年第8期23卷 490-494页

作者：林建东林名瑞肖雄箭福建医科大学附属第一医院ICU 福州350005

目的采用基因芯片技术检测乌司他丁（UTI）预处理脓毒症大鼠的脑组织基因表达，并分析推论其可能的作用机制。方法45只雄性Wistar大鼠按随机数字表法等分为对照组、脓毒症组和UTI组。采用盲肠结扎穿孔术（CLP）复制脓毒症大鼠模型；对... 详细信息

目的采用基因芯片技术检测乌司他丁（UTI）预处理脓毒症大鼠的脑组织基因表达，并分析推论其可能的作用机制。方法45只雄性Wistar大鼠按随机数字表法等分为对照组、脓毒症组和UTI组。采用盲肠结扎穿孔术（CLP）复制脓毒症大鼠模型；对照组仅开腹、关腹，不行CLP。UTI组于制模前1h肌肉注射（肌注）UTI 100kU／kg；脓毒症组及对照组肌注平衡液5ml／kg。采用RatRef-12大鼠表达谱基因芯片进行检测，用计算机软件筛选并分析比较脓毒症组和UTI组与对照组大鼠脑组织基因表达的变化，并初步分析脓毒症组和UTI组表达基因之间的差异。结果在22523个基因中，与对照组比较，脓毒症组大鼠脑组织差异表达基因共55个，占基因芯片总点数的0．244％；其中表达下调者47个，已知功能基因23个；表达上调者8个，已知功能基因6个。与对照组比较，UTI组大鼠脑组织差异表达基因共82个，占基因芯片总点数的0．364％；其中表达下调者66个，已知功能基因39个；表达上调者16个，已知功能基因8个。与对照组比较，脓毒症组与UTI组有同向表达的基因19个，其中下调18个，包括Adora2a、Avp、Cart、Gng7、Myh7、Oxt、Pde1b、Pdyn、Prkcd、Prkch、Rgs9、Rxrg、Six3、Slc17a6、Slco1a5、Sostdc1、Tac1、Ttr；上调1个，为S100a8。结论脓毒症时存在脑功能障碍相关的基因表达紊乱；UTI预处理可部分纠正脓毒症大鼠过度炎症反应及免疫抑制所致脑组织基因表达异常，从基因水平上对脑组织起到保护作用；同时脓毒症时机体可能存在一定的自我调节作用，一定程度上对脑组织具有保护作用。

关键词：脓毒症乌司他丁脑基因表达谱基因芯片

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

基于早期产量的马尾松第1代种子园高产无性系选择

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福建林业科技 2012年第1期39卷 9-12页

作者：林建东福建省尤溪国有林场福建尤溪365100

通过对福建省尤溪国有林场马尾松第1代种子园早期产量的研究,进行高产无性系选择。结果表明:即使在种子园初产期,大小年现象明显。以各年度无性系种子均重、出籽率大于建园无性系平均值为标准选择各年度高产无性系,无性系种子均重平均... 详细信息

通过对福建省尤溪国有林场马尾松第1代种子园早期产量的研究,进行高产无性系选择。结果表明:即使在种子园初产期,大小年现象明显。以各年度无性系种子均重、出籽率大于建园无性系平均值为标准选择各年度高产无性系,无性系种子均重平均可提高59.94%,出籽率平均可提高41.53%,增产效果选择明显;但各年度入选无性系差别较大,存在产量不稳定型无性系。选择3 a均入选的9个无性系为高产稳产建园无性系,入选率为18.00%,其无性系种子均重可提高75.92%,出籽率可提高54.39%。

关键词：马尾松无性系第1代种子园早期产量

乌司他丁对脓毒症大鼠心脏组织基因表达的影响

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中国危重病急救医学 2010年第11期22卷 688-692页

作者：林建东蔡毅肖雄箭林名瑞福建医科大学附属第一医院ICU 福州350000

目的应用基因芯片技术观察乌司他丁（UTI）预处理对脓毒症大鼠心脏组织基因表达的调控作用.方法 45只雄性Wistar大鼠按照随机数字表法均分为对照组、脓毒症组和UTI组.采用盲肠结扎穿孔术（CLP）复制脓毒症大鼠模型;对照组仅开腹、关腹... 详细信息

目的应用基因芯片技术观察乌司他丁（UTI）预处理对脓毒症大鼠心脏组织基因表达的调控作用.方法 45只雄性Wistar大鼠按照随机数字表法均分为对照组、脓毒症组和UTI组.采用盲肠结扎穿孔术（CLP）复制脓毒症大鼠模型;对照组仅开腹、关腹,不行***组制模前1 h肌肉注射（肌注）UTI100 kU/kg;脓毒症组及对照组肌注平衡液5 ml/kg.采用RatRef-12大鼠表达谱基因芯片进行检测,以Cy3和Cy5两种荧光信号强度结果比值＞2.0或＜0.5的基因为差异表达基因,用计算机软件筛选并分析比较脓毒症组和UTI组与对照组大鼠心脏组织基因表达的变化,并初步分析脓毒症组和UTI组表达基因之间的差异.结果在22 523条基因中,与对照组比较,脓毒症组差异表达基因418条,占基因芯片总点数的1.856%,其中表达上调200条,已知功能基因84条,只在脓毒症组表达上调而UTI组表达正常者43条;表达下调218条,已知功能基因74条,只在脓毒症组表达下调而UTI组表达正常者37条.与对照组比较,UTI组共筛选出差异表达基因202条,占基因芯片总点数的0.897%,其中表达上调111条,已知功能基因57条,只在UTI组表达上调而脓毒症组表达正常者17条;表达下调91条,已知功能基因48条,只在UTI组表达下调而脓毒症组表达正常者18条.与对照组比较,UTI组和脓毒症组大鼠心脏组织基因表达同时上调41条,下调37条.结论 UTI预处理可减轻脓毒症晚期大鼠心脏的损害,具有一定的心脏保护效应;其基因机制可能涉及UTI对应激反应、细胞信号转导、物质能量代谢、免疫反应等方面相关基因表达的调控.

关键词：脓毒症心脏组织基因表达乌司他丁基因芯片

生物信息学方法分析乌司他丁作用下脓毒症大鼠基因的差异表达

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中国急救医学 2013年第12期33卷 1072-1076页

作者：林建东林名瑞肖雄箭福建医科大学附属第一医院ICU 福建福州350005 福建中医药大学附属人民医院ICU 福建福州350005

目的探讨乌司他丁（UTI）对脓毒症大鼠重要脏器（脑、肝、脾、肺）作用的分子机制。方法45只雄性Wistar大鼠按随机数字表法等分为对照组、脓毒症组和UTI组。各组分别在制模后24h取组织，采用RatRef-12大鼠表达谱基因芯片进行检测，并使... 详细信息

目的探讨乌司他丁（UTI）对脓毒症大鼠重要脏器（脑、肝、脾、肺）作用的分子机制。方法45只雄性Wistar大鼠按随机数字表法等分为对照组、脓毒症组和UTI组。各组分别在制模后24h取组织，采用RatRef-12大鼠表达谱基因芯片进行检测，并使用AgilentGeneSpringGX11．5软件进行差异基因筛选、Pathway分析。用String9．0软件进行关键性基因分析。结果一些炎症、凋亡及能量代谢相关基因在脓毒症组倾向于使其恶化的趋势表达，而在UTI组表达有所恢复。结论UTI可能是通过调节炎症、凋亡及能量代谢相关基因的表达起到保护脓毒症大鼠的作用。

关键词：基因芯片生物信息学脓毒症乌司他丁