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Chinese Journal of Astronomy and Astrophysics 2002年第3期2卷 207-215页

作者： lin-Peng Cheng , jian-yan Wei and Yong-Heng ZhaoNational Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 National Astronomical Observatories Chinese Academy of Sciences Beijing 100012

We examined the correlation between the ROSAT Hardness Ratio 1 and Count Rates eight Narrow-line Seyfert 1 Galaxies (NLSls) and 14 Broad-line Seyfertl Galaxies (BLSls). We found that six of the NLSls show a positive HR1-CTs correlation, and seven of the BLSls, a negative correlation. The other two NLSls and seven BLSls do not show any clear HR1-CTs correlation. Thus, the spectral behavior is statistically different for the NLSls and BLSls. The different behaviors can possibly be interpreted in terms of a stable 'soft excess' that is strong in NLSls and weak in BLSls, plus a power law component, common to both, which softens with increasing flux.

关键词： galaxies: Seyfert - galaxies: active - X-ray: galaxies

Epidemiological and Clinical Characteristics of Non-neonatal Tetanus Patients in Guangxi,China:An 11-year Retrospective Study(2011–2021)

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Biomedical and Environmental Sciences 2023年第9期36卷 880-885页

作者： KANG Yi Wen MAI Guo Feng ZHU Xiao ling DENG Shang Qin yanG Shi Xiong TENG Hong Li YUAN Zong Xiang MO Chu Ye lin jian yan YE Li TANG Hua Min Guangxi Key Laboratory of AIDS Prevention and Treatment School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Department of Emergency the Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007GuangxiChina The Fourth People's Hospital of Nanning Nanning 530023GuangxiChina Department of Emergency Guangxi International Zhuang Medicine HospitalNanning 530000GuangxiChina

Tetanus is the only non-communicable disease among vaccine-preventable infectious *** is caused by an infection with Clostridium tetanus bacterium and is characterized by continuous tonic contraction and paroxysmal sp... 详细信息

关键词： Tetanus vaccine neonatal

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： jian‑En Zhou Yilin Li Xiaoming lin Jiaye Ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

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非综合征性唇腭裂基因环境交互作用研究进展

现代预防医学 2009年第15期36卷 2949-2951+2964页

作者：林健燕栾荣生四川大学华西公共卫生学院流行病学教研室广西右江民族医学院预防医学教研室

非综合征性唇腭裂(NSCL/P)是一种多基因易感性疾病,环境因素和遗传因素的交互作用对NSCL/P发生的影响是理解该病发病机制的关键之一。近年来,陆续出现环境因素和遗传因素交互作用对唇腭裂发生的影响研究,所涉及的因素主要有母亲吸烟、... 详细信息

非综合征性唇腭裂(NSCL/P)是一种多基因易感性疾病,环境因素和遗传因素的交互作用对NSCL/P发生的影响是理解该病发病机制的关键之一。近年来,陆续出现环境因素和遗传因素交互作用对唇腭裂发生的影响研究,所涉及的因素主要有母亲吸烟、饮酒、孕期维生素补充、家族史、种族、孕期药物使用等环境因素以及TGFα、TGFβ3、TGFβ2、MSX1、CYP1A1、GST、NAT、MTHFR、BCL3、RARA、EPHX1等基因。本文分别从环境-基因和基因-基因交互作用两方面的研究概况做一综述。

关键词：非综合征性唇腭裂基因环境因素交互作用

Comparative Study of Solution and Solid-State CD Spectroscopy for Chiral Compounds—Methods and Structures

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Comparative Study of Solution and Solid-State CD Spectroscop...

心理干预对哮喘患者心理及Th1/Th2平衡的影响

中国化学会第六届全国结构化学学术会议

作者： Hui Zhang,Fang Zou,Yi-Ji lin,jian-Xin yan,Li-Rong lin~*,Ding Lei Department of Chemistry,College of Chemistry and Chemical Engineering, Xiamen University,361005,Xiamen

＜正＞Crystal structure analysis usually supplies reliable structure information for the research on the stereochemistry of chiral compounds,but it is sometimes not rigorous to illustrate the solution structures of chiral compounds only basing on the crystal structures or to identify the solid-state structures only by the solution chiroptical spectroscopy（CD,VCD or CPL）,because solution and solid-state structures of some

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来源： cnki会议评论

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现代预防医学 2010年第17期37卷 3292-3294页

作者：马迎教林健燕右江民族医学院预防医学教研室

[目的]分析心理干预对哮喘患者心理、生存质量及Th1/Th2平衡的影响。[方法]将106例哮喘患者随机分为实验组和对照组,在常规药物治疗的基础上,实验组同时接受心理干预。采用激惹、抑郁和焦虑自评量表(IDA)及支气管哮喘生存质量评估表(AQ... 详细信息

[目的]分析心理干预对哮喘患者心理、生存质量及Th1/Th2平衡的影响。[方法]将106例哮喘患者随机分为实验组和对照组,在常规药物治疗的基础上,实验组同时接受心理干预。采用激惹、抑郁和焦虑自评量表(IDA)及支气管哮喘生存质量评估表(AQLQ)分别比较两组治疗前后的心理状态、生存质量及血清中白细胞介素12、13(IL-12、13)含量的变化。[结果]治疗后实验组的抑郁、焦虑、外向性激惹评分均低于对照组(P﹤0.01);治疗后实验组的活动受限、哮喘症状、心理状况3个因子的得分均高于对照组(P﹤0.01);治疗后实验组IL-12含量升高及IL-13降低较对照组明显,差异有统计学意义(P﹤0.05)。[结论]心理干预能改善哮喘患者心理状态、提高其生存质量,且能上调IL-12,下调IL-13,调节Th1/Th2免疫失衡,从而达到控制哮喘的目的。

关键词：哮喘心理干预细胞因子

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin Zhu Teng jiang Junshan Zhou Fuling yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

CREG accelerates vasculogenesis in mouse embryonic stem sellsderived embryonic bodies

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岭南心血管病杂志 2011年第S1期17卷 193-194页

作者： ZHANG Na,HAN Ya-ling,TIAN Xiao-xiang,ZHANG Xiao-lin, KAN jian,yan Cheng-Hui (Department of Cardiology,Cardiovascular Institute of PLA, Shenyang Northern Hospital.Shenyang,China)

Background Cellular repressor of ElA-stimulated genes(CREG) is homeostatic modulated gene,which regulate a number of cellular processes,including cell differentiation, motility and *** studies have demonstrated that CREG was expressed in all three germ layers,suggesting that it might act as a vital regulator during embryonic *** aim of the present study was to investigate the role of CREG in an embryonic stem cell(ESC) differentiation model that recapitulates the developmental steps of *** The ES cells were stably transfected either pCXN2-FLAG-CREG-IRES-EGFP plasmid or pDS1- shRNA-CREG plasmid to produce the CREG+/ES cells and CREG-siRNA/ES cells,*** was detected by whole mount immunostainings for *** labeled acLDL staining assay was used to detect branching pseudopods in cultures in ***-time PCR and Western blot analysis were employed to determine expressions of VEGF and *** CREG +/ES-derived embryoid bodies(EBs) were found to form spontaneously a primitive vascular network after 6 days of *** contrast, wildtype EBs exhibit theirs vasculogenesis until 13 days of differentiation by whole mount immunostainings for CD31. CREG +/EBs developed more rapidly branching pseudopods at 9 days compared with that of wildtype EBs by Dil labeled acLDL staining *** contrast,CREG-siRNA/ES exhibits an undifferentiated morphogenesis associated with an increase in apoptotic cells in spite of being derived from LIF and feeder *** of CREG-siRNA/ES cells with recombinant CREG protein rescued the phenomena that CREG boosted vasculogenesis in a dose-dependent fasion. Mechanically,Real-time PCR and Western blot analysis revealed the expressions both VEGF and Flk-1 significantly in- creased in CREG+/***,after treatment of CREG+ /EBs with neurtralizing antibody against VEGF,the rapid vasculogenesis was significantly *** Our data strongel

关键词： CREG accelerates vasculogenesis in mouse embryonic stem sellsderived embryonic bodies stem

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng yang jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing Dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin