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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu lin Yiming Qian Jiashu Lian Xin Hua Jianhong dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Improved position estimates for the Chinese Deep Space Station Kashi derived by geodetic very long baseline interferometry

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Science China(Technological Sciences) 2016年第9期59卷 1346-1351页

作者： XU DeZhen dong GuangLiang ZHOU huan LI HaiTao Beijing Institute of Tracking and Telecommunications Technology Beijing 100094 China

A dedicated 24 h S/X dual-band geodetic very long baseline interferometry(VLBI) experiment was conducted in January 2015 with the goal of improving the position estimates for the Chinese Deep Space Station Kashi. Previously, the position estimates had been only accurate to ~20 cm, which is insufficient for future Chinese deep space explorations. The experiment design and data reduction are described with special emphasis on the limited frequency ranges of Kashi for bandwidth synthesis. A narrowed multi-band delay search window based on post-fit residuals was utilized to resolve the sub-ambiguities due to the drop of a frequency channel in fringe fit, which saved ~22% of the observations from the affected baseline. Final position estimates of Kashi were obtained from the global solution by using more than 5300 international VLBI sessions from August 1979 to September 2015, and estimates were found to be accurate to about 10, 25, and 20 mm in the X, Y, and Z components. Various statistical tests were run, and the estimates and precisions are believed to be reliable.

关键词： VLBI Chinese Deep Space Station station position determination bandwidth synthesis quantitative efficiency

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A Multi-component Matrix Loop Algebra and Its Application

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Communications in Theoretical Physics 2005年第6X期44卷 997-1001页

作者： dong huan-He ZHANG Ning Information School Shandong University of Science and Technology Qingdao 266510 China

A set of multi-component matrix Lie algebra is constructed. It follows that a type of new loop algebra AM-1 is presented. An isospectral problem is established. Integrable multi-component hierarchy is obtained by Tu pattern, which possesses tri-Hamiltonian structures. Furthermore, it can be reduced to the well-known AKNS hierarchy and BPT hierarchy. Therefore, the major result of this paper can be regarded as a unified expression integrable model of the AKNS hierarchy and the BPT hierarchy.

关键词： Liouville integrable tri-Hamiltonian structures Loop algebra

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A New Loop Algebra and Corresponding Computing Formula of Constant γ in Quadratic-Form Identity

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Communications in Theoretical Physics 2007年第6期47卷 981-986页

作者： GUO Fu-Kui dong huan-He School of Information Science and Engineering Shandong University of Science and Technology Qingdao 266510 China

A new loop algebra containing four arbitrary constants is presented, -whose commutation operation is concise, and the corresponding computing formula of constant γ in the quadratic-form identity is obtained in this paper, which can be reduced to computing formula of constant γ in the trace identity. As application, a new Liouville integrable hierarchy, which can be reduced to AKNS hierarchy is derived.

关键词： loop algebra computing formula of constant γ quadratic-form identity

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Effect of flue gas outlet temperature in evaporator on thermal economic performance of organic Rankine cycle system for sinter waste heat recovery

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Journal of Iron and Steel Research International 2023年第12期30卷 2378-2390页

作者： Jun-sheng Feng Xin-ni Cheng huan-huan Wang Liang Zhao Hui dong School of Environment and Energy Engineering Anhui Jianzhu UniversityHefei230601AnhuiChina School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina

In order to improve the recovery and utilization rates of sinter waste heat effectively,the organic Rankine cycle(ORC)system with subcritical cycle was designed to recover the low-temperature sinter cooling flue gas waste heat in an annular cooler for power *** thermodynamic,economic and multi-objective optimization models of ORC system were established,and R600a was selected as the ORC working ***,the variations in system thermodynamic performance and economic performance with the ORC thermal parameters were discussed in detail,and the optimal ORC thermal parameters were *** results show that the system net output power increases with increasing the evaporation temperature and decreasing the condensation temperature and increases first and then,decreases with the increase in superheat degree for a given flue gas outlet temperature in the evaporator,while the heat transfer area per unit net output power appears different variation trends in various ranges of flue gas outlet *** the sinter cooling flue gas waste heat of 160℃as the ORC heat source,the optimal thermal parameters of ORC system were the flue gas outlet temperature of 90℃,the evaporation temperature of 95℃,the superheat degree of 10℃,and the condensation temperature of 28℃.

关键词： Sinter.Waste heat recovery Organic Rankine cycle Performance analysis:Parameter optimization:Fluegasoutlettemperature

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An Improved Approach for Interaction of Wave with Floating Spheres and Its Applications

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China Ocean Engineering 2023年第1期37卷 115-130页

作者： LIU Can dong Zhi-yong PAN Yun TONG huan-huan YANG li-jing College of Civil Engineering Zhejiang University of TechnologyHangzhou 310023China School of Naval Architecture and Maritime Zhejiang Ocean UniversityZhoushan 316022China School of Marine Engineering Equipments Zhejiang Ocean UniversityZhoushan 316022China

To develop and utilize marine resources in the deep sea, the higher requirements for floating structures, which are operated in marine environment for a long term, have been put forward. Reasonable structure type and accurate force analysis are favorable guarantees to improve the survival performance and working performance of the floating structures. Floating spheres fastened by mooring cable were widely used in floating structures. In this paper, the wave forces of the floating sphere are efficiently and accurately calculated by solving the geometric relationship between the non-submerged floating sphere and wave surface. Combined with the hydrodynamic calculation of mooring cables based on the lumped mass method, the coupled motion model of multi-floating spheres fastened by multi-mooring cable was established under wave action. Furthermore, according to the floating structures fastened by mooring cable in the actual ocean engineering, the topological method of multi-mooring cables fastening the multifloating spheres was expounded from simple to complex. Finally, the modeling method and preliminarily hydrodynamic characteristics of the fastened floating structures, including the mooring system of renewable energy devices, ocean buoy, and coral nursery, were presented and analyzed in detail. The obtained results showed that the method for calculating the wave force on the floating sphere developed in this paper can accurately describe the motion process of the floating mooring sphere and the force on the mooring cable. Also, the topological method of multiple buoys and multiple mooring cables could efficiently establish various numerical hydrodynamic models of fastened buoys in ocean engineering.

关键词： floating sphere mooring cable wave forces hydrodynamic model ocean engineering

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Selective N-Methylation of N-Methylaniline with CO_(2) and H_(2) over Cu/In_(2)O_(3) Catalyst

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Chinese Journal of Chemistry 2024年第3期42卷 276-282页

作者： huan Zheng Bo Qian lin He State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China University of Chinese Academy of Sciences Beijing100049 China

N-Methylation of amines with CO_(2) and H2 is a potential approach for CO_(2) utilization because N-methylated amines can be used as solvents and organic intermediates. In_(2)O_(3)-supported Cu (Cu/In_(2)O_(3)) acts as an effective heterogeneous catalyst for N-methylation reaction of N-methylaniline (MA) with CO_(2) and H_(2),showing higher N,N-dimethylaniline (DMA) selectivity than other supported Cu catalysts. On one hand,the dispersion of Cu can be improved by the defective In_(2)O_(3) support. On the other hand,In_(2)O_(3) support is active in the dissociative adsorption of CO_(2) through C—O bond breaking. In addition,the H_(2) dissociation ability of In_(2)O_(3) can also be enhanced by Cu. The combination of Cu and In_(2)O_(3) is effective in the activation of CO_(2),the adsorption of intermediate N-methylformanilide (MFA),the hydrogenation of MFA to DMA and the prohibition of C—N bond cleavage side reactions,thereby enhancing the reaction rate of MA conversion and the selectivity to DMA.

关键词： N-Methylation CO_(2) Cu/In_(2)O_(3) Supported catalysts Heterogeneous catalysis

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Picoliter droplet array based on bioinspired microholes for in situ single-cell analysis

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Microsystems & Nanoengineering 2020年第1期6卷 951-959页

作者： lin Du huan Liu Jia Zhou State Key Laboratory of ASIC and System School of MicroelectronicsAcademy for Engineering&TechnologyFudan UniversityShanghai 200433China Tian Jin Tuo Rui Med Technology Co. LtdTianjin 200438China

The division of aqueous samples into microdroplet arrays has many applications in biochemical and medical *** by biological features,we propose a method to produce picoliter droplet arrays for single-cell analysis based on physical structure and interface.A 0.9 pL droplet array with an RSD(relative standard deviation)less than 6.3%and a density of 49,000 droplets/cm^(2) was successfully generated on a PDMS chip(polydimethylsiloxane)from a micromachined glass *** droplet generation principle of the wetting behavior in the microholes with splayed sidewalls on the PDMS chip by liquid smearing was *** feasibility of the picoliter droplets for bacterial single-cell analysis was verified by the separation of mixed bacteria into single droplets and isolated in situ bacteria propagation.

关键词： analysis analysis PDMS

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Effect of parenteral and early intrajejunal nutrition on pancreatic digestive enzyme synthesis, storage and discharge in dog models of acute pancreatitis

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World Journal of Gastroenterology 2007年第7期13卷 1123-1128页

作者： huan-Long Qin Zhen-dong Su Lei-Guang Hu Zai-Xian Ding Qing-Tian lin Institute of Parenteral Nutrition and EnteralNutrition Department of Surgery Shanghai Jiaotong UniversityAffiliated Sixth People's Hospital Yishan Rd. 600 Shanghai200233 China

AIM： To study the effect of early intrajejunal nutrition on enzyme-protein synthesis and secretion during acute pancreatitis. METHODS： Fifteen dogs were randomly divided into parenteral nutrition （n = 7） and early intrajejunal nutrition groups （n = 8）. An acute pancreatitis model was induced by injecting 5% sodium taurocholate and trypsin into the pancreas via the pancreatic duct. Intrajejunal nutrition was delivered with a catheter via a jejunostomy tube after the model was established for 24 h. On d 1 and 7 and at the beginning of nutritional support, radioactive tracing and electron microscopes were used to evaluate the enzyme-protein synthesis in acinar cells, the subcellular fractionation and the change in zymogen granules after 1.85 × 10^6 Bq L-3H phenylalanine was infused at 30, 60, 120, and 180 min. RESULTS： The 3H radioactivity in pancreatic acinar cells reached its peak level at 60 min, and the contents in the early intrajejunal nutrition group were higher than those in the parenteral nutrition group, which were then decreased. The mean number and area of zymogen granules did not show any significant statistical difference in both groups on d i or on d 7 （P 〉 0.05）. CONCLUSION： Early intrajejunal nutrition might be effective in dogs with acute pancreatitis.

关键词： Parenteral nutrition Enteral nutrition Digestive enzyme Acute pancreatitis

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NO_3^-/NH_4^+ ratios affect plant growth, chlorophyll content,respiration rate, and morphological structure in Malus hupehensis seedlings

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Journal of Forestry Research 2015年第4期26卷 983-991页

作者： Yu dong huan-huan Zhi Qian Zhao Jun-feng Guan Plant Genetic Engineering Center of Hebei Province Institute of Genetics and PhysiologyHebei Academy of Agricultural and Forestry Sciences School of Food and Bioengineering Zhengzhou University of Light Industry

Malus hupehensis （Pamp.） Rehd. is a widely cultivated rootstock in China. We studied the effect of three NO3-/NH4＋ ratios （100/0, 50/50, and 0/100, molar basis） at total nitrogen （N） concentration of 8 mmoL L-1 in a nutrient solution on M. hupehensis seedlings. Plant biomass, NO3- and NH4＋concentrafion, chlorophyll con- tent, respiratory rate, and cellular structure were investi- gated. M. hupehensis seedlings at the NO3-/NH4＋ ratio of 50/50 had the highest level of fresh weight, dry weight, shoot length, and chlorophyll （a, b, and a ＋ b） content, but the lowest respiration rate in the leavesand roots. In addition, thickness and numbers of palisade and spongy tissue cells of the leaves were greater with this treatment than with other treatments. At the NO3-/NH4＋ ratio of 100/0, the leaves and roots had higher NO3- concentration and lower NH4＋ concentration. However, the opposite trend occurred at the NO3-/NH4＋ ratio of 0/100. Chloro- phyll （a, b, and a ＋ b） content was lowest at the NO3-/NH4＋ ratio of 100/0 than at the other ratios. At the NO3-/ NH4＋ ratio of 0/100, oxygen （02） consumption increased in the leaves and roots, and irregular epidermis and cortex cells were observed in the root apical meristematic and mature region. Our results indicated that the NO3-INH4＋ ratio at 50/50 was suitable for growth of M. hupehensis seedling to achieve the highest biomass production and efficiency.

关键词： Cellular structure Chlorophyll content Malus hupehensis (Pamp.) Rehd. NO3- NH4+ Respiratory rate

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