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Glycated Haemoglobin in Diagnosis of Diabetes Mellitus and Pre-diabetes among Middle-aged and Elderly Population:Shanghai Changfeng Study

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Biomedical and Environmental Sciences 2013年第3期26卷 155-162页

作者： MA Hui GAO Xin lin huan dong HU Yu LI Xiao Ming GAO Jian ZHAO Nai Qing Department of Endocrinology and Metabolism Zhongshan HospitalFudan University Department of Geriatrics Clinical Epidemiology CenterZhongshan HospitalFudan University Department of Clinical Nutrition Zhongshan HospitalFudan University Department of Biostatistics College of Public HealthFudan University

Objective To investigate the optimal glycated haemoglobin （HbAlc） cut off points and evaluate the impact of HbAlc on diabetes and pre-diabetes in middle-aged and elderly population. Methods Subjects were recruited from Shanghai Changfeng Study. A total of 1 973 community-based participants （age_〉45） without known diabetes underwent oral glucose tolerance test （OG3-r） by using a 75-g oral glucose load and HbAlc was measured by using high performance liquid chromatography （HPLC）. Subjects were classified as normal glucose tolerance （NGT）, pre-diabetes（impaired glucose regulation, IGR） and new diagnosed diabetes （NDD） per 1999 WHO criteria. Two tests are compared with receiver operating characteristic curve （ROC）. Results Among 1973 subjects, 271 （13.7%） were diagnosed as NDD and 474 （24.0%） as IGR by using OGTT. HbAlc was 5.7%_＋0.7% in this population. Use of 6.5% as the HbAIC cutoff point has sensitivity of 38.7% and specificity of 98.5%. We recommend 6.0% as a better cutoff value for diagnosis of diabetes in this population （AUC 0.829, 95% CI 0.798-0.860, P〈0.001） with its sensitivity and specificity as 66.1% and 86.8%. For IGR, the results showed low sensitivity （44.9%） and specificity （66.7%） with an AUC of 0.571 for HbAlc when 5.8% was used as the cutoff point. Participants detected with HbAlc_〉6.0% were associated with nearly the same metabolic characteristics, including body mass index （BMI）, blood pressure, lipid profile and urine albumin-creatinine ratio （uACR） compared with diabetic subjects detected by OGTT. Conclusion The optimum HbAlc cutoff point for diabetes in our study population was lower than ADA criteria, and HbAlc may not be used to identify IGR.

关键词： Glycated haemoglobin(HbAlc) Diabetes Pre-diabetes Impaired glucose regulation (IGR)

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The structure features of stick-slip mechanism of the strike-slip earthquake generating structure in the interior of the Chinese mainland

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Acta Seismologica Sinica(English Edition) 1997年第3期10卷 2-9,11-12页

作者： WEN lin huan XIAO dong ZHANG ZHAO YI SONGInstitute of Geophysics, State Seismological Bureau, Beijing 100081, China

This is the third one of the paper series on the strike slip earthquake generating structure in the interior of the Chinese mainland. The features of the tectonic stress field of strike slip earthquake generating structure were discussed in the first paper (huan et al ., 1994), and the features of the deformation field of strike slip earthquake were presented in the second paper (Hun et al ., 1994). In the first section of this paper, through the analysis of the strike slip earthquake generating structure of several dozen large earthquakes with magnitude greater than 6.0, it is concluded that almost all strike slip earthquake generating faults are characterized by the oblique arranged distribution, and the barrier structure mode about the adhesive slip movement of strike slip is put forward; then in the second section, its four types, due to the different fracture form of the barrier at the ends, are also discussed; finally in the third section, the fracture terminating scale of the barrier of strike slip earthquake generating fault is also discussed.

关键词： the Chinese mainland stick slip movement barrier earthquake generating structure

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口服葡萄糖耐量试验呈糖尿病模式的胰岛素瘤

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中华内分泌代谢杂志 2010年第8期26卷 730-731页

作者：姚霞孙蔚林寰东纪元高鑫山东省胜利油山中心医院保健病房东营257034 复旦大学附属中山医院内分泌科上海

胰岛素瘤在胰腺内分泌肿瘤中最常见，但其发病率低症状复杂多变，易致误诊漏诊。充分剖析胰岛素瘤的误诊原因有助于提高诊断的准确性。本组报道一例曾被误诊为糖尿病的胰岛素瘤病例。

关键词：口服葡萄糖耐量试验胰岛素瘤糖尿病胰腺内分泌肿瘤误诊原因发病率

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新诊断2型糖尿病血脂谱特点及低密度脂蛋白颗粒直径的影响因素分析

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复旦学报（医学版） 2008年第2期35卷 282-285页

作者：任利民高鑫林寰东高键吴丹复旦大学附属中山医院内分泌科上海200032 复旦大学附属中山医院营养科上海200032

目的探讨新诊断2型糖尿病患者的血脂谱及低密度脂蛋白(low density lipoprotein,LDL)颗粒直径的特点,分析LDL颗粒直径的影响因素。方法对240例新诊断2型糖尿病患者和60例非糖尿病个体进行体重指数、腰臀比、血糖、血脂谱的比较,以多元... 详细信息

目的探讨新诊断2型糖尿病患者的血脂谱及低密度脂蛋白(low density lipoprotein,LDL)颗粒直径的特点,分析LDL颗粒直径的影响因素。方法对240例新诊断2型糖尿病患者和60例非糖尿病个体进行体重指数、腰臀比、血糖、血脂谱的比较,以多元逐步回归模型分析LDL颗粒直径的影响因素。结果新诊断糖尿病组血脂异常者171例,发生率为71.3%,新诊断糖尿病组与对照组比较,三酰甘油升高,HDL-c降低,LDL-c升高,LDL颗粒直径减小,差别均存在统计学意义(P<0.05),LDL颗粒直径与体重指数,HDL-c正相关,与舒张压,空腹血糖负相关(P<0.05)。结论新诊断2型糖尿病患者有较高的血脂异常发生率,其血脂异常的特点为高三酰甘油,低密度脂蛋白胆固醇升高,高密度脂蛋白胆固醇降低和LDL颗粒直径缩小,以小而密表型为主,LDL颗粒直径的缩小与舒张压、空腹血糖和HDL-c有关。

关键词： 2型糖尿病小而密低密度脂蛋白 LDL颗粒直径

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Engineering of Fe d-band center in Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles via orbital coupling for high-efficiency oxygen reduction electrocatalysis

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Nano Research 2025年第1期18卷 129-139页

作者： Jiayi Liu Jingwen Yin Yingzi lin Mingxin Pang huan Pang Songtao Zhang lin Xu Jun Yang Yawen Tang Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023Chin a 2 State Key Laboratory of Multiphase Complex Systems Center of MesoscienceInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China Testing Center Yangzhou UniversityYangzhou 225009China

The deliberate engineering of the d-band center of metal site represents an effective strategy to boost the intrinsic electrocatalytic performance toward the oxygen reduction reaction(ORR).Herein,following a heterointerfaceinduced orbital coupling rationale,we report a judicious design of an efficient ORR electrocatalyst consisting of Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles in-situ encased into N-doped carbon nanofibers(abbreviated as Fe_(3)O_(4)/CeO_(2)@N-CNFs hereafter).The theoretic calculations uncover that the Fe_(3)O_(4)/CeO_(2)heterointerface-triggered orbital coupling can cause the down shift of the d-band center positions of Fe sites,which leads to the weakened chemisorption of oxygenated groups and lowered energy barrier for the potential-determining step,ultimately dramatically boosting the ORR intrinsic *** a consequence,the well-designed Fe_(3)O_(4)/CeO_(2)@N-CNFs display admirable ORR activity with a half-wave potential of 0.84 V and outstanding structural/electrochemical stability in an alkaline electrolyte,surpassing the commercial Pt/C benchmark and a majority of recently reported Fe_(3)O_(4)-based *** encouragingly,the Fe_(3)O_(4)/CeO_(2)@N-CNFsincorporated Zn-air battery outperforms the Pt/C-assembled counterpart with higher power density,larger energy density,and excellent cycling stability,serving as a competent candidate for ORR-involved renewable energy *** study offers an innovative approach for the rational manipulation of the d-band center and interfacial electron behavior of active sites toward the optimization of electrocatalytic performance.

关键词： hetero-nanoparticles electrospinning interfacial engineering orbital coupling oxygen reduction reaction

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-lin Jiang Bao-Xia dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien Lee Cheng-Hui lin Chi-huan Wu Yung-Kuan Tsou Kai-Feng Sung Sheng-Fu Wang Nai-Jen Liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

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经脐水平测定腹围与腹内脂肪体积关系的研究

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中华内分泌代谢杂志 2012年第2期28卷 121-125页

作者：林寰东颜红梅饶圣祥姚秀忠高鑫复旦大学附属中山医院内分泌代谢科上海200032 复旦大学附属中山医院放射科上海200032

目的比较临床常用的3种腹围测量方法与CT测定的腹内脂肪体积的关系,探讨最能反映腹内脂肪堆积程度的腹围测量方法和临床应用价值.方法对147例18岁以上经年龄和性别匹配的成年人进行身高、体重和臀围测量,分别采用髂嵴上缘水平（WC1）... 详细信息

目的比较临床常用的3种腹围测量方法与CT测定的腹内脂肪体积的关系,探讨最能反映腹内脂肪堆积程度的腹围测量方法和临床应用价值.方法对147例18岁以上经年龄和性别匹配的成年人进行身高、体重和臀围测量,分别采用髂嵴上缘水平（WC1）、肋骨下缘和髂嵴上缘连线中点水平（WC2）和脐水平（ WC3）测量腹围,与CT测量的腹内脂肪体积进行比较.结果男性腹内脂肪体积高于女性[（1 236.0±608.4对931.0±665.0）cm3,P＜0.01].相关性分析显示WC1 （r=0.634）,WC2（r =0.677）和WC3（r=0.712）均与腹内脂肪体积呈正相关（均P＜0.01）,经性别、体重或体重指数校正后,WC3（r分别为0.488和0.432）与腹内脂肪体积的相关性优于WC1（r分别为0.347和0.293）和WC2（r分别为0.424和0.365）.多元逐步线性回归分析显示WC2和WC3均与腹内脂肪体积独立相关,其中以WC3相关性最强（β=0.270,R2C=0.504,P＜0.01）.结论经髂嵴上缘水平、肋骨下缘与髂嵴上缘连线中点水平以及经脐水平腹围均能反映腹内脂肪含量,其中经脐水平测量腹围是简便易行、更好地反映腹内脂肪体积的方法.

关键词：腹围形体测量腹内脂肪体层摄影术,X线计算机

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Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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采用不同代谢综合征诊断标准对2型糖尿病患者血脂谱的分析

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中华全科医师杂志 2006年第7期5卷 399-403页

作者：林寰东胡予吴丹高鑫复旦大学附属中山医院内分泌科上海200032

目的采用3种不同的代谢综合征建议诊断标准,观察2型糖尿病患者代谢综合征的发生状况以及组分数目的累积对血脂谱的影响,探讨2型糖尿病患者心血管疾病增加的可能原因。方法横断面观察157例2型糖尿病患者。采用1999年世界卫生组织(WHO)、2... 详细信息

目的采用3种不同的代谢综合征建议诊断标准,观察2型糖尿病患者代谢综合征的发生状况以及组分数目的累积对血脂谱的影响,探讨2型糖尿病患者心血管疾病增加的可能原因。方法横断面观察157例2型糖尿病患者。采用1999年世界卫生组织(WHO)、2001年美国国家胆固醇教育计划第三次报告(NCEP-ATPⅢ)和2004年中华医学会糖尿病学分会(CDS)的代谢综合征建议诊断标准对这些患者的代谢综合征组分和血脂谱进行分析。结果在2型糖尿病患者中WHO, NCEP-ATPⅢ和CDS定义的代谢综合征发生率分别为73．90%、49．7％和52．9％。血脂异常发生率分别为54．8％、61.2％和54．8％。最常见的代谢综合征组合中均包括血脂异常。随着代谢综合征组分数目的增加,均显示甘油三酯水平显著升高,高密度脂蛋白胆固醇水平显著下降,低密度脂蛋白颗粒直径显著缩小。其中CDS标准的相关系数高于其他两种标准。结论2型糖尿病患者中,代谢综合征的发生率可达50％以上,且通常都伴有血脂异常,这种血脂异常表现为容易导致心血管疾病的血脂谱,即甘油三酯水平升高、高密度脂蛋白胆固醇水平降低和低密度脂蛋白颗粒直径的缩小。在中国人群中,CDS诊断标准能更客观地反映这种血脂谱的变化。

关键词：代谢综合征糖尿病,非胰岛素依赖型高脂血症

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