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Mechanical Property of Low Chromium Semi-Steel Grinding Ball Prepared by Cross Rolling

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Journal of Iron and Steel Research(International) 2004年第5期11卷 50-54页

作者： CHANGLi-min MENGDe-liang NIEPu-lin LIUJian-hua JilinNormalUniversity Siping136000China YanshanUniversity Qinhuangdao066004China

The preparing method,rolling technology and mechanical properties of low chromium semi-steel grinding ball by cross rolling were studied.The results show that when the low chromium semi-steel bar is forged from55mm to50mm,cross-rolled into grinding ball at 1 000-1 050℃,air cooled and tempered at 550℃for 2h,the best mechanical properties,especially the abrasive resistance under the action of hard abrasive,can be obtained.

关键词： low chromium semi-steel grinding ball cross rolling mechanical property

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大数据背景下大学生创新创业实践路径探讨

内蒙古财经大学学报 2019年第3期17卷 74-76页

作者：林化亮浙江旅游职业学院旅行社管理系

近年来,随着高校教育的发展,大学生创新创业教育及实践已经成为社会关注的重点问题。在大数据时代下,为创业者带来了新的挑战与机遇,但大学生由于社会经验较少,对大数据的认识不深刻,往往无法处理大数据带来的一系列问题。本文对目前大... 详细信息

近年来,随着高校教育的发展,大学生创新创业教育及实践已经成为社会关注的重点问题。在大数据时代下,为创业者带来了新的挑战与机遇,但大学生由于社会经验较少,对大数据的认识不深刻,往往无法处理大数据带来的一系列问题。本文对目前大数据背景下大学生创新创业实践路径进行了探讨。

关键词：大数据大学生创新创业实践路径

Hypoxic hepatitis in children after cardiac surgery

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 205-209页

作者： Xia-Di Zhao Jing Ye Yi-Kan Sun Jian-Feng liang Lei Hu Anthony CChang Li-Zhong Du Hao-Min Li Qiang Shu Xi Chen lin-hua Tan Department of Surgical ICU Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Faculty of Medicine University of New South WalesSydneyNSW 2052Australia Department of Medical Statistics Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Children’s Hospital of Orange County Pediatric Heart InstituteOrangeCA 92868USA Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province Hangzhou 310052China Department of Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Cardiac Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Central Laboratory Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

To the Editor: Hypoxic hepatitis(HH), also known as ischemic hepatitis or shock liver, is a liver injury characterized by necrosis of centrilobular hepatocytes with a rapid increase in serum aminotransferase levels. The incidence rate of HH among patients in the intensive care unit(ICU) was found to be 0.9%-11.9% [1]. Occurrence of HH appears to have a significant impact on the clinical outcome.

关键词： hepatitis liver surgery

高锰酸钾改性桉木生物炭对Pb(Ⅱ)的吸附特性

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环境科学 2021年第11期42卷 5440-5449页

作者：莫贞林曾鸿鹄林华 Asfandyar Shahab 石清亮张华桂林理工大学环境科学与工程学院广西环境污染控制理论与技术重点实验室桂林541006 桂林理工大学环境科学与工程学院广西岩溶地区水污染控制与用水安全保障协同创新中心桂林541006 广西环境污染控制理论与技术重点实验室科教结合科技创新基地桂林541006

以桉木为原料,使用高锰酸钾对桉木生物炭(BC)进行改性,制备改性生物炭(KBC).对其进行表征,并进行了水溶液中Pb(Ⅱ)的静态吸附实验,探究了溶液pH、吸附剂投加量、吸附时间、温度和初始浓度对Pb(Ⅱ)的吸附效果影响.结果表明,最佳吸附反应p... 详细信息

以桉木为原料,使用高锰酸钾对桉木生物炭(BC)进行改性,制备改性生物炭(KBC).对其进行表征,并进行了水溶液中Pb(Ⅱ)的静态吸附实验,探究了溶液pH、吸附剂投加量、吸附时间、温度和初始浓度对Pb(Ⅱ)的吸附效果影响.结果表明,最佳吸附反应pH为5,吸附在6 h达到饱和,当温度为25℃,Pb(Ⅱ)的初始浓度为100 mg·L^(-1),吸附剂投加量为0.06 g时,KBC对Pb(Ⅱ)的最大吸附量为83.059 mg·g^(-1),去除率为99.67%.KBC对Pb(Ⅱ)的吸附遵循二级动力学模型和Langmuir等温吸附模型,其是发生在均匀表面的单层吸附.采用BET、SEM-EDS、XRD、FT-IR和XPS对吸附剂进行表征分析,发现吸附机制主要是KBC含氧和KBC含锰基团通过络合作用和沉淀作用来吸附Pb(Ⅱ),以及在吸附过程中生物炭表面会形成—O—Pb—O—双齿配合物.因此,高锰酸钾改性BC可以作为一种很好的Pb(Ⅱ)吸附剂.

关键词：高锰酸钾改性桉木生物炭吸附 Pb(Ⅱ)

Genotyping Characteristics of Human Fecal Escherichia coli and Their Association with Multidrug Resistance in Miyun District, Beijing

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Biomedical and Environmental Sciences 2023年第5期36卷 406-417页

作者： ZHANG Wei Wei ZHU Xiao lin DENG Le Le HAN Ya Jun LI Zhuo Wei WANG Jin Long CHEN Yong liang WANG Ao lin TIAN Er Li CHENG Bin XU lin hua CHEN Yi Cong TIAN Li Li HE Guang Xue National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Miyun District Center for Disease Control and Prevention Beijing 101520China Berger Bioengineering Co. LtdShanghai 201401China Xicheng District Commission of Health of Beijing Municipality Beijing 100044China Miyun District Hospital Beijing 101520China Hebei North University Zhangjiakou 075000HeibeiChina

Objective To explore the genotyping characteristics of human fecal Escherichia coli(E. coli) and the relationships between antibiotic resistance genes(ARGs) and multidrug resistance(MDR) of E. coli in Miyun District, Beijing, an area with high incidence of infectious diarrheal cases but no related data.Methods Over a period of 3 years, 94 E. coli strains were isolated from fecal samples collected from Miyun District Hospital, a surveillance hospital of the National Pathogen Identification Network. The antibiotic susceptibility of the isolates was determined by the broth microdilution method. ARGs,multilocus sequence typing(MLST), and polymorphism trees were analyzed using whole-genome sequencing data(WGS).Results This study revealed that 68.09% of the isolates had MDR, prevalent and distributed in different clades, with a relatively high rate and low pathogenicity. There was no difference in MDR between the diarrheal(49/70) and healthy groups(15/24).Conclusion We developed a random forest(RF) prediction model of TEM.1 + baeR + mphA + mphB +QnrS1 + AAC.3-IId to identify MDR status, highlighting its potential for early resistance identification. The causes of MDR are likely mobile units transmitting the ARGs. In the future, we will continue to strengthen the monitoring of ARGs and MDR, and increase the number of strains to further verify the accuracy of the MDR markers.

关键词： E.coli Multidrug resistance Whole-genome sequencing Antibiotic resistance genes Randomforest

Implantable Polyurethane Scaffolds Loading with PEG-Paclitaxel Conjugates for the Treatment of Glioblastoma Multiforme

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Chinese Journal of Polymer Science 2022年第5期40卷 491-503页

作者： He-Cheng Wu Yuan Feng Xing-Ying Song Chun-Yang Song Jin-lin Chen Yan-Chao Wang Xue-ling He Rui-Chao liang Jie-hua Li Hong Tan College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China Laboratory Animal Center of Sichuan University Chengdu 610041China

Improvement of the treatment for Glioblastoma multiforme(GBM)especially the development of in situ controllable drug release is still a major concern.In this study,we developed waterborne biodegradable polyurethane(WBPU)scaffolds incorporated with redox-sensitive and RGD-decorated paclitaxel(PTX)polymer-drug conjugates(PDCs)for targeted GBM therapy in situ.The drug scaffolds could be implanted at residual GBM site post-operation.Dual-targeting PTX-PDCs were obtained through step-by-step conjugation of disulfide linked PTX,poly(ethylene glycol)(PEG),and arginine-glycine-aspartic acid(RGD).The RGD-modified PTX-PDCs were spherical nanoparticles(NPs)that would be released from scaffolds and identified GBM cells actively.Internalized redox-sensitive PTX-PDCs would be decomposed and release PTX inside GBM cells under the circumstances of glutathione(GSH).The release profiles of PTX from the scaffolds with/without GSH were investigated.In vitro cytotoxicity assay revealed that the dual-targeting PTX-PDCs from scaffolds could specifically kill GBM cells and protect normal cells,suggesting that dual-targeting PTX-PDC-loaded scaffolds may have the potential to repair tumor-induced brain injury.In vivo anti-recurrence assay indicated that the PTX-PDC-scaffolds could deliver PTX-PDCs to the GBM cells followed by inhibiting tumor growth and inducing apoptosis.In general,the PTX prodrug-loaded devices exhibited significant anti-GBM effects and normal tissue protection simultaneously,indicating that the WBPU scaffolds incorporated with dual-targeting PTX-PDCs may be a promising strategy for local therapy of GBM.

关键词： GBM PDCs WBPU Scaffolds Controlled release

Laser cladding of NiCrSiB on Monel 400 to enhance cavitation erosion and corrosion resistance

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Rare Metals 2022年第12期41卷 4257-4265页

作者： Chun-hua Zhang Chen-liang Wu Song Zhang Yong-Feng Jia Meng Guan Jun-Zhe Tan Bin lin School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Nuclear Power Pump Industry Co. Ltd.Shenyang Blower Works Group CorporationShenyang 110869China

NiCrSiB modified layer was synthesized on Monel 400 by laser cladding,aiming at improving cavitation erosion and corrosion resistance.The microstructure,chemical composition,phase constituents and microhardness were investigated using scanning electron microscope(SEM),energy-dispersive spectrometer(EDS),X-ray diffractometry(XRD) and microhardness tester.The cavitation erosion and corrosion behaviors of the modified layer were also evaluated using an ultrasonic vibrator and potentiodynamic polarization measurement,respectively.Experimental results show that by varying the laser fluence,a hard NiCrSiB modified layer with little airholes,cracks or other defects could be obtained.NiCrSiB modified layer is ~1.1 mm in thickness.The microstructure of the modified layer exhibits cellular dendrite,flake-like dendrite and multiple eutectic phase.The modified layer is mainly composed of γ-Ni solid solution,chromium carbide(Cr_(7)C_(3)and Cr_(23)C_(6)) and Ni_(3)B.The microhardness of the modified layer is ~6.8 times that of Monel 400 substrate.Both the cavitation erosion and corrosion resistance of the modified layer are improved.In the cavitation erosion test,the cumulative erosion loss and erosion loss rate of the modified layer are one order of magnitude lower than that of the substrate.In the electrochemical corrosion test,the corrosion potentials of the substrate and the modified layer are similar.The corrosion current densities of the substrate and the modified layer are 11.12 and 1.95 μA·cm^(-2),respectively.By comparing their corrosion current densities,the corrosion resistance of the modified layer is about 5.7 times that of the substrate.

关键词： NiCrSiB Laser cladding Microstructure Cavitation erosion Corrosion

基于民族记忆构建的蒙古文档案文献遗产资源外围建设研究

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档案学通讯 2019年第5期 35-42页

作者：华林张伟梁思思云南大学历史与档案学院

开展蒙古文档案文献遗产资源外围建设,是完整构建与传承蒙古族记忆的重要方式。论文提出外围建设问题,构建建设模式,分析建设依据、优势与滞后问题,探寻实现路径。在民族记忆构视域下,依托自治区档案馆,将图书馆、博物馆、民委古籍办等... 详细信息

开展蒙古文档案文献遗产资源外围建设,是完整构建与传承蒙古族记忆的重要方式。论文提出外围建设问题,构建建设模式,分析建设依据、优势与滞后问题,探寻实现路径。在民族记忆构视域下,依托自治区档案馆,将图书馆、博物馆、民委古籍办等收藏单位纳入资源建设范畴,通过构建工作机制、编制联合目录、统一标准规范,以及数字资源整合共建等方式,可实现蒙古文档案文献资源的体系化建设,重建蒙古族记忆,更好地保护与传承这一珍贵民族文化遗产。

关键词：民族记忆蒙古文档案文献遗产资源共建

Expression and significance of angiostatin, vascular endothelial growth factor and matrix metalloproteinase-9 in brain tissue of diabetic rats with ischemia reperfusion

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 568-572页

作者： Yu-Zhi liang Zhi-Lei Zeng lin-lin hua Jin-Feng Li Yun-liang Wang Xi-Zhuang Bi Department of Cardiology Shangqiu No.1 People's Hospital Department of Neurology the Second Affiliated Hospital of Zhengzhou University Department of Neurology No.148 Hospital of P.L.A. School of Medicine Shandong University

Objective: To discuss the expression and significance of angiostatin, vascular endothelial growth factor and matrix metalloproteinase-9 in the brain tissue of diabetic rats with ischemia reperfusion. Methods: A total of 60 male Wistar rats were randomly divided into the normal group, sham group, diabetic cerebral infarction group and single cerebral infarction group according to the random number table, with 15 rats in each group. The high sucrose diet and intraperitoneal injection of streptozotocin were performed for the modeling of diabetic rats, while the thread-occlusion method was employed to build the model of cerebral ischemia reperfusion. The immunohistochemical staining was performed to detect the expression of angiostatin, vascular endothelial growth factor(VEGF) and matrix metalloproteinase-9(MMP-9) in the brain tissue. Results: The expression of angiostatin after the reperfusion in the brain tissue of rats in the single cerebral infarction group and diabetic cerebral infarction group was increased 6 h after the reperfusion, reached to the peak on 1 d and then decreased gradually. The expression of angiostatin in the diabetic cerebral infarction group 6 h, 1 d, 3 d and 7 d after the reperfusion was significantly higher than that in the single cerebral infarction group(P<0.05). VEGF began to be increased 1 h after the reperfusion in the single cerebral infarction group and diabetic cerebral infarction group, reached to the peak at 6 h and then decreased gradually. The expression of VEGF in the diabetic cerebral infarction group at each time point after the reperfusion was significantly lower than that in the single cerebral infarction group(P<0.05). MMP-9 began to be be increased 1 h after the reperfusion in the single cerebral infarction group and diabetic cerebral infarction group, reached to the peak on 1 d and then decreased gradually. The expression of MMP-9 in the diabetic cerebral infarction group at each time point after the reperfusion was significantly higher than that in the single cerebral i

关键词： Angiostatin Vascular endothelial growth factor Matrix metalloproteinase-9 Diabetes mellitus Cerebral infarction Ischemia reperfusion