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RNA-binding protein lin28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells

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Signal Transduction and Targeted Therapy 2018年第1期3卷 96-106页

作者： Xiaojuan lin Jianfeng Shen Dan Peng Xinhong He Congjian Xu Xiaojun Chen Janos LTanyi Kathleen Montone Yi Fan Qihong Huang lin Zhang Xiaomin Zhong Center for Research on Reproduction and Women’s Health University of PennsylvaniaPhiladelphiaPA 19104USA Department of Gynecology and Obstetrics Key Laboratory of Obstetrics&Gynecologic and Pediatric Diseases and Birth Defects of Ministry of EducationWest China Second HospitalSichuan UniversityChengdu 610041P.R.China Key Laboratory for Stem Cells and Tissue Engineering Ministry of EducationCenter for Stem Cell Biology and Tissue EngineeringDepartment of BiologyZhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080P.R.China Beijing Friendship Hospital Capital Medical UniversityBeijing 100050P.R.China Obstetrics and Gynecology Hospital of Fudan University Shanghai 200011P.R.China Department of Obstetrics and Gynecology University of PennsylvaniaPhiladelphiaPA 19104USA Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPA 19104USA Department of Radiation Oncology University of PennsylvaniaPhiladelphiaPA 19104USA Shanghai Respiratory Research Institute Shanghai 200032P.R.China Department of Pulmonary and Critical Care Medicine Zhongshan HospitalFudan UniversityShanghai 200032P.R.China Institute of Clinical Science Zhongshan HospitalFudan UniversityShanghai 200032P.R.China

lin28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells and developing *** evidence demonstrates that lin28B is activated in cancer and serves as a critical ***,the underlying molecular mechanisms of lin28B function in tumorigenesis are still largely *** we report that lin28B was expressed in over half of the patients with epithelial ovarian cancer who were examined(n=584).Functional experiments demonstrated that lin28B inhibited ovarian cancer cell ***,we showed that the proapoptotic factor BIM played an essential role in the antiapoptotic function of ***-IP microarray analysis suggested that lin28B binds to mRNAs that are associated with the DNA damage pathway,such as AKT2,in ovarian cancer *** binding to AKT2 mRNA and enhancing its protein expression,lin28B regulated FOXO3A protein phosphorylation and decreased the transcriptional level of BIM,which antagonized the antiapoptosis activity of *** together,these results mechanistically linked lin28B and the AKT2/FOXO3A/BIM axis to the apoptosis *** findings may have important implications in the diagnosis and therapeutics of ovarian cancer.

关键词： AKT2 diagnosis apoptosis

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Letter from Ambassador lin Songtian,president of the CPAFFC

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Voice of Friendship 2020年第1期 1-2页

作者： lin Songtian CPAFFC

On April 9,2020,the Chinese People’s Association for Friendship with Foreign Countries National Council held its Executive Council conference to pass a decision that lin Songtian,former ambassador extraordinary and plenipotentiary of the People’s Republic of Chinato the Republic of South Africa,succeeded Li Xiaolin as member of the Executive Council and president of the *** his new capacity,Ambassador lin Songtian sent a letter to the readers of the Voice of Friendship.

关键词： letter Republic president

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President lin Songtian meets with representatives of Indian mainstream media, business and cultural bodies

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Voice of Friendship 2021年第2期 22-23页

作者： Ai lin 不详

On April 14,CPAFFC President lin Songtian met a group of guests from India at the headquarters of the Chinese People’s Association for Friendship with Foreign *** group comprised journalists from the Press Trust of India,Hindustan Times and Prasar Bharati,as well as representatives of Indian businesses and cultural bodies,including the Federation of Indian Chambers of Commerce&Industry,Ispat.

关键词： Indian journal India

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CPAFFC Vice-President lin Yi attends video seminar celebrating the 70th anniversary of the establishment of diplomatic relations between China and Pakistan

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Voice of Friendship 2021年第3期 17-18页

作者： Ai lin 不详

On July 14,the All Pakistan-China Friendship Association hosted a video seminar commemorating 70 years of China-Pakistan relations and recalling the past and building a community with a shared future for the new era.

关键词： anniversary diplomatic Pakistan

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CPAFFC President lin Songtian on China-India relations——an interview with The ***

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Voice of Friendship 2020年第4期 13-15页

作者： Ai lin 不详

On Oct10,CPAFFC President lin Songtian gave an exclusive interview to ***,briefing it on the online activities hosted by the CPAFFC on the 11 0th birth anniversaiy of *** *** and answered questions about China-India relations,public opinion and people-topeople cooperation between the two countries and China-India cooperation in fighting COVID-19.

关键词： interview fighting India

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Zhu lin: Recollections of an Ambassador's Wife(Ⅱ)

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China Today 1995年第11期44卷 44-46页

作者： $$$$Zhu lin

ＺｈｕＬｉｎ：ＲｅｃｏｌｌｅｃｔｉｏｎｓｏｆａｎＡｍｂａｓｓａｄｏｒ＇ｓＷｉｆｅ（Ⅱ）ＦｏｕｒＹｅａｒｓｉｎＨｕｎｇａｒｙＡｆｔｅｒｓｉｘｍｏｎｔｈｓｏｆｐｒｅｐａｒａｔｉｏｎ．ｗｅｌｅｆｔＢｅｉｊｉｎｇｆｏｒＨｕｎ... 详细信息

ＺｈｕＬｉｎ：ＲｅｃｏｌｌｅｃｔｉｏｎｓｏｆａｎＡｍｂａｓｓａｄｏｒ＇ｓＷｉｆｅ（Ⅱ）ＦｏｕｒＹｅａｒｓｉｎＨｕｎｇａｒｙＡｆｔｅｒｓｉｘｍｏｎｔｈｓｏｆｐｒｅｐａｒａｔｉｏｎ．ｗｅｌｅｆｔＢｅｉｊｉｎｇｆｏｒＨｕｎｇａｒｙｉｎｍｉｄＪｕｌｙ１９５０...

关键词： Recollections of an Ambassador’s Wife Zhu lin

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lin DAN:LEADER OF‘RIESIDENTS’ATTENDANTS'

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Women of China 2021年第11期 10-13页

作者： XIE lin 不详

Junmen Community is located in the busy area of Gulou District,in *** community has about 3,500 families,and a population of 13,000 *** the residents,more than 1,200 people are 60 or *** is a well-known,and harmonious... 详细信息

关键词：林丹 harmonious District

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lin-28 Transactivation is Necessary for let-7 Repression and Proliferation in Lung Cancer Cells

LIN-28 Transactivation is Necessary for let-7 Repression and...

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华东六省一市生物化学与分子生物学会2010年学术交流会

作者： lin Pan Yanping Le Zhiwei Zong Xiange Long Zhaohui Gong School of Medicine Ningbo University

Human tumors show a global reduction in microRNA(miRNA) expression such as let-7 family. The let-7 family of miRNAs are known to act as tumor *** miRNAs down-regulate oncogenes such as Myc,Ras,*** of let-7 represses cellular proliferation pathways, inhibits cell growth and impairs tumor ***,the RNA-binding protein lin-28 was

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lin-28 transactivation is necessary for let-7 repression and proliferation in lung cancer cells

LIN-28 transactivation is necessary for let-7 repression and...

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中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： lin Pan Yanping Le Zhiwei Zhong Xiang-e Long Zhaohui Gonga School of Medicine Ningbo University

Human tumors show a global reduction in microRNA (miRNA) expression such as let-7 *** let-7 family of miRNAs are known to act as tumor suppressors. These miRNAs down-regulate oncogenes such as Myc, Ras,*** of let-7 represses cellular proliferation pathways,inhibits cell growth and impairs tumor ***,the RNA-binding protein lin-28 was found to be over-expressed in some human cancer cell lines and was demonstrated to bind directly to let-7 stem loops and inhibit biogenesis of let-7 miRNAs by blocking both Drosha- and Dicer- mediated cleavage and accelerating decay of let-7 ***,recent study revealed that lin-28 could be induced by c-Myc

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江西早奥陶世武宁动物群中Wuningia multisegmenlata lin,1990再研究

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古生物学报 2018年第3期57卷 329-332页

作者：林天瑞南京大学地球科学与工程学院南京210093

文中通过对江西早奥陶世武宁动物群再研究,对其中Wuningia multisegmenlata lin,1990有了更全面的认识。该种背壳狭长,外骨骼可分为头甲、躯干和尾甲三部分,头甲由两个亚椭圆形瓣壳组成,外边缘具极窄的脊,头甲腹面前部伸出一对细长、由... 详细信息

文中通过对江西早奥陶世武宁动物群再研究,对其中Wuningia multisegmenlata lin,1990有了更全面的认识。该种背壳狭长,外骨骼可分为头甲、躯干和尾甲三部分,头甲由两个亚椭圆形瓣壳组成,外边缘具极窄的脊,头甲腹面前部伸出一对细长、由多分节组成的单肢型触角;躯干窄而长,可分40多个体节,每个体节分为一个轴区和两个肋区;尾甲呈剑状。该文不仅丰富了节肢动物化石资料,同时也可为研究节肢动物系统演化和早奥陶世生物相及地层划分与对比提供依据。

关键词：节肢动物门甲壳超纲软甲纲武宁动物群早奥陶世江西

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