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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu zhicheng lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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Effects of phosphorus-doping upon the electronic structures of single wall carbon nanotubes

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Science China(Physics,Mechanics & Astronomy) 2009年第8期52卷 1139-1145页

作者： CHEN AQing SHAO QingYi lin zhicheng School of Telecommunication Engineering South China Normal UniversityGuangzhou 510006China

The phosphorus-doped single wall carbon nanotube(PSWCNT) is studied by using First-Principle methods based on Density Function Theory(DFT).The formation energy,total energy,band structure,geometry structure and density of states are *** is found that the formation energy of the P-doped single carbon nanotubes increases with diameters;the total energy of carbon nanotubes with the same diameter decreases as the doping rate *** effects of impurity position on the impurity level are *** illustrates that the position of the impurity level may depend on the C-P-C bond *** to the above results,it is feasible to substitute a carbon atom with a phosphorus atom in *** is also found that P-doped carbon nanotubes are N type semiconductor.

关键词： single wall carbon nanotubes P-doped first-principle calculation formation energy density of state

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Fossil Liverworts from the Lower Cretaceous Huolinhe Formation in Inner Mongolia, China

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Acta Geologica Sinica(English Edition) 2016年第3期90卷 838-846页

作者： LI Ruiyun WANG Xuelian JIN Peihong MA Fujun YAN Defei lin zhicheng SUN Bainian School of Earth Sciences&Key Laboratory of Mineral Resources in Western China(Gansu Province) Lanzhou University Northwest University Museum Northwest University Key Laboratory of Economic Stratigraphy and Palaeogeography Nanjing Institute of Geology and PalaeontologyCAS School of Petroleum Engineering Chongqing University of Science & Technology

A new genus and species, Rebouliothallus huolinhensis sp. nov., and two uncertain species, Ricciopsis sp. and Hepaticites sp., are described. The fossils were collected from the Lower Cretaceous Huolinhe Formation of Huolinhe Basin, northeastern China. The new genus Rebouliothallus was established in the Aytoniaceae family of Marchantiales. Rebouliothallus huolinhensis appears to be quite similar to species of the extant genus Reboulia Raddi. The species is characterized by the relatively large ventral scales. Ventral scales are large, imbricate and arranged in two rows on the ventral surface. Rhizoids are either pegged or smooth. Ricciopsis sp. is characterized by the rosette- forming thallus. Hepaticites sp. shows some similarities to liverworts. Of the forty-nine Early Cretaceous floras of China, only two floras, one from the Huolinhe basin, Inner Mongolia and the other from the Jixi Basin, Heilongjiang Province, contain fossil liverworts. The rare fossil liverwort records in the Early Cretaceous floras of China may be the result of taphonomic bias.

关键词： Rebouliothallus Ricciopsis Hepaticites Early Cretaceous Huolinhe Formation

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A New Material of lindera (Lauraceae) of the Late Pliocene from Tengchong, Yunnan and the Genus' Biogeography Significance

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Acta Geologica Sinica(English Edition) 2013年第3期87卷 690-706页

作者： DAO Kequn CHEN Junlin JIN Peihong DONG Chong YANG Yi XU Xiaohui WU Jingyu XIE Sanping lin zhicheng SUN Bainian School of Earth Sciences and Key Laboratory of Mineral Resources in Western China (Gansu Province) Lanzhou University School of Petroleum Engineering Chongqing University of Science & Technology

lindera is a large genus of graceful, pleasantly scented and common native trees and shrubs of southern China and neighboring regions of SE Asia. There is a well-documented Cenozoic fossil record not only in these regions but also from elsewhere. A new fossil leaf record has been found in diatomite beds from the Upper Pliocene Mangbang Formation of Tuantian, Tengchong County, Yunnan. The leaves are identified and assigned to lindera acuminatissima K. Q. Dao et B. N. Sun sp. nov., by comparing their leaf architecture and epidermal characteristics with those of 51 extant Lauraceae species and with 15 known fossil lindera taxa. The specimens have well-preserved cuticles, with typical leaf architecture and epidermal characteristics of the Lanraceae, including entire leaf margin, intramarginal veins, basal ternate acrodromous primary veins, one-cell trichome base, paracytic stomatal apparatus, sunken guard cells, subsidiary hardly staining cells and presence of oil cells. These characteristics are consistent with lindera sect. Daphnidium but are different from reported fossil and extant species of lindera. The cuticles of lindera are fragile and delicate with only three lindera fossils reported based on this tissue. In terms of paleobiogeography, the fossil record indicates that lindera is distributed in high- to mid-latitude regions of the Late Cretaceous to Paleocene northern hemisphere. Coincidentally, the records of lindera located on both sides of the Bering Land Bridge possibly support the hypothesis that ancient plants extended via transcontinental exchanges through the Bering Corridor. In the Eocene, ancient lindera spread to Europe through the Northern Degeer Route and the Southern Thulian Route. At the same time, ancient lindera spread into Central Asia. Climatic changes and tectonization since the Neogene prevented the propagation of lindera throughout Asia, North America and Europe, and hence the distribution areas have just regressed to the low-latitude regi

关键词： paleobotany fossil leaves cuticle biogeography Piacenzian Yunnan province

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Simultaneous optimization of conduction and polarization losses in CNT@NiCo compounds for superior electromagnetic wave absorption

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Journal of Materials Science & Technology 2023年第35期166卷 34-46页

作者： Yongpeng Zhao zhicheng lin Li Huang Zitong Meng Hao Yu Xin Kou Zhiyong Zou Peng Huang Yuchao Wang Ding Xi Pengfei Yin Gehong Su Zhiqiang Fan Zhiping Su Dongbei Xu Lujun Pan Lijia Xu College of Mechanical and Electrical Engineering Sichuan Agricultural UniversityYa’an 625000China School of Education Northwest Normal UniversityLanzhou 730000China College of Graduate Sichuan Agricultural UniversityChengdu 610000China College of Science Sichuan Agricultural UniversityYa’an 625000China College of Agriculture Sichuan Agricultural UniversityChengdu 610000China School of Physics Dalian University of TechnologyDalian 116024China

Polarization and conduction losses are the two most crucial dielectric loss mechanisms for carbon-based composites,but their synergistic effects in different frequency bands need to be further *** importantly,for polarization and conduction losses,the strengthening of one party always comes at the expense of the other,which inevitably limits the overall performance of the ***,we have developed a composite of CNT and NiCo hybrid particles via a scalable wet chemical process and an-nealing *** the adjustment of the precursor and the annealing temperature,the conduction and polarization losses of the composite are optimized *** optimized samples achieved the full absorption of the X and Ku bands under conditions of low filling rate and thin *** theoretical and experimental studies have revealed conduction loss and polarization loss laws at different frequency *** synergistic effect of conductive loss and magnetic loss in the low-frequency region ensures that the sample exhibits high microwave dissipation ***,in the medium and high-frequency part,the magnetic loss can be almost ignored and the timely replenishment of polar-ization loss keeps the wave-absorbing performance at a high *** excellent multi-band absorption characteristics make the as-obtained absorbers meet the needs of future applications.

关键词： CNT@NiCo compounds Conduction loss Polarization loss Electromagnetic wave absorption

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眼睛注视:独特的还是不独特的?

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心理科学进展 2005年第4期13卷 398-405页

作者：林志成北京大学心理学系北京100871

眼睛注视作为面孔信息的一个重要成分,越来越多的研究表明其具有特殊的心理学性质。文章从眼睛注视的特殊性出发,综述了眼睛的特殊形态、心理学功能与面孔识别在机制上的独立性,并重点阐述了其在反射性注意中的行为、电生理和脑成像研究... 详细信息

眼睛注视作为面孔信息的一个重要成分,越来越多的研究表明其具有特殊的心理学性质。文章从眼睛注视的特殊性出发,综述了眼睛的特殊形态、心理学功能与面孔识别在机制上的独立性,并重点阐述了其在反射性注意中的行为、电生理和脑成像研究,最后探讨了眼睛注视在心理理论、情绪及自我方面的研究。

关键词：眼睛注视社会认知社会性注意空间注意

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联合注意:早期发展的里程碑

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心理科学 2007年第5期30卷 1155-1157页

作者：林志成北京大学心理学系北京100871

联合注意作为早期的社会认知能力,对语言、社会认知等能力的发展有很大的影响。文章综述了联合注意出现的先兆、联合注意的行为、联合注意的形式与功能,并阐述了其在发展中的重要作用。最后文章讨论了当前研究中存在的问题并指出联合注... 详细信息

联合注意作为早期的社会认知能力,对语言、社会认知等能力的发展有很大的影响。文章综述了联合注意出现的先兆、联合注意的行为、联合注意的形式与功能,并阐述了其在发展中的重要作用。最后文章讨论了当前研究中存在的问题并指出联合注意新的研究方向。

关键词：联合注意心理理论自闭症语言发展社会性发展

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华人华侨与近代厦门体育的发展

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成都体育学院学报 2019年第4期45卷 60-64页

作者：毕金泽林致诚厦门大学体育教学部

梳理了近代从厦门出海的华人华侨在引进西方现代体育和推动近代厦门体育事业整体发展方面的实践和贡献。认为:近代体育教育在厦门的普及,促成了近代厦门健儿参与国际赛事的热情,构建了近代国家体育形象;华人华侨建立体育组织、资助并参... 详细信息

梳理了近代从厦门出海的华人华侨在引进西方现代体育和推动近代厦门体育事业整体发展方面的实践和贡献。认为:近代体育教育在厦门的普及,促成了近代厦门健儿参与国际赛事的热情,构建了近代国家体育形象;华人华侨建立体育组织、资助并参与体育赛事,也是近代厦门对外体育交流的重要平台,并以此为媒介促进两岸交流合作做出了贡献。

关键词：厦门华人华侨西方现代体育中华传统体育

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从“普适”到“差异”——对农民工体育参与缺失的救治路径研究

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体育与科学 2011年第4期32卷 39-42页

作者：何元春林致诚厦门大学体育教学部

研究表明:当前,我国庞大的农民工群体就是差异公民的典型代表。农民工体育参与存在经济资本、余暇时间的严重不足;存在社会歧视和农民工体育权益屡遭侵害,等诸多问题。为此,以差异公民理论为研究视角,本文就农民工体育参与缺失的制约因... 详细信息

研究表明:当前,我国庞大的农民工群体就是差异公民的典型代表。农民工体育参与存在经济资本、余暇时间的严重不足;存在社会歧视和农民工体育权益屡遭侵害,等诸多问题。为此,以差异公民理论为研究视角,本文就农民工体育参与缺失的制约因素及发展对策也进行了探讨和研究。最后提出:借鉴成功经验,赋予农民工群体以特殊的群体代表权;代农民工立言,建构农民工体育需求的利益表达机制;重文化差异,提升农民工群体自我认同感和城市归宿感等相关对策和重要举措。

关键词：农民工体育参与差异公民

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可能最大降水估算研究综述

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水利学报 2018年第1期49卷 92-102,114页

作者：林炳章兰平张叶晖林智琛陈晓旸南京信息工程大学水文气象学院江苏南京210044 南京信息工程大学大气科学学院江苏南京210044

可能最大降水PMP用于推求重要水利水电工程、核电工程和滨海大城市防洪的可能最大洪水。80多年来,国内外已经对可能最大降水估算开展了大量深入的研究。本文比较系统地从统计估算法、当地暴雨放大法、暴雨移置法、概化估算法、暴雨模式... 详细信息

可能最大降水PMP用于推求重要水利水电工程、核电工程和滨海大城市防洪的可能最大洪水。80多年来,国内外已经对可能最大降水估算开展了大量深入的研究。本文比较系统地从统计估算法、当地暴雨放大法、暴雨移置法、概化估算法、暴雨模式法、数值模拟法和多重分形法等方面综述PMP估算方法研究应用现状。对PMP估算研究5个方面的前沿与热点问题:山区暴雨移置、短历时PMP估算、PMP估算的不确定性、气候变化对PMP估算的影响和PMP的概率等进行了阐述。最后展望了PMP估算未来的发展趋势和研究方向。

关键词：可能最大降水水文气象途径数值模拟短历时不确定性气候变化

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