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Will partial splenic embolization followed by splenectomy increase intraoperative bleeding?

World Journal of Gastrointestinal Surgery 2024年第2期16卷 318-330页

作者： Long Huang Qing-lin Li Qing-sheng Yu Hui Peng Zhou Zhen Yi Shen Qi Zhang Department of No.1 Surgery The First Hospital Affiliated to Anhui University of Traditional Chinese MedicineHefei 230031Anhui ProvinceChina Anhui University of Traditional Chinese Medicine Anhui University of Traditional Chinese MedicineHefei 230038Anhui ProvinceChina Department of Surgery The Second Hospital Affiliated to Anhui University of Traditional Chinese MedicineHefei 230061Anhui ProvinceChina

BACKGROUND Partial splenic embolization(PSE)has been suggested as an alternative to splenectomy in the treatment of ***,some patients may experience recurrence of hypersplenism after PSE and require ***,there is a lack of evidence-based medical support regarding whether preoperative PSE followed by splenectomy can reduce the incidence of *** To investigate the safety and therapeutic efficacy of preoperative PSE followed by splenectomy in patients with cirrhosis and *** Between January 2010 and December 2021,321 consecutive patients with cirrhosis and hypersplenism underwent splenectomy at our *** on whether PSE was performed prior to splenectomy,the patients were divided into two groups:PSE group(n=40)and non-PSE group(n=281).Patient characteristics,postoperative complications,and follow-up data were compared between *** score matching(PSM)was conducted,and univariable and multivariable analyses were used to establish a nomogram predictive model for intraoperative bleeding(IB).The receiver operating characteristic curve,Hosmer-Lemeshow goodness-of-fit test,and decision curve analysis(DCA)were employed to evaluate the differentiation,calibration,and clinical performance of the *** After PSM,the non-PSE group showed significant reductions in hospital stay,intraoperative blood loss,and operation time(all P=0.00).Multivariate analysis revealed that spleen length,portal vein diameter,splenic vein diameter,and history of PSE were independent predictive factors for IB.A nomogram predictive model of IB was constructed,and DCA demonstrated the clinical utility of this *** groups exhibited similar results in terms of overall survival during the follow-up *** Preoperative PSE followed by splenectomy may increase the incidence of IB and a nomogram-based prediction model can predict the occurrence of IB.

关键词： Partial splenic embolization Splenectomy Hypertension,Portal Liver Cirrhosis Intraoperative bleeding

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Zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy

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Rare Metals 2024年第10期43卷 5152-5163页

作者： Dong-Wei Ma Jing-sheng Lu Xiang-Xin Cao Yan-Wei Cheng Gang Wang Zi-Qian Zhang Bo-Cheng Chen Ning lin Qing Chen College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine Center of Engineering and Technology

The rational design of a specific co-drug delivery platform that can address the unavoidable resistance, toxic side effects and low targeting efficiency of traditional cancer treatments is of great ***, Zn-based MOF-zeolitic imidazole framework-90(ZIF-90) was selected as the drug delivery carrier, with the cancer therapeutic drug mercaptopurine(6-MP) and glucose oxidase(GOD) as the drug models, hyaluronic acid(HA) was used for protection and targeted delivery, which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA). This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome. Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity, which provides new possibilities for the development of more precise and effective treatment strategies.

关键词： Cancer treatment Combination therapy Drug delivery Metal-organic framework Reduced toxicity

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4种中药注射剂皮肤过敏试验方法与意义的探讨

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中国中药杂志 2007年第24期32卷 2649-2652页

作者：翁维良林洪生高蕊陈长怀中国中医科学院西苑医院北京100091 中国中医科学院广安门医院北京100053

黄芪多糖粉针剂皮下法皮肤过敏试验阳性率12．3％，清开灵粉针剂3．0％，清开灵注射液7．6％，双黄连注射液6．3％。青霉素过敏反应率为0．7％～10％。不同剂型（粉针与液剂），不同浓度等均可能会影响皮试阳性率。皮试阳性不用药。皮... 详细信息

黄芪多糖粉针剂皮下法皮肤过敏试验阳性率12．3％，清开灵粉针剂3．0％，清开灵注射液7．6％，双黄连注射液6．3％。青霉素过敏反应率为0．7％～10％。不同剂型（粉针与液剂），不同浓度等均可能会影响皮试阳性率。皮试阳性不用药。皮试阴性用药，用药后仍有过敏反应发生。黄芪多糖粉针剂皮试阴性，用药后过敏反应发生率为2．1％。清开灵为0．4％（1／224），双黄连注射液为0．9％～2．6％。双黄连注射液在人群中的致敏率为8．6％（31／360包括皮试阳性数加过敏反应数）。清开灵粉针剂组致敏率为4．5％（6／132），清开灵注射液组致敏率9．1％（12／132）。黄芪多糖粉针剂组致敏率15．4％（62／402）。合计致敏率10．8％（111／1026）。青霉素皮下法试验阳性主要表现以皮丘为主，伴有周围红晕，而中药注射液皮肤以红晕为主，皮丘多不明显。皮试对减少黄芪多糖粉针剂、清开灵粉针剂、双黄连注射液用药后过敏反应有一定意义。可作为临床减少不良反应的措施之一。

关键词：中药注射剂黄芪多糖清开灵双黄连过敏反应皮内试验

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Single crystal growth and transport properties of narrow-bandgap semiconductor RhP_(2)

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Chinese Physics B 2024年第8期33卷 545-549页

作者：吴德胜郑萍雒建林 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China Quantum Science Center of Guangdong–hong Kong–Macao Greater Bay Area(Guangdong) Shenzhen 518045China

We report the growth of high-quality single crystals of RhP_(2),and systematically study its structure and physical properties by transport,magnetism,and heat capacity ***-crystal x-ray diffraction reveals that RhP_(2) adopts a monoclinic structure with the cell parameters a=5.7347(10)A,b=5.7804(11)A,and c=5.8222(11)A,space group P2_(1)/c(No.14).The electrical resistivityρ(T)measurements indicate that RhP_(2) exhibits narrow-bandgap behavior with the activation energies of 223.1 meV and 27.4 meV for two distinct regions,*** temperaturedependent Hall effect measurements show electron domain transport behavior with a low charge carrier *** find that RhP_(2) has a high mobilityμ_(e)~210 cm^(2)·V^(-1)·s^(-1)with carrier concentrations n_(e)~3.3×10^(18)cm^(3) at 300 K with a narrow-bandgap *** high mobilityμ_(e) reaches the maximum of approximately 340 cm^(2)·V^(-1)·s^(-1)with carrier concentrations n_^(e)~2×10^(18)cm^(-3)at 100 *** magnetic phase transitions are observed from the susceptibilityχ(T)and specific heat C_(p)(T)measurements of RhP_(2).Our results not only provide effective potential as a material platform for studying exotic physical properties and electron band structures but also motivate further exploration of their potential photovoltaic and optoelectronic applications.

关键词： single crystal growth narrow band system electrical transport high mobilities

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Analytical solutions to the precession relaxation of magnetization with uniaxial anisotropy

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Chinese Physics B 2024年第4期33卷 656-660页

作者：张泽南贾镇林薛德胜 Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000China

Based on the Landau-Lifshitz-Gilbert(LLG)equation,the precession relaxation of magnetization is studied when the external field H is parallel to the uniaxial anisotropic field H_(k).The evolution of three-component magnetization is solved analytically under the condition of H=nH_(k)(n=3,1 and 0).It is found that with an increase of H or a decrease of the initial polar angle of magnetization,the relaxation time decreases and the angular frequency of magnetization *** comparison,the analytical solution for H_(k)=0 is also *** the magnetization becomes stable,the angular frequency is proportional to the total effective field acting on the *** analytical solutions are not only conducive to the understanding of the precession relaxation of magnetization,but also can be used as a standard model to test the numerical calculation of LLG equation.

关键词： precession relaxation Landau-Lifshitz-Gilbert(LLG)equation uniaxial anisotropy analytical solutions

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基于节点聚类的可伸缩多应用无线传感器网络模拟

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通信学报 2008年第11期29卷 213-219页

作者：李文军林宏生周晓聪郑尧展中山大学信息科学与技术学院广东广州510275

提出一种基于节点聚类的无线传感器网络模拟方法,部署同类应用的节点在模拟器中采用单一实体建模,通过多个实体之间的通信实现不同节点的交互,并利用实体之间的同步驱动模拟事件的顺序进行。基于节点聚类方法,在主流模拟工具TOSSIM的基... 详细信息

提出一种基于节点聚类的无线传感器网络模拟方法,部署同类应用的节点在模拟器中采用单一实体建模,通过多个实体之间的通信实现不同节点的交互,并利用实体之间的同步驱动模拟事件的顺序进行。基于节点聚类方法,在主流模拟工具TOSSIM的基础上设计并实现了一个无线传感器网络模拟器ETMA;实验结果表明,基于节点聚类的模拟方法不仅可支持多应用无线传感器网络的模拟,同时还具有良好的可伸缩性。

关键词：无线传感器网络节点聚类可伸缩性多应用模拟

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Pleural empyema with endobronchial mass due to Rhodococcus equi infection after renal transplantation: A case report and review of literature

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World Journal of Clinical Cases 2024年第1期12卷 224-231页

作者： Guo-Fu Liang sheng Chao Zhou Sun Ke-Jing Zhu Qian Chen Lei Jia Yu-lin Niu Department of Organ Transplantation School of Clinical MedicineGuizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Organ Transplantation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Kidney transplantation is the best option for patients with end-stage renal ***,the need for lifelong immunosuppression results in renal transplant recipients being susceptible to various *** equi(***)is a rare opportunistic pathogen in humans,and there are limited reports of infection with *** in post-renal transplant recipients and no uniform standard of *** article reports on the diagnosis and treatment of a renal transplant recipient infected with *** 21 mo postoperatively and summarizes the charac-teristics of infection with *** after renal transplantation,along with a detailed review of the ***,we present the case of a 25-year-old man who was infected with *** 21 mo after renal *** the clinical features at the time of presentation were not specific,chest computed tomography(CT)showed a large volume of pus in the right thoracic cavity and right middle lung atelectasis,and fiberoptic bronchoscopy showed an endobronchial mass in the right middle and lower lobe *** culture and metagenomic next-generation sequen-cing sequencing of the pus were suggestive of *** *** immunosup-pressive drugs were immediately suspended and intravenous vancomycin and azithromycin were administered,along with adequate drainage of the *** endobronchial mass was then *** the patient’s clinical symptoms and chest CT presentation resolved,he was switched to intravenous ciprofloxacin and azithromycin,followed by oral ciprofloxacin and *** patient was re-hospitalized 2 wk after discharge for recurrence of *** *** recovered after another round of adequate abscess drainage and intravenous ciprofloxacin and *** Infection with *** in renal transplant recipients is rare and complex,and the clinical presentation lacks *** antibiotic therapy is required,and adequate abscess drainage and s

关键词： Kidney transplantation Rhodococcus equi Pleural empyema Pulmonary atelectasis Immunosuppression Case report

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癌症相关性乏力的临床干预及其机制概述

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中华中医药杂志 2014年第11期29卷 3484-3487页

作者：张玉人林洪生中国中医科学院广安门医院北京100053 北京中医药大学北京100029

癌症相关性乏力是癌症患者最常见、最痛苦的临床表现之一,发生机制尚不明确,因其发生率高,临床中应针对癌症患者对乏力实施广泛筛查、评估并积极干预。在治疗方面,中、重度乏力的有效干预措施证据尚不充分,中医药扶正培本法具有相对优势... 详细信息

癌症相关性乏力是癌症患者最常见、最痛苦的临床表现之一,发生机制尚不明确,因其发生率高,临床中应针对癌症患者对乏力实施广泛筛查、评估并积极干预。在治疗方面,中、重度乏力的有效干预措施证据尚不充分,中医药扶正培本法具有相对优势,可能通过维护和提高患者免疫功能而实现对乏力症状的缓解,使生活质量得以改善,具有实际临床意义。

关键词：癌症相关性乏力中医药免疫功能扶正培本机制综述

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Changes in postoperative depression and anxiety and their relationship with recovery from femoral head necrosis:A longitudinal study

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World Journal of Psychiatry 2024年第10期14卷 1506-1512页

作者： Guo-Zheng Fang Jie lin Lie-Hu Cao Tong-sheng Liu Yu-hong Ma Lu Yang Department of Orthopedics Shanghai Baoshan Luodian HospitalShanghai 201908China Department of Orthopedics Shanghai Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China

BACKGROUND Femoral head necrosis(FHN)can significantly affect patients'psychological well-being and functional ***,the long-term relationship between postoperative depression,anxiety,and functional recovery in patients with FHN remains *** To investigate the dynamic changes in postoperative depression and anxiety and their relationship with functional recovery in patients with FHN for 3 *** Ninety-three patients with FHN who underwent surgical treatment in March 2020 to 2023 were enrolled in this longitudinal *** and anxiety status were assessed using the hospital anxiety and depression scale(HADS)at baseline,6 months,1,2,and 3 years *** recovery was evaluated using the Harris hip score(HHS).The dynamic changes in HADS and HHS were analyzed using repeated measures ANOVA;the relationship between depre-ssion/anxiety status and functional recovery was examined using Pearson’s correlation *** The mean HADS-depression(HADS-D)and HADS-anxiety(HADS-A)scores significantly improved over time(Pline to 10.8%and 12.9%,respectively,at 3 years *** mean HHS increased sig-nificantly from 52.3±10.5 at baseline to 88.1±7.2 at 3 years postoperatively(P<0.001).Significant negative correl-ations were found between HADS-D/HADS-A scores and HHS at all time points(P<0.05).CONCLUSION The severity of depression and anxiety negatively correlated with functional recovery,highlighting the importance of psychological interventions in the management of patients with FHN.

关键词： Femoral head necrosis Postoperative depression Postoperative anxiety Functional recovery Longitudinal study Psychological intervention

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不同功率微波烹调对马齿苋营养品质的影响

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食品科技 2016年第7期41卷 97-100页

作者：陈蔚辉林洪升韩山师范学院旅游管理与烹饪学院潮州521041 韩山师范学院生命科学与食品科技学院潮州521041

采用微波炉对马齿苋进行烹调处理,研究不同功率微波处理后马齿苋营养成分的变化。结果表明:不同功率微波烹调均使马齿苋叶片变软,颜色变暗;中火微波后马齿苋菜品口感最好。不同功率微波烹调均使马齿苋中叶绿素、Vc、蛋白质、总糖、水分... 详细信息

采用微波炉对马齿苋进行烹调处理,研究不同功率微波处理后马齿苋营养成分的变化。结果表明:不同功率微波烹调均使马齿苋叶片变软,颜色变暗;中火微波后马齿苋菜品口感最好。不同功率微波烹调均使马齿苋中叶绿素、Vc、蛋白质、总糖、水分含量下降,但中火微波(480 W)下降幅度最小。从保存菜品营养成分考虑,使用微波炉烹调马齿苋的最佳微波火力为中火。

关键词：马齿苋微波烹调营养成分微波火力

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