检索结果-南通市图书馆

Oncology Research 2024年第4期32卷 643-658页

作者： LEI LIU NA GUO XIANGLING LI QIAN XU RUILONG HE limin cheng CHUNYAN DANG XINYU BAI YIYING BAI XIN WANG QIANHUI CHEN LI ZHANG Department of Immunology Chengde Medical UniversityChengde067000China Department of Pathology Chengde Medical UniversityChengde067000China Department of Oncology The Affiliated Hospital of Chengde Medical UniversityChengde067000China Department of Hepatobiliary Surgery The Affiliated Hospital of Chengde Medical UniversityChengde067000China

The platinum-based chemotherapy is one of the most frequently used treatment protocols for lung adenocarcinoma(LUAD),and chemoresistance,however,usually results in treatment failure and limits its application in the *** has been shown that microRNAs(miRNAs)play a significant role in tumor *** this study,miR-125b was identified as a specific cisplatin(DDP)-resistant gene in LUAD,as indicated by the bioinformatics analysis and the real-time quantitative PCR *** decreased serum level of miR-125b in LUAD patients was correlated with the poor treatment response rate and short survival ***-125b decreased the A549/DDP proliferation,and the multiple drug resistance-and autophagy-related protein expression levels,which were all reversed by the inhibition of *** addition,xenografts of human tumors in nude mice were suppressed by miR-125b,demonstrating that through autophagy regulation,miR-125b could reverse the DDP resistance in LUAD cells,both in vitro and in *** mechanistic studies indicated that miR-125b directly repressed the expression levels of RORA and its downstream BNIP3L,which in turn inhibited autophagy and reversed *** on these findings,miR-125b in combination with DDP might be an effective treatment option to overcome DDP resistance in LUAD.

关键词： Lung adenocarcinoma miRNAs Cisplatin Resistance Autophagy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

童年期创伤对精神障碍影响的研究进展

系统医学 2024年第6期9卷 195-198页

作者：程利民铜陵市第三人民医院精神科安徽铜陵244000

现如今,童年期创伤是一个普遍又严重的社会问题,主要表现为情感的忽视和虐待,对今后人格、情感和认知功能等都存在很大的影响,更容易引起一系列精神障碍。童年期经历过的创伤在大脑发育的关键时期会引起大脑的个别脑区结构和功能产生改... 详细信息

现如今,童年期创伤是一个普遍又严重的社会问题,主要表现为情感的忽视和虐待,对今后人格、情感和认知功能等都存在很大的影响,更容易引起一系列精神障碍。童年期经历过的创伤在大脑发育的关键时期会引起大脑的个别脑区结构和功能产生改变,并与其后期精神障碍的发生存在密切关联。本综述通过文献检索回顾性分析童年期创伤对精神障碍的影响,旨在为有童年创伤经历者在预防和干预精神障碍问题上提供科学依据,进而为儿童心理健康的发展提供有力支持。

关键词：童年创伤精神障碍抑郁症海马

维普期刊数据库博看期刊

中医药调控PI3K/AKT信号通路干预溃疡性结肠炎研究进展

在线全文

学校读者我要写书评

暂无评论

河南中医 2024年第3期44卷 453-461页

作者：王浩程丽敏黑龙江中医药大学黑龙江哈尔滨150040

通过干预磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)/蛋白激酶B(protein kinase B,AKT)信号通路中的相关因子而发挥治疗作用的中医药疗法可分为清热解毒燥湿、活血化瘀止血、健脾温肾祛湿和攻补兼施等,能有效遏制UC的发生发... 详细信息

通过干预磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)/蛋白激酶B(protein kinase B,AKT)信号通路中的相关因子而发挥治疗作用的中医药疗法可分为清热解毒燥湿、活血化瘀止血、健脾温肾祛湿和攻补兼施等,能有效遏制UC的发生发展,其作用机制为:(1)通过抑制上游信号因子表皮生长因子受体,进而抑制PI3K/AKT通路,减少肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)和白细胞介素-6(interleukin-6,IL-6)在内的促炎细胞因子的表达,降低结肠炎症反应,减轻炎症所引起的结肠组织损伤;(2)直接作用于PI3K-AKT通路,进而抑制核转录因子-κB(nuclear transcription factor-κB,NF-κB)的表达,减少细胞凋亡和促炎因子的表达,缓解肠黏膜组织损伤,修复肠黏膜屏障功能的完整性;(3)通过PI3K/AKT途径下调辅助性T细胞17(T helper cell 17,Th17)和辅助性T细胞3(T helper cell 3,Th3)的分化,调节免疫反应及细胞凋亡,改善肠黏膜屏障,缓解UC结肠炎症反应。中医药具有成分复杂,有效成分作用靶点多,治疗途径多样等特点,但其具体分子生物学作用机制尚未完全明确,今后,需对分子生物学作用机制进行深入研究,为临床治疗溃疡性结肠炎等易反复发作的消化性疾病和新药的开发提供新策略。

关键词：溃疡性结肠炎磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT) 信号通路中医药

基于PSO-LSTM的短时交通流量预测网站设计

在线全文

学校读者我要写书评

暂无评论

廊坊师范学院学报（自然科学版） 2024年第1期24卷 29-32页

作者：王宁成利敏甄景涛段晓霞廊坊师范学院河北廊坊065000

短时交通流量预测是智能交通系统中的重要环节,选用在短时交通流量预测方面表现出色的LSTM神经网络,并利用PSO算法优化LSTM神经网络模型。实验结果表明,与传统LSTM模型相比,所构建的PSO-LSTM模型对未来5分钟和10分钟两种短时交通流量预... 详细信息

短时交通流量预测是智能交通系统中的重要环节,选用在短时交通流量预测方面表现出色的LSTM神经网络,并利用PSO算法优化LSTM神经网络模型。实验结果表明,与传统LSTM模型相比,所构建的PSO-LSTM模型对未来5分钟和10分钟两种短时交通流量预测,达到了更高的准确率。在此基础上,设计了一个交通流量预测网站更好地展示了预测结果,也方便用户随时查询。

关键词：智能交通系统短时交通流量预测 LSTM神经网络 PSO算法交通流量预测网站

A universal multifunctional dual cation doping strategy towards stabilized ultra-high nickel cobalt-free lithium layered oxide cathode

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第8期95卷 296-305,I0007页

作者： Yabin Shen Dongming Yin limin Wang Gang Huang Yong cheng Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450002HenanChina State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina

Ultra-high nickel cobalt-free lithium layered oxides are promising cathode material for lithium-ion batteries(LIBs)because of their relatively high capacity and low ***,the high nickel content would induce bulk structure degradation and interfacial environment deterioration,and the absence of Co element reduces the lithium diffusion kinetics,severely limiting the performance liberation of this kind of ***,a multifunctional Ti/Zr dual cation co-doping strategy has been employed to improve the lithium storage performance of LiNi_(0.9)Mn_(0.1)O_(2)(NM91)*** the one hand,the Ti/Zr co-doping weakens the Li^(+)/Ni^(2+)mixing through magnetic interactions due to the inexistence of unpaired electrons for Ti^(4+)and Zr^(4+),increasing the lithium diffusion rate and suppressing the harmful coexistence of H1 and H2 *** the other hand,they enhance the lattice oxygen stability because of the strong Ti-O and Zr-O bonds,inhibiting the undesired H3 phase transition and lattice oxygen loss,improving the bulk structure and cathode-electrolyte interface *** a result,the Ti/Zr co-doped NM91(NMTZ)exhibits a 91.2%capacity retention rate after 100 cycles,while that of NM91 is only82.9%.Also,the NMTZ displays better rate performance than NM91 with output capacities of 115 and93 mA h g^(-1)at a high current density of 5 C,***,the designed NMTZ could enable the full battery to deliver an energy density up to 263 W h kg^(-1),making the ultra-high nickel cobaltfree lithium layered oxide cathode closer to practical applications.

关键词： Lithium-ion battery Ultra-high nickel cobalt-free cathode Ti/Zr co-doping Li^(+)/Ni^(2+)mixing Lattice oxygen stability

CC类趋化因子22、叉头框蛋白P1在急性髓系白血病外周血中的表达及对预后的预测价值

在线全文

学校读者我要写书评

暂无评论

安徽医药 2024年第2期28卷 371-375页

作者：胡婕刘瑞菡王高翔熊婷黄欣程利民孝感市中心医院血液内科湖北孝感432099 孝感市中心医院检验科湖北孝感432099 华中科技大学同济医学院附属同济医院血液内科湖北武汉430030 咸宁市中心医院血液内科湖北咸宁437199

目的探讨急性髓系白血病(AML)病人外周血中CC类趋化因子22(CCL22)、叉头框蛋白P1(FOXP1)表达水平及其预后预测价值。方法选择2018年5月至2019年5月在孝感市中心医院、华中科技大学医学院附属同济医院及咸宁市中心医院确诊的68例AML病人... 详细信息

目的探讨急性髓系白血病(AML)病人外周血中CC类趋化因子22(CCL22)、叉头框蛋白P1(FOXP1)表达水平及其预后预测价值。方法选择2018年5月至2019年5月在孝感市中心医院、华中科技大学医学院附属同济医院及咸宁市中心医院确诊的68例AML病人设为观察组,另取同期健康体检者68例作为对照组,采用酶联免疫法测定外周血CCL22,FOXP1表达水平,分析其与临床特征的关系;采用Pearson法分析AML病人外周血中CCL22,FOXP1表达的相关性;采用Kaplan-Meier生存分析法分析CCL22,FOXP1表达与总体生存时间(OS)的关系;采用Cox比例风险回归模型分析病人预后死亡的影响因素。结果与对照组相比,观察组CCL22[(600.27±62.89)ng/L比(756.84±100.86)ng/L],FOXP1[(56.02±13.68)ng/L比(103.06±22.16)ng/L]表达均明显升高(t=10.86,14.90,均P0.05),与脾肿大、白细胞计数(WBC)有关(χ^(2)=5.90~8.59,均P<0.05);Pearson法分析结果显示,AML病人外周血中CCL22与FOXP1表达呈正相关(r=0.27,P<0.05);Kaplan-Meier法分析结果显示,AML病人外周血CCL22,FOXP1高表达组3年生存率均低于低表达组(47.06%比70.59%,44.12%比73.53%)(χ^(2)=6.50,P<0.05);多因素logistic回归分析结果显示,CCL22,FOXP1是影响AML病人预后的独立危险因素(P<0.05)。结论CCL22,FOXP1在AML病人外周血中呈高表达,CCL22,FOXP1高表达组病人3年生存率均低于低表达组,二者有望成为AML病人预后评估的分子标志物。

关键词：白血病髓样急性 CC类趋化因子22 叉头框蛋白P1 预后价值

Unlocking the potential of ultra-thin two-dimensional antimony materials:Selective growth and carbon coating for efficient potassium-ion storage

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第5期92卷 440-449页

作者： Dongyu Zhang Zhaomin Wang Yabin Shen Yeguo Zou Chunli Wang limin Wang Yong cheng State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences(CAS)Changchun 130022JilinChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026AnhuiChina

Antimony-based anodes have attracted wide attention in potassium-ion batteries due to their high theoretical specific capacities(∼660 mA h g^(-1))and suitable voltage ***,severe capacity fading caused by huge volume change and limited ion transportation hinders their practical ***,strategies for controlling the morphologies of Sb-based materials to improve the electrochemical performances have been *** these,the two-dimensional Sb(2D-Sb)materials present excellent properties due to shorted ion immigration paths and enhanced ion ***,the synthetic methods are usually tedious,and even the mechanism of these strategies remains elusive,especially how to obtain large-scale 2D-Sb ***,a novel strategy to synthesize 2D-Sb material using a straightforward solvothermal method without the requirement of a complex nanostructure design is *** method leverages the selective adsorption of aldehyde groups in furfural to induce crystal growth,while concurrently reducing and coating a nitrogen-doped carbon *** to the reported methods,it is simpler,more efficient,and conducive to the production of composite nanosheets with uniform thickness(3–4 nm).The 2D-Sb@NC nanosheet anode delivers an extremely high capacity of 504.5 mA h g^(-1) at current densities of 100 mA g^(-1) and remains stable for more than 200 *** characterizations and molecular dynamic simulations,how potassium storage kinetics between 2D Sb-based materials and bulk Sb-based materials are explored,and detailed explanations are *** findings offer novel insights into the development of durable 2D alloy-based anodes for next-generation potassium-ion batteries.

关键词： Antimony Two-dimensional materials Selective growth Nitrogen-doped carbon Potassium-ion batteries

Observer-based adaptive control of uncertain time-delay switched systems with stuck actuator faults

在线全文

学校读者我要写书评

暂无评论

控制理论与应用（英文版） 2009年第2期7卷 219-223页

作者： limin WANG cheng SHAO Institute of Advanced Control Technology Dalian University of Technology Dalian Liaoning 116024 China

This paper concerns the observer-based adaptive control problem of uncertain time-delay switched systems with stuck actuator faults. Under the case where the original controller cannot stabilize the faulty system, multiple adaptive controllers are designed and a suitable switching logic is incorporated to ensure the closed-loop system stability and state tracking. New delay-independent sufficient conditions for asymptotic stability are obtained in terms of linear matrix inequalities based on piecewise Lyapunov stability theory. On the other hand, adaptive laws for on-line updating of some of the controller parameters are also designed to compensate the effect of stuck failures. Finally, simulation results for reference [1] model show that the design is feasible and efficient.

关键词： Observer-based adaptive control Tuck actuator faults Delay-independent Uncertain time-delay switched systems

Tuning microstructures of Mg-Ce-Ni hydrogen storage alloys via Cu and carbon nanotube additions

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 7203-7211页

作者： Linlin Zhang Liang Xiong Bingyang Gao Qingyun Shi Ying Wang Zhiya Han Zhenhua Zhang Chunli Wang limin Wang Yong cheng State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Purification Equipment Research Institute of CSIC Handan 056002China

Mg-based alloys are regarded as highly promising materials for hydrogen *** significant improvements of the properties for Mg-based alloys,challenges such as slow hydrogen absorption/desorption kinetics and high thermodynamic stability continue to limit their practical *** this study,to assess hydrogen storage alloys with enhanced properties,incorporating both internal microstructure modulation through the preparation of amorphous/nanocrystalline structures and surface property enhancement with the addition of Cu and carbon nanotubes(CNTs),the kinetic properties of activation and hydrogenation,thermodynamic properties,and dehydrogenation kinetics are *** results reveal a complementary interaction between the added Cu and CNTs,contributing to the superior hydrogen storage performance observed in sample 7A-2Cu-1CNTs with an amorphous/nanocrystalline structure compared to the other experimental ***,the samples are fully activated after the initial hydrogen absorption and desorption cycle,demonstrating outstanding hydrogenation kinetics under both high and low temperature experimental *** noteworthy is that the hydrogen absorption exceeds 1.8 wt.%within one hour at 333 ***,the activation energy for dehydrogenation is decreased to 64.71 kJ·mol^(–1).This research may offer novel insights for the design of new-type Mg-based hydrogen storage alloys,which possess milder conditions for hydrogen absorption and desorption.

关键词： Mg-Ni-Ce alloy hydrogen storage amorphous/nanocrystalline structure kinetics Cu and carbon nanotubes(CNTs)codoping

Multidimensional regulation of Ti-Zr-Cr-Mn hydrogen storage alloys via Y partial substitution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第5期17卷 4211-4220页

作者： Haixiang Xiu Wanqiang Liu Dongming Yin Nan Ding Wenfeng Qiao Shaolei Zhao Long Liang Cong Liu Shaohua Wang Qingshuang Wang Bingbing Chen limin Wang Yong cheng School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences(CAS)Changchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Energy Science and Engineering Nanjing Tech UniversityNanjing 211816China National Engineering Research Center of Nonferrous Metals Materials and Products for New Energy GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China College of Life Science and Technology Changchun University of Science and TechnologyChangchun 130022China

High density and safe storage of hydrogen are the preconditions for the large-scale application of hydrogen ***,the hydrogen storage properties of Ti_(0.6)Zr_(0.4)Cr_(0.6)Mn_(1.4) alloys are systematically studied by introducing Y element instead of Ti element through vacuum arc *** the partial substitution of Y,a second phase of rare earth oxide is added in addition to the main suction hydrogen phase,C14 Laves *** to the unique properties of rare earth elements,the partial substitution of Y can not only improve the activation properties and plateau pressure of the alloys,but also increase the effective hydrogen storage capacity of the *** comprehensive properties of hydrogen storage alloys are improved by multidimensional regulation of rare earth *** them,Ti_(0.552)Y_(0.048)Zr_(0.4)Cr_(0.6)Mn_(1.4) has the best comprehensive *** alloy can absorb hydrogen without activation at room temperature and 5 MPa,with a maximum hydrogen storage capacity of 1.98 wt.%.At the same time,it reduces the stability of the hydride and the enthalpy change value,making it easier to release *** theoretical analysis and first-principle simulation,the results show that the substitution of Y element reduces the migration energy barrier of hydrogen and the structural stability of the system,which is conducive to hydrogen *** alloy has superior durability compared to the original alloy,and the capacity retention rate was 96.79%after 100 hydrogen absorption/desorption cycles.

关键词： AB_(2)-type hydrogen storage alloy rare earth element first-principles simulation multidimensional regulation