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Voxel-based statistical analysis of regional cerebral glucose metabolism in children with attention-deficit hyperactivity disorder

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Neural Regeneration Research 2011年第36期6卷 2850-2855页

作者： Ji-hoon Kim Young-In Chung jung Sub Lee In-Joo Kim Yong-Ki Kim Seong-Jang Kim Division of Child-Adolescent Psychiatry Department of Psychiatry Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Medical Research Institute Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Psychiatry Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Orthopedic Surgery Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Nuclear Medicine Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea

The technique of region of interest-based positron emission tomography is limited by its poor reli-ability and relatively few examined brain regions. In the present study, we compared brain metabo-lism assessed using fluorine-18-fluorodeoxyglucose positron emission tomography between 14 at-tention-deficit hyperactivity disorder （ADHD） patients and 15 normal controls with scoliosis at resting state by statistical parametric mapping. Glucose metabolism was decreased in the left parahippo-campal gyrus, left hippocampus, left anterior cingulate gyrus, right anterior and posterior lobes of the cerebellum, left superior temporal gyrus, left insula, left medial and middle frontal gyri, right medial frontal gyrus, and left basal ganglia （putamen, amygdala, and caudate nucleus） in children with ADHD. These data suggest that children with ADHD exhibit hypometabolism in various brain regions compared to controls, indicating that ADHD symptoms are unlikely the result of abnormalities in specific areas.

关键词： attention-deficit hyperactivity disorder positron emission tomography statistical parametric mapping

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Is the AIM65 score useful in predicting outcomes in peptic ulcer bleeding?

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World Journal of Gastroenterology 2014年第7期20卷 1846-1851页

作者： Sung hoon jung jung Hwan Oh Hye Yeon Lee Joon Won Jeong Se Eun Go Chan Ran You Eun jung Jeon Sang Wook Choi Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 130-709South Korea

AIM:To evaluate the applicability of AIMS65 scores in predicting outcomes of peptic ulcer ***:This was a retrospective study in a single center between January 2006 and December *** enrolled 522 patients with upper gastrointestinal haemorrhage who visited the emergency *** patients were regarded as those who had rebleeding within 30 d from the first endoscopy as well as those who died within 30 d of visiting the Emergency room.A total of 149 patients with peptic ulcer bleeding were analysed,and the AIMS65 score was used to retrospectively predict the high-risk ***:A total of 149 patients with peptic ulcer bleeding were *** poor outcome group comprised 28 patients[male:23(82.1%)vs female:5(10.7%)]while the good outcome group included 121patients[male:93(76.9%)vs female:28(23.1%)].The mean age in each group was not significantly *** mean serum albumin levels in the poor outcome group were slightly lower than those in the good outcome group(P=0.072).For the prediction of poor outcome,the AIMS65 score had a sensitivity of35.5%(95%CI:27.0-44.8)and a specificity of 82.1%(95%CI:63.1-93.9)at a score of *** AIMS65 score was insufficient for predicting outcomes in peptic ulcer bleeding(area under curve=0.571;95%CI:0.49-0.65).CONCLUSION:The AIMS65 score may therefore not be suitable for predicting clinical outcomes in peptic ulcer *** albumin levels may be a risk factor associated with high mortality in peptic ulcer bleeding.

关键词： Gastrointestinal haemorrhage Peptic ulcer Mortality Morbidity Prognosis

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High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy

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World Journal of Gastroenterology 2007年第48期13卷 6492-6497页

作者： jung Sub lim Sang Bum Kim Ho-Yoon Bang Gi Jeong Cheon Jong-Inn Lee Department of Pediatrics Korea Cancer Center Hospital Department of Surgery Korea Cancer Center Hospital Department of Nuclear Medicine Korea Cancer Center Hospital

AIM： To evaluate the prevalence and predictive factors of osteoporosis in patients with gastric adenocarcinoma alter gastrectomy.METHODS： The study included 133 patients diagnosed with gastric adenocarcinoma but who did not undergo prior diagnostic work-up for osteoporosis. Bone mineral density （BMD） was measured by dual-energy X-ray absorptiometry （DXA） and vertebral deformity was assessed by plain X-rays. We evaluated the effects of age, sex, body mass index （BMI）, anemia, back pain, vertebral deformity, tumor staging, reconstruction type, and past medical history to determine predictive factors of osteoporosis in these patients.RESULTS： The prevalence of osteoporosis in the lumbar spine was 38.3% （male, 28.9%; female, 54.0%）, and 15.0% in the femoral neck （male, 10.8%; female, 22.0%）. The vertebral deformity rate was 46.6% （male, 43.4%; female, 52.0%）. Age, BMI and hemoglobin correlated with BMD （P 〈 0.01）. In males, anemia and age 〉 64 years were independent predictive factors of osteoporosis in multivariate analysis. In females, back pain was an independent factor for osteoporosis.CONCLUSION： The results of this study revealed that prevalence of osteoporosis and vertebral bone deformity rate were high in gastric cancer patients, regardless of post-gastrectomy duration and operation type. Early diagnosis and a proper management plan must be established in these patients.

关键词： Gastric adenocarcinoma Gastrectomy Bone mineral density Osteoporosis Vertebral deformity Anemia Back pain

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Evaluation of non-ampullary duodenal polyps: Comparison of non-neoplastic and neoplastic lesions

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World Journal of Gastroenterology 2010年第43期16卷 5474-5480页

作者： Sung hoon jung Woo Chul Chung Eun jung Kim Seol Hye Kim Chang Nyol Paik Bo In Lee Young Seok Cho Kang-Moon Lee Department of Internal Medicine College of Medicine The Catholic University of Korea

AIM: To evaluate duodenal polyps, divided into nonneoplastic and neoplastic lesions. In addition, the clinical characteristics of duodenal hyperplastic polyps are determined. METHODS: We analyzed medical records of 50 114 consecutive patients submitted to for first diagnostic esophago-gastroduodenoscopy between January 2004 and December 2009. We excluded lesions on the ampulla of Vater and submucosal tumors. We studied 510 cases that were diagnosed endoscopically with duodenal polyps and enrolled a total of 221 cases that had undergone tissue biopsy. We analyzed the differences between non-neoplastic and neoplastic lesions, and determined the clinical features of duodenal hyperplastic polyps. RESULTS: Non-neoplastic lesions were found in 196 patients and neoplastic lesions in 25 patients. On uni-variate analysis, there were significant differences in shape, location, and size. Polyps more than 10 mm in diameter or polyps in the second portion had independent risk factors for being neoplastic lesions, as identified by multivariate analysis. In 23 cases of hyperplastic polyps (79.3%), they were accompanied by gastroduodenal pathology, which was possibly associated with Helicobacter pylori . CONCLUSION: Polyps of more than 10 mm or polyps in the second portion of the duodenum should be evaluated by histological examination.

关键词： Duodenum Polyp Helicobacter pylori

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Transient involuntary movement disorder after spinal anesthesia: A case report

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World Journal of Clinical Cases 2021年第26期9卷 7917-7922页

作者： Giyoung Yun Eunsoo Kim Wangseok Do Young-hoon jung Hyun-Ju Lee Yesul Kim Department of Anesthesia and Pain Medicine Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Anesthesia and Pain Medicine Pusan National UniversitySchool of MedicineYangsan 50612South Korea

BACKGROUND Spinal anesthesia is commonly used for various *** many complications occur after induction of spinal anesthesia,involuntary movement is an extremely rare *** SUMMARY Herein,we report the case of a 54-year-old healthy male patient who experienced involuntary movements after intrathecal injection of local *** patient had undergone metal implant removal surgery in both the lower extremities;7 h after intrathecal hyperbaric bupivacaine administration,involuntary raising of the left leg began to occur every 2 *** the movement disorder appeared,the patient was conscious and *** other specific symptoms were noted in the physical examination conducted immediately after the involuntary leg raising started;moreover,the patient's motor and sensory assessments were *** symptom gradually *** hours after the symptom first occurred,its frequency decreased to approximately once every three *** days postoperatively,the symptoms had completely disappeared without *** Anesthesiologists should be aware that movement disorders can occur after spinal anesthesia and be able to identify the cause,such as electrolyte imbalance or epilepsy,since immediate action may be required for ***,it is crucial to know that involuntary movement that develop following spinal anesthesia is mostly self-limiting and may not require additional costly examinations.

关键词： Movement disorder Spinal anesthesia Bupivacaine Dexmedetomidine Case report

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Optic radiation injury in patients with aneurismal subarachnoid hemorrhage: a preliminary diffusion tensor imaging report

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Neural Regeneration Research 2018年第3期13卷 563-566页

作者： Sung Ho Jang Chul hoon Chang Young Jin jung Seong Ho Kim Jeong Pyo Seo Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Neurosurgery College of Medicine Yeungnam University

Visual field defect is one of the various clinical manifestations in patients with subarachnoid hemorrhage（SAH）. Little is known about the pathogenic mechanism of visual field defect in SAH. In the current study,we investigated the diffusion tensor imaging （DTI） finding of the optic radiation in patients with SAH followingrupture of a cerebral artery aneurysm. We recruited 21 patients with aneurismal SAH （12 males, 9 females, mean age, 52.67 years; range, 41–68 years） who showed no definite lesion along the visual ***-one age-and sex-matched normal control subjects were also recruited. DTI data were acquired at an average of 5.9 weeks （range： 3–12 weeks） after onset and reconstruction of the optic radiation was performed using DTI-Studio software. The fractional anisotropy value, apparent diffusion coefficient value,and fiber number of the optic radiation were measured. The fractional anisotropy value of the optic radiation was significantly decreased, and the apparent diffusion coefficient value was significantly increased, in patients with aneurismal SAH than in normal control subjects. However, there was no significant difference in the fiber number of the optic radiation between patients with aneurismal SAH and normal control subjects. The decrement of fractional anisotropy value and increment of apparent diffusion coefficient value of the optic radiation in patients with aneurismal SAH suggest optic radiation injury. Therefore, we recommend a thorough evaluation for optic radiation injury in patient with aneurismal SAH.

关键词： nerve regeneration diffusion tensor imaging optic radiation subarachnoid hemorrhage visual field defect neural regeneration

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Effect of the glyceryl monooleate-based lyotropic phases on skin permeation using in vitro diffusion and skin imaging

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Asian Journal of Pharmaceutical Sciences 2014年第6期9卷 324-329页

作者： Dae Gon lim Won-Wook Jeong Nam Ah Kim Jun Yeul lim Seol-hoon Lee Woo Sun Shim Nae-Gyu Kang Seong hoon Jeong College of Pharmacy Dongguk University-SeoulGoyangGyeonggi 410-820Republic of Korea LG Household&Health Care Daejeon 305-343Republic of Korea

Glyceryl monooleate(GMO)is a polar lipid that can exist in various liquid crystalline phases in the presence of different amounts of *** is regarded as a permeation enhancer due to its amphiphilic *** phases of GMO/solvent system containing sodium fluorescein were prepared to compare permeability using confocal laser scanning microscopy(CLSM).GMO was melted in a vial in a water bath heated to 45℃.Propylene glycol and hexanediol were homogeneously dissolved in the melted *** fluorescein in aqueous solution was diluted to various ratios and thoroughly mixed by an ultrasonic *** GMO/Solvent system with fluorescein was applied onto the epidermal side of excised pig skin and incubated *** was performed to observe how the GMO/solvent system in its different phases affect skin *** and lamellar phase formulations enhanced the fluorescein permeation through the stratum corneum.A solution system had the weakest permeability compared to the other two *** to the amphiphilic nature of GMO,cubic and lamellar phases might reduce the barrier function of stratum corneum which was observed by CLSM as fluorescein accumulated in the *** on the results,the glyceryl monooleate lyotropic mixtures could be applied to enhance skin permeation in various topical and transdermal formulations.

关键词： Confocal microscopy Imaging Glyceryl monooleate Skin permeation Cubic phase Lamellar phase

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Arthroscopic treatment of iliopsoas tendinitis after total hip arthroplasty with acetabular cup malposition: Two case reports

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World Journal of Clinical Cases 2020年第21期8卷 5326-5333页

作者： Heejae Won Kwang-Hwan Kim Jae-Wook jung Shin-Yoon Kim Seung-hoon Baek Department of Orthopedic Surgery School of MedicineKyungpook National UniversityKyungpook National University Hospital130 Dongdeok-roJung-GuDaegu 41944South Korea

BACKGROUND Optimal treatment for iliopsoas tendinitis after total hip arthroplasty(THA)with cup malposition,iliopsoas release alone or with cup revision,is controversial,particularly in young,active ***,arthroscopic iliopsoas tendon(IPT)release in these patients has been rarely described,and midterm effects of this procedure on THA longevity and groin pain recurrence remain *** performed arthroscopic IPT release after THA and report midterm outcomes in two young patients with acetabular cup *** SUMMARY In the two patients,groin pain started early after *** examination revealed nonspecific findings,and laboratory tests showed no evidence of *** and computed tomography showed reduced acetabular component anteversion angle and anterior cup prominence of more than 16 *** therapeutic diagnosis,ultrasonography-guided lidocaine with steroid was injected into the IPT *** both patients,groin pain improved initially but worsened after a few ***,the patients underwent arthroscopic IPT release under spinal *** revealed synovitis with fibrous tissues around the IPT and various lesions related to the implants after *** tenotomy and debridement with biopsy were performed;histopathologic studies showed chronic inflammation with synovial *** patients were encouraged to start walking immediately after surgery,and they returned to complete daily function early after *** experienced no recurrence of groin pain or any implant-related problems 5 years *** Arthroscopic IPT release for cup malposition produced excellent midterm outcomes without recurrence of groin pain and implant-related problems.

关键词： Iliopsoas tendinitis Total hip arthroplasty Cup malposition Arthroscopy Tenotomy Case report

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Dynamic Changes in Left and Right Cerebral Oxygen Saturation during Selective Cerebral Perfusion in Young Infants

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Congenital Heart Disease 2023年第6期18卷 639-647页

作者： Hwa-Young Jang Sang-Jun Beon Sung-hoon Kim In-Kyung Song Won-jung Shin Department of Anesthesiology and Pain Medicine Laboratory for Cardiovascular DynamicsAsan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Korea Department of Physician Education and Training Asan Medical CenterSeoul05505Korea

Objectives:We investigated whether the selective cerebral perfusion(SCP)technique causes differences in changes in cerebral perfusion between both hemispheres in young infants,using cerebral oxygen saturation(ScO2)as an ***,we determined the association between the discrepancy in ScO2 and cerebral perfu-sion pressure during ***:The difference in ScO2 between the left and right cerebral hemispheres(ΔScO2 Rt-Lt)was calculated during clamping of the innominate artery(IA)and during ***:In 25 infants(aged 2 to 78 days),the left and right ScO2 were well maintained(median 63.2%and 60.9%during IA clamping,respectively;64.0%and 65.6%during SCP,respectively).During IA clamping,right and left ScO2 decreased(med-ian-1.4%and-1.0%,respectively).During SCP,rightΔScO2 was higher compared to leftΔScO2(median 1.5%vs.0.6%;p<0.001).Eight patients had a higher rightΔScO2 than leftΔScO2 throughout *** had lowerΔScO2 Rt-Lt during IA clamping(median-3.2%vs.0.0%;p<0.001)and higherΔScO2 Rt-Lt during SCP than others(median 5.0%vs.-0.8%;p<0.001).During and after SCP,the correlation coefﬁcient between rightΔScO2 and change in the mean arterial pressure was higher in patients with a discrepancy than in others(r=0.731 vs.r=0.519;p<0.001).Conclusions:This study suggests that SCP permits adequate bilateral cerebral ***,the unilateral cerebral perfusion technique may cause a difference in cerebral perfusion between both hemispheres in young infants;this may depend on the perfusion pressure.

关键词： Cerebral circulation congenital heart defects monitoring near-infrared spectroscopy

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Occurrence of human leukocyte antigen B51-related ankylosing spondylitis in a family:Two case reports

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World Journal of Clinical Cases 2022年第3期10卷 992-999页

作者： Mie Jin lim Eul Noh Ro-Woon Lee Kyong-Hee jung Won Park Rheumatology/Internal Medicine Inha UniversityIncheon 22332South Korea Radiology Inha UniversityIncheon 22332South Korea

BACKGROUND Ankylosing spondylitis(AS)is strongly associated with the human leukocyte antigen(HLA)B27 *** regions where conventional polymerase chain reaction for HLA typing is available for antigens such as HLA B27 or HLA B51,it is common to perform the HLA B27 test for evaluation of *** HLA B27-associated clustered occurrences of AS have been reported in families,we report the first case series of HLA B51-related occurrences of AS in a *** SUMMARY A father and his daughters were diagnosed with AS and did not have the HLA B27 *** they were positive for HLA B51,they exhibited no signs of Behçet’s disease(BD).Of the five daughters,one had AS,and three,including the daughter with AS,were positive for HLA *** two daughters with the HLA B51 haplotype(excluding the daughter with AS)exhibited bilateral grade 1 sacroiliitis,whereas the daughters without the HLA B51 haplotype did not have ***,this Korean family exhibited a strong association with the HLA B51 haplotype and clinical sacroiliitis,irrespective of the symptoms of *** It is advisable to check for HLA B51 positivity in patients with AS/spondyloarthropathy who test negative for HLA B27.

关键词： Ankylosing spondylitis Spondyloarthropathy Human leukocyte antigen B51 Human leukocyte antigen B27 Sacroiliitis Case report

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