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Neuralgic.amyotrophy w.th hourglass-like c.nstric.ions:A c.se report

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w.rld Journal of c.inic.l c.ses 2024年第34期12卷 6728-6735页

作者： Mi-Hyeon Bang Ha-lim Song Seok Hahn w.nil Kim Hw.n-Kw.n Do Department of Physic.l Medic.ne and Rehabilitation Haeundae Paik HospitalInje University College of MedicineBusan 48108South Korea Department of Radiology Haeundae Paik HospitalInje University College of MedicineBusan 48108South Korea Division of Bioc.emistry Department of Convergence Medical ScienceInstitute of Medical ScienceGyeongsang National University College of MedicineJinju 52727South Korea Department of Physic.l Medic.ne and Rehabilitation Dongnam Institute of Radiological and Medical SciencesBusan 46033South Korea

BAc.GROUND Neuralgic.amyotrophy(NA)is a rare disease w.th sudden upper limb pain follow.d by affec.ed musc.e *** most c.mmonly affec.ed area in NA is the upper part of the brac.ial plexus,and the paraspinal musc.es are rarely affec.ed(1.5%),making these c.ses diffic.lt to distinguish from c.rvic.l *** SUMMARY A 76-year-old male presented to the emergenc. department w.th left hip pain *** undergoing left femoral nec. frac.ure surgery,he experienc.d sudden left shoulder pain for 10 days w.th subsequent left arm *** spine c.mputed tomography revealed mild right asymmetric.intervertebral disc.bulging w.th a dec.eased c.-6disc.*** w.eks later,an elec.rodiagnostic.study c.nfirmed brac.ial plexopathy findings involving the c.rvic.l *** resonanc. neurography w.s performed for a differential *** enhanc.ment w.s identified at the upper trunk of the brac.ial plexus,inc.uding the c. nerve root.A suprasc.pular nerve hourglass-like foc.l c.nstric.ion(HLFc.w.s also identified,c.nfirming *** being diagnosed w.th NA,the patient rec.ived 15 mg prednisolone,tw.c. daily,for 3 *** therapy w.s initiated,inc.uding left arm strengthening exerc.ses and elec.ric.l stimulation *** shoulder musc.e strength signific.ntly improved one c.Nc.USION NA's unique features like HLFc.and paraspinal involvement are c.uc.al for ac.urate diagnosis,avoiding c.nfusion w.th c.rvic.l radic.lopathy.

关键词： Neuralgic.amyotrophy c.rvic.l radic.lopathy Hourglass-like foc.l c.nstric.ion Paraspinal musc.e Magnetic.resonanc. neurography c.se report

Static.analysis of ultra-thin beams based on a semi-c.ntinuum model

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Ac.a Mec.anic. Sinic. 2011年第5期27卷 713-719页

作者： c.eng Li Zhi-Jun Zheng Ji-Lin Yu c.w. lim c.S Key Laboratory of Mec.anic.l Behaviorand Design of Materials University of Science and Technology of China230027 Hefei China Department of Building and c.nstruc.ion City University of Hong KongTat Chee Avenue KowloonHong Kong SAR China

A linear semi-c.ntinuum model w.th disc.ete atomic.layers in the thic.ness direc.ion w.s developed to investigate the bending behaviors of ultra-thin beams w.th nanosc.le *** theoretic.l results show.that the deflec.ion of an ultra-thin beam may be enhanc.d or reduc.d due to different relaxation *** the relaxation c.effic.ent is greater/less than one,the deflec.ion of mic.o/nano-sc.le struc.ures is enhanc.d/reduc.d in c.mparison w.th mac.o-sc.le ***,tw. opposite types of size-dependent behaviors are observed and they are mainly c.used by the relaxation *** w.th the c.assic.l c.ntinuum model,exac. nonloc.l stress model and finite element model （FEM） verify the validity of the present semi-c.ntinuum *** partic.lar,an explanation is proposed in the debate w.ether the bending stiffness of a mic.o/nano-sc.le beam should be greater or w.aker as c.mpared w.th the mac.o-sc.le *** c.arac.eristic. of bending stiffness are proved to be assoc.ated w.th the relaxation c.effic.ents.

关键词： Bending stiffness · MEMS/NEMS · Relaxation c.effic.ent · Semi-c.ntinuum model · Size-dependenc.

An analytic.l symplec.ic.approac. to the vibration analysis of orthotropic.graphene sheets

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Ac.a Mec.anic. Sinic. 2017年第5期33卷 912-925页

作者： Xinsheng Xu Dalun Rong c.w.lim c.angyu Yang Zhenhuan Zhou State Key Laboratory of Struc.ure Analysis of Industrial Equipment Department of Engineering MechanicsInternational Research Center for Computational MechanicsDalian University of Technology Department of Arc.itec.ure and c.vil Engineering City University of Hong Kong

A nonloc.l c.ntinuum orthotropic.plate model is proposed to study the vibration behavior of single-layer graphene sheets (SLGSs) using an analytic.l symplec.ic.approac.. A Hamiltonian system is established by introduc.ng a total unknow. vec.or c.nsisting of the displac.ment amplitude, rotation angle, shear forc., and bending moment. The high-order governing differential equation of the vibration of SLGSs is transformed into a set of ordinary differential equations in symplec.ic.spac.. Exac. solutions for free vibration are obtianed by the method of separation of variables w.thout any trial shape func.ions and c.n be expanded in series of symplec.ic.eigenfunc.ions. Analytic.l frequenc. equations are derived for all six possible boundary c.nditions. Vibration modes are expressed in terms of the symplec.ic.eigenfunc.ions. In the numeric.l examples, c.mparison is presented to verify the ac.urac. of the proposed method. c.mprehensive numeric.l examples for graphene sheets w.th Levy-type boundary c.nditions are given. A parametric.study of the natural frequenc. is also inc.uded.

关键词： Hamiltonian system Analytic.l method Nonloc.l elastic.ty theory Orthotropic.graphene sheet Natural frequenc.

Envita’s Prec.sion c.nc.r c.re: 35-Fold Improvement in Response Rates

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Journal of c.nc.r Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany John c. Oertle III Ronald Matthias Jr. Daniel w.rren David Medina Rory Sears Robert Zieve Kendra Quart c.ristopher Aussems Jon Moma Shannon Miller Zac. Poteet c.nner c.ffin c.urtney Middleton Erika w.re Phylic.a Zarnosky Julie Now.k w.nlove Suasin Daniel c.nw.y c.ad Burk Ruth Tan-lim Dino Prato Envita Medic.l c.nters Scottsdale AZ USA

New.c.inic.l approac.es are imperative beyond the w.dely adopted National c.mprehensive c.nc.r Netw.rk (Nc.N) guidelines, utilized by prominent c.nc.r institutions. c.nc.r is the leading c.use of death among individuals younger than 85 years w.thin the United States. Despite signific.nt tec.nologic.l advanc.s, inc.uding the expenditure of hundreds of billions, treatment outc.mes and overall survival have not notably improved for most types of advanc.d c.nc.r over the last several dec.des. Over the past 24 years, Envita Medic.l c.nters has pioneered a unique form of personalized treatment approac. for late-stage and refrac.ory c.nc.r patients, introduc.ng groundbreaking innovations in the field. Our integrated algorithm utilizes advanc.d genomic., transc.iptomic., and highly tailored immunotherapy, resulting in remarkable outc.me improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outc.mes of 199 late-stage c.nc.r patients treated at Envita Medic.l c.nters over a tw.-year period. c.mpared to standard of c.re and palliative c.emotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting w.th Stage 3 or 4 c.nc.r, experienc.d a 43-fold improvement in quality of life w.th minimal side effec.s, as c.mpared to standard of c.re c.emotherapy and palliative c.re. This revolutionary suc.ess is attributed to Envita’s personalized therapeutic.algorithms, w.ic. inc.rporate c.stomized immunotherapy. Envita’s prec.sion c.re approac. has also ac.ieved a 100% better response rate c.mpared to over 65 global c.emotherapy c.inic.l trials w.th more than 2700 patients. The results from this study suggest that a w.der utilization of Envita’s personalized approac. c.n signific.ntly benefit patients w.th late-stage and refrac.ory c.nc.r.

关键词： Envita Medic.l c.nters Late-stage c.nc.r Overall Response Rate Quality of Life c.rc.lating Tumor c.lls (c.c.) Mutant Allele Frequenc. (MAF) Prec.sion c.re

Fac.ors affec.ing visual outc.me of myopic.c.oroidal neovasc.larization treated w.th verteporfin photodynamic.therapy

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 327-330页

作者： c.lin S. Tan Milton c. c.ew.Kai-Hung lim Toc.-Han lim National Healthc.re Group Eye Institute Tan Tock Seng Hospital Fundus Image Reading c.nter National Healthcare Group Eye Institute

AIM: To evaluate the visual outc.mes of c.oroidal neovasc.larization (c.V) sec.ndary to pathologic.l myopia and the impac. of novel risk fac.ors affec.ing the final visual outc.me. ·METHODS: Interventional c.se series of 18 c.nsec.tive patients w.th pathologic.l myopia treated w.th photodynamic.therapy (PDT). Inc.usion c.iteria w.re spheric.l equivalent -6D or w.rse or features of pathologic.l myopia on retinal examination. The main outc.me measure w.s final best -c.rrec.ed visual ac.ity (Bc.A). ·RESULTS: Of 18 eyes, 13 (72.2%) avoided moderate visual loss (≥3 lines of LogMAR Bc.A) and 5 eyes (27.8%) improved by at least 1 line after 1 year. Patients w.th LogMAR Bc.A ≤0.3 (Snellen equivalent 20/40) at one year w.re younger than those w.th Bc.A >0.3 (mean age 39.0 vs 61.6 years, P =0.001). A higher proportion of eyes w.th greatest linear dimension (GLD) of ≤1 000μm avoided moderate visual loss (100% vs 50%, P =0.026). Among patients w.o w.re treated w.thin 2 w.eks of visual symptoms, 88.9% avoided the loss of 3 or more lines c.mpared to 55.6% for those w.o presented later. The mean improvement in LogMAR Bc.A of those w.th GLD ≤1 000μm w.s +0.12 c.mpared to a loss of 0.55 LogMAR units for those w.th GLD >1 000μm (P =0.02). Visual outc.mes w.re not assoc.ated w.th gender or refrac.ive error.·c.Nc.USION: Good visual outc.me in myopic.c.V is assoc.ated w.th younger age, smaller lesion size and earlier initiation of treatment. These fac.ors are relevant for ophthalmologists c.nsidering treatment options for myopic.c.V.

关键词： myopic.c.oroidal neovasc.larization pathologic.myopia photodynamic.therapy

NUMERIc.L SIMULATIONS OF HYDRODYNAMIc.BEHAVIORS IN c.NIc.L SPOUTED BEDS

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c.ina Partic.ology 2006年第3期4卷 194-203页

作者： c. J. lim Fluidization Researc. c.ntre Department of Chemical and Biological Engineering University of British Columbia Vancouver BC V6T 1Z3 Canada

The axial and radial distributions of static.pressures and vertic.l partic.e veloc.ties of c.nic.l spouted beds have been simulated and c.mpared w.th experimental data. Simulation results show.that, among all fac.ors investigated, the Ac.ual Pressure Gradient （the APG term） in c.nic.l spouted beds, introduc.d as the default gravity term plus an empiric.l axial solid phase sourc. term, has the most signific.nt influenc. on static.pressure profiles, follow.d by the restitution c.effic.ent and fric.ional visc.sity, w.ile other fac.ors almost have no effec.. Apart from the solid bulk visc.sity, almost all other fac.ors affec. the radial distribution of the axial partic.e veloc.ty, although the influenc. of the APG term is less signific.nt. For c.mplex systems suc. as c.nic.l spouted beds w.ere a fluidized spout region and a defluidized annulus region c.-exist, the new.term introduc.d in this w.rk c.n improve the c.D simulation. Furthermore, for other systems w.th the Ac.ual Pressure Gradient different from either fluidized beds or pac.ed beds, the new.approac. c.n also be applied.

关键词： c.nic.l spouted bed hydrodynamic. numeric.l simulation multiphase model

V_(2)O_(3)/VN elec.roc.talysts w.th c.herent heterogeneous interfac.s for selec.ing low.energy nitrogen reduc.ion pathw.ys

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SusMat 2024年第4期4卷 90-103页

作者： Tae-Yong An c.engkai Xia Minyeong Je Hyunjung Lee Seulgi Ji Min-c.eol Kim Subramani Surendran Mi-Kyung Han Jaehyoung lim Dong-Kyu Lee Joon Young Kim Tae-Hoon Kim Heec.ae c.oi Jung Kyu Kim Uk Sim Hydrogen Energy Tec.nology Laboratory Korea Institute of Energy Technology(KENTECH)NajuRepublic of Korea Sc.ool of c.emic.l Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea Materials&c.emistry Group Institute of Inorganic ChemistryUniversity of CologneCologneGermany Department of Polymer Engineering Graduate SchoolAlan G.MacDiarmid Energy Research Institute&School of Polymer Science and EngineeringChonnam National UniversityGwangjuRepublic of Korea Researc. Institute NEEL SciencesJeollanamdoRepublic of Korea Department of Materials Sc.enc. and Engineering Chonnam National UniversityGwangjuRepublic of Korea Department of c.emistry Xi’an Jiaotong-Liverpool UniversitySuzhouChina

Elec.roc.emic.l nitrogen reduc.ion reac.ion(NRR)is a sustainable alterna-tive to the Haber-Bosc. proc.ss for ammonia(NH3)***,the signific.nt uphill energy in the multistep NRR pathw.y is a bottlenec. for favorable serial *** overc.me this c.allenge,w. designed a vanadium oxide/nitride(V_(2)O_(3)/VN)hybrid elec.roc.talyst in w.ic. V_(2)O_(3)and VN c.ex-ist c.herently at the heterogeneous *** single-phase V_(2)O_(3)and VN exhibit different surfac. c.talytic.kinetic. for NRR,the V_(2)O_(3)/VN hybrid elec.troc.talyst c.n provide alternating reac.ion pathw.ys,selec.ing a low.r energy pathw.y for eac. material in the serial NRR *** a result,the ammo-nia yield of the V_(2)O_(3)/VN hybrid elec.roc.talyst w.s 219.6µg h^(-1)c.^(-2),and the Faradaic.effic.enc. w.s 18.9%,w.ic. is muc. higher than that of single-phase VN,V_(2)O_(3),and VNxOy solid solution c.talysts w.thout *** func.ional theory c.lc.lations c.nfirmed that the c.mposition of these hybrid elec.roc.talysts allow. NRR to proc.ed from a multistep reduc.ion reac.ion to a low.energy reac.ion pathw.y through the migration and adsorption of interme-diate ***,the design of metal oxide/nitride hybrids w.th c.herent heterointerfac.s provides a novel strategy for synthesizing highly effic.ent elec.troc.emic.l c.talysts that induc. steps favorable for the effic.ent low.energy progression of NRR.

关键词： c.herent heterogeneous interfac.s green ammonia synthesis hybrid elec.roc.talyst low.energy progression nitrogen reduc.ion reac.ion(NRR) vanadium oxide/nitride(V_(2)O_(3)/VN)

Viral-host molec.lar interac.ions and metabolic.modulation:Strategies to inhibit flaviviruses pathogenesis

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w.rld Journal of Virology 2024年第4期13卷 41-50页

作者： Zeeshan Ahmad Khan Mukesh Kumar Yadav Dong-w.o lim Hojun Kim Jing-Hua w.ng AbuZar Ansari Biohealth Produc.s Researc. c.nter(BPRc. Research Center for Agedlife Redesign(RCAR)Department of Physical TherapyINJE UniversityGimhae 5084South Korea Department of Mic.obiology Central University of PunjabBathinda 151401India Department of Diagnostic. College of Korean MedicineDongguk UniversityGoyang 10326South Korea Division of Rehabilitation Medic.ne of Korean Medic.ne Department of Oriental Rehabilitation MedicineDongguk UniversityIlsan HospitalGoyang 10326South Korea Institute of Oriental Medic.ne Dongguk UniversityGoyang 10326South Korea Department of Obstetric. and Gynec.logy Ewha Womans UniversitySeoul 07985South Korea

Flaviviruses,w.ic. inc.ude globally impac.ful pathogens,suc. as w.st Nile virus,yellow.fever virus,Zika virus,Japanese enc.phalitis virus,and dengue virus,c.ntribute signific.ntly to human *** the ongoing emergenc. and resurgenc. of flavivirus-mediated pathogenesis,the absenc. of spec.fic.therapeutic.options remains a c.allenge in the prevention and treatment of flaviviral *** the intric.te proc.sses of fusion,transc.iption,replic.tion,and maturation,the c.mplex interplay of viral and host metabolic.interac.ions affec.s *** interac.ions involve metabolic.molec.les,suc. as amino ac.ds,gluc.se,fatty ac.ds,and nuc.eotides,eac. playing a pivotal role in the replic.tion and maturation of *** viral-host metabolic.molec.lar interac.ions hijac. and modulate the molec.lar mec.anisms of host metabolism.A c.mprehensive understanding of these intric.te metabolic.pathw.ys offers valuable insights,potentially unveiling novel targets for therapeutic.interventions against flaviviral *** review.emphasizes promising avenues for the development of therapeutic.agents that target spec.fic.metabolic.molec.les,suc. as amino ac.ds,gluc.se,fatty ac.ds,and nuc.eotides,w.ic. interac. w.th flavivirus replic.tion and are c.osely linked to the modulation of host *** c.inic.l limitations of c.rrent drugs have prompted the development of new.inhibitory strategies for flaviviruses based on an understanding of the molec.lar interac.ions betw.en the virus and the host.

关键词： Flavivirus Nonstruc.ural proteins Virus-host interac.ion Metabolism Inhibitors Vac.ines

Experimental and FEM Modal Analysis of a Deployable-Retrac.able w.ng

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Modern Mec.anic.l Engineering 2014年第4期4卷 183-197页

作者： P. Jia S. K. Lai w. Zhang c. w. lim Department of Arc.itec.ure and c.vil Engineering City University of Hong Kong Hong Kong China Shenzhen Researc. Institute City University of Hong Kong Shenzhen China c.llege of Mec.anic.l Engineering Beijing University of Technology Beijing China Meinhardt (M & E) Ltd Hong Kong China

The aim of this paper is to c.nduc. experimental modal analysis and numeric.l simulation to verify the struc.ural c.arac.eristic. of a deployable-retrac.able w.ng for airc.aft and spac.c.aft. A modal impac. test w.s c.nduc.ed in order to determine the free vibration c.arac.eristic.. Natural frequenc.es and vibration mode shapes w.re obtained via measurement in LMS Test. Lab. The frequenc. response func.ions w.re identified and c.mputed by forc. and ac.eleration signals, and then mode shapes of this morphing w.ng struc.ure w.re subsequently identified by PolyMAX modal parameter estimation method. FEM modal analysis w.s also implemented and its numeric.l results c.nvinc.ngly presented the mode shape and natural frequenc. c.arac.eristic. w.re in good agreement w.th those obtained from experimental modal analysis. Experimental study in this paper foc.ses on the transverse response of morphing w.ng as its moveable part is deploying or retreating. Vibration response to different rotation speeds have been c.llec.ed, managed and analyzed through the use of c.mparison methodology w.th eac. other. Evident phenomena have been disc.vered inc.uding the resonanc. on w.ic. most analysis is foc.sed bec.use of its potential use to generate large amplitude vibration of spec.fic.frequenc. or to avoid suc. resonant frequenc.es from a w.de spec.rum of response. Manufac.ured deployable-retrac.able w.ngs are studied in stage of experimental modal analysis, in w.ic. some nonlinear vibration resulted should be partic.larly noted bec.use suc. w.ng struc.ure displays a low.resonant frequenc. w.ic. is alw.ys optimal to be avoided for struc.ural safety and stability.

关键词： Deployable-Retrac.able w.ng Experimental Modal Analysis FEM Mode Shapes Natural Frequenc. LMS Test. Lab