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Benefit of aerosol reduction to winter wheat during China's clean air action:A case study of Henan Province

Journal of Environmental Sciences 2024年第7期141卷 90-101页

作者： Yang Bai Pengfei Zhao Xueyang Chen lijun wang Wenjuan Chang Jianzhong Guo Jiayao wang College of Geography and Environmental Science Henan UniversityKaifeng 475004China Henan Industrial Technology Academy of Spatio-Temporal Big Data Henan UniversityZhengzhou 475000China Henan Technology Innovation Center of Spatio-Temporal Big Data Henan UniversityZhengzhou 450046China Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions(Henan University) Ministry of EducationKaifeng 475000China

A strongly declining aerosol radiative effect has been observed in China since 2013 after implementing the clean air action,yet its impact on wheat(Triticum aestivum L.)production remains *** use satellite measures and a biophysical crop model to assess the impact of aerosol-induced radiative perturbations on winter wheat production in the agricultural belt of Henan province from 2013 to *** calibrating parameters with the extended Fourier Amplitude Sensitivity Test(EFAST)and the generalized likelihood uncertainty estimation(GLUE)method,the DSSAT CERES-Wheat model was able to simulate crop biomass and yield more *** found that the aerosol negatively impacted wheat biomass by 21.87%and yield by 22.48%from 2006 to 2018,and the biomass effects from planting to anthesis were more significant compared to anthesis to *** to the strict clean air action,under all-sky conditions,the surface solar shortwave radiation(SSR)in 2018 increased by about 7.08%over 2006-2013 during the wheat growing *** a result of the improvement of crop photosynthesis,winter wheat biomass and yield increased by an average of 5.46%and 2.9%,*** findings show that crop carbon uptake and yield will benefit from the clean air action in China,helping to ensure national food and health security.

关键词： Haze pollution Clean air action Aerosol-induced radiative perturbation Wheat production DSSAT model

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Cryptococcus splenic abscess in primary biliary cholangitis: a case report

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World Journal of Emergency Medicine 2024年第4期15卷 319-321页

作者： Yuxin Dong Qing Tang lijun wang Songtao Shou Department of Emergency Medicine Tianjin Medical University General HospitalTianjin 300052China

Chronic liver diseases,including primary biliary cholangitis(PBC),are recognized as immunosuppressive conditions due to the impaired functionality of hepatic sinusoidal Kupffer cells.[1]PBC is specifically characterized by cholangitis and progressive liver pathology,which may eventually lead to *** compromised liver function and reduced efficacy of Kupffer cells in patients with PBC weaken their cell-mediated immune responses,increasing their susceptibility to opportunistic pathogens such as Cryptococcus.[2]Cryptococcosis is an infectious disease caused by pathogenic encapsulated yeasts of the genus Cryptococcus,which is distributed worldwide and exhibits diverse clinical presentations.[3]Most case reports on cryptococcal infections are associated with HIV infection or other conditions that compromise the immune system.[4]Case reports related to primary biliary cholangitis are ***,this case report underscores a rare cryptococcal infection in a patient with primary biliary cholangitis,emphasizing the need to consider opportunistic infections in those with compromised liver function and immune dysregulation.

关键词： cholangitis impaired diseases

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Mitochondrial genomes of Tapes dorsatus and Cardita variegata:insights into Heteroconchia phylogeny

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Journal of Oceanology and Limnology 2024年第3期42卷 943-959页

作者： Xumin wang Hua ZHANG Xindong TENG Wenhui SUN Zhikai XING Shuang wang Xiumei LIU Jiangyong QU lijun wang College of Life Science Yantai UniversityYantai 264005China Qingdao International Travel Healthcare Center Qingdao 266071China

Heteroconchia,a widespread and abundant aquatic invertebrate,is an important clade of bivalve *** relationship between the three branches of Heteroconchia,Palaeoheterodonta,Archiheterodonta,and Euheterodonta has become a main controversy in molecular studies of the relationships between *** the present study,we assembled the complete mitochondrial genomes of Tapes dorsatus(Veneridae)and Cardita variegata(Carditidae)using high-throughput *** is the first mitochondrial genome belonging to the family Carditidae to be *** used 12 protein coding genes(excluding atp8)from the complete mitochondrial genomes of 146 species to recover the internal relationships of *** results support the traditional view of early branching of Palaeoheterodonta and the recovery of the monophyly of Palaeoheterodonta,Anomalodesmata,*** analysis show that gene arrangement within Venerida was highly ***-calibrated phylogenetic studies based on a relaxed molecular clock model suggested that Veneridae originated approximately 337.62 million years ago(Ma)and split into two major clades,whereas Carditidae originated approximately 510.09 *** results provide evidence of the internal relationships of Heteroconchia.

关键词： Tapes dorsatus Cardita variegata mitochondrial genome phylogeny

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Chronic Obstructive Pulmonary Disease-Associated Mortality — China, 2014–2021

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China CDC weekly 2024年第43期6卷 1105-1110页

作者： Zifang Zhou lijun wang Maigeng Zhou Peng Yin National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:China faces a growing burden of chronic obstructive pulmonary disease(COPD).Previous mortality estimations were primarily based on the underlying cause of *** study analyzed COPD-associated death and its comorbidities using all COPD cases listed on the chain of events on death ***:A retrospective analysis of the National Mortality Surveillance System(NMSS)was conducted to estimate COPD-associated mortality from 2014 to ***-standardized mortality rates(ASMRs)were calculated stratified by sex,region,and *** regression was used to estimate the average annual percentage change(AAPC)during the study ***:From 2014 to 2021,the ASMR of COPD decreased from 91.85 to 45.90 per 100,000 *** but uneven decreases in COPD mortality were observed across gender[females:AAPC:−11.2%,95%confidence interval(CI):−11.9 to−10.4%;males:AAPC:−8.0%,95%CI:−9.2 to−6.8%],regions(eastern:AAPC:−10.7%,95%CI:−11.5 to−9.9%;central:AAPC:−9.9%,95%CI:−10.9 to−8.9%;western:AAPC:−7.7%,95%CI:−10.6 to−4.7%),and residential areas(urban:AAPC:−10.9%,95%CI:−12.3 to−9.5%;rural:AAPC:−8.3%,95%CI:−9.1 to−7.4%).Other than COPD,cardiovascular diseases and respiratory conditions were the major underlying causes of death in COPDassociated ***:COPD is a significant comorbidity of other disorders in *** COPDassociated mortality substantially decreased from 2014 to 2021,the burden remained high in underdeveloped regions.

关键词： mortality listed stratified

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The landscape of epigenetic regulation and therapeutic application of N^(6)-methyladenosine modifications in non-coding RNAs

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Genes & Diseases 2024年第5期11卷 236-251页

作者： Gui-e Xu Xuan Zhao Guoping Li Priyanka Gokulnath lijun wang Junjie Xiao Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)and School of Life SciencesShanghai UniversityNantongJiangsu 226011China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA

RNA N^(6)-methyladenosine(m^(6)A)methylation is the most abundant and conserved RNA modification in *** participates in the regulation of RNA metabolism and various pathophysiological ***-coding RNAs(ncRNAs)are defined as small or long transcripts which do not encode proteins and display numerous biological regulatory *** to mRNAs,m^(6)A deposition is observed in *** RNA m^(6)A modifications on ncRNAs is of great importance specifically to deepen our understanding of their biological roles and clinical *** this review,we summarized the recent research findings regarding the mutual regulation between RNA m^(6)A modification and ncRNAs(with a specific focus on microRNAs,long non-coding RNAs,and circular RNAs)and their *** also discussed the challenges of m^(6)A-containing ncRNAs and RNA m^(6)A as therapeutic targets in human diseases and their future perspective in translational roles.

关键词： Circular RNA Epigenetic regulation Long non-coding RNA MicroRNA Non-coding RNA RNA m^(6)A modification

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Gene characterization and phylogenetic analysis of four mitochondrial genomes in Caenogastropoda

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Acta Oceanologica Sinica 2024年第2期43卷 137-150页

作者： Jiangyong Qu Wanqi Yang Xindong Teng Li Xu Dachuan Zhang Zhikai Xing Shuang wang Xiumei Liu lijun wang Xumin wang College of Life Science Yantai UniversityYantai 264005China Qingdao International Travel Healthcare Center Qingdao 266071China Qingdao Dagang Customs Qingdao 266071China

Caenogastropoda is a highly diverse group,containing~60%of all existing *** in this subclass predominantly inhabit marine environments and have a high ecological and economic *** to the increase in relevant phylogenetic studies,our understanding of between species relatedness in Caenogastropoda has ***,the biodiversity,taxonomic status,and phylogenetic relationships of this group remain *** the present study,we performed next-generation sequencing of four complete mitochondrial genomes from three families(Buccinidae,Columbellidae,and Cypraeidae)and the four mitogenomes were classical circular structures,with a length of 16177 bp in Volutharpa ampullacea,16244 bp in Mitrella albuginosa,16926bp in Mauritia arabica asiatica and 15422 bp in Erronea *** composition analysis indicated that whole sequences were biased toward A and *** compared them with 171 complete mitochondrial genomes of *** phylogenetic relationship of Caenogastropoda derived from Maximum Likelihood(ML)and Bayesian Inference(BI)trees constructed based on CDS sequences was consistent with the results of traditional morphological analysis,with all three families showing close *** study supported Caenogastropoda at the molecular level as a separate clade of *** to our divergence time estimations,Caenogastropoda was formed during the middle Triassic period(~247.2–237 Ma).Our novel mitochondrial genomes provide evidence for the speciation of Caenogastropoda in addition to elucidating the mitochondrial genomic evolution of this subclass.

关键词： mitochondrial genome phylogenetic analysis Caenogastropoda

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MiR-30a-5p alleviates LPS-induced HPMEC injury through regulation of autophagy via Beclin-1

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BIOCELL 2024年第3期48卷 431-441页

作者： RAN PAN JIAYAN MAO YUELIANG ZHENG WEI CHEN JUNPING GUO lijun wang Rainbowfish Rehabilitation and Nursing School Hangzhou Vocational&Technical CollegeHangzhou310018China Cancer Institute of Integrated Traditional Chinese and Western Medicine Key Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western MedicineZhejiang Academy of Traditional Chinese MedicineHangzhou310012China Geriatric Medicine Center Department of EndocrinologyZhejiang Provincial People’s Hospital(Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou310015China

Background:Sepsis,a type of systemic disease,can impact nearly all organs,tissues and *** them,endothelial cells are amongst theﬁrst to be affected and respond to the *** this study,we investigated the protective effects of microRNA-30a-5p(miR-30a-5p)on human pulmonary microvascular endothelial cells(HPMECs)treated with lipolysaccharide(LPS).Methods:An in vitro model of sepsis was established in HPMECs with the use of *** with different tools(mimetic and inhibitor)to modify miR-30a-5p *** viability,proliferation and apoptosis were detected by the CCK-8 assay,the EdU kit andﬂuorescence staining,*** autophagy-related protein and mRNA expression,the number of autophagosomes were separately examined through Western blot analysis,qPT-PCR and confocal *** and the luciferase reporter assays were used to probe target genes interacting with ***:LPS caused a reduction in the viability and proliferation of HPMECs,as well as an elevation in the number of apoptotic ***,we observed that miR-30a-5p might play a role in preventing LPS-induced inhibition of cell damage and decreasing HPMEC apoptosis,suggesting the potential function of miR-30a-5p in this injury ***,we conﬁrmed that miR-30a-5p exerts its protective effect by regulating cell autophagy,possibly by targeting ***:Our study provided evidence that autophagy is a crucial aspect in the protective role of miR-30a-5p against LPS-induced HPMEC injury,identifying a promising target for sepsis-related endothelial cell injury.

关键词： Sepsis Endothelial cells MicroRNA Systemic inflammatory response syndrome

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Mortality Burden of Liver Cancer in China: An Observational Study From 2008 to 2020

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 371-380页

作者： Huixin Liu Xiaoxiao wang lijun wang Peng Yin Feng Liu Lai Wei Yu wang Maigeng Zhou Jinlei Qi Huiying Rao Department of Clinical Epidemiology and Biostatistics Peking University People's HospitalBeijingChina Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijingChina National Center for Chronic Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Beijing Tsinghua Changgung Hospital Tsinghua UniversityBeijingChina Chinese Foundation for Hepatitis Prevention and Control BeijingChina

Background and Aims:China accounts for nearly half of liver cancer deaths globally.A better understanding of the current liver cancer mortality will be helpful to establishing priorities for intervention and to decreasing the disease burden of liver *** study aimed to explore and predict the mortality burden of liver cancer in ***:Data were extracted from the Disease Surveillance Point system of the Chinese Center for Disease Control and Prevention from 2008 to *** and age-standardized liver cancer mortality rates were reported by sex,urban or rural residence,and *** in liver cancer mortality rates from 2008 to 2020 were estimated as average annual percentage change(AAPC).The changing trend of live cancer mortality in the future is also ***:In 2020,the crude mortality of liver cancer was 25.57/100,000,and males and people lived in rural areas had higher age-standardized liver cancer mortality rates than females and people lived in people in urban *** mortality and age-standardized mortality rates in southwest provinces(Guangxi,Sichuan,Tibet)and in a northeast province(Heilongjiang)were higher than that in other provinces,and age-specific mortality rates increased with *** 2008 to 2020,liver cancer mortality rates decreased,but people under 50 years of age had a higher AAPC than those over 50 years of age,possibly because of the adoption of hepatitis B virus vaccination in newborns and ***,the mortality of liver cancer in 2021–2030 is predicted to have a downward ***:Liver cancer mortality rates declined in China from 2008 to *** interventions to control liver cancer mortality need to focus on people of male sex,older age,and living in rural areas or less developed provinces.

关键词： Liver cancer Mortality Burden Trend China Prediction

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Trends in Mortality of Cirrhosis in China: An Analysis of the China Death Surveillance Database from 2008 to 2020

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Journal of Clinical and Translational Hepatology 2024年第3期12卷 236-244页

作者： Xiaoxiao wang Huixin Liu Jinlei Qi lijun wang Peng Yin Feng Liu Lai Wei Yu wang Maigeng Zhou Huiying Rao Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijingChina Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijingChina National Center for Chronic Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Beijing Tsinghua Changgung Hospital Tsinghua UniversityBeijingChina Chinese Foundation for Hepatitis Prevention and Control BeijingChina

Background and Aims:China accounts for 14.9%of total cirrhosis deaths worldwide.A detailed and comprehensive understanding of the contemporary status of cirrhosis mortality in China is crucial for establishing strategies for intervention and decreasing the disease burden of cirrhosis *** study aimed to report the cirrhosis mortality rates in our whole country or province over ***:Mortality data from 2008 to 2020 were retrieved from the Disease Surveillance Point System(DSPs)of the Chinese Center for Disease Control and *** crude mortality rate and age-standardized mortality rate of patients with cirrhosis were stratified by sex,residential location,and *** average annual percentage change(AAPC)in cirrhosis mortality rates from 2008 to 2020 was also ***:The crude mortality rate of cirrhosis was 4.57/100,000 people in *** with females and individuals living in urban areas,males and people living in rural areas had greater age-standardized *** crude mortality rate and age-standardized mortality rate in provinces in Southwest China(Guangxi,Yunnan,Guizhou,and Qinghai)were greater than those in other ***,with increasing age,the age-specific mortality rate increased *** 2008 to 2020,the mortality rate of cirrhosis in China decreased except for in males aged 50–59 years,females aged 45–49 years and females aged 80–84 ***:The mortality rate of patients with cirrhosis in China decreased from 2008 to *** the future,interventions of cirrhosis mortality control need to pay more attention to all males,females aged 45–49 and 80–84 years,and people living in rural areas and in provinces in Southwest China.

关键词： Cirrhosis Mortality Trend China

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Research progress on the role of adipocyte exosomes in cancer progression

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Oncology Research 2024年第10期32卷 1649-1660页

作者： YUN wang XIAOJIANG LI DALONG LIU ZHIFENG wang JICHEN XIA lijun wang XUDONG ZHANG Department of Breast and Thyroid Surgery Affiliated Hospital of Changchun University of Traditional Chinese MedicineChangchun130021China Department of Orthopaedics Affiliated Hospital of Changchun University of Traditional Chinese MedicineChangchun130021China Department of Internal Medicine Changchun Chaoyang District Hospital of Traditional Chinese MedicineChangchun130061China Department of Orthopedics and Traumatology Jilin Integrated Traditional Chinese and Western Medicine Hospital of Jilin ProvinceJilin132012China Department of Oncology Liaoyuan Second People’s HospitalLiaoyuan136299China Department of Brain Surgery Affiliated Hospital of Changchun University of Traditional Chinese MedicineChangchun130021China

Exosomes,minute vesicles ubiquitously released by diverse cell types,serve as critical mediators in intercellular *** pathophysiological relevance,especially in malignancies,has garnered significant attention.A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and clinically valuable *** cargo conveyed by exosomes exerts transformative effects on both local and distant microenvironments,thereby influencing a broad spectrum of biological responses in recipient *** membranebound extracellular vesicles(EVs)play a pivotal role in delivering bioactive molecules among cells and *** and biological processes in recipient cells,ranging from stromal cell reprogramming to immunological responses,extracellular matrix formation,and modulation of cancer cell activation,expansion,and metastasis,are subject to exosome-mediated cell-to-cell ***,exosomes have been implicated in endowing cancer cells with resistance to *** research has explored the potential of exosomes as therapeutic targets and diagnostic *** comprehensive review seeks to provide an in-depth understanding of the pivotal components and roles of exosomes in tumorigenesis,growth,progression,and therapeutic *** insights into the multifaceted involvement of exosomes in malignant cancers are essential for the scientific community,fostering the development of novel therapeutic and diagnostic strategies in the relentless pursuit of cancer.

关键词： Exosomes Extracellular vesicles Adipose tissue Tumor microenvironment Obesity

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