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Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

Oncology Research 2025年第1期33卷 225-234页

作者： WEI ZHANG WEICHENG WANG RUI WANG XIAO HAN lijun zhu WENJIE GUO YANHONG GU Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Department of Oncology The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou225300China

Background:As a novel blocker of vascular endothelial growth factor receptor(VEGFR),fruquintinib has been approved for treating colorectal cancer(CRC).However,its dosage and therapeutic efficacy are limited by its widespread adverse ***,recognized as the initial inhibitor of B-cell lymphoma protein 2(BCL2),has shown potential in boosting the effectiveness of immunotherapy against *** study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating *** and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against *** we employed various techniques to evaluate different aspects of the experimental *** was used to detect cell proliferation and angiogenesis in tumor *** blot analysis was utilized to examine the occurrence of cell apoptosis,and flow cytometry to quantitate immune cells within the tumor ***,immunofluorescence was employed to measure cytokine ***:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax,as opposed to individual drug *** was found to amplify the impact of fruquintinib,leading to decreased cancer cell proliferation,increased cancer cell apoptosis,lowered angiogenesis,better vascular structure normalization,and improved immune cell ***:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune *** study presents the justification for utilizing the fruquintinib and venetoclax combination in treating *** holds promise in being assimilated into anticancer medications for CRC.

关键词： Colorectal cancer(CRC) B-cell lymphoma protein 2(BCL2) Venetoclax Vascular endothelial growth factor receptor(VEGFR) Fruquintinib Anti-angiogenesis Immunotherapy

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A two-field-scan harmonic Hall voltage analysis for fast,accurate quantification of spin-orbit torques in magnetic heterostructures

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 105-112页

作者： Xin Lin lijun zhu State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

We report on the development of a“two-field-scan”harmonic Hall voltage(HHV)analysis,which collects the second HHVas a function of a swept in-plane magnetic field at 45°and 0°relative to the excitation current,for the determination of the spin-orbit torques of transverse spins in magnetic heterostructures without significant perpendicular spins,longitudinal spins,and longitudinal/perpendicular Oersted *** demonstrate that this two-field-scan analysis is as accurate as the well-established but time-consuming angle-scan HHV analysis even in the presence of considerable thermoelectric effects but takes more than a factor of 7 less measurement *** also show that the fit of the HHV data from a single field scan at 0°,which is commonly employed in the literature,is not reliable because the employment of too many free parameters in the fitting of the very slowly varying HHV signal allows erroneous conclusion about the spin-orbit torque efficiencies.

关键词： spin-orbit torque spin current spin-orbit coupling spintronics

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Discovery of strong bulk Dzyaloshinskii-Moriya interaction in composition-uniform centrosymmetric magnetic single layers

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 174-180页

作者： lijun zhu David Lujan Xiaoqin Li State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China Department of Physics Center for Complex Quantum SystemsUniversity of Texas at AustinAustin 78712USA

Dzyaloshinskii-Moriya interaction(DMI)is the key ingredient of chiral spintronic phenomena and the emerging technologies based on such phenomena.A nonzero DMI usually occurs at magnetic interfaces or within non-centrosymmetric single ***,we report the observation of a strong unexpected DMI within a centrosymmetric polycrystalline ferromagnet that has neither a crystal inversion symmetry breaking nor a composition *** DMI is a bulk effect,increases with the thickness of the magnetic layer,and is insensitive to the symmetry of the interfaces or the neighboring *** observe a total DMI strength that is a factor of>2 greater than the highest interfacial DMI in the *** DMI most likely arises from the strong spin-orbit coupling,strong orbital hybrization,and a“hidden”long-range asymmetry in the *** discovery of the strong unconventional bulk DMI in centrosymmetric,composition-uniform magnetic single layers provides fundamental building blocks for the emerging field of spintronics and will stimulate the exploitation of unconventional spin-orbit phenomena in a wide range of materials.

关键词： Brillouin light scattering Dzyaloshinskii-Moriya interaction spin wave

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Adsorption of mercury on laterite from Guizhou Province,China

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Journal of Environmental Sciences 2008年第11期20卷 1328-1334页

作者： YU Xiaohong zhu lijun GUO Baiwei HE Shouyang The State Key Laboratory of Environmental Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Karst Environment and Geohazard Prevention Ministry of Education Guiyang 550003 China College of Civil Engineering and Building Construction of Guizhou University Guiyang 550003 China

The adsorption behaviors of Hg(Ⅱ) on laterite from Guizhou Province,China,were studied and the adsorption mechanism was *** results showed that different mineral compositons in the laterite will cause differences in the adsorption capacity of laterite to Hg(Ⅱ).Illite and non-crystalloids are the main contributors to enhancing the adsorption capacity of laterite to Hg(Ⅱ).The pH of the solution is an important factor affecting the adsorption of Hg(Ⅱ) on *** alkalescent environment (pH 7-9) ...

关键词： adsorption laterite Hg(Ⅱ) pH isotherm kinetics

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Weathering-pedogenesis of Carbonate Rocks and Its Environmental Effects in Subtropical Region

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Acta Geologica Sinica(English Edition) 2008年第5期82卷 982-993页

作者： zhu lijun HE Shouyang LI Jingyang Key Laboratory of Karst Environment and Geological Hazard Prevention （Guizhou University） Ministry of Education Guiyang Guizhou 550003 Bureau of Geology and Mineral Exploration and Development of Guizhou Province Guiyang Guizhou 550004 Laboraryfor Study of Earth＇s Interior and Geofluids Institute of Geochemistry Chinese Academy of Sciences Guiyang Guizhou 550002 Graduate University of the Chinese Academy of Sciences Beijing 100039

We investigated the weathering-pedogenesis of carbonate rocks and its environmental effects in subtropical regions of China. The investigation demonstrated that the weathering- pedogenesis of carbonate rocks is the process of a joint action of corrosion and illuviation and metasomatism in subtropical region. It is characterized by multi-stage, multi-path and multi-style. With the persisting development of weathering-pedogenesis of carbonate rocks, metasomatic pedogenesis progressively became the main process of the weathering-pedogenesis and the dominant style of formation of minerals. And it proceeds through the whole process of evolution of the weathering-pedogenesis of carbonate rocks. The stage evolution of weathering-pedogenesis of carbonate rocks and the fractionation evolution of newly produced minerals are characterized by obvious vertically zoning structures and the rules of gradation of elements geochemical characteristics in the carbonate rocks weathering profiles. The geochemical process of weathering-pedogenesis of carbonate rocks can be divided into three geochemical evolution stages, i.e., the Ca, Mg-depletion and Si, Al-enrichment stage; the Fe, Mn enrichment stage and the Si-depletion and Al-enrichment stage in the subtropical regions. Consistent with the three geochemical evolution stages, the sequence of formation and evolution of minerals can be divided into the clay mineral stage; the Fe, Mn oxide and the gibbsite stage. The influence of weathering-pedogenesis of carbonate rocks on the chemical forms of heavy elements is mainly affected via newly produced components and minerals in the process of weathering-pedogenesis, e.g., iron oxide minerals and organic matters. The important mechanism for the mobilization, transport and pollution of F and As is affected the selective adsorption and desorption of F and As on the surface of iron oxide minerals in the subtropical karst zones, i.e., the selective adsorption and desorption on mineral surfaces of

关键词： carbonate rocks weathering-pedogenesis metasomatic pedogenesis environmental effects subtropical region

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Existence of Positive Solutions for the Nonhomogeneous Schrodinger-Poisson System with Strong Singularity

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Journal of Partial Differential Equations 2021年第2期34卷 186-200页

作者： LIAO Jiafeng CHEN Qingfang zhu lijun College of Mathematics Education China West Normal UniversityNanchong 637002China School of Mathematics and Information China West Normal UniversityNanchong 637002China

In this paper,a class of nonhomogeneous Schrodinger-Poisson systems with strong singularity are *** with the variational method and Nehari method,we obtain a positive solution for this system which improves the recent... 详细信息

关键词： Schrodinger-Poisson system strong singularity positive solution Nehari method

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A study on the adsorption of chromium on laterite from Guizhou Province,China

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Chinese Journal Of Geochemistry 2009年第2期28卷 220-226页

作者： YU Xiaohong zhu lijun GUO Baiwei HE Shouyang The Institute of Geo-Environmental Monitoring of Guizhou Province Guiyang 550004 China Key Laboratory of Karst Environment and Geohazard Prevention Ministry of Education （Guizhou University）Guiyang 550003 China The School of Civil Engineering ＆ Architecture of Guizhou University Guiyang 550003 China The State Key Laboratory of Environmental Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Graduate University of the Chinese Academy of Sciences Beijing 100039 China

The adsorption behaviors of Cr(VI) on laterite from Guizhou Province were studied in this paper, and the adsorption mechanism was discussed as well. Results showed that different mineral compositions in the laterite would cause differences in the capacity of laterite to absorb Cr(VI). Gibbsite, iron oxide minerals and non-crystalloids are the main contributors to enhancing the capacity of laterite to absorb Cr(VI). The pH of the solution is an important factor affecting the adsorption of Cr(VI) on laterite. Acidic environment (pH=2-5) is favorable to the adsorption of Cr(VI). The amount of adsorbed Cr(VI) decreases with increasing pH of the solution. With increasing initial concentrations of Cr(VI), the amount of adsorbed Cr(VI) increases first, and then decreases. The optimal adsorption concentration of Cr(VI) on laterite is 250 μg/mL. The adsorption of Cr(VI) on laterite is a rapid process, about 80% Cr(VI) will be adsorbed within 2 hours. And the adsorption of Cr(VI) on kaolinite is a slow process.

关键词：吸附行为贵州省红土铬中国初始浓度氧化铁矿物 pH值

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Enrichment of heavy metals in coal gangue by puff balls and mechanism research

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Chinese Journal Of Geochemistry 2014年第4期33卷 419-424页

作者： CHEN Miao zhu lijun WU Yonggui FU Tianling RAN Yan College of Resource and Environmental Engineering Guizhou University Department of Land and Resources of Guizhou Province Guizhou Academy of Instrumental Analysis

Coal gangue with/without wild puff balls growing on or covering up were analyzed by means of inductively coupled plasma atomic emission spectrometry(ICP-AES) and atomic fluorescence spectrometry(AFS) to detect the contents of heavy metal elements in the plants. Seven heavy metals were chosen to do the experiments, which showed that the puff balls have strong enrichment capacity for heavy metals(As, Pb, Mn and Ni). The highest enrichment level was Mn, 220.3 mg/kg(dry weight) for puffball fruiting bodies, and the highest As, Cr and Pb enrichment levels for puffball mycelium were 111, 265.3 and 86 mg/kg, respectively. Cd, Mn and Ni could transfer from puffball mycelium to its fruiting bodies, while As, Cr, Pb and Co mainly accumulated in the mycelium. The contents of five organic acids(tartaric acid, glycolic acid, lactic acid, citric acid and malic acid) in puffballs were determined with high performance liquid chromatography. With water, ethanol and ethyl acetate as solvents, the puffball extracts performed dissolution reactions with coal gangue, in which the water extract(containing a large amount of organic acids) was most effective in releasing heavy metals, especially As, Pb, Cr, Mn, Co and Ni from coal gangue. As a pioneer species, puff balls absorbed the hazardous trace elements in coal gangue matrix to reduce its eco-toxicity, on the other hand, it raised the p H value of coal gangue, improving the vegetation growing conditions for coal gangue matrix to a certain extent and laying the foundation for ecological restoration of coal gangue dumps.

关键词：重金属元素煤矸石电感耦合等离子体原子发射光谱原子荧光光谱仪 ICP-AES 高效液相色谱法机理有害微量元素

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The geochemical characteristics of aqueous rare-earth elements in shallow karst groundwater in Guiyang City, China

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Chinese Journal Of Geochemistry 2011年第1期30卷 114-124页

作者： HE Shouyang zhu lijun YANG Ruidong SHEN Zheng YU Xiaohong Key Laboratory of Karst Environment and Geological Hazard Prevention （Guizhou University） Ministry of Education Guiyang 550003 China College of Resource and Environment Guizhou University Guiyang 550003 China Postgraduate School of Guizhou University Guiyang 550025 China Guizhou Institute of Geo-Environment Monitoring Guiyang 550004 China

Fifty-seven shallow groundwater samples were collected from Guiyang karst basin, China, to analyze the aqueous rare-earth elements in low-water seasons and it is shown that the total amount of rare-earth elements (ΣREE) in karst groundwater is exceedingly low compared with that in carbonate rocks or weathering crusts of carbonate rocks, and ranges from 0.01 to 0.43, from 0.03 to 0.27, from 0.03 to 0.19 and from 0.05 to 1.38 μg·L-1 for dolomite, dolomitic & limestone, limestone and clastic rock aquifer, respectively. Both distributions and contents of rare-earth elements (REE) in karst groundwater reflect the lithology of host rocks or weathering crusts of carbonate rocks through which groundwater flows. The chondrite-normalized patterns show a non-flat profile with higher enrichment of slightly light rare-earth elements (LREE) than heavy rare-earth elements (HREE), prominent fractionation between LREE and HREE, negative Ce anomalies and negative or positive Eu anomalies. There is more obvious fractionation between LREE and HREE in groundwater than that in carbonate rocks and their weathering crusts due to high contents of HCO3? and PH in groundwater. In shallow karst groundwater, REE(CO3)n2n-3 (n=1 and 2) is the main inorganic species of REE. But for a clastic rock aquifer, both REESO4+ and REECO3+ are the main inorganic species of REE. Species of REE in groundwater is closely associated with the hydrochemical type of groundwater which is predominated by the lithology of host rocks, groundwater-rock interaction and weathering-pedogenesis of carbonate rocks.

关键词：重稀土元素岩溶地下水地球化学特征贵阳市碳酸盐岩风化壳中国轻稀土元素浅水

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Effects of fluoride on the removal of cadmium and phosphate by aluminum coagulation

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Journal of Environmental Sciences 2015年第6期27卷 118-125页

作者： Ruiping Liu Bao Liu lijun zhu Zan He Jiawei Ju Huachun Lan Huijuan Liu Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences

This study focuses on the effects of p H and fluoride at different molar ratios of fluoride to Al（R F：Al） on the removal of cadmium（Cd^（2＋）） and phosphate by Al coagulation. Fluoride at R F：Al≥ 3：1 inhibits the removal of Cd over wide Al dose ranges from 5 to 10 mg/L as Al. The removal of phosphate decreases significantly at high R F：Al of 10：1 whereas at lowered R F：Al（i.e., ≤ 6：1）, an adverse effect is observed only at insufficient Al doses below 2 mg/L. Fluoride shows inhibitive effects towards the removal of Cd at p H 7 and 8 and that of phosphate at p H 6. Fluoride decreases the ζ-potential in both systems, and the decreasing extent is positively correlated to the elevated R F：Al. The Al fluoride interactions include the formation of Al-F complexes and the adsorption of fluoride onto Al（OH）3 precipitates, i.e., the formation of Al（OH）n F m. Al-F complex formation inhibits Al hydrolysis and increases residual Al levels, and a more significant increase was observed at lower p H. Al-F complexes at high R F：Al complicate the coagulation behavior of Al towards both negative and positive ionic species. Moreover, fluoride at low R F：Al shows little effect on Al coagulation behavior towards Cd^2＋and phosphate, and the spent defluoridation adsorbent,i.e., aluminum（Al） hydro（oxide） with adsorbed fluoride at R F：Al of below 0.1：1, may be reclaimed as a coagulant after being dissolved.

关键词： Fluoride Aluminum coagulation Al-F complexes ζ-Potential Adsorbent reclamation

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