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Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

Chinese Journal of Integrative Medicine 2024年第9期30卷 842-851页

作者： GAO Kai-xin YANG Yi-hong liang Qi MEI Li-yan liang you-bang WANG Mao-jie CHEN Xiu-min HUANG Qing-chun WEN Ze-huai HUANG Run-yue Section of Rheumatology and Immunology Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou510405China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou510405China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou510120China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510120China The Key Unit of Methodology of Clinical Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

Rheumatoid arthritis(RA)is a worldwide public health *** to delay or prevent the onset of RA have attracted much attention in recent years,and researchers are now exploring various prevention *** present,there is still no unified consensus for RA prevention,but targeting therapeutic windows and implementing interventions for at-risk individuals are extremely *** to the limited number of clinical trials on pharmacologic interventions,further studies are needed to explore and establish optimal intervention regimens and effective measures to prevent progression to *** this review,we introduce the RA disease process and risk factors,and present research on the use of both Western and Chinese medicine from clinical perspectives regarding RA ***,we describe several complete and ongoing clinical studies on the use of Chinese herbal formulae for the prevention of RA.

关键词： rheumatoid arthritis prevention Chinese medicine review

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Real-time distance field acceleration based free-viewpoint video synthesis for large sports fields

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Computational Visual Media 2024年第2期10卷 331-353页

作者： Yanran Dai Jing Li Yuqi Jiang Haidong Qin bang liang Shikuan Hong Haozhe Pan Tao Yang School of Telecommunications Engineering Xidian UniversityXi’an 710071China National Engineering Laboratory for Integrated AeroSpace-Ground-Ocean Big Data Application Technology SAIIPthe School of Computer ScienceNorthwestern Polytechnical UniversityXi’an 710129China

Free-viewpoint video allows the user to view objects from any virtual perspective,creating an immersive visual *** technology enhances the interactivity and freedom of multimedia ***,many free-viewpoint video synthesis methods hardly satisfy the requirement to work in real time with high precision,particularly for sports fields having large areas and numerous moving *** address these issues,we propose a freeviewpoint video synthesis method based on distance field *** central idea is to fuse multiview distance field information and use it to adjust the search step size *** step size search is used in two ways:for fast estimation of multiobject three-dimensional surfaces,and synthetic view rendering based on global occlusion *** have implemented our ideas using parallel computing for interactive display,using CUDA and OpenGL frameworks,and have used real-world and simulated experimental datasets for *** results show that the proposed method can render free-viewpoint videos with multiple objects on large sports fields at 25 ***,the visual quality of our synthetic novel viewpoint images exceeds that of state-of-the-art neural-rendering-based methods.

关键词： free-viewpoint video view synthesis camera array distance field sports video

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A Fluorine-Functionalized 3D Covalent Organic Framework with Entangled 2D Layers

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Chinese Journal of Polymer Science 2024年第8期42卷 1210-1216页

作者： Li-bang Xiao Zi-Han Wu Jun-Jie Xin Yuan-Peng Cheng Bo Gui Jun-liang Sun Cheng Wang College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular SciencesPeking UniversityBeijing 100871China

Constructing three dimensional(3D)covalent organic frameworks(COFs)through the entanglement of two dimensional(2D)nets is a promising but underdeveloped ***,we report the design and synthesis of a fluorine functionalized 3DCOF(3D-An-COF-F)formed by entangled 2D sql *** structure of 3D-An-COF-F was determined by the combination of continuous rotation electron diffraction technique and modelling based on the chemical information from real ***,compared to the isostructural 3D-An-COF without F atom s,3DAn-COF-F showed an improved CO_(2)sorption ability and higher CO_(2)/N_(2)*** study not only demonstrated the generality of constructing 3D COFs with entangled 2D nets by introducing bulky groups vertically in planar building blocks,but also will expand the diversity of 3D COFs for various applications.

关键词： 3D covalent organic frameworks Fluorine Entangled 2D layers Electron diffraction CO_(2)adsorption

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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-bang Xu Wei-Jie Guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

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Integrated gut microbiota,plasma metabolomics and network pharmacology to reveal the anti-ischemic stroke effect of cooked rhubarb

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Traditional Medicine Research 2024年第9期9卷 1-13页

作者： Ting Li Lan-Fang Tan Lin Shen Jie-Hui Kuang Si-Kai Zhan bang Liu Jia-Le Cai Sheng-Wang liang Ming-Hua Xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization Guangxi Institute of BotanyChinese Academy of SciencesGuilin 541006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527300China

Background:Cooked rhubarb(CR)is obtained by steaming raw rhubarb(Rheum palmatum L.,Rheum officinale Baill.,or Rheum tanguticum *** Balf.)with millet *** is used as a traditional Chinese medicine for treating cerebral stroke,where patients often face severe *** study explored the pharmacological effects and mechanisms of CR against ischemic stroke(IS)in *** used integrated analysis of gut microbiota,metabolomics,and network ***:The compounds in CR were identified using LC-MS/*** impact of CR on rat middle cerebral artery occlusion/reperfusion(MCAO/R)-induced cerebral infarct size and brain tissue pathology was assessed through 2,3,5-triphenyl tetrazolium chloride and HE *** in hemorheology were measured by evaluating blood viscosity,and serum levels of pro-inflammatory cytokine were also *** microbiota composition was analyzed through 16S rRNA gene *** metabolites were examined using untargeted metabolomics and Spearman correlation *** pseudo-germ-free test was used to determine whether tumour necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)improvement in IS are dependent on gut ***:In vivo studies showed CR enhances neurobehavioral function in MCAO/R rats and reduces cerebral infarction *** also ameliorates brain and intestinal barrier damage caused by *** also decreased inflammation and oxidative stress in IS ***,CR promotes the growth of Akkermansia and Verrucomicrobia,aiding in intestinal barrier ***,CR primarily influences the primary bile acid biosynthesis *** pseudo-germ-free experiment and network pharmacology confirmed TNF-αand IL-1βas potential *** relies on gut microbiota for its anti-inflammatory effects to improve ***:Cooked rhubarb offers neuroprotective benefits by enhancing beneficial bacteria abundance and regulating bile acid *** emerges as a potential therapeutic agent for

关键词： cooked rhubarb ischemic stroke gut microbiota metabolomics

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考虑连续山体影响的耐张型悬索支撑输电结构风振响应分析

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工程力学 2024年第S1期41卷 31-37页

作者：王涛王邦杰李正良哈尔滨工业大学交通科学与工程学院黑龙江哈尔滨150090 哈尔滨工业大学重庆研究院重庆401151 重庆大学土木工程学院重庆400045 风工程及风资源利用重庆市重点实验室(重庆大学) 重庆400045

针对适用于山区的新型输电结构——悬索支撑输电结构,为了评估连续山体数量对该结构性能的影响,该文进行了连续山体影响下边界层风洞试验;基于试验数据,分析了平均和脉动风速在不同数量连续山体影响下的演变趋势,并给出了平均风修正系... 详细信息

针对适用于山区的新型输电结构——悬索支撑输电结构,为了评估连续山体数量对该结构性能的影响,该文进行了连续山体影响下边界层风洞试验;基于试验数据,分析了平均和脉动风速在不同数量连续山体影响下的演变趋势,并给出了平均风修正系数和脉动风修正系数的建议公式;提出了连续山体影响下悬索支撑输电结构的风致非线性动力分析方法;针对位于某耐张段的悬索支撑输电结构,评估了其风致动力响应受不同数量连续山体的影响。研究结果表明:当连续山体数量增加时,在山顶处,平均风修正系数先增大后平稳,在背风面山脚处,平均风修正系数先增大后减小,而最大脉动风修正系数呈现先减小后增大的趋势;就导线、支撑导线悬索的跨中位移和跨中张力而言,其均值和标准差随着连续山体数量增加呈现先减小再增加后逐渐平稳的趋势;不同数量连续山体对导线、支撑导线悬索跨中位移均值影响较为显著,对其标准差影响较小,而对于跨中张力则恰好相反。

关键词：连续山体风洞试验悬索支撑输电结构耐张段风振

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Gas microchannel plate-pixel detector for X-ray polarimetry

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Nuclear Science and Techniques 2024年第5期35卷 60-73页

作者： Huan-Bo Feng Hong-bang Liu Dong Wang Zi-Li Li Shu-Lin Liu Qian Liu Hang-Zhou Li Bin-Long Wang Yan-Jun Xie Zong-Wang Fan Hui Wang Ran Chen Di-Fan Yi Rui-Ting Ma Fei Xie Bo Peng Xiang-Ming Sun Jin Li En-Wei liang Present Address:Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Science Huzhou UniversityHuzhou 313000China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China The 13th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050057China

POLAR-2 is a gamma-ray burst(GRB)polarimeter that is designed to study the polarization in GRB radiation emissions,aiming to improve our knowledge of related ***-2 is expected to utilize an on-board polarimeter that is sensitive to soft X-rays(2-10 keV),called low-energy polarization *** have developed a new soft X-ray polari-zation detector prototype based on gas microchannel plates(GMCPs)and pixel chips(Topmetal).The GMCPs have bulk resistance,which prevents charging-up effects and ensures gain stability during *** detector is composed of low outgassing materials and is gas-sealed using a laser welding technique,ensuring long-term stability.A modulation factor of 41.28%±0.64% is obtained for a 4.5 keV polarized X-ray beam.A residual modulation of 1.96%±0.58% at 5.9 keV is observed for the entire sensitive area.

关键词： X-ray polarimetry Gas microchannel plate-pixel detector Gamma-ray bursts

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小天体柔性着陆任务规划的动态时间约束推理方法

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宇航学报 2024年第2期45卷 212-221页

作者：王棒徐瑞李朝玉朱圣英梁子璇北京理工大学宇航学院北京100081 深空自主导航与控制工信部重点实验室(北京理工大学) 北京100081

针对小天体柔性着陆任务规划中的复杂耦合时间约束一致性推理效率问题,建立任务规划时间约束网络,通过划分时间约束类型,设计约束动态添加策略,提出动态弧一致时间约束推理方法,限制新添加约束的传播范围,局部求解时间网络一致性,实现... 详细信息

针对小天体柔性着陆任务规划中的复杂耦合时间约束一致性推理效率问题,建立任务规划时间约束网络,通过划分时间约束类型,设计约束动态添加策略,提出动态弧一致时间约束推理方法,限制新添加约束的传播范围,局部求解时间网络一致性,实现规划过程中时间约束网络一致性的高效维护。最后,构建小天体着陆规划场景,生成着陆任务规划活动及时间约束。仿真结果表明,与现有时间约束推理方法相比,所提出方法提高了时间约束推理效率,进而可为小天体柔性着陆任务规划提供支撑。

关键词：小天体探测柔性着陆器着陆任务规划动态弧一致时间约束推理

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竹炭-沸石混合料可渗透反应墙修复镉污染地下水的试验

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中国环境科学 2024年第10期44卷 5607-5619页

作者：李子邦张亮刘豪龚星广东工业大学土木与交通工程学院广东广州510006 水利部长江勘测技术研究所湖北武汉430011 广东粤路勘察设计有限公司广东广州510630

本文结合物理力学测试、静态批和动态柱试验、微观表征分析、地下水数值模拟等手段分析了竹炭-沸石混合料填充可渗透性反应墙(PRB)对镉的吸附机理和时效性.竹炭(粒径大于0.18mm)和沸石(粒径大于0.5mm)按照质量分数1:10∼3:10混合时,不... 详细信息

本文结合物理力学测试、静态批和动态柱试验、微观表征分析、地下水数值模拟等手段分析了竹炭-沸石混合料填充可渗透性反应墙(PRB)对镉的吸附机理和时效性.竹炭(粒径大于0.18mm)和沸石(粒径大于0.5mm)按照质量分数1:10∼3:10混合时,不仅能有效去除地下水中镉,而且具备良好的渗透性和抗剪强度.竹炭-沸石混合料对镉的吸附能力随竹炭配比增加而增大,随粒径减小而增加;PRB柱穿透和耗竭时间随地下水流量和镉浓度增加而缩短.竹炭-沸石混合料去除镉的过程主要是发生络合反应、螯合作用、离子交换反应.地下水镉污染场地的PRB墙体厚度越大,地下水流速越慢,PRB的有效运行时间越长.

关键词：地下水镉污染可渗透反应墙长效性

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UV油墨对凹印烟标VOCs含量影响的实验研究

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印刷与数字媒体技术研究 2024年第1期 83-91页

作者：刘静何邦贵夏家良王琪昆明理工大学机电工程学院昆明650500 云南九九彩印有限公司昆明650032

为研究UV油墨应用于烟标的凹版印刷后,能否满足生产质量要求且有效降低烟标生产中VOCs排放和残留,本研究对当前烟标的凹版印刷工艺进行分析,以UV油墨作为烟标的印刷油墨,使用凹印机组进行打样试生产,最后对凹印车间VOCs排放量以及打样... 详细信息

为研究UV油墨应用于烟标的凹版印刷后,能否满足生产质量要求且有效降低烟标生产中VOCs排放和残留,本研究对当前烟标的凹版印刷工艺进行分析,以UV油墨作为烟标的印刷油墨,使用凹印机组进行打样试生产,最后对凹印车间VOCs排放量以及打样所得到的样张进行卷烟盒包装纸安全性指标和表面印刷质量检测。实验结果表明,使用UV油墨后,烟标中VOCs溶剂残留的检测结果均低于国家烟草专卖局所给出的限量标准,其中VOCs总含量仅为0.01mg/m~2,相比于溶剂油墨样张中VOCs总含量减少了2.3mg/m~2;同时车间VOCs总排放量减少了55.31mg/m~3,且烟标表面印刷质量相较于标准样张能达到90%以上的色彩还原度。实验可说明使用UV油墨有较好的VOCs减排作用,同时也大大提升了烟标的安全性能,成功解决了溶剂型油墨在烟标凹版印刷中VOCs排放量大和有害物质残留问题。

关键词：烟标凹版印刷 UV油墨 VOCs残留印刷工艺

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