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Effect of aflibercept combined with triamcinolone acetonide on aqueous humor growth factor and inflammatory mediators in diabetic macular edema

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 297-303页

作者： De-Shuang Li Hong-xia liao Jing-Lin Zhang Bo Qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To investigate the efficacy of aflibercept combined with sub-tenon injection of triamcinolone acetonide(TA)in treating diabetic macular edema(DME)and to examine changes in growth factors and inflammatory mediator levels in aqueous humor after ***:Totally 67 DME patients(67 eyes)and 30 cataract patients(32 eyes)were enrolled as the DME group and the control group,*** DME group was divided into the aflibercept group(34 cases)and the aflibercept combined with TA group(combined group,33 cases).The aqueous humor of both groups was collected during the study *** aqueous levels of vascular endothelial growth factor(VEGF),monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6),interleukin-8(IL-8),and interleukin-1β(IL-1β)were detected using a microsphere suspension array technology(Luminex 200TM).Aqueous cytokines,best-corrected visual acuity(BCVA),central macular thickness(CMT),and complications before and after treatment were compared between the aflibercept group and combined ***:The concentrations of VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor were significantly higher in the DME group than those of the control group(all P0.05).CONCLUSION:The cytokines VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor of DME patients are significantly *** and aflibercept combined with TA have good efficacy in DME patients,can effectively reduce CMT,improve the patient’s vision,and have high *** combined with TA can quickly downregulate the aqueous humor cytokines and help to relieve macular edema ***,the long-term eff

关键词： diabetic macular edema aqueous humor cytokines aflibercept triamcinolone acetonide

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Aflibercept combined with triamcinolone acetonide in the treatment of diabetic macular edema:optical coherence tomography and optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 670-675页

作者： De-Shuang Li Hong-xia liao Chuan-He Zhang Jian-Guo Huang Wei Chen Jing-Lin Zhang Bo Qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Department of Ophthalmology the University of Hong Kong-Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To analyze the relationship between optical coherence tomography(OCT)and OCT angiography(OCTA)imaging in patients with diabetic macular edema(DME)who are treated with a combination of aflibercept and triamcinolone acetonide(TA).METHODS:A total of 76 eyes newly diagnosed DME were included in this *** were randomly assigned to receive either aflibercept or a combination of aflibercept and *** once a month for a total of three *** macular thickness(CMT),number of hyperreflective foci(HRF),height of subretinal fluid(SRF),and area of foveal avascular zone(FAZ)were evaluated using OCT and OCTA at baseline and after each monthly ***:Both groups showed improvement in best corrected visual acuity(BCVA)and reduction in macular edema after treatment,and the difference in BCVA between the two groups was statistically significant after each treatment(P<0.05).The difference in CMT between the two groups was statistically significant after the first two injections(P<0.01),but not after the third injection(P=0.875).The number of HRF(1mo:7.41±8.25 vs 10.86±7.22,P=0.027;2mo:5.33±6.13 vs 9.12±8.61,P=0.034;3mo:3.58±3.00 vs 6.37±5.97,P=0.007)and height of SRF(1mo:82.39±39.12 vs 105.77±42.26μm,P=0.011;2mo:36.84±10.02 vs 83.59±37.78μm,P<0.01;3mo:11.57±3.29 vs 45.43±12.60μm,P<0.01)in combined group were statistically significant less than aflibercept group after each injection,while the area of FAZ showed no significant change before and after treatment in both ***:The combination therapy of aflibercept and TA shows more significant effects on DME eyes with decreased HRF and ***,both aflibercept and combination therapy show no significant change in the area of FAZ.

关键词： diabetic macular edema optical coherence tomography optical coherence tomography angiography hyperreflective foci subretinal fluid foveal avascular zone aflibercept

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Unearthing the impact of urban sprawl on transport carbon dioxide emissions:Fresh evidence from 274 Chinese cities

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Journal of Geographical Sciences 2024年第10期34卷 1953-1976页

作者： SHU Tianheng YU Taofang liao xia YANG Shuo School of Architecture Tsinghua UniversityBeijing 100084China Institute of Geographic Sciences and Natural Resources Research CASBeijing 100101China

Urban sprawl has been a prevailing phenomenon in developing countries like China,potentially resulting in significant carbon dioxide(CO_(2))emissions from the transport ***,the impact of urban sprawl on transport CO_(2) emissions(TCEs)is still not fully understood and remains somewhat *** systematically investigate how urban sprawl influences TCEs,we employ panel regression and panel threshold regression for 274 Chinese cities(2005-2020),and obtain some new *** results affirm that the degree of urban sprawl is positively associated with TCEs,and this holds true in different groups of city size and geographical region,while significant heterogeneity is observed in terms of such ***,we find urban sprawl nonlinearly impacts TCEs—with an equal increase in urban sprawl degree,TCEs are even lower in cities with larger population size and better economic condition,particularly in East ***,the low-carbon city pilot policy shows potential in mitigating sprawl's impact on *** on our findings,we argue that to achieve the target of TCEs reduction in China by curbing urban sprawl,more priority should be placed on relatively small,less developed,and geographically inferior cities for cost-efficiency reasons when formulating future urban development strategies.

关键词： transport carbon dioxide emissions urban sprawl heterogeneous impact carbon mitigation China

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厦门海沧隧道排水系统设计

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中国给水排水 2024年第14期40卷 63-68页

作者：廖改霞刘星郭志杰中交第二公路勘察设计研究院有限公司湖北武汉430050 武汉中交交通工程有限责任公司湖北武汉430050

厦门海沧隧道内排水系统设计的重难点是废水排除。为解决排水系统设计的关键技术问题,对隧道的排水量、废水泵房及污水泵房的形式、排水泵选型及数量、隧道运营初期的临时排污泵设计、废水泵房的出水总干管等进行分析。结果表明:对于矿... 详细信息

厦门海沧隧道内排水系统设计的重难点是废水排除。为解决排水系统设计的关键技术问题,对隧道的排水量、废水泵房及污水泵房的形式、排水泵选型及数量、隧道运营初期的临时排污泵设计、废水泵房的出水总干管等进行分析。结果表明:对于矿山法海底隧道,其内部的结构渗水与消防废水等宜采用清污分排;位于隧道最低点的废水池建议设计为共墙的2格水池,其内部可围绕废水泵设计不锈钢检修平台;废水泵房可选用长轴式深井排污泵;隧道运营初期可采用2台临时排污泵进行排水;废水泵房的出水总干管建议1用1备,可采用316L不锈钢管与内外涂环氧树脂钢管相组合的设计。

关键词：海底隧道排水系统结构渗水消防废水废水泵房

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东风堰灌溉工程遗产历史及价值研究

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四川水利 2024年第2期45卷 5-8页

作者：廖霞敖红漫夹江县东风堰保护服务中心四川乐山614100

东风堰灌溉工程位于长江三级支流青衣江夹江段左岸,始建于清康熙元年(1662年),在建成至今的360余年里,取水口经历三次上移,通过官方与民间持续共同管理,工程社会、经济、环境效益显著,为当地的社会经济发展做出了不可磨灭的贡献。在当... 详细信息

东风堰灌溉工程位于长江三级支流青衣江夹江段左岸,始建于清康熙元年(1662年),在建成至今的360余年里,取水口经历三次上移,通过官方与民间持续共同管理,工程社会、经济、环境效益显著,为当地的社会经济发展做出了不可磨灭的贡献。在当前大力推动文化强国、乡村振兴战略实施及生态文明建设的背景下,通过研究东风堰灌溉工程遗产的发展史、管理模式、产生的效益及科技文化价值等,对学习借鉴古代灌溉工程的人水和谐与可持续发展理念和智慧,促进东风堰灌溉工程遗产保护利用和可持续发展具有重要的现实意义。

关键词：东风堰遗产保护历史价值灌溉工程

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数字化绿色行为溢出的助推策略及其机理——基于蚂蚁森林情境的研究

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外国经济与管理 2024年第7期46卷 38-52页

作者：佘升翔李事成侯治平王建国廖夏广州工商学院商学院广东广州528138 贵州财经大学中国西部绿色发展战略研究院贵州贵阳550025 贵州财经大学工商管理学院贵州贵阳550025 浙江财经大学工商管理学院浙江杭州310018

行为溢出理论对于促进绿色生活方式变革有着重要涵义,但数字化情景下的研究还处于初步阶段。本研究在蚂蚁森林情境下,采用心理所有权和环境自我感知双重视角,构建了一个数字化绿色行为溢出效应模型,并首次同时检验了溢出过程的三种中介... 详细信息

行为溢出理论对于促进绿色生活方式变革有着重要涵义,但数字化情景下的研究还处于初步阶段。本研究在蚂蚁森林情境下,采用心理所有权和环境自我感知双重视角,构建了一个数字化绿色行为溢出效应模型,并首次同时检验了溢出过程的三种中介机制:心理所有权、环境自我认同和绿色效能。以蚂蚁森林用户为对象,设计了一个行为清单任务,操纵实验参与者选择更多或更少的绿色能量收集行为数量。均值比较结果表明,绿色能量收集行为提醒是有效的,即高绿组比低绿组产生了显著更高的心理所有权、环境自我感知以及进一步的亲环境行为意愿。此外,结构方程模型分析表明绿色能量收集行为选择数量与其他不同类型的亲环境行为之间存在积极的影响关系,并验证了心理所有权、环境自我认同和绿色效能在溢出过程中的共同中介作用。研究结论表明,数字化的日常绿色行为可以作为其他亲环境行为的催化剂,通过积极的行为溢出产生更深远的环保效果。

关键词：数字化绿色行为亲环境行为溢出心理所有权环境自我认同绿色效能

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Arsenic species analysis in porewaters and sediments using hydride generation atomic fluorescence spectrometry

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Journal of Environmental Sciences 2006年第5期18卷 995-999页

作者： liao Meng-xia DENG Tian-long College of Materials Chemistry and Chemical Engineering Chengdu University of Technology Chengdu 610059 China Qinghai Institute of Salt Lakes Chinese Academy of Sciences Xining 810008 China

It was observed that the atomic fluorescence emission due to signal during the determination of As（Ⅲ） in the mixture of As（Ⅲ） and As（V） could has a 10% to 40% of fluorescence emission As（V）. Besides, interferes from heavy metals such as Pb（Ⅱ）, Cu（Ⅱ） can cause severe increase of the signals as compared to the insignificant effects caused by Cd（Ⅱ）, Zn（Ⅱ）, Mn（Ⅱ） and Fe（Ⅲ）. On the basis of further studies, the masking agent of 8-hydroxyquinoline was used as an efficient agent to eliminate interference of As（V） emission and the heavy metal of Cu^2＋ and Pb^2＋ in the measurements of arsenic species, After a series standard additions and CRM researches, a sensitive and interference-free analytical procedure was developed for the speciation of arsenic in samples of porewaters and sediments in Poyang Lake, China.

关键词： arsenic speciation 8-hydroxyquinoline porewaters sediments Poyang Lake

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Reduction of SO2 to elemental sulfur over rare earth-iron catalysts

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Journal of Rare Earths 2009年第5期27卷 744-748页

作者： DENG Gengfeng JIANG Kun CAO xia liao Chunfa School of Materials and Chemical Engineering Jiangxi University of Science and Technology Ganzhou 341000 China School of Materials and Chemical Engineering Jiangxi University of Science and Technology Ganzhou 341000 China Nanchang Engineering and Research Institute of Nonferrous Metals Nanchang 330000 China School of Materials and Chemical Engineering Jiangxi University of Science and Technology Ganzhou 341000 China

With coal gas as a reducing agent, the catalytic reduction of SO2 to sulfur in the flue gas produced in metallurgical processes was studied over catalysts of rare earth-Fe/Al2O3 (REFe/Al2O3). The catalytic activity of the REFe/Al2O3 catalyst on the reduction of SO2 to sul-fur was investigated based on kinds and the contents of rare earths and different preparation method of the catalyst. Additionally, the mecha-nism of this catalytic reduction reaction was also explored. Results showed that different rare earth imposed different effect on the activity of the Fe/Al2O3 catalyst. Especially, the addition of Sm and Dy greatly improved the catalytic activity of Fe/Al2O3. The yield of sulfur over SmFe/Al2O3was increased to 86.62% at 360 ℃, which was 40.5% higher than that over Fe/Al2O3at the same temperature; and the sulfur yield over DyFe/Al2O3was increased to 91.62% at 400 ℃, 26.4% higher than that over Fe/Al2O3. The catalytic activity of REFe/Al2O3 was somehow dependent on the content of rare earth. For SmFe/Al2O3, the content of Sm was optimized to be about 1.0 wt.%. The rare earth catalyst prepared with different methods also showed varied activity. The sulfur yield over rare-earth transition metal catalysts follows the order: Sm and iron solution mixing impregnationSm first, then iron solution impregnationiron first, then Sm solution impregnation. The reaction mechanism of SO2 reduction to sulfur with coal gas was proposed to be an intermediate mechanism.

关键词： sulfur dioxide catalytic reduction sulfur flue gas rare earths

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A HYBRID MODEL FOR SIMULATING VELOCITY FIELD OF A RIVER WITH COMPLEX GEOMETRY PLUNGED BY MULTIPLE JETS

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Journal of Hydrodynamics 2006年第6期18卷 752-759页

作者： LI Lian-xia liao Hua-sheng LI Tian-xiang State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Chengdu 610065China

A hybrid model that combines both physical and numerical models was employed to simulate the velocity field in a river area in complex geometry with multiple plunging jets. The simulation was based on experiments concerning energy dissipation and scour prevention at the Xiluodu Hydropower Station on the Yangtze River. The calculated results indicate that the complex geometry of the river area has a significant influence on the velocity field, especially on the circulation flow pattern at upstream and downstream of the plunging area and on the asymmetric characteristics of the spiral flow near both banks. The scour characteristics of the downstream river bed caused by the multiple jets were also predicted and analyzed according to the characteristics of the calculated velocity field. The good agreement between the simulated and experimental results indicates that the hybrid model can be used to effectively solve complicated 3-D problems with complex geometric and inlet conditions. Such problems may not easily be solved by using either a physical or a numerical model alone, and therefore the method presented in this article is considered to be a practical and effective way of dealing with this kind of problems.

关键词： hybrid models turbulence model scour multiple jets

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Traditional Chinese medicine as supportive care for the management of liver cancer: Past, present, and future

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Genes & Diseases 2020年第3期7卷 370-379页

作者： xia liao Yang Bu Qingan Jia Department of Nutrition First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Hepatobiliary Surgery General HospitalNingxia Medical UniversityYinchuan750001China Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China

Liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death *** medicine and therapies are the primary treatment strategies of hepatocellular carcinoma(HCC),but the general prognosis for HCC patients is still *** these circumstances,HCC prevention is particularly *** Chinese medicine(TCM)encompasses a wealth of documented therapeutic resources,and“preventative treatment”is the principle of *** China,TCM has been used for HCC prevention for thousands of years,and has also been demonstrated to be effective for the treatment of HCC in modern ***,the TCM theory for prevention and treatment of HCC is more widely accepted in China than *** this review,we first summarize the herbs and ancient formulas with therapeutic effects on *** also review the research status of TCM in modern medicine as well as the current obstacles in its ***,we discuss the future of TCM in the context of precision and integrated *** reviewing the literature,we believe that TCM,through ancient development,is an advanced method of cancer treatment with positive curative effects,despite its surrounding ***,precise analyses and systematic research methods provides novel approaches to modernize TCM for the future.

关键词： Chinese herbal medicine Hepatocellular carcinoma Molecular mechanism Network pharmacology Traditional Chinese medicine

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