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Inonotus obliquus(Chaga)against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway

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Chinese Journal of Natural Medicines 2024年第7期22卷 619-631页

作者： FENG Yating LIU Jing GONG Le HAN Zhaodi ZHANG Yan LI Rongshan liao hui School of Pharmacy Shanxi Medical UniversityTaiyuan 030001China Drug Clinical Trial Institution The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)Taiyuan 030012China Department of Nephrology The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)Taiyuan 030012China

Our prior investigations have established that Inonotus obliquus(Chaga)possesses hypoglycemic *** hyperglycemia is known to precipitate renal function *** functionality of the kidneys is intricately linked to the levels of cyclic guanosine-3',5'-monophosphate(cGMP),which are influenced by the activities of nitric oxide synthase(NOS)and phosphodiesterase(PDE).Enhanced cGMP levels can be achieved either through the upregulation of NOS activity or the downregulation of PDE *** objective of the current study is to elucidate the effects of Chaga on disorders of glucolipid metabolism and renal abnormalities in rats with type 2 diabetes mellitus(T2DM),while concurrently examining the NOS-cGMP-PDE5 signaling pathway.A model of T2DM was developed in rats using a high-fat diet(HFD)combined with streptozotocin(STZ)administration,followed by treatment with Chaga extracts at doses of 50 and 100 mg·kg^(−1)for eight *** findings revealed that Chaga not only mitigated metabolic dysfunctions,evidenced by improvements in fasting blood glucose,total cholesterol,triglycerides,and insulin resistance,but also ameliorated renal function markers,including serum creatinine,urine creatinine(UCr),blood urea nitrogen,24-h urinary protein,and estimated creatinine ***,enhancements in glomerular volume,GBM thickness,podocyte foot process width(FPW),and the mRNA and protein expressions of podocyte markers,such as nephrin and wilms tumor-1,were *** was found to elevate cGMP levels in both serum and kidney tissues by increasing mRNA and protein expressions of renal endothelial NOS and neural NOS,while simultaneously reducing the expressions of renal inducible NOS and *** summary,Chaga counteracts HFD/STZ-induced glucolipid metabolism and renal function disturbances by modulating the NOS-cGMP-PDE5 signaling *** research supports the potential application of Chaga in the clinical prevention and treatment of T2DM and

关键词： Inonotus obliquus Diabetic nephropathy Glucolipid metabolism disorders Renal functions NOS-cGMP-PDE5 signaling

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A numerical survey of parameters to reach ignition condition for axial compression of a large-sized field reversed configuration

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Plasma Science and Technology 2024年第5期26卷 47-55页

作者：李宜霖廖晖周海洋孙玄 Department of Plasma Physics and Fusion Engineering School of Nuclear Science and TechnologyUniversity of Science and Technology of ChinaHefei 230026People’s Republic of China

Field reversed configuration(FRC)is widely considered as an ideal target plasma for magnetoinertial ***,its confinement and stability,both proportional to the radius,will deteriorate inevitably during radial ***,we propose a new fusion approach based on axial compression of a large-sized *** axial compression can be made by plasma jets or plasmoids converging onto the axial ends of the *** parameter space that can reach the ignition condition while preserving the FRC's overall quality is studied using a numerical model based on different FRC confinement *** is found that ignition is possible for a large FRC that can be achieved with the current FRC formation techniques if compression ratio is greater than 50.A more realistic compression is to combine axial with moderate radial compression,which is also presented and calculated in this work.

关键词： field reversed configuration magnetized target fusion axial compression

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Microbial community dynamics and flavor formation mechanisms during fermentation of fermented chilies from different regions based on macro-genome sequencing， SPME-GC-MS， electronic nose， and electronic tongue

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Food Science and Human Wellness 2024年

作者： hui liao Yi Luo Xiang Lian Hussain Asif Xinlei Huang Xiaole Xia The Key Laboratory of Industrial Biotechnology， Ministry of Education， School of Biotechnology， Jiangnan University College of Food Science and Engineering， Tianjin University of Science & Technology

Fermented chili products are popular traditional fermented foods around the world. However， differences in microbial communities in fermented chilies from different regions and how they affect the flavor compounds in chili fermentation have not been reported. In this study， the dynamics of flavor compounds and microbial communities in fermented chilies from Sichuan， Guizhou， and Hunan were systematically investigated by macro-genome sequencing， solid phase microextraction-gas chromatograph-mass spectrometry (SPME-GC-MS)， electronic nose， and electronic tongue techniques. Simultaneously， the microbial metabolic mechanisms and the relationship between flavor compounds and microbiome were unraveled through staged and simulated fermentation analysis. The results showed that 53 chemical odorants， including alcohols， esters， aldehydes， and acids， were identified as chemical markers to differentiate the regional samples. Twelve microbial species， including Staphylococcus xylosus， Unclassified staphylococcus species， Weissella confusus， Lactococcus cremoris， Lactococcus garvieae， Lactiplantibacillus sakei， Pediciococcus propionicigenes， Pediciococcus idahonensis， Pediciococcus aciditolerans， Nocardioides antri， Debaryomyces hansenii， and Colletotrichum scovillei， were identified as microbial markers to differentiate the regional samples. Correlation analysis showed that Lactobacillaceae was associated with fruity， floral， spicy， and fatty aromas. The electronic nose and tongue analysis results showed that 9 flavor and 8 taste indicators significantly differed between regional samples (P < 0.05). Additionally， flavor compounds and microbial diversity were robust under initial selection stress and showed higher diversity under metabolome-microbiome interactions. Importantly， simulated fermentation confirmed that metabolome-microbiome interactions drove the shift in microbial structure， metabolism， and flavor in regionally fermented chilies. These results provide insights into

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Effectiveness of the A3 robot on lower extremity motor function in stroke patients:A prospective,randomized controlled trial

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World Journal of Clinical Cases 2024年第24期12卷 5523-5533页

作者： Lin-Jian Zhang Xin Wen Yang Peng Wei Hu hui liao Zi-Cai Liu hui-Yu Liu Department of Rehabilitation Medicine Yuebei People's HospitalShaoguan 512000Guangdong ProvinceChina Department of Rehabilitation Medicine Shaoguan First People's HospitalShaoguan 512000Guangdong ProvinceChina Department of Rehabilitation Medicine Yuebei Second People's HospitalShaoguan 512026Guangdong ProvinceChina

BACKGROUND The results of existing lower extremity robotics studies are conflicting,and few relevant clinical trials have examined short-term *** addition,most of the outcome indicators in existing studies are scales,which are not objective *** used the combination of objective instrument measurement and scale to explore the short-term efficacy of the lower limb A3 robot,to provide a clinical *** To investigate the improvement of lower limb walking ability and balance in stroke treated by A3 lower limb *** Sixty stroke patients were recruited prospectively in a hospital and randomized into the A3 group and the control *** received 30 min of A3 robotics training and 30 min of floor walking training in addition to 30 min of regular rehabilitation *** training was performed five times a week,once a day,for 2 *** t-test or non-parametric test was used to compare the threedimensional gait parameters and balance between the two groups before and after *** The scores of basic activities of daily living,Stroke-Specific Quality of Life Scale,FM balance meter,Fugl-Meyer Assessment scores,Rivermead Mobility Index,Stride speed,Stride length,and Time Up and Go test in the two groups were significantly better than before treatment(19.29±12.15 vs 3.52±4.34;22.57±17.99 vs 4.07±2.51;1.21±0.83 vs 0.18±0.40;3.50±3.80 vs 0.96±2.08;2.07±1.21 vs 0.41±0.57;0.89±0.63 vs 0.11±0.32;12.38±9.00 vs 2.80±3.43;18.84±11.24 vs 3.80±10.83;45.12±69.41 vs 8.41±10.20;29.45±16.62 vs 8.68±10.74;P<0.05).All outcome indicators were significantly better in the A3 group than in the control group,except the area of the balance *** For the short-term treatment of patients with subacute stroke,the addition of A3 robotic walking training to conventional physiotherapy appears to be more effective than the addition of ground-based walking training.

关键词： Stroke Robotics Gait Robot-assisted gait training Neurological rehabilitation Walking training

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Acquired immune thrombotic thrombocytopenic purpura(TTP)associated with inactivated COVID-19 vaccine CoronaVac

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Frontiers of Medicine 2024年第4期18卷 744-751页

作者： Zhangbiao Long Suyu Jiang Honglei Xin Lu Zhang Ruinan Lu Fengqi Liu Yong Xu Linv Wang Jun Wang Xuezhong Zhang hui liao Jinning Shi Xue Yan Xiang Zhu Ruonan Shao Zijian Li Yilin Zhu Han Yan Jiao Wu Chao Fang Xiaodong Xi Xiaofeng Shi Department of Hematology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Hematology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing210003China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing210029China Department of Hematology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing210008China Department of Hematology The Affiliated Hospital of Nanjing University of Chinese MedicineThe First Clinical Medical College of Nanjing University of Chinese MedicineNanjing210009China Department of Hematology Zhongda Hospital of Southeast UniversityNanjing210044China Department of Hematology Nanjing First HospitalNanjing Medical UniversityNanjing210006China Department of Hematology The Air Force Hospital of Eastern Theater commandNanjing210016China Department of Hematology Jiangning Hospital Affiliated of Nanjing Medical UniversityNanjing211199China Department of Hematology Nanjing Hospital of Chinese MedicineNanjing210006China Department of Pharmacology School of Basic MedicineTongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseasesHuazhong University of Science and TechnologyThe Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei ProvinceWuhan430030China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China

Corona virus disease 2019(COVID-19)due to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has affected the whole *** thrombotic thrombocytopenic purpura(TTP)has been reported after administration of mRNA-or adenoviral vector-based COVID-19 vaccines,including ***2-S,BNT162b2,mRNA-1273,and ChAdOx1 ***,whether inactivated vaccines,such as CoronaVac,could cause TTP and whether the symptoms in TTPs caused by inactivated vaccines are different from previously reported cases are *** this study,two cases were *** cases developed TTP after the second CoronaVac vaccination shot,but not the *** demonstrated symptoms of fever,neurological abnormalities,renal dysfunction,thrombocytopenia,and *** patients achieved complete remission through several sessions of plasma exchanges and immune *** incidence of TTP in Nanjing area was *** number of patients with TTP was 12 in 2019,6 in 2020,16 in 2021,and 19 in *** the authors’knowledge,this report is the first report of TTP associated with inactivated COVID-19 vaccine(CoronaVac).The rarity and delayed onset may be due to the relatively milder immune response caused by the inactivated vaccines than mRNA-based *** plasma exchange is a vital treatment for CoronaVac-related TTP,similar to activated vaccine-related TTP.

关键词： thrombotic thrombocytopenia purpura(TTP) corona virus disease 2019(COVID-19) CoronaVac acute respiratory syndrome coronavirus 2(SARS-CoV-2) vaccine

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数据挖掘技术在社交媒体大数据分析中的应用及挑战

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移动信息 2024年第7期46卷 282-285页

作者：廖慧中国传媒大学北京100024

社交平台的普及使得海量用户数据持续积淀于数据库,为广大研究者呈现了一批宝贵且稀缺的知识资源。数据挖掘技术被认为是高效的应用方法,社交媒体大数据分析在诸多领域中具有重要应用价值。文中主要探讨了数据挖掘在处理社交媒体大数据... 详细信息

社交平台的普及使得海量用户数据持续积淀于数据库,为广大研究者呈现了一批宝贵且稀缺的知识资源。数据挖掘技术被认为是高效的应用方法,社交媒体大数据分析在诸多领域中具有重要应用价值。文中主要探讨了数据挖掘在处理社交媒体大数据中遇到的机遇与挑战,详述了社交媒体大数据的特性,及数据挖掘在此领域的基础运作原理。经过对数据挖掘技术在社交媒体大数据分析领域的深入研究,归纳出了涉及用户行为分析、情感解读、社交网络探究等的关键应用。

关键词：社交媒体大数据分析数据挖掘技术用户行为分析情感分析

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血常规+凝血5项指标检验在不同孕期孕产妇临床妊娠期间的应用价值研讨

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科技与健康 2024年第3期3卷 35-38页

作者：廖慧开阳县妇幼保健院贵州贵阳550300

研究分析孕产妇临床妊娠期间不同孕期血常规+凝血5项指标检验的应用价值及检验作用。将开阳县妇幼保健院孕期保健科2021年3月—2022年12月建档的192例孕产妇分为孕早期、孕中期、临晚期孕妇各64例,对其实施血常规+凝血5项指标检验,分析... 详细信息

研究分析孕产妇临床妊娠期间不同孕期血常规+凝血5项指标检验的应用价值及检验作用。将开阳县妇幼保健院孕期保健科2021年3月—2022年12月建档的192例孕产妇分为孕早期、孕中期、临晚期孕妇各64例,对其实施血常规+凝血5项指标检验,分析不同孕期孕产妇检验所得指标数据有无差异及检验在临床的应用价值。血常规指标项中,白细胞计数、红细胞计数、血红蛋白、红细胞分布宽度、平均红细胞体积及血小板计数等血常规指标数据相比均具有统计学意义(P<0.05);将孕早期、孕中期、临晚期孕妇血常规指标项数据做统计比较,可见不同孕期孕妇血常规检验指标项部分具有差异性(P<0.05);将凝血5项指标检验所得指标数据实施比对,孕早期、孕中期、临晚期孕妇各项指标数据相比,部分指标项数据具有差异性(P<0.05)。研究发现,随孕期变化,孕产妇机体凝血系统功能会出现改变,由此可指证孕产妇机体凝血系统状态,检出有异常情况孕产妇并协同临床及时予以其相应诊疗干预,由此保障母婴安全。

关键词：血常规凝血5项指标不同孕期孕产妇妊娠期间

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基于资源池视角的废弃电子产品逆向物流系统协同模型研究

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物流研究 2024年第5期 74-81页

作者：廖瑞辉江苏大学管理学院江苏镇江212013

废弃电子产品具有双重属性,其逆向物流网络分布范围广并且数量增长迅速。不同主体对废弃电子产品逆向物流的需求是不同的,单个的逆向物流节点很难同时满足不同需求,如何合理高效地协调各个逆向物流节点的资源,以满足各个逆向物流任务是... 详细信息

废弃电子产品具有双重属性,其逆向物流网络分布范围广并且数量增长迅速。不同主体对废弃电子产品逆向物流的需求是不同的,单个的逆向物流节点很难同时满足不同需求,如何合理高效地协调各个逆向物流节点的资源,以满足各个逆向物流任务是亟待解决的重要问题。在数字技术的支持下,逆向物流信息协同领域得到丰富和完善,针对传统模式中废弃电子产品回收处理过程存在的资源利用率低、浪费严重等情况,将整个逆向物流网络看作资源池,采用智能体(Agent)处理功能网络的任务迁移模式代替传统方法中大量的数据迁移模式,构建了基于多智能体(Multi-Agent)的废弃电子产品逆向物流系统资源协同模型,最后仿真结果验证了所建模型的有效性和可行性,为废弃电子产品逆向物流系统的资源调度分配提供了新的解决方案。

关键词： Multi-Agent 废弃电子产品资源池逆向物流调度优化

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肌酸类运动营养补充剂的研究进展

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食品与发酵工业 2024年第10期50卷 318-326页

作者：廖惠朱松赵砚婷李菲李翔李玥江南大学食品学院江苏无锡214122 食品科学与资源挖掘全国重点实验室(江南大学) 江苏无锡214122 雅培营养中国研发中心上海200003

肌酸是一种天然存在的含氮化合物,别名N-甲基胍基乙酸,能够作为能量来源促进细胞代谢。肌酸补充剂已被广泛应用于运动营养领域,以改善运动表现、提高运动能力。运动员在补充肌酸的过程中,往往还会补充其他的营养物质,期望结合不同补充... 详细信息

肌酸是一种天然存在的含氮化合物,别名N-甲基胍基乙酸,能够作为能量来源促进细胞代谢。肌酸补充剂已被广泛应用于运动营养领域,以改善运动表现、提高运动能力。运动员在补充肌酸的过程中,往往还会补充其他的营养物质,期望结合不同补充剂的促进作用,产生协同效应,获得最佳的运动表现。该文综述了肌酸在人体内的合成和肌酸补充剂的形式、安全性,总结了不同样品中肌酸的检测方法及优缺点,重点阐述了补充肌酸以及肌酸与碳水化合物、β-羟基-β-甲基丁酸、咖啡因、碳酸氢钠和α-硫辛酸联合补充对运动的作用,以期为肌酸在运动营养中的研究和在运动训练过程中的应用提供参考。

关键词：肌酸代谢检测补充运动营养

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中国科技政策合力下的地方创新活动——基于地方政府政策文本的分析

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财经研究 2024年第6期50卷 19-33页

作者：于云云朱平芳孟醒廖辉上海社会科学院数量经济研究中心上海交通大学安泰经济与管理学院

要加快实现高水平科技自立自强,当下科技创新“九龙治水”的问题亟待破解,科技政策制定和实施过程中存在的资源碎片化投入、措施分散式出台等问题迫切需要解决,因此开展关于科技政策综合治理效力的相关研究具有重要意义。文章首先阐述... 详细信息

要加快实现高水平科技自立自强,当下科技创新“九龙治水”的问题亟待破解,科技政策制定和实施过程中存在的资源碎片化投入、措施分散式出台等问题迫切需要解决,因此开展关于科技政策综合治理效力的相关研究具有重要意义。文章首先阐述了科技政策合力影响创新活动的机理,然后运用文本方法基于31个省份近20年的科技政策文件测算了政策合力,最后对其如何影响创新活动进行了实证检验。研究发现,科技政策主体合力和措施合力均能促进创新活动。科技政策合力能够通过增强市场活力对创新活动的激励效应和减弱寻租行为对创新活动的抑制效应,促进科技创新。此外,科技政策合力还能显著提高创新投入的转化效率。在照搬中央政策及延续往年政策而导致政策同质化严重的地区,科技政策合力对创新活动的促进作用会被削弱；在创新资源禀赋丰富的地区,科技政策合力对创新活动的促进作用更加显著。文章的研究为提升科技治理成效提供了重要的依据和启示。

关键词：政策合力创新活动寻租政策同质化

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