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A hybrid pigeon inspired optimization algorithm based on Nelder-Mead simplex operations

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A hybrid pigeon inspired optimization algorithm based on Nel...

One-step Synthesis of Polysubstituted N-Sulfonylazetidin-2-imines via Copper-catalyzed Sequential Multicomponent/S-S Coupling Reaction

第三十九届中国控制会议

作者： Yi Zhong Yaping Zhang kaisheng liao Zhenghong Zhang Southwest China Research Institute of Electronic Equipment

As a recent swarm-based intelligent optimization algorithm, Pigeon Inspired Optimization（PIO）, is motivated by the natural bio-mechanism of pigeons for their superior skills in destination finding and navigating. The standard PIO has been successfully implemented to solve complex optimization problems. Similar to other swarm intelligent techniques, PIO is suitable to solve global optimization problems for its robustness in adapting to dynamic environments, where the convergence rate is generally limited, since the algorithm does not employ much local information to establish a most promising direction for optima searching. In this paper, we propose a novel hybridized optimization algorithm, Nelder-Mead Pigeon Inspired Optimization（NMPIO）, incorporating the global optimization ability of PIO and the capability of fast local convergent of the Nelder-Mead Simplex method. With the implementation of synthesizing a bio-inspired optimization algorithm and a direct local search method, feasible global optimal solution can be found with a faster convergence rate, compared with the original PIO algorithm. Numerical experiments for several well-known benchmarks are conducted to study the performance of this algorithm. The results reveal that our hybridization strategy is effective and efficient for solving global optimization problems.

关键词： Mathematical Optimization Pigeon-Inspired Optimization Nelder-Mead Simplex Global Optimization

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One-step Synthesis of Polysubstituted N-Sulfonylazetidin-2-i...

Key characterization factors of accurate power modeling for Fin FET circuits

第十七届全国金属有机化学学术讨论会

作者： Xinwei He kaisheng liao Zhenglei Yan Fuyin Zhou Manman Hu Yongjia Shang Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Key Laboratory of Molecule-Based MaterialsCollege of Chemistry and Materials Science Anhui Normal University

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Science China(Information Sciences) 2015年第2期58卷 182-194页

作者： MA kaisheng CUI XiaoXin liao Kai liao Nan WU Di YU DunShan Institution of Microelectronics Peking University Department of Computer Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16801 USA

Due to its excellent device features, manufacture process compatibility and diversity of the circuit structures, The Fin FET is considered appropriate candidate for the conventional bulk-MOSFET in sub-22 nm technology nodes. However, the power estimation CAD tools for Fin FET are missing at the moment, which mainly results from the absence of Fin FET power analysis and Fin FET power model. Three key factors for Fin FET power model are: the dimension of the look-up-tables, that to find out the most significant factors that influence Fin FET power and to make them as indexes for the look-up-tables; the distance between sampling points; and the interpolation method. In this paper, various factors that may contribute to the Fin FET power consumption are evaluated. Of all the factors, the continuous ones are compared with sensitivity method. As to other discrete factors, methods of building them in power model are given according to the features of the each factor and the way it influences the power. Based on the simulation result, standard cell power library model for Fin FET is proposed. The research work lays foundation for accurate power analysis and modeling for high-level power analysis of Fin FET circuits. Besides, these key factors are also crucial for low-power Fin FET circuit design.

关键词： Fin FET power modeling leakage power internal power input slew output load

Ultra-low power dissipation of improved complementary pass-transistor adiabatic logic circuits based on FinFETs

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Science China(Information Sciences) 2014年第4期57卷 273-285页

作者： liao Kai CUI XiaoXin liao Nan MA kaisheng WU Di WEI Wei LI Rui YU DunShan Institute of Microelectronics Peking University

With the technology scaling down,low power dissipation has become one of the research focuses in the field of integrated circuit *** types of adiabatic logics have been invented for low-power ***,the expanding leakage current degrades the performance of conventional adiabatic *** this article,a novel improved complementary pass-transistor adiabatic logic(ICPAL)based on fin-type fieldeffect transistor(FinFET)devices with ultra-low power dissipation has been *** proposed ICPAL takes full advantage of different FinFET operating modes,that is,shorted-gate mode,independent-gate mode,and low-power mode,to make a tremendous reduction in power *** explication and verification,the power dissipation of different ICPAL standard cells has been investigated and compared with other types of adiabatic circuits based on *** results show that the ICPAL circuits have ultra-low power dissipation in a wide range of clock frequencies(30-800 MHz)under the condition of similar number of transistors,and the average reduction in power dissipation is about 23.1%,75.0%,and 50.0%relative to 2N-2N2P,improved passtransistor adiabatic logic,and complimentary pass-transistor adiabatic logic,***,ICPAL supports a better pre-evaluation of system power dissipation in VLSI design and has an intrinsic characteristic for the resistance to some types of side channel attacks.

关键词： low power dissipation adiabatic logic ICPAL FinFETs standard logic cells

Low power adiabatic logic based on FinFETs

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Science China(Information Sciences) 2014年第2期57卷 194-206页

作者： liao Nan CUI XiaoXin liao Kai MA kaisheng WU Di WEI Wei LI Rui YU DunShan Institute of Microelectronics Peking University

With the aggressive scaling of device technology,the leakage power has become the main part of power consumption,which seriously reduces the energy recovery efciency of adiabatic *** this paper,a novel low-power adiabatic logic based on FinFET devices has been *** to the lower leakage current,higher on-state current and design flexibility of FinFETs,the proposed adiabatic logic shows considerable power reduction,performance improvement and area saving compared with CMOS adiabatic *** 8-state clock chain as the test circuit has been demonstrated based on the 32-nm FinFET Predictive Technology *** simulation results show that adiabatic circuit based on FinFET devices achieves a power reduction of up to84.8%and a limiting frequency of up to 55 GHz.

关键词： leakage power FinFET adiabatic logic power reduction limiting frequency

LSD1对结肠癌细胞侵袭转移能力的影响及其机制探讨

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中华医学杂志 2017年第10期97卷 743-748页

作者：丁杰张忠民董奇糜睿徐开盛杨晓飞廖国庆贵州省人民医院胃肠外科贵阳550002 中南大学湘雅医院胃肠外科

目的探讨赖氨酸特异性组蛋白去甲基化酶1（lysine-specific demethylase 1, LSD1）对结肠癌细胞侵袭转移能力的影响及其机制。方法利用RNAi技术和单胺氧化酶抑制剂（Pargyline）在体外抑制结肠癌细胞（SW620）中LSD1的表达，采用MTT细... 详细信息

目的探讨赖氨酸特异性组蛋白去甲基化酶1（lysine-specific demethylase 1, LSD1）对结肠癌细胞侵袭转移能力的影响及其机制。方法利用RNAi技术和单胺氧化酶抑制剂（Pargyline）在体外抑制结肠癌细胞（SW620）中LSD1的表达，采用MTT细胞增殖实验、Transwell细胞侵袭实验、FCM细胞凋亡实验检测抑制LSD1的表达对结肠癌细胞SW620增殖、侵袭、凋亡的影响。结果体外合成了三段siRNA序列（siRNA-1554、siRNA-705、siRNA-1973），经检测siRNA-705的沉默效率最高。利用siRNA-705和单胺氧化酶抑制剂体外干预SW620细胞，能明显抑制SW620细胞的增殖、侵袭和转移能力，并能诱导细胞凋亡。同时我们发现，使用siRNA-705和单胺氧化酶抑制剂处理72 h后，结肠癌细胞的E钙黏蛋白的表达水平明显上调，N钙黏蛋白的表达水平明显下调（P〈0.05）。结论体外抑制LSD1的表达能抑制结肠癌细胞的增殖、侵袭转移能力，诱导细胞凋亡，并能上调E钙黏蛋白的表达，下调N钙黏蛋白的表达，三者可能在结肠癌的侵袭转移过程中发挥了重要作用。

关键词：结肠肿瘤赖氨酸特异性组蛋白去甲基化酶1 E-钙黏蛋白 N-钙黏蛋白转移

TGF-β/Smads信号通路对胃肠间质瘤细胞增殖和侵袭能力的影响

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肿瘤 2018年第1期38卷 10-17页

作者：丁杰张忠民徐开盛董奇糜睿刘航蒋专杨晓飞廖国庆贵州省人民医院胃肠外科贵州贵阳550002 中南大学湘雅医院胃肠外科湖南长沙410008

目的:探讨转化生长因子β(transforming growth factor-β,TGF-β)/Smads信号通路对胃肠间质瘤(gastrointestinal stromal tumor,GIST)细胞增殖、侵袭能力的影响及可能的作用机制。方法:分别采用外源性TGF-β1单独或联合不同浓度的SB-43... 详细信息

目的:探讨转化生长因子β(transforming growth factor-β,TGF-β)/Smads信号通路对胃肠间质瘤(gastrointestinal stromal tumor,GIST)细胞增殖、侵袭能力的影响及可能的作用机制。方法:分别采用外源性TGF-β1单独或联合不同浓度的SB-431542处理GIST882细胞,激活和阻断GIST882细胞的TGF-β/Smads信号转导通路;采用MTT法检测激活和阻断TGF-β/Smads信号通路对GIST882细胞增殖能力的影响,Transwell小室侵袭实验检测对GIST882细胞侵袭能力的影响;实时荧光定量PCR和蛋白质印迹法检测激活和阻断TGF-β/Smads信号通路后对GIST882细胞中Slug mRNA和蛋白表达的影响。采用siRNA干扰的方法沉默Smad3基因的表达,并采用实时荧光定量PCR和蛋白质印迹法检测Smad3基因的沉默效率,及对GIST882细胞中Slug mRNA及蛋白表达的影响。结果:TGF-β1激活TGF-β/Smads信号通路后,GIST882细胞的增殖活性和侵袭能力均明显增高(P值均<0.05),而SB-431542阻断TGF-β/Smads信号通路后GIST882细胞的增殖活性和侵袭能力均较TGF-β1单药组明显下降(P值均<0.05)。激活TGF-β/Smads信号通路后,GIST882细胞中转录因子Slug mRNA和蛋白的表达水平明显上调(P值均<0.01);而采用SB-431542阻断该信号通路后Slug mRNA和蛋白的表达水平均较TGF-β1单药组明显下调(P值均<0.05),且呈浓度依赖性。Smad3-siRNA2能有效沉默GIST882细胞中Smad3基因的表达,Slug mRNA和蛋白水平也明显下调(P<0.05和P<0.01)。结论:TGF-β/Smads信号通路能介导GIST882细胞的增殖和侵袭能力,调控Slug的表达,且该调控是Smad3依赖性的。Slug可能在TGF-β/Smads信号通路介导的GIST转移过程中发挥重要的作用。

关键词：胃肠间质瘤转化生长因子β 细胞增殖肿瘤转移

中间入路与侧方入路腹腔镜结直肠切除术比较的Meta分析

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中华胃肠外科杂志 2014年第5期17卷 480-485页

作者：丁杰廖国庆张忠民潘扬徐开盛王少勇李东苗晏仲舒贵州省人民医院胃肠外科贵阳550002 中南大学湘雅医院胃肠外科

目的：评价中间入路与侧方入路腹腔镜结直肠切除术治疗结直肠疾病的安全性与有效性。方法以Medline、Embase和Cochrane Library数据库作为已发表国外文献的主要来源，以万方数据知识服务平台和中国知网数据出版平台作为已发表国内文献... 详细信息

目的：评价中间入路与侧方入路腹腔镜结直肠切除术治疗结直肠疾病的安全性与有效性。方法以Medline、Embase和Cochrane Library数据库作为已发表国外文献的主要来源，以万方数据知识服务平台和中国知网数据出版平台作为已发表国内文献的主要来源；检索时间：2013年4月20日。收集1994年1月1日至2013年4月20日公开发表的比较中间入路和侧方入路腹腔镜结直肠切除术的队列研究的中文和英文文献。结果筛选出符合纳入标准的队列研究5项，其中实施中间入路和侧方入路的患者分别为416例和465例。与侧方入路相比，中间入路腹腔镜手术的中转开腹率（OR＝0．42，95％CI：0．25～0．72，P＝0．001）、手术时间（WMD＝-51．56，95％CI：-72．72～-30．41，P＜0．01）均明显减少；出血量和住院费用仅有1篇文献报道未作合并分析；中间入路手术清扫的淋巴结数目也明显较少（WMD＝-1．17，95％CI：-1．89～-0．45，P＝0．001）。两种手术入路的术中并发症发生率（OR＝0．57，95％CI：0．15～2．18，P＝0．41）和术后并发症发生率（OR＝0．78，95％CI：0．52～1．17，P＝0．23）差异均无统计学意义。结论中间入路的腹腔镜结直肠切除术具有手术时间短、中转开腹率低的优势，而且其与侧方入路的手术安全性相当。但中间入路是否具有出血量少和住院费用低的优点，以及与侧方入路相似的肿瘤学安全性都有待于进一步研究。

关键词：腹腔镜结直肠切除中间入路侧方入路 Meta分析

MIKE11模型在河道防洪评价中的应用研究——以深圳市观澜河为例

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人民珠江 2023年第S1期44卷 74-78页

作者：史凯升白佳喆白老朋廖廷光深圳市观澜河流域管理中心广东深圳518000 清华大学深圳国际研究生院广东深圳518055

以观澜河4条支流口增设的汀步为研究对象,根据确定成灾水位、保证水位以及警戒水位的原则和洪峰流量成果,考虑选用MIKE11模型计算4个典型断面的特征水位对河道进行防洪评价。通过评价河道典型断面的防洪能力,确定各个河段的过流能力和... 详细信息

以观澜河4条支流口增设的汀步为研究对象,根据确定成灾水位、保证水位以及警戒水位的原则和洪峰流量成果,考虑选用MIKE11模型计算4个典型断面的特征水位对河道进行防洪评价。通过评价河道典型断面的防洪能力,确定各个河段的过流能力和防洪安全可靠性,为河道防洪治理规划和防汛调度安全提供一定的指导作用。

关键词： MIKE11模型防洪评价观澜河