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Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling

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World Journal of Gastroenterology 2024年第26期30卷 3229-3246页

作者： juan Sun Jin-Xiu Zhang Meng-Shi Li Meng-Bin Qin Ruo-Xi Cheng Qing-Ru Wu Qiu-Ling Chen Dan Yang Cun liao Shi-Quan liu Jie-An Huang Department of Gastroenterology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007Guangxi Zhuang Autonomous RegionChina Department of Colorectal&Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Monopolar spindle-binding protein 3B(MOB3B)functions as a signal transducer and altered MOB3B expression is associated with the development of human *** To investigate the role of MOB3B in colorectal cancer(CRC).METHODS This study collected 102 CRC tissue samples for immunohistochemical detection of MOB3B expression for association with CRC *** overexpression and knockdown of MOB3B expression were induced in CRC cell lines,changes in cell viability,migration,invasion,and gene expression were *** cell autophagy was detected using transmission electron microscopy,while nude mouse xenograft experiments were performed to confirm the in-vitro *** MOB3B expression was reduced in CRC vs normal tissues and loss of MOB3B expression was associated with poor CRC *** of MOB3B protein in vitro attenuated the cell viability as well as the migration and invasion capacities of CRC cells,whereas knockdown of MOB3B expression had the opposite effects in CRC *** the molecular level,microtubule-associated protein light chain 3 II/I expression was elevated,whereas the expression of matrix metalloproteinase(MMP)2,MMP9,sequestosome 1,and phosphorylated mechanistic target of rapamycin kinase(mTOR)was downregulated in MOB3B-overexpressing RKO *** contrast,the opposite results were observed in tumor cells with MOB3B *** nude mouse data confirmed these in-vitro findings,i.e.,MOB3B expression suppressed CRC cell xenograft growth,whereas knockdown of MOB3B expression promoted the growth of CRC cell *** Loss of MOB3B expression promotes CRC development and malignant behaviors,suggesting a potential tumor suppressive role of MOB3B in CRC by inhibition of mTOR/autophagy signaling.

关键词： Colorectal cancer Monopolar spindle-binding protein 3B Mechanistic target of rapamycin kinase Autophagy Prognosis

A transcriptional cascade involving BBX22 and HY5 finely regulates both plant height and fruit pigmentation in citrus

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Journal of Integrative Plant Biology 2024年第8期66卷 1752-1768页

作者： Jialing Fu Li liao Jiajing Jin Zhihao Lu juan Sun Lizhi Song Yue Huang Shengjun liu Ding Huang Yuantao Xu Jiaxian He Bin Hu Yiqun Zhu Fangfang Wu Xia Wang Xiuxin Deng Qiang Xu National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070P.R.China Hubei Hongshan Laboratory Wuhan 430070P.R.China Science and Technology Innovation Research Center of Majia Pomelo Shangrao 334000China

Dwarfing is a pivotal agronomic trait affecting both yield and *** species exhibit substantial variation in plant height,among which internode length is a core ***,the molecular mechanism governing internode elongation remains ***,we unveiled that the transcriptional cascade consisting of B-BOX DOMAIN PROTEIN 22(BBX22)and ELONGATED HYPOCOTYL 5(HY5)finely tunes plant height and internode elongation in ***-of-function mutations of BBX22 in an early-flowering citrus(Citrus hindsii“SJG”)promoted internode elongation and reduced pigment accumulation,whereas ectopic expression of BBX22 in SJG,sweet orange(***),pomelo(***)or heterologous expression of BBX22 in tomato(Solanum lycopersicum)significantly decreased internode ***,exogenous application of gibberellin A3(GA3)rescued the shortened internode and dwarf phenotype caused by *** experiments revealed that BBX22 played a dual role in regulation internode elongation and pigmentation in *** the one hand,it directly bound to and activated the expression of HY5,GA metabolism gene(GA2 OXIDASE 8,GA2ox8),carotenoid biosynthesis gene(PHYTOENE SYNTHASE 1,PSY1)and anthocyanin regulatory gene(Ruby1,a MYB DOMAIN PROTEIN).On the other hand,it acted as a cofactor of HY5,enhancing the ability of HY5 to regulate target genes ***,our results reveal the critical role of the transcriptional cascade consisting of BBX22 and HY5 in controlling internode elongation and pigment accumulation in *** the crosstalk regulatory mechanism between internode elongation and fruit pigmentation provides key genes for breeding of novel types with both dwarf and health-beneficial fortification in citrus.

关键词： anthocyanins BBX22 carotenoids citrus HY5 internode elongation plant height

Simultaneous guidance of electromagnetic and elastic waves via glide symmetry phoxonic crystal waveguides

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Chinese Physics B 2024年第3期33卷 363-368页

作者：雷林霖何灵娟廖清华刘文兴于天宝 School of Physics and Materials Science Nanchang UniversityNanchang 330031China

A phoxonic crystal waveguide with the glide symmetry is designed,in which both electromagnetic and elastic waves can propagate along the glide plane at the same *** to the glide symmetry,the bands of the phoxonic crystal super-cell degenerate in pairs at the boundary of the Brillouin *** is the so-called band-sticking effect and it causes the appearance of gapless *** adjusting the magnitude of the glide dislocation the edge bandgaps,the bandgap of the guided-modes at the boundary of the Brillouin zone,can be further *** photonic and phononic guided-modes can then possess only one mode for a certain frequency with relatively low group velocities,achieving single-mode guided-bands with relatively flat dispersion *** addition,there exists acousto-optic interaction in the cavity constructed by the glide *** proposed waveguide has potential applications in the design of novel optomechanical devices.

关键词： phoxonic crystals glide symmetry waveguide acousto-optic interaction

正负气压组合滚轮式油菜精密排种器设计与试验

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农业机械学报 2024年第5期55卷 63-76页

作者：廖宜涛刘嘉诚廖庆喜郑娟李甜蒋杉华中农业大学工学院武汉430070 农业农村部长江中下游农业装备重点实验室武汉430070

针对油菜种子粒径小、质量轻,单粒排种难度较大的问题,设计了一种正负气压组合滚轮式精密排种器。阐明了排种器工作原理,开展排种器吸种、携种和卸种环节受力分析和排种滚轮对种群拖带过程解析;提出了通过控制充种区种层高度和种群压力... 详细信息

针对油菜种子粒径小、质量轻,单粒排种难度较大的问题,设计了一种正负气压组合滚轮式精密排种器。阐明了排种器工作原理,开展排种器吸种、携种和卸种环节受力分析和排种滚轮对种群拖带过程解析;提出了通过控制充种区种层高度和种群压力的防拖带堆积机理,设计了一种侧向充种、拖带种子自由回落的充种室结构,利用离散元仿真研究了充种种层高度和充种室结构对排种器充种区内充种性能的影响及对种群拖带堆积的解决情况;仿真结果表明,排种器内种子随着充种种层高度的增大,种群平均动能均值逐渐增大,对种群平均扰动能力逐渐增强;在充种种层高度50 mm条件下,设计的防拖带堆积充种室降低了充种区域底部种群所受的压力,未出现种群拖带堆积现象,且保持了对充种区域种群的扰动作用。在JPS-12型排种器检测试验台上进行了排种器性能试验,结果表明,当排种转速为15~30 r/min、吸种负压为1.0~1.2 kPa时,排种器合格指数均保持在90%以上;设计装配正负气压组合滚轮式精密排种器的播种机开展播种试验,田间实测出苗后株距稳定性变异系数为4.4%,各行苗数一致性变异系数为8.14%;研究结果表明设计的排种器满足精密播种要求。

关键词：油菜精密排种器正负气压组合滚轮式

新型冠状病毒感染后长期嗅觉障碍患者嗅裂的CT影像学表现

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中国中西医结合耳鼻咽喉科杂志 2024年第2期32卷 149-153,135页

作者：廖娟刘剑锋北京中医药大学北京100029 中日友好医院耳鼻咽喉头颈外科北京

目的观察新型冠状病毒感染后长期嗅觉障碍患者嗅裂的CT影像学表现,探讨嗅裂混浊程度CT比值评分法对此类患者嗅觉功能的评估价值。方法回顾性分析中日友好医院嗅觉味觉障碍诊疗中心2023年1~7月期间接诊的新冠感染后长期嗅觉障碍患者30... 详细信息

目的观察新型冠状病毒感染后长期嗅觉障碍患者嗅裂的CT影像学表现,探讨嗅裂混浊程度CT比值评分法对此类患者嗅觉功能的评估价值。方法回顾性分析中日友好医院嗅觉味觉障碍诊疗中心2023年1~7月期间接诊的新冠感染后长期嗅觉障碍患者30例,行嗅觉视觉模拟量表(VAS)评分、T&T嗅觉计嗅觉觉察阈和识别阈测试评分;再行鼻窦CT薄层扫描,精确测量嗅裂长度、宽度和高度,测定嗅裂长度、宽度和高度最大值与嗅裂长度、宽度和高度的比值,采用新的评分法评估嗅裂混浊程度;然后,将嗅裂CT评分值与嗅觉功能测试结果进行相关性分析。结果鼻窦CT结果显示,90%患者存在不同程度嗅裂混浊。相关性分析显示,患者嗅觉VAS评分与T&T嗅觉察觉阈值相关性无统计学意义(P>0.05),嗅裂宽度与嗅觉VAS评分显示正相关(r=0.370,P=0.044);T&T嗅觉察觉阈值与嗅裂混浊程度CT比值评分法中,嗅裂混浊长度分值、宽度分值、总分值均存在正相关(r=0.398、0.376、0.377,P=0.029、0.041、0.040),差异有统计学意义(P<0.05)。结论结果提示,嗅裂炎可能是新冠病毒感染后长期嗅觉障碍的重要原因。嗅裂混浊程度CT比值评分法可作为新冠病毒感染后长期嗅觉障碍患者嗅觉功能的影像学评价指标。

关键词：新型冠状病毒感染嗅觉障碍嗅裂混浊度嗅觉功能影像学评估

静息态功能磁共振成像在青少年精神分裂症中的应用进展

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磁共振成像 2024年第5期15卷 168-174,180页

作者：王露刘芮杉廖娟李宏伟卓丽华川北医学院医学影像学院南充637000 绵阳市第三人民医院(四川省精神卫生中心)放射科绵阳621000

青少年精神分裂症(adolescent-onset schizophrenia,AOS)属于早发性精神分裂症的范畴,是指发病年龄在13~18岁之间的精神分裂症,与成人发病的精神分裂症相比,其症状更不典型,程度更严重,对抗精神病药物的治疗反应更差,并且其病因及发病... 详细信息

青少年精神分裂症(adolescent-onset schizophrenia,AOS)属于早发性精神分裂症的范畴,是指发病年龄在13~18岁之间的精神分裂症,与成人发病的精神分裂症相比,其症状更不典型,程度更严重,对抗精神病药物的治疗反应更差,并且其病因及发病机制至今尚不明确。静息态功能MRI(resting-state functional MRI,rs-fMRI)是一种操作便捷、无创客观且受试者易于配合的MRI技术,它能够从局部和整体反映脑神经元的自发性活动情况,为AOS神经病理学机制研究提供了强有力的手段。本文从功能分离分析和功能整合分析两方面展开,围绕rs-fMRI在AOS研究中应用的最新进展进行综述,探讨了当前研究的不足之处,并对未来进一步研究的方向进行了展望,旨在为进一步探索精神分裂症的病理生理学机制提供一定线索和依据。

关键词：精神分裂症青少年磁共振成像静息态功能磁共振成像

双金属电催化CO_(2)还原催化剂的合成、表征和机理研究进展

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新型炭材料（中英文） 2024年第3期39卷 367-387页

作者：廖银丽黄恒波邹如玉沈淑玲刘心娟唐志红上海理工大学材料与化学学院上海200093 上海圣升化工科技有限公司上海200082

电催化二氧化碳还原反应(CO_(2)RR)是一种将CO_(2)转化为有价值的化学品的有效方法。然而,CO_(2)的转化是一个复杂的过程,涉及2、4、6、8和12等多电子转移步骤。因此,开发高效的催化剂以精确控制CO_(2)转化过程中的电子转移数目具有重... 详细信息

电催化二氧化碳还原反应(CO_(2)RR)是一种将CO_(2)转化为有价值的化学品的有效方法。然而,CO_(2)的转化是一个复杂的过程,涉及2、4、6、8和12等多电子转移步骤。因此,开发高效的催化剂以精确控制CO_(2)转化过程中的电子转移数目具有重要意义。单金属催化剂存在活性位点单一、反应动力学慢、产物选择性低和稳定性不足等缺点。双金属催化剂因其独特的结构和优异的性能而受到广泛关注。通过引入次金属,可以改变催化剂的电子结构,促进新的活性位点的形成,从而优化中间体与活性位点之间的相互作用。因此,本文综述了以炭材料为基底的单原子双金属催化剂和合金、异质结构等非原子级的双金属催化剂以及它们的制备方法、结构表征和催化产物,归纳双金属催化剂的催化机理。最后,提出CO_(2)RR中遇到的挑战并对今后的发展进行展望。

关键词： CO_(2)还原反应双金属催化剂协同效应电催化剂

基于HPLC指纹图谱结合化学计量学及多成分定量测定的腰痹通胶囊质量评价研究

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中草药 2024年第8期55卷 2579-2588页

作者：廖嘉穗付娟张日美柳芊如胡军华王振中肖伟南京中医药大学江苏南京210000 中药制药过程控制与智能制造技术全国重点实验室江苏连云港222001 江苏康缘药业股份有限公司江苏连云港222001

目的建立腰痹通胶囊(Yaobitong Capsules,YC)的HPLC指纹图谱及多成分定量测定方法,并结合相关化学计量学评价多批次制剂的质量。方法建立YC的指纹图谱,采用层次聚类分析(hierarchical cluster analysis,HCA)、主成分分析(principal comp... 详细信息

目的建立腰痹通胶囊(Yaobitong Capsules,YC)的HPLC指纹图谱及多成分定量测定方法,并结合相关化学计量学评价多批次制剂的质量。方法建立YC的指纹图谱,采用层次聚类分析(hierarchical cluster analysis,HCA)、主成分分析(principal component analysis,PCA)评价多批次制剂质量,同时采用Hotelling’s T^(2)和DMod X方法对不同批次制剂的质量设定控制范围;HPLC法测定多批次YC中绿原酸、芍药内酯苷、芍药苷、阿魏酸4种有效成分的含量,并结合聚类热图分析进行质量评价。结果YC指纹图谱方法学考察结果符合测定要求,标记17个共有峰,并对共有峰进行归属,通过对照品比对指认出8个色谱峰,14批样品相似度大于0.90;HCA和PCA中未见异常批次,表明批间一致性较好,Hotelling’s T^(2)和DMod X控制上限为15.077和1.653;14批YC样品中芍药内酯苷、芍药苷、绿原酸、阿魏酸的质量分数分别为1.733~2.853、4.674~8.127、1.128~2.417、0.586~1.232 mg/g,线性关系良好(r≥0.9993);聚类热图分析结果表明,14批样品可聚为3类。结论建立的HPLC指纹图谱方法和多成分含量测定方法准确可靠,可用于YC的质量评价。多批次制剂数据结合化学计量学评价方法,表明YC多批次制剂之间一致性较好。

关键词：腰痹通胶囊 HPLC 指纹图谱化学计量学质量评价层次聚类分析主成分分析绿原酸芍药内酯苷芍药苷阿魏酸聚类热图分析

Asymmetric and Single-Side Splitting of Dissipative Solitons in Complex Ginzburg–Landau Equations with an Asymmetric Wedge-Shaped Potential

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Chinese Physics Letters 2019年第1期36卷 24-27页

作者： Yun-Cheng liao Bin liu juan liu Jia Chen National Engineering Laboratory for Destructive Testing and Optoelectronic Sensing Technology and Application Nanchang HangKong University Nanchang Institute of Science and Technology

We report some novel dynamical phenomena of dissipative solitons supported by introducing an asymmetric wedge-shaped potential(just as a sharp ‘razor') into the complex Ginzburg–Landau equation with the cubicquintic nonlinearity. The potentials corresponding to a local refractive index modulation with breaking symmetry can be realized in an active optical medium with respective expanding antiwaveguiding structures. Using the razor potential acting on a central dissipative soliton, possible outcomes of asymmetric and single-side splitting of dissipative solitons are achieved with setting different strengths and steepness of the potentials. The results can potentially be used to design a multi-route splitter for light beams.

关键词： Dissipative Solitons Complex Ginzburg-Landau Equations Asymmetric Wedge-Shaped Potential