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Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

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Frontiers of Medicine 2007年第1期1卷 87-92页

作者： LIN Ji YAN Guangtao GAO Xiaoning liao jie HAO Xiuhua ZHANG Kai Research Laboratory of Biochemistry General Hospital of PLABeijing 100853China Department of Pediatrics General Hospital of PLABeijing 100853China Medical and Experimental Analysis Center General Hospital of PLABeijing 100853China

The aim of this paper is to explore the effect of intestinal ischemia/reperfusion(I/R)injury on leptin and orexin-A levels in peripheral blood and central secretory tissues,and to examine the roles of leptin and orexin-A in acute inflammatory responses.An intestinal I/R injury model of rats was made;the rats were grouped according to the time of after 60 min ischemia.Radioimmunoassay was employed to detect the levels of leptin in serum and adipose tissue and orexin-A levels in plasma and hypothalamus.Reverse transcriptase-polymerase chain reaction was used to detect mRNA expressions of adipose leptin and hypothalamus orexin-A.Compared with the levels before the injury,serum leptin in 60 min ischemia/30 min reperfusion(I60pR30p)group decreased and that of I60pR360p group increased.Compared with sham-operation group(sham group)after injury,serum leptin level of I60pR360p group increased,adipose leptin levels of I60pR30p and I60pR90p decreased,and adipose leptin in I60pR360p group increased.After the injury,adipose leptin mRNA expressions of I60pR30p,I60pR240p and I60pR360p increased,whereas that of I60pR150p group decreased as compared with the sham group.There was no significant difference in the protein levels of orexin-A,either between plasma and hypothalamus or between pre-and post-I/R injury.Compared with sham group,hypothalamus orexin-A mRNA expressions of I60pR30p and I60pR90p decreased gradually after the injury,with that of I60pR150p group reaching the lowest,and those of I60pR240p and I60pR360p recovering gradually,although they were still significantly lower than that of sham group.Leptin and orexin-A respond to intestinal I/R injury in a time-dependent manner,with leptin responding more quickly than orexin-A does,and both of them may contribute to the metabolic disorders in acute inflammation.

关键词： reperfusion injury intestine leptin orexin-A radioimmunoassay reverse transcriptase polymerase chain reaction adipose tissue hypothalamus

Quartz grain surface microtextural evidence for provenance of the Quaternary aggradation red earth deposit, southern China

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Journal of Mountain Science 2021年第8期18卷 2048-2060页

作者： FAN Qing-bin liao jie Li Yan YE Wei WANG Tao FENG Xiao Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China University of Chinese Academy of Sciences Beijing100049China College of Forestry Nanjing Forestry UniversityNanjing210037China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua321004China

The Quaternary aggradation red earth(QARE)deposit in the middle reaches of the Yangtze River(MRYR)in southern China provides important evidence for understanding the paleoenvironment.However,its provenance remains controversial.In this study,the surface microtextures of grains from the QARE were observed,and compared with those of grains from the loess deposit on the Loess Plateau in northern China.The results show that the surface microtextures and morphologies of the quartz grains in the QARE are distinctly different from those in the northern loess,indicating that the deposits in the two regions have different provenances.The Gobi and deserts in inland northwestern China are not considered as the primary provenance for the QARE in southern China.It is suggested that the large areas of dry and bare river and lake beds and floodplains in the MRYR,which became exposed during glacial periods,provided the dominant source for materials in the QARE.We suggest that against the background of the middle-Pleistocene climate transition(MPT),regional aridification and a strengthened east Asian winter monsoon(driven by global cooling and the rapid uplift of the Tibetan Plateau)were primary drivers for the initiation of the QARE deposit in the MRYR region in southern China.The development of large areas of aeolian red earth deposit is direct evidence of environmental deterioration in the MRYR,indicating a cold and dry environment with frequent aeolian activity,in an area that now experiences a warm and humid subtropical monsoon climate.The results are also evidence of a regional response in the mid-subtropics of southern China to the MPT global cooling event around 1.2 Ma.

关键词： Quaternary aggradation red earth East Asian winter monsoon Global cooling Uplift of the Tibetan Plateau

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中国近30年短时极端降水特征分析

大气科学 2024年第3期48卷 1144-1156页

作者：赵煜飞张强鞠晓慧肖栋杨和平陈杰廖捷邓悦国家气象信息中心北京100081 中国气象局上海城市气候变化应对重点开放实验室上海200030 广西壮族自治区气象信息中心南宁530000

由于观测资料的限制,以往对于日尺度以下的短时极端降水特征和短时极端降水阈值的研究较少。本文基于中国气象局最新研制的1991~2021年中国2464个台站逐小时降水资料,分析了全国1 h、3 h降水频率特征,采用百分位法分别统计1 h和3 h极端... 详细信息

由于观测资料的限制,以往对于日尺度以下的短时极端降水特征和短时极端降水阈值的研究较少。本文基于中国气象局最新研制的1991~2021年中国2464个台站逐小时降水资料,分析了全国1 h、3 h降水频率特征,采用百分位法分别统计1 h和3 h极端降水阈值,探究了中国短时极端降水气候特征。分析结果表明四川、贵州、湖南、江西、福建和浙江等省的部分台站1 h降水频率较大,可达12%,西北地区1 h降水频率普遍偏低,大部分台站低于3%。1991~2021年期间,1 h、3 h极端降水频率呈减少趋势。共有64.7%的站3 h极端降水频率线性趋势与1 h极端降水频率线性趋势一致。我国降水极值和极端降水阈值空间特征明显,1 h降水极端降水阈值基本呈东南大、西北小的空间特征,广东、广西、海南阈值相比我国其他地区偏大。海南、广东、广西和江苏省1 h降水历史平均极值超过80 mm h^(-1),其中海南省平均极值最高,达102.7 mm h^(-1)。

关键词：地面观测降水质量控制日变化

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师陀早期乡土小说碎片化叙述与现代启蒙范式——以《头》《人下人》为例

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闽西职业技术学院学报 2024年第2期26卷 59-63页

作者：廖亚婕上海师范大学人文学院上海200030

碎片化叙述是师陀早期短篇乡土小说创作的典型特点。不同于现代左翼文学书写乡土世界采用宏大叙事,师陀的乡土小说运用碎片化叙述对小说内部风景与生活细节进行描摹。碎片化叙述不仅凸显师陀早期小说创作形式的独特性,而且在主题上实现... 详细信息

碎片化叙述是师陀早期短篇乡土小说创作的典型特点。不同于现代左翼文学书写乡土世界采用宏大叙事,师陀的乡土小说运用碎片化叙述对小说内部风景与生活细节进行描摹。碎片化叙述不仅凸显师陀早期小说创作形式的独特性,而且在主题上实现了对中原乡土世界个体精神状态的还原,对现代文学的启蒙范式进行了补充。

关键词：师陀乡土小说碎片化叙述现代启蒙

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials:Based on the mechanisms of occurrence and development of adhesions

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Bioactive Materials 2023年第8期26卷 387-412页

作者： jie liao Xiaoming Li Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

Postoperative adhesion(POA)widely occurs in soft tissues and usually leads to chronic pain,dysfunction of adjacent organs and some acute complications,seriously reducing patients’quality of life and even being life-threatening.Except for adhesiolysis,there are few effective methods to release existing adhesion.However,it requires a second operation and inpatient care and usually triggers recurrent adhesion in a great incidence.Hence,preventing POA formation has been regarded as the most effective clinical strategy.Biomaterials have attracted great attention in preventing POA because they can act as both barriers and drug carriers.Nevertheless,even though much reported research has been demonstrated their efficacy on POA inhibition to a certain extent,thoroughly preventing POA formation is still challenging.Meanwhile,most biomaterials for POA prevention were designed based on limited experiences,not a solid theoretical basis,showing blindness.Hence,we aimed to provide guidance for designing anti-adhesion materials applied in different soft tissues based on the mechanisms of POA occurrence and development.We first classified the postoperative adhesions into four categories according to the different components of diverse adhesion tissues,and named them as“membranous adhesion”,“vascular adhesion”,“adhesive adhesion”and“scarred adhesion”,respectively.Then,the process of the occurrence and development of POA were analyzed,and the main influencing factors in different stages were clarified.Further,we proposed seven strategies for POA prevention by using biomaterials according to these influencing factors.Meanwhile,the relevant practices were summarized according to the corresponding strategies and the future perspectives were analyzed.

关键词： Prevention of postoperative adhesions(POA) Soft tissues Mechanisms of occurrence and development Biomaterials

基于时间价值和深度强化学习的信号灯控制研究

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电子技术（上海） 2024年第2期53卷 25-27页

作者：廖杰梁成雄中国科学技术大学软件学院江苏215127

阐述一种基于时间价值和深度强化学习的信号灯控制方法,实现对信号灯路口进行实时控制,并以最小化路口总的浪费时间价值为目标进行控制。通过仿真实验对比传统固定的信号灯控制方法,证明该方法能够大幅减少系统总浪费的时间价值。

关键词：信号灯控制时间价值深度强化学习

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基于区块链的互联网远程医疗系统设计

电子技术（上海） 2024年第2期53卷 61-63页

作者：梁成雄廖杰中国科学技术大学软件学院安徽230026 中国科学技术大学苏州高等研究院江苏215009

阐述一种区块链的互联网远程医疗系统设计,利用区块链的去中心化特性,允许各级医院和医生公平地加入远程医疗系统,并结合加密存储和共识机制确保医疗数据的安全共享和保护,从而充分利用医生资源,实现线上分级诊疗。

关键词：计算机系统区块链计算机网络远程医疗加密算法智能合约

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骨H型血管生成机制及影响因素的研究现状

中国矫形外科杂志 2024年第6期32卷 525-529页

作者：唐生平廖世杰黄乾丁晓飞广西医科大学第一附属医院创伤骨科手外科广西南宁530021

骨血管在骨生长、重塑和损伤修复中发挥重要作用,H型血管是一类同时高表达CD31与Emcn的骨血管亚型,具有显著的解剖特征与年龄依赖性减少特点,深度参与血管生成与骨形成之间的偶联。一些细胞因子如缺氧诱导因子1α、血管内皮生长因子A、... 详细信息

骨血管在骨生长、重塑和损伤修复中发挥重要作用,H型血管是一类同时高表达CD31与Emcn的骨血管亚型,具有显著的解剖特征与年龄依赖性减少特点,深度参与血管生成与骨形成之间的偶联。一些细胞因子如缺氧诱导因子1α、血管内皮生长因子A、血小板衍生生长因子BB、神经轴突导向因子3等可参与调控H型血管的生成,同时药物治疗、物理治疗和转移性肿瘤也能对H型血管产生影响。本文通过回顾近年文献,总结H型血管生成的分子机制与影响因素,以期为骨折不愈合、骨代谢异常等骨病的治疗提供新思考。

关键词： H型血管血管生成骨形成影响因素

血管通路引起的肢体远端缺血征的危险因素分析

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中国血液净化 2024年第3期23卷 219-222页

作者：曹雪玲廖洁虞丽利荣县人民医院肾病内科(血液透析室) 自贡643100

目的分析血管通路引起的肢体远端缺血征(hemodialysis access-induced distal ischemia,HAIDI)的危险因素。方法选取2020年5月—2022年5月在荣县人民医院肾病内科首次行动静脉内瘘手术进行血液透析的终末期肾病患者。根据患者手术后是... 详细信息

目的分析血管通路引起的肢体远端缺血征(hemodialysis access-induced distal ischemia,HAIDI)的危险因素。方法选取2020年5月—2022年5月在荣县人民医院肾病内科首次行动静脉内瘘手术进行血液透析的终末期肾病患者。根据患者手术后是否出现HAIDI相关症状分为HAIDI组与非HAIDI组;收集并比较2组临床资料,通过组间单因素分析筛选出导致HAIDI发生的可能危险因素,并对可能的危险因素进行量化,行二元Logistic回归分析。结果共纳入70例患者,其中HAIDI组15例,非HAIDI组55例。单因素分析结果显示:HAIDI组年龄≥60岁、女性、高血压史、糖尿病史、系统性红斑狼疮、血管炎、透析龄>1年、血管通路类型(移植物动静脉内瘘、肱动脉自体动静脉内瘘比例)均高于非HAIDI组(χ^(2)/t分别为4.419、4.272、4.904、6.360、10.972、7.231、5.657、18.670,P分别为0.036、0.039、0.027、0.012、0.001、0.007、0.017、<0.001);二元Logistic回归分析结果显示:高龄、女性、高血压史、糖尿病史、系统性红斑狼疮、血管炎、透析龄长、移植物动静脉内瘘及高位动静脉内瘘是导致HAIDI发生的主要危险因素(OR分别为0.286、3.353、0.274、0.224、0.051、0.074、4.111、0.055、0.049;95%CI分别为0.086~0.954、1.030~10.920、0.084~0.895、0.066~0.755、0.005~0.500、0.007~0.775、1.223~13.818、0.010~0.303、0.007~0.321,P分别为0.042、0.045、0.032、0.016、0.011、0.030、0.022、0.001、0.002)。结论年龄、性别、高血压、糖尿病、系统性红斑狼疮、血管炎、透析龄及血管通路类型是HAIDI的危险因素,对于HAIDI高危人群进行针对性的预防控制措施,有助于减少血管通路引起的HAIDI发生。

关键词：血液透析肢体远端缺血征危险因素预防