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An iron-based metal-organic framework nanoplatform for enhanced ferroptosis and oridonin delivery as a comprehensive antitumor strategy

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4073-4086页

作者： mengru Cai Tingting Fu Rongyue Zhu Panxiang Hu Jiahui Kong Shilang liao Yuji Du Yongqiang Zhang Changhai Qu Xiaoxv Dong Xingbin Yin jian Ni School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China

Ferroptosis is a recently discovered pathway for regulated cell death ***,its efficacy is affected by limited iron content and intracellular ion ***,we designed a metalorganic framework(MOF)-based nanoplatform that incorporates calcium peroxide(CaO2)and oridonin(ORI).This platform can improve the tumor microenvironment and disrupt intracellular iron homeostasis,thereby enhancing ferroptosis *** cell membranes(FM)were used to modify nanoparticles(ORI@CaO2@Fe-TCPP,NPs)to produce FM@ORI@CaO2@Fe-TCPP(FM@NPs).The encapsulated ORI inhibited the HSPB1/PCBP1/IREB2 and FSP1/COQ10 pathways simultaneously,working in tandem with Fe3t to induce *** therapy(PDT)guided by porphyrin(TCPP)significantly enhanced ferroptosis through excessive accumulation of reactive oxygen species(ROS).This selfamplifying strategy promoted robust ferroptosis,which could work synergistically with FM-mediated *** vivo experiments showed that FM@NPs inhibited 91.57%of melanoma cells within six days,a rate 5.6 times higher than chemotherapy ***@NPs were biodegraded and directly eliminated in the urine or faeces without substantial ***,this study demonstrated that combining immunotherapy with efficient ferroptosis induction through nanotechnology is a feasible and promising strategy for melanoma treatment.

关键词： Metal-organic frameworks Immunotherapy Self-amplifying ferroptosis Photodynamic therapy Chemodynamic therapy Oridonin Fused cell membrane coating Metabolization

Laparoscopic partial splenectomy in the treatment of splenic ectopic pregnancy

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 569-572页

作者： Ke-Xi liao Li Cao Yan-Zhou Wang Bao-Lin Wang Shu-Guo Zheng jian-Wei Li Institute of Hepatobiliary Surgery First Affiliated HospitalArmy Medical UniversityChongqingChina Department of Gynecology and Obstetrics First Affiliated HospitalArmy Medical UniversityChongqingChina

Ectopic pregnancy is a pregnancy that occurred outside the uterus,usually in the fallopian tube,followed by other abdominal *** pregnancy could not develop normally to term and requires sufficient evaluation and intervention with medication or surgery in most cases(1).As a rare form of abdominal pregnancy(2),splenic ectopic pregnancy could be treated by drug treatment(3)or surgical interventions,including laparotomy and laparoscopy,which focused on total splenectomy(4,5).A previous study(6)indicated that laparoscopic partial splenectomy for selected patients was safe and *** to the fragile texture of the spleen,the suture method during laparoscopic partial splenectomy was technically demanding since it might encounter higher risk of splenic vascular hemorrhage than total ***,few reports focused on the treatment of splenic ectopic pregnancy via laparoscopic partial splenectomy(7).In order to avoid the potential severe complications such as hemoperitoneum(8)caused by drug treatment alone,and to avert impaired hematopoietic and immune function caused by total splenectomy,we herein presented a case(Video 1)of a 30-year-old woman(gravida 2,para 1)undergoing laparoscopic partial splenectomy performed by hepatobiliary surgeons to treat splenic ectopic pregnancy.

关键词： pregnancy splenectomy impaired

Bioinspired polysaccharide-based nanocomposite membranes with robust wet mechanical properties for guided bone regeneration

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National Science Review 2024年第3期11卷 215-226页

作者： jian-Hong Xiao Zhen-Bang Zhang JiaHao Li Si-Ming Chen Huai-Ling Gao YinXiu liao Lu Chen ZiShuo Wang YiFan Lu YuanZhen Hou HengAn Wu DuoHong Zou Shu-Hong Yu Department of Chemistry New Cornerstone Science Laboratory Institute of Biomimetic Materials&Chemistry Anhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Department of Dental Implant Center Stomatologic Hospital and College Key Laboratory of Oral Diseases Research of Anhui Province Anhui Medical University CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China Department of Oral Surgery College of Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Institute of Innovative Materials(I2M) Department of Chemistry Department of Materials Science and Engineering Southern University of Science and Technology

Polysaccharide-based membranes with excellent mechanical properties are highly desired. However, severe mechanical deterioration under wet conditions limits their biomedical applications. Here, inspired by the structural heterogeneity of strong yet hydrated biological materials, we propose a strategy based on heterogeneous crosslink-and-hydration（HCH） of a molecule/nano dual-scale network to fabricate polysaccharide-based nanocomposites with robust wet mechanical properties. The heterogeneity lies in that the crosslink-and-hydration occurs in the molecule-network while the stress-bearing nanofiber-network remains unaffected. As one demonstration, a membrane assembled by bacterial cellulose nanofiber-network and Ca2+-crosslinked and hydrated sodium alginate molecule-network is designed. Studies show that the crosslinked-and-hydrated molecule-network restricts water invasion and boosts stress transfer of the nanofiber-network by serving as interfibrous bridge. Overall, the molecule-network makes the membrane hydrated and flexible; the nanofiber-network as stress-bearing component provides strength and *** HCH dual-scale network featuring a cooperative effect stimulates the design of advanced biomaterials applied under wet conditions such as guided bone regeneration membranes.

关键词： bioinspiration heterogeneous crosslink-and-hydration dual-scale network nanocomposite membrane wet mechanical properties guided bone regeneration

The effect of bladder function on the efficacy of transurethral prostatectomy in patients with benign prostatic hyperplasia:a retrospective,single-center study

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Asian Journal of Andrology 2024年第1期26卷 112-118页

作者： Jin Li Xian-Yan-Ling Yi Ze-Yu Chen Bo Chen Yin Huang Da-Zhou liao Pu-Ze Wang De-Hong Cao jian-Zhong Ai Liang-Ren Liu West China School of Medicine Sichuan UniversityChengdu 610041China Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China

We investigated the impact and predictive value of bladder function in patients with benign prostatic hyperplasia(BPH)on the efficacy of transurethral ***,imaging,and urodynamic data of patients who underwent transurethral prostatectomy at West China Hospital of Sichuan University(Chengdu,China)from July 2019 to December 2021 were ***-up data included the quality of life(QoL),International Prostate Symptom Score(IPSS),and IPSS storage and voiding(IPSS-s and IPSS-v).Moreover,urinary creatinine(Cr),nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),and prostaglandin estradiol(PGE2)were measured in 30 patients with BPH and 30 healthy *** indicators were determined by subgroup analyses and receiver operating characteristic(ROC)curve *** the 313 patients with BPH included,patients with severe micturition problems had more improvements but higher micturition grades postoperatively than those with moderate ***,good bladder sensation,compliance,and detrusor contractility(Dc)were predictors of low postoperative IPSS and *** urinary concentrations of BDNF/Cr,NGF/Cr,and PGE2/Cr in patients were significantly higher than those in healthy participants(all P<***1).After evaluation,only DC was significantly related to both urinary indicators and postoperative recovery of *** with good DC,as predicted by urinary indicators,had lower IPSS and IPSS-v than those with reduced DC at the 1st month postoperatively(both P<0.05).In summary,patients with impaired bladder function had poor *** combined levels of urinary BDNF/Cr,NGF/Cr,and PGE2/Cr in patients with BPH may be valid predictors of preoperative bladderfunction and postoperative recovery.

关键词： BPH function of bladder IPSS:urodynamics

Cinnamaldehyde targets SarA to enhance β-lactam antibiotic activity against methicillin-resistant Staphylococcus aureus

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mLife 2024年第2期3卷 291-306页

作者： jianguo Li Tingyin Lu Yuefei Chu Yuejun Zhang Jing Zhang Wenzhen Fu jian Sun Yahong Liu Xiao-Ping liao Yu-Feng Zhou State Key Laboratory for Animal Disease Control and Prevention South China Agricultural UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation South China Agricultural UniversityGuangzhouChina Yantai Fushan Center for Animal Disease Control and Prevention YantaiChina

Methicillin-resistant Staphylococcus aureus(MRSA)is a current global public health problem due to its increasing resistance to the most recent antibiotic *** critical approach is to develop ways to revitalize existing ***,we show that the phytogenic compound cinnamaldehyde(CIN)and β-lactam antibiotic combinations can functionally synergize and resensitize clinical MRSA isolates to β-lactam therapy and inhibit MRSA biofilm *** studies indicated that the CIN potentiation effect on β-lactams was primarily the result of inhibition of the mecA expression by targeting the staphylococcal accessory regulator *** alone or in combination with β-lactams decreased sarA gene expression and increased SarA protein phosphorylation that impaired SarA binding to the mecA promoter element and downregulated virulence genes such as those encoding biofilm,α-hemolysin,and *** of SarA-mecA binding thus interfered with PBP2a biosynthesis and this decreased MRSA resistance to β-***,CIN fully restored the anti-MRSA activities of β-lactam antibiotics in vivo in murine models of bacteremia and biofilm ***,our results indicated that CIN acts as a β-lactam adjuvant and can be applied as an alternative therapy to combat multidrug-resistant MRSA infections.

关键词： cinnamaldehyde MRSA SarA β-lactamresistance

基于高精度热泵模型的电热协同独立微网设备优化配置

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电力自动化设备 2024年第7期44卷 198-204,213页

作者：孙健柯德平徐箭廖思阳孙元章武汉大学电气与自动化学院湖北武汉430072

为实现含丰富工业余热、数据中心余热、生活污水余热等低品位热源的区域协同供能,以及提高区域清洁能源利用效率,针对区域独立微网供能系统的设备优化配置策略进行研究。基于多类型低品位热源的不同温度品位特征,提出用于提升热源温度... 详细信息

为实现含丰富工业余热、数据中心余热、生活污水余热等低品位热源的区域协同供能,以及提高区域清洁能源利用效率,针对区域独立微网供能系统的设备优化配置策略进行研究。基于多类型低品位热源的不同温度品位特征,提出用于提升热源温度品位的关键电热泵设备多参数拟合模型,并生成热泵拟合模型的误差不确定性场景;考虑微网在实际运行不确定性场景下产生的供热舒适度补偿、切负荷与切光伏风险,提出基于多条件风险价值(CVaR)理论的独立微网设备容量优化配置双层模型,上层模型基于全寿命周期成本费用年值与年CVaR值优化设备配置方案,下层模型基于场景分析法优化运行成本;采用遗传算法对双层模型进行求解。算例结果证明:考虑热泵拟合模型误差有效降低了系统运行风险,且低品位热源的回收利用具有较大经济性潜力。

关键词：微网低品位热源热泵不确定性场景条件风险价值设备配置双层模型

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气相色谱-质谱法测定汽油中醇类、醚类和酯类添加剂

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冶金分析 2016年第6期36卷 50-54页

作者：林海廖建萌李春雄李展江李丹周明辉湛江出入境检验检疫局广东湛江524022 湛江市食品药品监督管理局广东湛江524020 广东出入境检验检疫局广东广州510623

目前市场上一些加油站中存在着在汽油中非法添加一些醇类、醚类、酯类氧化物添加剂的现象,对车辆的机动性、安全性和环保性存在潜在危害。实验建立了气相色谱-质谱法测定汽油中19种醇类、醚类和酯类添加剂含量的分析方法。通过试验优化... 详细信息

目前市场上一些加油站中存在着在汽油中非法添加一些醇类、醚类、酯类氧化物添加剂的现象,对车辆的机动性、安全性和环保性存在潜在危害。实验建立了气相色谱-质谱法测定汽油中19种醇类、醚类和酯类添加剂含量的分析方法。通过试验优化了色谱分析的主要条件,确定了最佳分流比为1∶100,溶剂为正十一烷,稀释倍数10~100倍,同时研究了溶剂的切换时间。利用选择离子法（SIM）确定定量离子和参考离子,可以有效消除汽油中复杂成分对目标组分的影响。以各目标组分的峰面积对其相应的质量浓度作图,发现甲醇、乙醇质量浓度在5.0~100.0mg/L、其他化合物质量浓度在1.0~20.0mg/L范围内线性良好,校准曲线的线性相关系数在0.998 6~0.999 9之间。各组分的检出限为0.5~1.0mg/L。对添加了标准溶液的实际样品进行精密度和正确度考察,19种组分测定结果的相对标准偏差（RSD,n=8）为2.1%~6.2%,回收率为85%~108%。对市售92#、95#、98#常见标号汽油样品进行测定,结果发现部分汽油中含有甲醇、甲基叔丁基醚（MTBE）、乙酸仲丁酯等氧化物添加剂,质量浓度在20~1 200mg/L之间。

关键词：气相色谱-质谱法汽油醇类添加剂醚类添加剂酯类添加剂

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Relationship between preoperative psychological stress and shortterm prognosis in elderly patients with femoral neck fracture

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World Journal of Psychiatry 2024年第6期14卷 838-847页

作者： Wen-Hui Fu Zhi-Long Hu Yuan-Jun liao Ri-jiang Chen jian-Bin Qiu Wu-Tang Que Wan-Tao Wang Wei-Hua Li Wei-Bin Lan Department of Orthopedics Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 361000Fujian ProvinceChina

BACKGROUND Older adults are at high risk of femoral neck fractures(FNFs).Elderly patients face and adapt to significant psychological burdens,resulting in different degrees of psychological stress *** hip replacement is the preferred treatment for FNF in elderly patients;however,some patients have poor postoperative prognoses,and the underlying mechanism is *** speculated that the postoperative prognosis of elderly patients with FNF may be related to preoperative psychological *** To explore the relationship between preoperative psychological stress and the short-term prognosis of elderly patients with *** In this retrospective analysis,the baseline data,preoperative 90-item Symptom Checklist score,and Harris score within 6 months of surgery of 120 elderly patients with FNF who underwent total hip arthroplasty were *** analyzed the indicators of poor short-term postoperative prognosis and the ability of the indicators to predict poor prognosis and compared the correlation between the indicators and the Harris *** Anxiety,depression,garden classification of FNF,cause of fracture,FNF reduction quality,and length of hospital stay were independent influencing factors for poor short-term postoperative prognoses in elderly patients with FNF(P<0.05).The areas under the curve for anxiety,depression,and length of hospital stay were 0.742,0.854,and 0.749,*** sensitivities of anxiety,depression,garden classification of FNF,and prediction of the cause of fracture were 0.857,0.786,0.821,and 0.821,*** specificities of depression,FNF quality reduction,and length of hospital stay were the highest at 0.880,0.783,and 0.761,***,depression,and somatization scores correlated moderately with Harris scores(r=-0.523,-0.625,and-0.554;all P<0.001).CONCLUSION Preoperative anxiety,depression,and somatization are correlated with poor short-term prognosis in elderly patients with FNF and warrant consid

关键词： Psychological stress Old age Femoral neck fracture Hip replacement Short-term prognosis Correlation

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氟苯尼考在红笛鲷体内的药代动力学研究

中国兽药杂志 2016年第11期50卷 58-64页

作者：黄郁葱汤菊芬秦青英简纪常黄月雄廖建萌广东海洋大学水产学院广东湛江524088 广东省水产经济动物病原生物学及流行病学重点实验室广东湛江524088 广东省湛江市食品药品监督管理局广东湛江524022

为研究氟苯尼考在红笛鲷体内的药代动力学特征,在水温(20±2)℃条件下,氟苯尼考以10 mg/kg单剂量腹注和口灌健康红笛鲷(Lutjanus sanguineus),采用HPLC-MS/MS测定组织中的药物浓度,数据用DAS3.0软件分析。结果显示,两种给药方式下红笛... 详细信息

为研究氟苯尼考在红笛鲷体内的药代动力学特征,在水温(20±2)℃条件下,氟苯尼考以10 mg/kg单剂量腹注和口灌健康红笛鲷(Lutjanus sanguineus),采用HPLC-MS/MS测定组织中的药物浓度,数据用DAS3.0软件分析。结果显示,两种给药方式下红笛鲷血浆药时数据均符合一级吸收二室模型;腹注给药后血浆、肝脏、肾脏和肌肉的峰浓度(C_(max))分别为10.62μg/m L、8.36、22.57和4.76μg/g,达峰时间(T_(max))分别为1.2、1.0、1.0和6.0 h,消除半衰期(t_(1/2β))分别为29.76、17.84、17.23和19.48 h;口灌给药后血浆、肝脏、肾脏和肌肉的C_(max)分别为2.35μg/m L、1.45μg/g、4.06μg/g和1.73μg/g,T_(max)分别为2.69、1.5、1.5和4.0 h,t_(1/2β)分别为40.59、12.29、37.78和47.34 h。结果表明,腹注给药方式下氟苯尼考在红笛鲷体内的吸收快于口灌给药,在血浆和肝脏中的消除快于口灌给药,在肌肉和肾脏中的消除则慢于口灌给药。研究结果为氟苯尼考在临床上的合理应用提供了科学依据。

关键词：氟苯尼考红笛鲷药代动力学

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