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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao liang Xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Formula of Overtopping Discharge of Vertical Seawall with A Form Similar to Solitary Wave Function

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China Ocean Engineering 2022年第5期36卷 802-807页

作者： LI xiao-liang School of Naval Architecture&Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

An empirical formula to predict overtopping discharge of vertical wall is presented,in which an expression similar to the solitary wave function is proposed to describe the rule of the influence of relative water *** formula is derived from performing an investigation to the well-known overtopping graphs of Goda,and for the sake of interest,the process of the derivation is *** make clear the formula’s performance,relevant test datasets in the CLASH database are extracted to examine the error levels of the *** a result,an overall good agreement has been found between the predictions of the formula and the extracted datasets in a wide range outside the extreme shallow region,i.e.,the range of relative water depth smaller than 0.6,in which the water depth near the wall is so shallow that nearly all the incoming waves have been broken before reaching the wall.

关键词： overtopping discharge formula vertical wall Goda graph

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Decentralized Optimal Control and Stabilization of Interconnected Systems With Asymmetric Information

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 698-707页

作者： Na Wang xiao liang Hongdan Li xiao Lu the College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266000China the School of Automation and Electrical Engineering Linyi UniversityLinyi 276000China the College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266000China

The paper addresses the decentralized optimal control and stabilization problems for interconnected systems subject to asymmetric *** with previous work,a closed-loop optimal solution to the control problem and sufficient and necessary conditions for the stabilization problem of the interconnected systems are given for the first *** main challenge lies in three aspects:Firstly,the asymmetric information results in coupling between control and estimation and failure of the separation ***,two extra unknown variables are generated by asymmetric information(different information filtration)when solving forward-backward stochastic difference ***,the existence of additive noise makes the study of mean-square boundedness an *** adopted technique is proving and assuming the linear form of controllers and establishing the equivalence between the two systems with and without additive noise.A dual-motor parallel drive system is presented to demonstrate the validity of the proposed algorithm.

关键词： Asymmetric information decentralized control forwardbackward stochastic difference equations interconnected system stalibization

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贻贝肽对厚壳贻贝稚贝生长发育及微生物群落结构的影响

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渔业科学进展 2025年第1期46卷 115-126页

作者：林倩李政杨金龙马蕃梁箫上海海洋大学水产与生命学院科技部海洋生物科学国际联合研究中心上海201306 上海市水产动物良种创制与绿色养殖协同创新中心上海201306 中国-葡萄牙星海“一带一路”联合实验室上海200120

为探究海洋生物活性肽对厚壳贻贝(Mytilus coruscus)生长发育的影响,本研究以厚壳贻贝稚贝为实验对象,通过投喂不同浓度的贻贝肽(0、7、9、10、70和90 mg/L),测定壳长、壳高、湿重等指标,以确定最适贻贝肽浓度,并对投喂前后的稚贝微生... 详细信息

为探究海洋生物活性肽对厚壳贻贝(Mytilus coruscus)生长发育的影响,本研究以厚壳贻贝稚贝为实验对象,通过投喂不同浓度的贻贝肽(0、7、9、10、70和90 mg/L),测定壳长、壳高、湿重等指标,以确定最适贻贝肽浓度,并对投喂前后的稚贝微生物群落进行分析,实验周期为56 d。结果显示,相较于未投喂贻贝肽的对照组,投喂9 mg/L的贻贝肽显著促进稚贝生长,且壳长、壳高和湿重分别提升了27.37%、32.35%和115.49%;同时发现,高浓度贻贝肽(70 mg/L和90 mg/L)对厚壳贻贝稚贝产生了致死效应。通过16S rRNA基因扩增和测序对比分析了28 d和56 d贻贝肽投喂组与未投喂组的厚壳贻贝稚贝微生物组群落结构变化。研究结果显示,投喂9 mg/L贻贝肽改变了稚贝微生物群落结构组成,提高了拟杆菌门(Bacteroidota)和变形菌门(Proteobacteria)的丰度,降低了放线菌门(Actinobacteriota)的丰度;同时,属水平分析发现,贻贝肽投喂组有效增加了鲁杰氏菌属(Ruegeria)、黏着杆菌属(Tenacibaculum)、居海杆菌属(Maribacter)、栖砂杆菌属(Arenibacter)、十八碳杆菌属(Octadecabacter)和希瓦氏菌属(Shewanella)等有益菌的物种丰度,显著减少了红球菌属(Rhodococcus)、气单胞菌属(Aeromonas)等潜在致病菌的丰度。综上,贻贝肽能有效促进厚壳贻贝的稚贝生长发育,并且可以优化厚壳贻贝微生物群落结构,研究成果将为后续开展贻贝肽等海洋生物活性肽对贝类稚贝中间培育以及海水贝类养殖可持续发展提供基础和数据支撑。

关键词：厚壳贻贝生长微生物群落结构贻贝肽

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Removing mixed noise in low rank textures by convex optimization

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Computational Visual Media 2016年第3期2卷 267-276页

作者： xiao liang Institute for Advanced Study Tsinghua University

This paper introduces a new low rank texture image denoising algorithm, which can restore low rank texture contaminated by both Gaussian and salt-and-pepper noise. The algorithm formulates texture image denoising in terms of solving a low rank matrix optimization problem. Simply assuming low rank is insufficient to describe the properties of natural images, causing high noise amplitudes which lead to unsatisfactory denoising results or serious loss of image details. Thus, in addition to the low rank assumption,the continuity of natural images is also assumed by the algorithm, by adding a total variation regularizer to the optimization objective function. We further give an effective algorithm to solve this optimization problem. By combining the low rank and continuity assumptions, the proposed algorithm overcomes the deficiencies of using either the low rank assumption or total variation regularization alone. Experiments show that our algorithm can effectively remove mixed noise in low rank texture images, and is better than existing algorithms in both its subjective visual effects and in terms of quantitative objective measures.

关键词： image denoising low rank texture total variation convex optimization augmented Lagrangian method

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ITERATIVE METHODS FOR THE FORWARD-BACKWARD HEAT EQUATION

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Journal of Computational Mathematics 2005年第4期23卷 419-424页

作者： xiao-liang Cheng Jie Sun Department of Mathematics Zhejiang University Hangzhou 310028 China Department of Mathematics Zhejiang University of Finance and Economics Hangzhou 310012 China

In this paper we propose the finite difference method for the forward-backward heat equation. We use a coarse-mesh second-order central difference scheme at the middle line mesh points and derive the error estimate. Then we discuss the iterative method based on the domain decomposition for our scheme and derive the bounds for the rates of convergence. Finally we present some numerical experiments to support our analysis.

关键词： Forward-backward heat equation Finite difference method Iterative method Coarse mesh

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Verification and validation of detonation modeling

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Defence Technology（防务技术） 2019年第3期15卷 398-408页

作者： xiao liang Rui-li Wang Institute of Applied Physics and Computational Mathematics Beijing 100094 China College of Mathematics and Information Science Shandong University of Science and Technology Qingdao 266590 China

The mathematical model used to describe the detonation multi-physics phenomenon is usually given by highly coupled nonlinear partial differential equations. Numerical simulation and the computer aided engineering (CAE) technique has become the third pillar of detonation research, along with theory and experiment, due to the detonation phenomenon is difficult to explain by the theoretical analysis, and the cost required to accredit the reliability of detonation products is very high, even some physical experiments of detonation are impossible. The numerical simulation technique can solve these complex problems in the real situation repeatedly and reduce the design cost and time stunningly. But the reliability of numerical simulation software and the serviceability of the computational result seriously hinders the extension, application and the self-restoration of the simulation software, restricts its independently innovational ability. This article deals with the physical modeling, numerical simulation, and software development of detonation in a unified way. Verification and validation and uncertainty quantification (V&V&UQ) is an important approach in ensuring the credibility of the modeling and simulation of detonation. V&V of detonation is based on our independently developed detonation multiphysics software-LAD2D. We propose the verification method based on mathematical theory and program function as well as availability of its program execution. Validation is executed by comparing with the experiment data. At last, we propose the future prospect of numerical simulation software and the CAE technique, and we also pay attention to the research direction of V&V&UQ.

关键词： Verification and validation Detonation Equation of state Detonation diffraction Reaction rate law

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Study on Effectiveness of Solitary-Wave-Like Form Based on Overtopping Data from Irregular Wave Tests

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China Ocean Engineering 2024年第4期38卷 701-710页

作者： LI xiao-liang Huang Gui-biao School of Naval Architecture&Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

The previous study conducted by Li(2022)demonstrates that the Goda graph can be adequately represented by a solitary-wave-like form across the entire range of relative water depth,with the exception of the extremely shallow ***,it remains uncertain whether this form is equally effective when applied to test data generated by irregular waves,as the Goda graph was initially developed based on overtopping data from regular wave ***,it is unclear whether this form is suitable for formulating overtopping discharge at composite vertical *** order to address these questions,a 2D overtopping experiment was conducted,incorporating both simple and composite types of vertical walls,with various relative water depths across the entire range,excluding the extremely shallow zone.A novel analysis procedure was developed,which proved to be highly productive and can be considered a general method for data ***,the study yielded two conclusions:(1)the solitary-wave-like form is remarkably effective in formulating overtopping test data generated by irregular waves,regardless of whether the vertical wall is simple or composite,and(2)the resulting formulas exhibit definitely better performance compared with existing formulas.

关键词： solitary-wave-like form overtopping discharge overtopping formula vertical wall

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Up-conversion of Nd^(3+)/Yb^(3+)/Tm^(3+) tri-doped CaTeO3 compound under excitation of 808 nm

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Rare Metals 2021年第4期40卷 1008-1013页

作者： Zhong-Qiang Ye Si-Guo xiao xiao-liang Yang School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China

Nd^(3+)/Yb^(3+)/Tm^(3+) tri-doped CaTeO3 compounds were prepared by a solid-state reaction *** blue up-conversion(UC) luminescence at around 476 nm,which corresponds to the Tm^(3+):^(1)G_(4)→^(3)H_(6) transition,was observed under 808-nm *** Nd^(3+)→Yb^(3+)→Tm^(3+) energy transfer process was responsible for the strong blue up-conversion emission in the tri-doped *** Tm^(3+) blue up-conversion emission intensity was strongly dependent on the concentrations of Yb^(3+) and Nd^(3+).The possible up-conversion mechanisms for the Nd^(3+)/Yb^(3+)/Tm^(3+) tri-doped CaTeO_(3) phosphor are discussed,based on the Nd^(3+) and Yb^(3+) concentration-dependent UC spectra,near-infrared luminescence spectra and luminescence decay curves.

关键词： Up-conversion Tellurite 808 nm Energy transfer

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LINEAR FINITE ELEMENT APPROXIMATIONS FOR THE TIMOSHENKO BEAM AND THE SHALLOW ARCH PROBLEMS

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Journal of Computational Mathematics 2002年第1期20卷 15-22页

作者： xiao-liang Cheng Wei-min Xue Department of Mathematics Zhejiang UniversityXixi CampusHangzhou 310028China Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong Kong

Focuses on a study that discusses the linear finite element approximations for the Timoshenko beam and the shallow arch problems with shear dampening and reduced integration. Information on the Timoshenko beam; Detail... 详细信息

关键词： Timoshenko beam shallow arch shear dampening reduced integration

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