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Four centrosome-related genes to predict the prognosis and drug sensitivity of patients with colon cancer

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1908-1924页

作者： hui-Yan Wang Yan Diao Pei-Zhu Tan Huan liang Department of Clinical Laboratory Harbin Medical University Cancer HospitalHarbin 150086Heilongjiang ProvinceChina Department of Clinical Laboratory Heilongjiang Province HospitalHarbin 150000Heilongjiang ProvinceChina Translational Medicine Center of Northern China Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina

BACKGROUND As the primary microtubule organizing center in animal cells,centrosome abnormalities are involved in human colon *** To explore the role of centrosome-related genes(CRGs)in colon *** CRGs were collected from public *** clustering analysis was performed to separate the Cancer Genome Atlas *** Cox and least absolute shrinkage selection operator regression analyses were performed to identify candidate prognostic CRGs and construct a centrosome-related signature(CRS)to score colon cancer patients.A nomogram was developed to evaluate the CRS risk in colon cancer *** integrated bioinformatics analysis was conducted to explore the correlation between the CRS and tumor immune microenvironment and response to immunotherapy,chemotherapy,and targeted ***-cell transcriptome analysis was conducted to examine the immune cell landscape of core prognostic *** A total of 726 CRGs were collected from public databases.A CRS was constructed,which consisted of the following four genes:TSC1,AXIN2,COPS7A,and *** cancer patients with a high-risk signature had poor *** with a high-risk signature exhibited decreased levels of plasma cells and activated memory CD4+T *** treatment response,patients with a high-risk signature were resistant to immunotherapy,chemotherapy,and targeted ***7A expression was relatively high in endothelial cells and ***1 expression was high in endothelial cells,fibroblasts,and malignant *** We constructed a centrosome-related prognostic signature that can accurately predict the prognosis of colon cancer patients,contributing to the development of individualized treatment for colon cancer.

关键词： Colon cancer Centrosome Signature Prognostic Immune microenvironment Therapy

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改变镍钛合金人工食管管体结构在防止脱管中的作用

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中国组织工程研究与临床康复 2008年第35期12卷 6806-6810页

作者：梁建辉周星梁显亮广州医学院第二附属医院胸外科广东省广州市510260 广州迪克医疗器械有限公司广东省广州市510095

背景:应用涤纶连接环的设计有效地解决了人工食管研制中发生早期吻合口漏和脱管的难题,实验动物均能长期存活。但带涤纶连接环记忆合金组合式人工食管还存在中晚期脱管的问题未能完全解决。目的:观察改变镍钛合金组合式人工食管的管体... 详细信息

背景:应用涤纶连接环的设计有效地解决了人工食管研制中发生早期吻合口漏和脱管的难题,实验动物均能长期存活。但带涤纶连接环记忆合金组合式人工食管还存在中晚期脱管的问题未能完全解决。目的:观察改变镍钛合金组合式人工食管的管体结构在防止脱管中的作用。设计、时间及地点:对比观察动物实验,于2007-09/2008-05在广州医学院第二附属医院动物实验室完成。材料:健康小型实验香猪6只由广东省医学实验动物中心提供。带涤沦连接环编织型外层裸管体双层结构镍钛合金组合式人工食管和带涤沦连接环网格型覆膜单管结构镍钛合金组合式人工食管均由北京有色金属研究学院制作提供。方法:通过手术切除一段长约7cm的胸段食管,应用编织型和网格型两种不同管体结构的镍钛合金组合式人工食管替代胸段食管重建食管通道的方法,建立两组实验动物模型,每组3只。主要观察指标:人工食管的位置,新生食管与植入体的结合状况。结果:实验动物均存活超过3个月。网格型组3只(100%)术后3个月内全部出现脱管,脱管发生时间60～68d(平均63d)。编织型组3只(100%)术后3个月内无发生脱管,远近端正常食管无扩张及狭窄,新生食管中间段部分管壁组织向植入体网孔内长入紧密固定。结论:编织型镍钛合金组合式人工食管替代胸段食管后,成功诱导新生食管与管体紧密结合,提示改变镍钛合金组合式人工食管管体结构是防止脱管的有效方法,同时也是解决永久性人工食管脱管这一难题的有效途径。

关键词：镍钛合金人工食管管体结构动物实验

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Rapid detection of nanoplastic particles by a luminescent Tb-based coordination polymer

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Chinese Chemical Letters 2024年第5期35卷 529-533页

作者： Tiankai Sun hui Min Zongsu Han liang Wang Peng Cheng Wei Shi Department of Chemistry College of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Separation Membranes and Membrane Processes School of Environmental Science and EngineeringTiangong UniversityTianjin 300387China Key Laboratory of Advanced Energy Materials Chemistry(MOE) Frontiers Science Center for New Organic Matter and Renewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Nanoplastics(NPs)in aqueous environment have become a category of emerging pollutants on account of their potential risks to both human health and *** detection of NPs is a great challenge due to the lack of sensitive and selective sensing materials with fast response time and wide sensing range of particle ***,a Tb-based coordination polymer has been synthesized for luminescent detection of nanopolystyrene with different particle sizes in aqueous solutions,showing a low limit of detection,fast response time within 10 s and high selectivity in the presence of other ***“turn-on”sensing mechanism is studied in *** work provides a facile method for the fast detection of NPs.

关键词： Coordination polymer Nano polystyrene Luminescent detection Sensing mechanism Water safety

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Mineralogical properties and co-sintering characteristics of fluxed iron ore with magnetite concentrates

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Journal of Iron and Steel Research International 2024年第2期31卷 318-328页

作者： Le-le Niu Zheng-jian Liu jian-liang Zhang Yao-zu Wang Zhen-xing Yang Si-da Li Chang-dong Shan Ben Feng School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Institute of Artificial Intelligence University of Science and Technology BeijingBeijing100083China Xinxing Casting Pipe Xinjiang Co. Bayingol841300XinjiangChina

To investigate the feasibility of co-sintering of fluxed iron ore with magnetite concentrates, the mineralogical properties of a novel fluxed iron ore were studied using particle size analysis, microscopic morphology characterization, and X-ray diffraction Rietveld analysis. Following that, the experiments for granulation performance and basic sintering characteristics were designed under seven different fluxed iron ore ratios, and the integrated ranking of different fluxed iron ore ratios was determined using gray relation analysis. Finally, the results of the industrial trails were combined with the feasibility analysis. Test and experimental results show that the fraction of the fluxed iron ore particles larger than 0.5 mm can account for more than 48%, and the particles have two morphologies: spherical-rough and flaky-smooth. Ca elements are found in the form of calcite (CaCO3) and dolomite (CaMg(CO3)2). The average particle size of granules and powder removal rate can be improved from 2.50 to 3.16 mm and 39.60% to 24.20%, respectively, with the increase in the fluxed iron ore ratio. Furthermore, the fluxed iron ore can improve assimilability and liquid fluidity of magnetite concentrates. In terms of overall granulation performance and sintering characteristics, the fluxed iron ore ratios are graded from best to worst as follows: 12%, 15%, 9%, 18%, 21%, 6% and 3%. The industrial trails show that when the fluxed iron ore ratio is increased, the beneficial effect of the superior sintering characteristics of the fluxed iron ore itself is ideally balanced with the negative effect of the lower amount of additional CaO at 12% ratio, and thus, it is feasible to bring the fluxed iron ore into production at a level of roughly 12%.

关键词： Fluxed iron ore Magnetite concentrate Granulation performance Sintering characteristics Gray relation analysis

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广东省普通高校排球队发展制约因素及对策研究

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广州体育学院学报 2012年第3期32卷 65-68页

作者：梁健辉广东药学院体育部广东广州510006

通过搜集文献资料、发放问卷、专家访谈等方法,从高校排球竞赛、教学与训练、教练员与运动员,以及场地设施等方面对广东普通高校排球队的现状进行调查研究,分析制约其发展的主要因素,并针对存在的问题提出完善竞赛制度、加强教练员队伍... 详细信息

通过搜集文献资料、发放问卷、专家访谈等方法,从高校排球竞赛、教学与训练、教练员与运动员,以及场地设施等方面对广东普通高校排球队的现状进行调查研究,分析制约其发展的主要因素,并针对存在的问题提出完善竞赛制度、加强教练员队伍建设、扩大学生排球队伍、加强训练管理,以及加大场地设施建设投入等相应对策,为广东普通高校排球运动的发展提供科学依据和理论参考。

关键词：高校排球队调查研究

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中美女子体操全能运动员单项能力比较

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体育文化导刊 2010年第12期 34-37页

作者：梁健辉广东药学院体育部广州510006

运用文献资料、逻辑分析、录像观察和数理统计等方法对近3次世界体操大赛中、美女子全能运动员成绩以及各单项前3名的成绩进行比较分析,找出我国女子全能运动员的不足。主要结论:稳定的发挥是保证,较强的单项能力是关键;我国运动员的单... 详细信息

运用文献资料、逻辑分析、录像观察和数理统计等方法对近3次世界体操大赛中、美女子全能运动员成绩以及各单项前3名的成绩进行比较分析,找出我国女子全能运动员的不足。主要结论:稳定的发挥是保证,较强的单项能力是关键;我国运动员的单项能力不强,缺少竞争力;我国该项目的后备人才储备不足,缺少年轻的优秀全能运动员。

关键词：竞技体育中美女子体操全能单项能力

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FC200现场总线模块在转炉炼钢厂的应用

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冶金自动化 2011年第2期35卷 66-68页

作者：梁建辉宜科(天津)电子有限公司工程部

介绍现场总线模块原理及FC200现场总线模块产品的特点,结合转炉工艺特点配置系统硬件及设置参数;根据转炉工艺要求介绍编程要点。FC200现场总线模块是成熟的产品,经现场应用结果表明它能出色应用在冶金等行业,相比传统集中式系统节约大... 详细信息

介绍现场总线模块原理及FC200现场总线模块产品的特点,结合转炉工艺特点配置系统硬件及设置参数;根据转炉工艺要求介绍编程要点。FC200现场总线模块是成熟的产品,经现场应用结果表明它能出色应用在冶金等行业,相比传统集中式系统节约大量有色金属,减少自动化系统的整体投资,提高可靠性,方便维护。

关键词：现场总线技术 FC200模块 PLC编程

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Change in self-image pressure level before and after autologous fat breast augmentation and its effect on social adaptability

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World Journal of Psychiatry 2024年第6期14卷 920-929页

作者： jian Li hui-Min Wang Yang jiang Zhen-Nan Liu Bai-hui He Department of Plastic Surgery The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina Department of Otolaryngology The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina

BACKGROUND There is an increasingly strong demand for appearance and physical beauty in social life,marriage,and other aspects with the development of society and the improvement of material living *** increasing number of people have improved their appearance and physical shape through aesthetic plastic *** female breast plays a significant role in physical beauty,and droopy or atrophied breasts can frequently lead to psychological inferiority and lack of confidence in ***,in turn,can affect their mental health and quality of *** To analyze preoperative and postoperative self-image pressure-level changes of autologous fat breast augmentation patients and their impact on social *** We selected 160 patients who underwent autologous fat breast augmentation at the First Affiliated Hospital of Xinxiang Medical University from January 2020 to December 2022 using random sampling *** general information,selfimage pressure level,and social adaptability of the patients were investigated using a basic information survey,body image self-assessment scale,and social adaptability *** self-image pressure-level changes and their effects on the social adaptability of patients before and after autologous fat breast augmentation were *** We collected 142 valid *** single-factor analysis results showed no statistically significant difference in the self-image pressure level and social adaptability score of patients with different ages,marital status,and monthly ***,there were significant differences in social adaptability among patients with different education levels and employment *** correlation analysis results revealed a significant correlation between the self-image pressure level and social adaptability score before and after *** factors analysis results showed that the degree of concern caused by appearance in selfimage pressure,the degree of possible behavior

关键词： Autologous fat breast augmentation surgery Self-image stress level Social adaptability Analysis of correlation Structural equation model

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Unlocking the Potential of Poly(butylene succinate)through Incorporation of Vitrimeric Network Based on Dynamic Imine Bonds

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Chinese Journal of Polymer Science 2024年第10期42卷 1414-1424,I0006页

作者： Shan-Song Wu hui-Juan Lu Yi-Dong Li Shui-Dong Zhang jian-Bing Zeng Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing400715China School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou510640China

Poly(butylene succinate)(PBS)exhibits many advantages,such as renewability,biodegradability,and impressive thermal and mechanical properties,but is limited by the low melt viscosity and strength resulted from the linear *** address this,vitrimeric network was introduced to synthesize PBS vitrimers(PBSVs)based on dynamic imine bonds through melt polymerization of hydroxyl-terminated PBS with vanillin derived imine containing compound and hexamethylene diisocyanate using trimethylolpropane as a crosslinking *** with different crosslinking degrees were synthesized through changing the content of the crosslinking *** effect of crosslinking degree on the thermal,theological,mechanical properties,and stress relaxation behavior of the PBSVs was studied in *** results demonstrated that the melt viscosity,melt strength,and heat resistance were enhanced substantially without obvious depression in crystallizability,thermal stability,and mechanical properties through increasing crosslinking *** addition,the PBSVs exhibit thermal reprocessability with mechanical properties recovered by more than 90%even after processing for three ***,PBSV with improved melt properties shows significantly improved foamability compared to commercial *** research contributes to the advancement of polymer technology by successfully developing PBS vitrimers with improved properties,showcasing their potential applications in sustainable and biodegradable materials.

关键词： Poly(butylene succinate) Vitrimer Imine bonds Foamability

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A Simple-Prepared and Multi-Reusable Adhesive Based on Epoxy Vitrimer

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Chinese Journal of Polymer Science 2024年第10期42卷 1589-1594,I0015页

作者： Yu-Ting Wang Huan liang Yen Wei jian-Long Wang Xiang-Ming He Yang Yang Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing100084China The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing100084China

Adhesives play an important role in modern society's production and daily *** robust and sustainable adhesives remains a great *** we report a sustainable epoxy-vitrimer adhesive with high adhesive strength(about 10 MPa)and reusability(82%strength after 3 times).This adhesive can be fabricated from commercially available products through a straightforward hot-pressing method without the need of *** adhesive process is also simple,requiring only 30 min at 180℃.In addition,the vitrimer adhesive has the advantages of both erasability for reuse and excellent water *** work provides a facile strategy to fabricate high-strength adhesive that ensures reusability,recyclability,low cost of raw materials,and simple processing ***,it expands the range of potential applications for epoxy vitrimers.

关键词： Epoxy Vitrimer Adhesive Reusable Sustainable

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