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Effects of sorafenib combined with chemoembolization and radiofrequency ablation for large, unresectable hepatocellular carcinomas

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Chinese Medical Journal 2013年第22期126卷 4270-4276页

作者： liang heng-yi lu li-gong hu bao-shan li yong shao pei-jian Division of Interventional Radiology of Guangdong General Hospital Guangdong Academy of Medical Science Guangzhou Guangdong 510080 China

Background The prognosis of unresectable large hepatocellular carcinomas is poor. This study evaluated the efficacy and safety of sorafenib combined with transcatheter arterial chemoembolization and radiofrequency ablation in the treatment of hepatocellular carcinomas larger than 5 cm. Methods The treatment of 22 patients with large, unresectable hepatocellular carcinomas （5.0-16.5 cm） treated with sorafenib after transcatheter arterial chemoembolization combined with radiofrequency ablation between 2007 and 2011 was reviewed. The local effects, survival rates, toxicity, and prognostic factors were analyzed. Results During a follow-up of 9-49 months, 19 patients died and three survived. The median overall survival was 32 months. The overall cumulative 12, 24, and 36-month survival rates were 85.9%, 66.8%, and 23.5% respectively. Technical effectiveness was achieved in 12 out of 28 lesions （42.85%） at the first CT check. The median time to tumor progression was 21 months. The progression-free survival rates at 6, 12, and 24 months were 90.9%, 72.0%, and 38.4%, respectively. Combined therapy was generally well tolerated. There was only one major procedure-related complication, biloma （4.5%）. Sorafenib-related adverse events exceeding grade 3 were hand-foot skin reaction （2/22, 9.1%）, gastrointestinal hemorrhage （1/22, 4.5%）, and diarrhea （2/22, 9.1%）. The absence of vascular invasion before treatment was found to be the best prognostic factor in the univariate analysis. Conclusions Sorafenib combined with transcatheter arterial chemoembolization and radiofrequency ablation is a promising approach to the treatment of large, unresectable hepatocellular carcinomas. However, large-scale randomized clinical trials are needed to determine the future role of this treatment.

关键词： hepatocellular carcinoma, sorafenib angiogenesis inhibitors transcatheter arterial chemoembolization radiofrequency ablation

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血浆碱性成纤维细胞生长因子预测TACE治疗肝细胞癌的疗效

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中国医学影像技术 2012年第10期28卷 1861-1865页

作者：禹娴怡陆骊工李勇胡宝山邵培坚广东省医学科学院广东省人民医院肿瘤中心介入治疗科广东广州510080

目的探讨血浆碱性成纤维细胞生长因子(bFGF)在肝细胞癌(HCC)患者TACE术后的变化,评价这种趋势与疗效的关系。方法对49例HCC行TACE,于术前及术后4周进行血浆bFGF、肝功能及CT检查。将术后4周血浆bFGF下降≥TACE术前bFGF的20%者纳入下降组... 详细信息

目的探讨血浆碱性成纤维细胞生长因子(bFGF)在肝细胞癌(HCC)患者TACE术后的变化,评价这种趋势与疗效的关系。方法对49例HCC行TACE,于术前及术后4周进行血浆bFGF、肝功能及CT检查。将术后4周血浆bFGF下降≥TACE术前bFGF的20%者纳入下降组,否则纳入未下降组。将TACE术后4周CT示肿瘤坏死区域面积≥肿瘤总面积的50%定义为肿瘤缓解。结果术前肿瘤直径≥5cm或合并乙型肝炎者bFGF较高。术后4周血浆bFGF下降组共16例,其肿瘤缓解率高于未下降组(P<0.05)。结论 HCC患者的血浆bFGF可能是预测TACE疗效的指标之一。TACE术后血浆bFGF下降的HCC患者更易发生肿瘤缓解,且其生存期明显延长。

关键词：癌,肝细胞化学栓塞,治疗性碱性成纤维细胞生长因子

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索拉非尼治疗中晚期肝癌相关的手足皮肤反应与疗效的关系

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中华医学杂志 2012年第13期92卷 889-893页

作者：罗小宁陆骊工邵培坚胡宝山李勇禹娴怡何旭南方医科大学广东省医学科学院广东省人民医院介入科广州510080

目的探讨索拉非尼治疗中晚期肝癌相关的手足皮肤反应（HFRS）与疗效的关系。方法分析广东省人民医院肿瘤介入科2008年5月至2011年6月51例索拉非尼联合经导管肝动脉化疗栓塞术（TACE）治疗的中晚期肝癌患者资料，比较HFRS0级、1—2级、3... 详细信息

目的探讨索拉非尼治疗中晚期肝癌相关的手足皮肤反应（HFRS）与疗效的关系。方法分析广东省人民医院肿瘤介入科2008年5月至2011年6月51例索拉非尼联合经导管肝动脉化疗栓塞术（TACE）治疗的中晚期肝癌患者资料，比较HFRS0级、1—2级、3级三组患者间的疾病控制率（DCR）、中位无疾病进展生存期（mPFS）、中位生存期（mOS）的差异，Cox模型分析影响PFS的因素。结果13／51例未出现HFRS（即0级），38／51例出现HFRS，其中，1～2级27例，3级11例，三组DCR分别为38．5％、70．4％、90．9％，0级组比1～3级组的DCR：38．5％比76．3％，P=0．031，1—2级组比3级组，P=0．352；三组的mPFS分别为2．8（95％CI1．6—4．0）、4．5（95％CI1．3—7．7）和12．8（95％CI3．7—21．9）个月，0级组比1～2级组，P=0．019，相关风险比（HR）：2．8（95％CI1．3—6．3），P=0．010，0级组比3级组，P〈0．01，HR：6．6（95％CI2．3～19．0），P〈0．01，差异均有统计学意义，1—2级组比3级组，P=0．054；三组mOS分别为8．5（95％CI5．9—11．1）、13．0（95％CI10．1～15．9）和25．4个月，两两比较，P〈0．05。结论HFRS可作为索拉非尼治疗中晚期肝癌临床疗效的预示指标，但是疗效是否随HFRS严重程度的递增而增加尚待论证。

关键词：癌,肝细胞药疹索拉非尼

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血清VEGFR-2浓度预测行肝动脉化疗栓塞肝癌患者的预后

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中华医学杂志 2013年第5期93卷 341-344页

作者：孟庆雯李勇胡宝山邵培坚占美晓禹娴怡陆骊工南方医科大学广东省医学科学院广东省人民医院介入科广州510080

目的探讨血清血管内皮生长因子受体-2（VEGFR-2）在预测行肝动脉栓塞化疗（TACE）的原发性肝癌患者（HCC）预后中的作用。方法选取2008年10月至2012年4月广东省人民医院介入科行TACE治疗的69例HCC患者，采用酶联免疫吸附实验（EMSA）方... 详细信息

目的探讨血清血管内皮生长因子受体-2（VEGFR-2）在预测行肝动脉栓塞化疗（TACE）的原发性肝癌患者（HCC）预后中的作用。方法选取2008年10月至2012年4月广东省人民医院介入科行TACE治疗的69例HCC患者，采用酶联免疫吸附实验（EMSA）方法检测行TACE术前及术后患者血清VEGFR-2浓度；分析血清VEGFR-2浓度与临床病理特征和预后的关系。结果血清VEGFR-2浓度在有无肝硬化组及肿瘤数目分组差异有统计学意义（P=0．021，P=0．049），与其他临床基线资料差异未发现有统计学意义；HCC患者行TACE术后[（10558±7007）ng/L]和术前[（8709±6510）ng/L]血清VEGFR-2浓度差异有统计学意义（P=0．045）；按术前血清VEGFR-2浓度平均数8709ng／L分组，术前血清VEGFR-2高浓度的HCC患者其总生存时间及无疾病进展时间短于血清VEGFR-2低浓度的患者（17个月比28个月，P=0．001；10个月比15个月，P=0．031）。Cox回归示术前血清VEGFR-2浓度是独立预后因素。结论术前血清VEGFR-2浓度可以预测行TACE的HCC患者的预后。

关键词：癌肝细胞药物疗法联合血管内皮生长因子受体2

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Investigation of 182W Interference for 182Hf AMS Measurement

Investigation of 182W Interference for 182Hf AMS Measurement

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作者： DONG Ke-jun HE Ming jianG shan li Zheng-yu WANG Xiang-gao li Chao-li WU shao-yong SHEN Hong-tao HE Guo-zhu YOU Qu-bo bao yi-wen li Shi-zhuo gong Jie ZHANG Wei HE Xian-wen lu li-yan WANG Wei hu Yue-ming YUAN jian Department of Physics Guangxi University

A series of compounds are used to investigate the interference of W for the experiment of Hf AMS *** result shows that the main interference comes from the isotope combination of O, Br,Cu,N etc.,rather than the form of WF Therefore,the key of measurement sensitivity is to decrease the element contents of O,Br,Cu,N *** the sample of HfF.

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肝动脉化疗栓塞联合索拉非尼治疗中晚期肝细胞癌的临床疗效观察

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中华放射学杂志 2012年第3期46卷 252-256页

作者：魏照光陆骊工邵培坚胡宝山李勇张磊何旭禹娴怡罗小宁广东省人民医院介入治疗科广州510080

目的探讨经导管肝动脉化疗栓塞（TACE）联合索拉非尼治疗中晚期肝细胞癌的疗效和安全性。方法回顾性对比分析2008年7月至2010年11月收治的TACE后口服索拉非尼的44例中晚期肝细胞癌患者（联合组），和同期仅行TACE的44例中晚期肝细胞癌... 详细信息

目的探讨经导管肝动脉化疗栓塞（TACE）联合索拉非尼治疗中晚期肝细胞癌的疗效和安全性。方法回顾性对比分析2008年7月至2010年11月收治的TACE后口服索拉非尼的44例中晚期肝细胞癌患者（联合组），和同期仅行TACE的44例中晚期肝细胞癌患者（介入组）的疗效。疗效判断采用修正后的实体瘤治疗疗效评价标准（mRECIST），观察患者从TACE治疗开始至疾病进展时间（TTP）、总生存期（OS）、不良事件。结果采用Kaplan—Meier法和Log—rank检验进行生存评估。结果随访至2011年1月，联合组24例患者存活（54．5％），20例（含失访）死亡（45．5％）；介入组13例存活（29．5％），31例（含失访）死亡（70．5％）；两组均没有完全缓解（CR）病例，联合组部分缓解1例、病灶稳定24例、疾病进展19例，介入组病灶稳定21例、疾病进展23例。疾病控制率（DCR）联合组为56．8％（25／44），介入组为47．7％（21／44），两者差异无统计学意义（χ2=0．729，P=0．393）。中位0s联合组为21．0[95％可信区间（CD：14．9～27．1]个月，介入组为10．0（95％CI：6．4～13．6）个月，两者差异有统计学意义（χ2=7．436，P=0．006）；中位TTP联合组为11．0（95％CI：8．7～13．3）个月，介入组为6．0（95％CI：3．9～8．1）个月，两者差异也有统计学意义（χ2=10．437，P=0．001）。联合组不良反应主要是手足皮肤反应、食欲下降、发热，乏力、腹泻等；单纯介入组不良反应主要是发热、食欲下降、恶心呕吐、乏力等。其中手足反应、脱发、腹泻的发生率联合组高于单纯介入组（P值均〈0．05），两组不良反应主要是1—2级，经对症处理后大部分能够缓解。结论TACE联合索拉非尼治疗中晚期肝细胞癌较单用TACE治疗能够延长患者OS和1TP，但DCR两组无差异。

关键词：化学栓塞治疗性癌肝细胞治疗效果

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门静脉支架联合肝动脉化疗栓塞治疗肝癌伴门静脉癌栓的临床研究

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介入放射学杂志 2011年第12期20卷 968-973页

作者：张磊陆骊工李勇邵培坚胡宝山魏照光何旭禹娴怡罗小宁广东省人民医院肿瘤中心介入治疗科广东省医学科学院 510080

目的探讨经皮肝门静脉内支架植入术(PTPVS)联合肝动脉化疗栓塞(TACE)治疗肝癌伴门静脉癌栓的临床疗效及安全性,并探索影响疗效的因素。方法 2009年1月-2010年10月在已临床确诊为肝癌伴门静脉癌栓患者中,按要求筛选病例62例,采用对照、... 详细信息

目的探讨经皮肝门静脉内支架植入术(PTPVS)联合肝动脉化疗栓塞(TACE)治疗肝癌伴门静脉癌栓的临床疗效及安全性,并探索影响疗效的因素。方法 2009年1月-2010年10月在已临床确诊为肝癌伴门静脉癌栓患者中,按要求筛选病例62例,采用对照、非随机方法分为治疗组和对照组,对照组30例单接受TACE治疗;治疗组32例先接受PTPVS再行TACE治疗,其中2例病例放置门静脉支架未成功。评价指标为总生存时间和安全性。随访患者生存时间,并记录PTPVS术后并发症。用Kaplan-Meier生存分析法分析患者生存时间,两组间生存时间比较用Log-rank法检验;用Cox比例风险回归模型探讨影响患者临床预后的因素。结果治疗组中位总生存期为6.5个月,对照组中位总生存期为4.5个月(治疗组风险比为0.570,95%CI为0.328～0.992,P=0.037),两组间差异有统计学意义(P<0.05)。治疗组30例患者在3、6、12和18个月积累生存率分别为70%、56.7%、10%、3.3%。治疗组在术后1周内未出现手术相关并发症,远期出现的并发症有肝性脑病(2例,6.6%)、上消化道出血(呕血或黑便,3例,10%)、肝肾综合征(1例,3.3%)。结论在肝癌合并门静脉一级分支或(和)门静脉主干不完全闭塞癌栓患者中,PTPVS联合TACE治疗组中位生存期比单独TACE治疗组延长约2个月。治疗方案的安全性较好。

关键词：肝癌门静脉癌栓经皮经肝门静脉内支架植入术经导管动脉化疗栓塞

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Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao Song Chen Yan-Fen Chai Xiao-hui Chen Yu-Guo Chen shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding Yang Deng Jie Fu Bang-jiang Fang Mai-ying Fan li Gui Ping gong Wei Guo Shu-Bin Guo liang huang Ji-Yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-Xu Jin Xin-Jun jiang Wang-Xiang jiang Jia-liang liu Xiao-Ran liu Zhi liu Chuan-Zhu Lv Feng lu Tan-Shi li Xin li yong li shang-lun li Shuang-Ming li Xiao-Gang li bao-Jun li pei-Wu li Chun-Sheng li Zhi-Jun li Chang-luo li Xiang-Min li yin-Ping li Zong-Jun lu Zu-Xun lu Zhong-Qiu lu Zhi-Qian luo Xiao-Xing liao jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma Qing-Bian Ma lin-Hao Ma Jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-Yang Peng Peng Qiao pei Shu-Ming Pan Guo-Zhong Qing li-Jie Qin Wu-ying Qiao Fei shao Wei Song Xing-Yue Song Zhen-Ju Song Rong-Ju Sun De-Ya shang Du-Juan Sha Gui-Lan Tao Guo-Gang Tian ying-Ping Tian jian-Guang Tian Chao-Yang Tong Zi-Ren Tang Meng-Xiong Tang Guo-Ping Wu Zhi Wan Tao Wang Xin Wang Peng Wang Zhong Wang Tong Wang Ri-Xing Wang yi-Xin Wang Xiao-Dan Wang ling Wu Wei Wei hua Xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu Wen yi li-shan Yang Shi-Jiao Yan Jin-jian Yao Shou-Chun Yan Xue-Zhong Yu Xian-Zhi Ye Xian-liang Yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou Qiang Zhou Jin Zhou Ping Zhou Chang-Ju Zhu hua-Dong Zhu Ji-Hong Zhu Hong Zhang Mao Zhang hua Zhang Na Zhang Guo-Qiang Zhang Guo-Xiu Zhang Jin-Song Zhang Wen-Wu Zhang Wen-Zhong Zhang jian-Feng Zhang yi-Min Zhu Jun Zeng Yuan Zheng Zhi-Jie Zheng Shen Zhao Yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade yong Ban Tripamo Bandyopadhyay Shou-shan bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai yijian Cai yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen shanhong Chen shanzhen Chen shao-Long Chen shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhu&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Reconstruction of Cherenkov image bymultiple telescopes of LHAASO-WFCTA

引用

Radiation Detection Technology and Methods 2022年第4期6卷 544-557页

作者： F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.bao D.Bastieri X.J.Bi Y.J.Bi J.T.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang E.S.Chen liang Chen liang Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen H.L.Cheng N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.D’Ettorre Piazzoli B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu Ddella Volpe K.K.Duan J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng X.T.Feng Y.L.Feng B.Gao C.D.Gao L.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.H.gong Q.B.Gou M.H.Gu F.L.Guo J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He S.L.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.hu Q.hu S.hu S.C.hu X.J.hu D.H.huang W.H.huang X.T.huang X.Y.huang Y.huang Z.C.huang X.L.Ji H.Y.Jia K.Jia K.jiang Z.J.jiang M.Jin M.M.Kang T.Ke D.Kuleshov K.Levochkin B.B.li Cheng li Cong li F.li H.B.li H.C.li H.Y.li J.li jian li Jie li K.li WLli XRli Xin li Xin li YZli Zhe li Zhuo li E.W.liang Y.F.liang S.J.lin B.liu C.liu D.liu H.liu H.D.liu J.liu J.L.liu J.S.liu J.Y.liu M.Y.liu R.Y.liu S.M.liu W.liu Y.liu Y.N.liu W.J.Long R.lu Q.luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood Z.Min W.Mitthumsiri Y.C.Nan Z.W.Ou B.Y.Pang P.Pattarakijwanich Z.Y.pei M.Y.Qi Y.Q.Qi B.Q.Qiao J.J.Qin D.Ruffolo A.Sáiz C.Y.shao L.shao O.Shchegolev X.D.Sheng J.Y.Shi H.C.Song Yu.V.Stenkin V.Stepanov Y.Su Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.Wang R.N.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin Y.L.Xin Y.Xing Z.Xiong D.L.Xu R.X.Xu L.Xue D.H.Yan J.Z.Yan C.W.Yang F.F.Yang H.W.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.yin N.yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang F.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang L.X.Zhang li Zhang lu Zhang P.F.Zhang P.P.Zhang R.Zhang S.B.Zhang S.R.Zhang S. Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics BeijingChina University of Science and Technology of China Hefei 230026AnhuiChina School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Physics Sichuan UniversityChengdu 610065SichuanChina School of Astronomy and Space Science Nanjing UniversityNanjing 210023JiangsuChina Center for Astrophysics Guangzhou UniversityGuangzhou 510006GuangdongChina Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Hebei Normal University Shijiazhuang 050024HebeiChina School of Physics and Astronomy(Zhuhai)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000China School of Physics(Guangzhou) Sun Yat-sen UniversityGuangzhou 510275GuangdongChina Dipartimento di Fisica dell’Universitàdi Napoli“Federico II” Complesso Universitario di Monte Sant’Angelovia Cinthia80126 NapoliItaly School of Physics and Astronomy Yunnan UniversityKunming 650091YunnanChina Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève

Introduction One of main scientiﬁc goals of the Large High Altitude Air Shower Observatory(LHAASO)is to accurately measure the energy spectra of different cosmic ray compositions around the‘knee’*** Wide Field-of-View(FoV)Cherenkov Telescope Array(WFCTA),which is one of the main detectors of LHAASO and has 18 telescopes,is built to achieve this *** telescopes are put together and point to connected directions for a larger *** Telescopes are deployed spatially as close as possible,but due to their own size,the distance between two adjacent telescopes is about 10 ***,the Cherenkov lateral distribution and the parallax between the two telescopes should be considered in the event building process for images crossing over the boundaries of FoVs of the *** event building method for Cherenkov images measured by multiple telescopes of WFCTA is *** performance of the shower measurements using the combined images is evaluated by comparing with showers that are fully contained by a virtual telescope in *** and conclusion It is proved that the developed event building process can help to increase the FoV of WFCTA by 30%while maintaining the same reconstruction quality,compared to the separate telescope reconstruction method.

关键词： method directions conclusion

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